The Association between KCNQ1 Gene Polymorphism and Type 2 Diabetes Risk: A Meta-Analysis

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Sun, Qiman ^a   Song, Kang ^a   Shen, Xizhong ^a   Cai, Yu ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL KCNQ1;

ADULT; AGED; ALLELE; ARTICLE; CONTROLLED STUDY; ETHNICITY; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC MODEL; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; KCNQ1 GENE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; RISK ASSESSMENT;

ACTION POTENTIALS; ADULT; AGED; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; KCNQ1 POTASSIUM CHANNEL; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, GENETIC; REGRESSION ANALYSIS; RISK;

EID: 84868328459     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048578     Document Type: Article

References (42)

1. van Tilburg J, van Haeften TW, Pearson P, Wijmenga C, (2001) Defining the genetic contribution of type 2 diabetes mellitus. J Med Genet 38: 569-578.
2. Frayling TM, (2007) Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet 8: 657-662.
3. Barhanin J, Lesage F, Guillemare E, Fink M, Lazdunski M, et al. (1996) K(V)LQT1 and IsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature 384: 78-80.
4. Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, et al. (1996) Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet 12: 17-23.
5. Neyroud N, Tesson F, Denjoy I, Leibovici M, Donger C, et al. (1997) A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome. Nat Genet 15: 186-189.
6. Splawski I, Shen J, Timothy KW, Lehmann MH, Priori S, et al. (2000) Spectrum of mutations in long-QT syndrome genes: KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation 102: 1178-1185.
7. Demolombe S, Franco D, de Boer P, Kuperschmidt S, Roden D, et al. (2001) Differential expression of KvLQT1 and its regulator IsK in mouse epithelia. Am J Physiol Cell Physiol 280: C359-C372.
8. Ullrich S, Su J, Ranta F, Wittekindt O, Ris F, et al. (2005) Effects of IKs channel inhibitors in insulin-secreting INS-1 cells. Pflugers Arch 451: 428-436.
9. Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, et al. (2008) Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 40: 1092-1097.
10. Chen Z, Zhang X, Ma G, Qian Q, Yao Y, (2010) Association study of four variants in KCNQ1 with type 2 diabetes mellitus and premature coronary artery disease in a Chinese population. Mol Biol Rep 37: 207-212.
11. Been LF, Ralhan S, Wander GS, Mehra NK, Singh J, et al. (2011) Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: a study of 3,310 subjects from India and the US. BMC Med Genet 12: 18.
12. Cochran WG, (1954) The combination of estimates from different experiments. Biometrics 10: 101-129.
13. DerSimonian R, Laird N, (1896) Meta-analysis in clinical trials. Control Clin Trials 7: 177-188.
14. Thompson SG, Sharp SJ, (1999) Explaining heterogeneity in meta-analysis: a comparison of methods. Stat Med 18: 2693-2708.
15. Egger M, Davey Smith G, Schneider M, Minder C, (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315: 629-634.
16. Unoki H, Takahashi A, Kawaguchi T, Hara K, Horikoshi M, et al. (2008) SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 40: 1098-1102.
17. Lee YH, Kang ES, Kim SH, Han SJ, Kim CH, et al. (2008) Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population. J Hum Genet 53: 991-998.
18. Takeuchi F, Serizawa M, Yamamoto K, Fujisawa T, Nakashima E, et al. (2009) Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes 58: 1690-1699.
19. Qi Q, Li H, Loos RJ, Liu C, Wu Y, et al. (2009) Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Hum Mol Genet 18: 3508-3515.
20. Jonsson A, Isomaa B, Tuomi T, Taneera J, Salehi A, et al. (2009) A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion. Diabetes 58: 2409-2413.
21. Hu C, Wang C, Zhang R, Ma X, Wang J, et al. (2009) Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population. Diabetologia 52: 1322-1325.
22. Liu Y, Zhou DZ, Zhang D, Chen Z, Zhao T, et al. (2009) Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China. Diabetologia 52: 1315-1321.
23. Yamauchi T, Hara K, Maeda S, Yasuda K, Takahashi A, et al. (2010) A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet 42: 864-868.
24. Han X, Luo Y, Ren Q, Zhang X, Wang F, et al. (2010) Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population. BMC Med Genet 11: 81.
25. Tsai FJ, Yang CF, Chen CC, Chuang LM, Lu CH, et al. (2010) A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet 6: e1000847.
26. Tan JT, Ng DP, Nurbaya S, Ye S, Lim XL, et al. (2010) Polymorphisms identified through genome-wide association studies and their ass ociations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore. J Clin Endocrinol Metab 95: 390-397.
27. Grallert H, Herder C, Marzi C, Meisinger C, Wichmann HE, et al. (2010) Association of genetic variation in KCNQ1 with type 2 diabetes in the KORA surveys. Horm Metab Res 42: 149-151.
28. Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, et al. (2010) Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 42: 579-589.
29. Xu M, Bi Y, Xu Y, Yu B, Huang Y, et al. (2010) Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies. PLoS One 5: e14022.
30. Zhou JB, Yang JK, Zhao L, Xin Z, (2010) Variants in KCNQ1, AP3S1, MAN2A1, and ALDH7A1 and the risk of type 2 diabetes in the Chinese Northern Han population: a case-control study and meta-analysis. Med Sci Monit 16: BR179-183.
31. Saif-Ali R, Muniandy S, Al-Hamodi Z, Lee CS, Ahmed KA, et al. (2011) KCNQ1 variants associate with type 2 diabetes in Malaysian Malay subjects. Ann Acad Med Singapore 40: 488-492.
32. Tabara Y, Osawa H, Kawamoto R, Onuma H, Shimizu I, et al. (2011) Genotype risk score of common susceptible variants for prediction of type 2 diabetes mellitus in Japanese: the Shimanami Health Promoting Program (J-SHIPP study). Development of type 2 diabetes mellitus and genotype risk score. Metabolism 60: 1634-1640.
33. Odgerel Z, Lee HS, Erdenebileg N, Gandbold S, Luvsanjamba M, et al. (2012) Genetic variants in potassium channels are associated with type 2 diabetes in Mongolian population. J Diabetes 4: 238-242.
34. Saif-Ali R, Ismail IS, Al-Hamodi Z, Al-Mekhlafi HM, Siang LC, et al. (2011) KCNQ1 Haplotypes Associate with Type 2 Diabetes in Malaysian Chinese Subjects. Int J Mol Sci 12: 5705-5718.
35. van Vliet-Ostaptchouk JV, van Haeften TW, Landman GW, Reiling E, Kleefstra N, et al. (2012) Common variants in the type 2 diabetes KCNQ1 gene are associated with impairments in insulin secretion during hyperglycaemic glucose clamp. PLoS One 7: e32148.36.
36. Campbell DD, Parra MV, Duque C, Gallego N, Franco L, et al. (2012) Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a colombian population. PLoS One 7: e33570.
37. Yu W, Ma RC, Hu C, et al. (2012) Association between KCNQ1 genetic variants and obesity in Chinese patients with type 2 diabetes. Diabetologia 55: 2655-2659.
38. MacDonald PE, Ha XF, Wang J, Smukler SR, Sun AM, et al. (2001) Members of the Kv1 and Kv2 Voltage-Dependent K+ Channel Families Regulate Insulin Secretion. Mol Endocrinol 15: 1423-1435.
39. MacDonald PE, Sewing S, Wang J, Joseph JW, Smukler SR, et al. (2002) Inhibition of Kv2.1 Voltage-dependent K+ Channels in Pancreatic beta-Cells Enhances Glucose-dependent Insulin Secretion. J Biol Chem 277: 44938-44945.
40. Roe MWm, Worley JF III, Mittal AA, Kuznetsov A, DasGupta S, et al. (1996) Expression and Function of Pancreatic beta-Cell Delayed Rectifier K+ Channels. Role in Stimulus-Secretion Coupling. J Biol Chem 271: 32241-32246.
41. Zhang M, Houamed K, Kupershmidt S, Roden D, Satin LS, (2005) Pharmacological Properties and Functional Role of Kslow Current in Mouse Pancreatic {beta}-Cells: SK Channels Contribute to Kslow Tail Current and Modulate Insulin Secretion. J Gen Physiol 126: 353-363.
42. Baier LJ, Hanson RL, (2004) Genetic studies of the etiology of type 2 diabetes in Pima Indians: hunting for pieces to a complicated puzzle. Diabetes 53: 1181-1186.