IFNα induces Fas expression and apoptosis in hedgehog pathway activated BCC cells through inhibiting Ras-Erk signaling

Oncogene

Volumn 23, Issue 8, 2004, Pages 1608-1617

  Li, Chengxin ^a,c   Chi, Sumin ^a   He, Nonggao ^a   Zhang, Xiaoli ^a   Guicherit, Oivin ^b   Wagner, Richard ^a   Tyring, Stephen ^a   Xie, Jingwu ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b CURIS INC   (United States)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

BCCs; FAs; Hedgehog; INF ; MEK; PDGFR ; Smoothened

Indexed keywords

ALPHA INTERFERON; CASPASE 8 INHIBITOR; FAS ANTIGEN; FAS LIGAND; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NEUTRALIZING ANTIBODY; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEIN SMO; RAF PROTEIN; RAS PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE KINASE; SHH PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; BASAL CELL CARCINOMA; CARCINOMA CELL; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENE INDUCTION; GENE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SERUM RESPONSIVE ELEMENT; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; ANIMAL; APOPTOSIS; BIOLOGICAL MODEL; CELL SURVIVAL; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANIMALIA; ERINACEIDAE;

ANIMALS; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, BASAL CELL; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME ACTIVATION; HEDGEHOG PROTEINS; HUMANS; INTERFERON-ALPHA; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MODELS, BIOLOGICAL; RAS PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 1542427154     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207273     Document Type: Article

References (34)

1. Aszterbaum M, Rothman A, Johnson RL, Fisher M, Xie J, Bonifas JM, Zhang X, Scott MP and Epstein Jr EH. (1998). J. Invest. Dermatol., 110, 885-888.
2. Bodak N, Queille S, Avril MF, Bouadjar B, Drougard C, Sarasin A and Daya-Grosjean L. (1999). Proc. Natl. Acad. Sci. USA, 96, 5117-5122.
3. Buechner SA, Wernli M, Harr T, Hahn S, Itin P and Erb P. (1997). J. Clin. Invest., 100, 2691-2696.
4. Chimenti S, Peris K, Di Cristofaro S, Fargnoli MC and Torlone G. (1995). Dermatology, 190, 214-217.
5. Darnell Jr JE. (1996). Recent Prog. Horm. Res., 51, 391-403.
6. Epstein Jr E. (2001). Med. Pediatr. Oncol., 36, 555-558.
7. Fenton RG, Hixon JA, Wright PW, Brooks AD and Sayers TJ. (1998). Cancer Res., 58, 3391-3400.
8. Filipowicz E, Adegboyega P, Sanchez RL and Gatalica Z. (2002). Cancer, 94, 814-819.
9. Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL and Porter JA. (2002). J. Biol., 1, 10.1-10.19.
10. Gailani MR, Stahle-Backdahl M, Leffell DJ, Glynn M, Zaphiropoulos PG, Pressman C, Unden AB, Dean M, Brash DE, Bale AE and Toftgard R. (1996). Nat. Genet., 14, 78-81.
11. Goodrich LV, Milenkovic L, Higgins KM and Scott MP. (1997). Science, 211, 1109-1113.
12. Gorlin RJ. (1987). Medicine (Baltimore), 66, 98-113.
13. Grob JJ, Collet AM, Munoz MH and Bonerandi JJ. (1988). Lancet, 1, 878-879.
14. Gutierrez-Steil C, Wrone-Smith T, Sun X, Krueger JG, Coven T and Nickoloff BJ. (1998). J. Clin. Invest., 101, 33-39.
15. Hahn H, Wojnowski L, Zimmer AM, Hall J, Miller G and Zimmer A. (1998). Nat. Med., 4, 619-622.
16. Hottiger MO, Dam TN, Nickoloff BJ, Johnson TM and Nabel GJ. (1999). Gene Ther., 6, 1929-1935.
17. Kazama H and Yonehara S. (2000). J. Cell. Biol., 148, 557-566.
18. Lam CW, Xie J, To KF, Ng HK, Lee KC, Yuen NW, Lim PL, Chan LY, Tong SF and McCormick F. (1999). Oncogene, 18, 833-836.
19. Larner A and Reich NC. (1996). Biotherapy, 8, 175-181.
20. Lee SH, Jang JJ, Lee JY, Kim SY, Park WS, Shin MS, Dong SM, Na EY, Kim KM, Kim CS, Kim SH and Yoo NJ. (1998). Br. J. Dermatol., 139, 186-191.
21. McCormick F. (1994). Curr. Opin. Genet. Dev., 4, 71-76.
22. Miller DL and Weinstock MA. (1994). J. Am. Acad. Dermatol., 30 (5 Part 1), 774-778.
23. Peli J, Schroter M, Rudaz C, Hahne M, Meyer C, Reichmann E and Tschopp J. (1999). EMBO J., 18, 1824-1831.
24. Reifenberger J, Wolter M, Weber RG, Megahed M, Ruzicka T, Lichter P and Reifenberger G. (1998). Cancer Res., 58, 1798-1803.
25. Romerio F and Zella D. (2002). FASEB J., 16, 1680-1682.
26. Toftgard R. (2000). Cell Mol. Life Sci., 57, 1720-1731.
27. Vander Straten M, Lee P, Weitzul S, Cockerell CJ and Tyring SK. (2000). Adv. Dermatol., 16, 299-318.
28. Vorechovsky I, Tingby O, Hartman M, Stromberg B, Nister M, Collins VP and Toftgard R. (1997a). Oncogene, 15, 361-366.
29. Vorechovsky I, Unden AB, Sandstedt B, Toftgard R and Stahle-Backdahl M. (1997b). Cancer Res., 57, 4677-4681.
30. Wolter M, Reifenberger J, Sommer C, Ruzicka T and Reifenberger G. (1997). Cancer Res., 57, 2581-2585.
31. Xie J, Aszterbaum M, Zhang X, Bonifas JM, Zachary C, Epstein E and McCormick F. (2001). Proc. Natl. Acad. Sci. USA, 98, 9255-9259.
32. Xie J, Johnson RL, Zhang X, Bare JW, Waldman FM, Cogen PH, Menon AG, Warren RS, Chen LC, Scott MP and Epstein Jr EH. (1997a). Cancer Res., 57, 2369-2372.
33. Xie J, Murone M, Luoh SM, Ryan A, Gu Q, Zhang C, Bonifas JM, Lam CW, Hynes M, Goddard A, Rosenthal A, Epstein Jr EH and de Sauvage FJ. (1998). Nature, 391, 90-92.
34. Xie J, Quinn A, Zhang X, Bare J, Rothman A, Collins C, Cutone S, Rutter M, McCormick MK and Epstein Jr E. (1997b). Genes Chromosomes Cancer, 18, 305-309.