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Volumn 213, Issue , 2012, Pages 233-265

Muscarinic mechanisms in psychotic disorders

Author keywords

Acetylcholine; Allosteric modulators; Antimuscarinic; Cholinergic; CHRM1 5; Knockout mice; M1 M5; Muscarinic receptor agonists; Schizophrenia; Xanomeline

Indexed keywords

2 ETHYL 8 METHYL 2,8 DIAZASPIRO[4.5]DECANE 1,3 DIONE; ALKALOID DERIVATIVE; APOMORPHINE; ARECOLINE; ATROPINE; CEVIMELINE; CHOLINERGIC RECEPTOR; CLOZAPINE; DOPAMINE RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; HALOPERIDOL; MILAMELINE; MUSCARINE; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; MUSCARINIC M1 RECEPTOR AGONIST; MUSCARINIC M2 RECEPTOR; MUSCARINIC M2 RECEPTOR AGONIST; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; MUSCARINIC RECEPTOR; NATURAL PRODUCT; OLANZAPINE; OXOTREMORINE; PILOCARPINE; SABCOMELINE; SCOPOLAMINE; UNINDEXED DRUG; XANOMELINE; NEUROLEPTIC AGENT;

EID: 84868306694     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-642-25758-2_9     Document Type: Article
Times cited : (16)

References (189)
  • 2
    • 79959720275 scopus 로고    scopus 로고
    • How prevalent are anxiety disorders in schizophrenia? A meta-analysis and critical review on a significant association
    • Achim AM, Maziade M, Raymond E, Olivier D, Merette C, Roy MA (2011) How prevalent are anxiety disorders in schizophrenia? A meta-analysis and critical review on a significant association. Schizophr Bull 37:811-821
    • (2011) Schizophr Bull , vol.37 , pp. 811-821
    • Achim, A.M.1    Maziade, M.2    Raymond, E.3    Olivier, D.4    Merette, C.5    Roy, M.A.6
  • 5
    • 0027200390 scopus 로고
    • Diagnosis and classification of schizophrenia
    • Andreasen NC, Carpenter WT Jr (1993) Diagnosis and classification of schizophrenia. Schizophr Bull 19(2):199-214 (Pubitemid 23183145)
    • (1993) Schizophrenia Bulletin , vol.19 , Issue.2 , pp. 199-214
    • Andreasen, N.C.1    Carpenter Jr., W.T.2
  • 7
    • 0029932501 scopus 로고    scopus 로고
    • Muscarinic receptors mediating depression and long-term potentiation in rat hippocampus
    • Auerbach JM, Segal M (1996) Muscarinic receptors mediating depression and long-term potentiation in rat hippocampus. J Physiol 492:479-493 (Pubitemid 26137757)
    • (1996) Journal of Physiology , vol.492 , Issue.2 , pp. 479-493
    • Auerbach, J.M.1    Segal, M.2
  • 8
    • 69249214135 scopus 로고    scopus 로고
    • Modeling cholinergic aspects of schizophrenia: Focus on the antimuscarinic syndrome
    • Barak S (2009) Modeling cholinergic aspects of schizophrenia: focus on the antimuscarinic syndrome. Behav Brain Res 204:335-351
    • (2009) Behav Brain Res , vol.204 , pp. 335-351
    • Barak, S.1
  • 9
    • 80053586432 scopus 로고    scopus 로고
    • Intact attentional processing but abnormal responding in M1 muscarinic receptor-deficient mice using an automated touchscreen method
    • Bartko SJ, Romberg C, White B, Wess J, Bussey TJ, Saksida LM (2011) Intact attentional processing but abnormal responding in M1 muscarinic receptor-deficient mice using an automated touchscreen method. Neuropharmacology 61:1366-1378
    • (2011) Neuropharmacology , vol.61 , pp. 1366-1378
    • Bartko, S.J.1    Romberg, C.2    White, B.3    Wess, J.4    Bussey, T.J.5    Saksida, L.M.6
  • 11
    • 0018606699 scopus 로고
    • Neurotransmitter receptors in frontal cortex of schizophrenics
    • Bennett JP Jr, Enna SJ, Bylund DB, Gillin JC, Wyatt RJ, Snyder SH (1979) Neurotransmitter receptors in frontal cortex of schizophrenics. Arch Gen Psychiatry 36:927-934 (Pubitemid 10121036)
    • (1979) Archives of General Psychiatry , vol.36 , Issue.9 , pp. 927-934
    • Bennett Jr., J.P.1    Enna, S.J.2    Bylund, D.B.3
  • 12
    • 0035543554 scopus 로고    scopus 로고
    • 1 muscarinic acetylcholine receptors activate extracellular signal-regulated kinase in CA1 pyramidal neurons in mouse hippocampal slices
    • DOI 10.1006/mcne.2001.1042
    • Berkeley JL, Gomeza J, Wess J, Hamilton SE, Nathanson NM, Levey AI (2001) M1 muscarinic acetylcholine receptors activate extracellular signal-regulated kinase in CA1 pyramidal neurons in mouse hippocampal slices. Mol Cell Neurosci 18:512-524 (Pubitemid 34008391)
    • (2001) Molecular and Cellular Neuroscience , vol.18 , Issue.5 , pp. 512-524
    • Berkeley, J.L.1    Gomeza, J.2    Wess, J.3    Hamilton, S.E.4    Nathanson, N.M.5    Levey, A.I.6
  • 14
    • 0025736130 scopus 로고
    • Cholinergic input to dopaminergic neurons in the substantia nigra: A double immunocytochemical study
    • Bolam JP, Francis CM, Henderson Z (1991) Cholinergic input to dopaminergic neurons in the substantia nigra: a double immunocytochemical study. Neuroscience 41:483-494
    • (1991) Neuroscience , vol.41 , pp. 483-494
    • Bolam, J.P.1    Francis, C.M.2    Henderson, Z.3
  • 15
    • 33847315633 scopus 로고    scopus 로고
    • Cognitive deficits and functional outcome in schizophrenia
    • DOI 10.2147/nedt.2006.2.4.531
    • Bowie CR, Harvey PD (2006) Cognitive deficits and functional outcome in schizophrenia. Neuropsychiatr Dis Treat 2:531-536 (Pubitemid 46321882)
    • (2006) Neuropsychiatric Disease and Treatment , vol.2 , Issue.4 , pp. 531-536
    • Bowie, C.R.1    Harvey, P.D.2
  • 20
    • 84868334532 scopus 로고    scopus 로고
    • Discovery of the first mAChR 5 (M5) selective ligand, an M5 positive allosteric modulator (PAM)
    • National Center for Biotechnology Information. PMID: 21433383
    • Bridges TM, Lewis LM, Weaver CD, Lindsley CW (2010) Discovery of the first mAChR 5 (M5) selective ligand, an M5 positive allosteric modulator (PAM). Probe Reports from the NIH Molecular Libraries Program. National Center for Biotechnology Information. PMID: 21433383
    • (2010) Probe Reports from the NIH Molecular Libraries Program
    • Bridges, T.M.1    Lewis, L.M.2    Weaver, C.D.3    Lindsley, C.W.4
  • 22
    • 0025330429 scopus 로고
    • Muscarinic receptor activation facilitates the induction of long-term potentiation (LTP) in the rat dentate gyrus
    • DOI 10.1016/0304-3940(90)90382-J
    • Burgard EC, Sarvey JM (1990) Muscarinic receptor activation facilitates the induction of long-term potentiation (LTP) in the rat dentate gyrus. Neurosci Lett 116:34-39 (Pubitemid 20237132)
    • (1990) Neuroscience Letters , vol.116 , Issue.1-2 , pp. 34-39
    • Burgard, E.C.1    Sarvey, J.M.2
  • 28
    • 0037691865 scopus 로고    scopus 로고
    • Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity
    • DOI 10.1046/j.1460-9568.2003.02588.x
    • Bymaster FP, Carter PA, Yamada M, Gomeza J, Wess J, Hamilton SE, Nathanson NM, McKinzie DL, Felder CC (2003a) Role of specific muscarinic receptor subtypes in cholinergic parasym-pathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity. Eur J Neurosci 17:1403-1410 (Pubitemid 36560839)
    • (2003) European Journal of Neuroscience , vol.17 , Issue.7 , pp. 1403-1410
    • Bymaster, F.P.1    Carter, P.A.2    Yamada, M.3    Gomeza, J.4    Wess, J.5    Hamilton, S.E.6    Nathanson, N.M.7    McKinzie, D.L.8    Felder, C.C.9
  • 30
    • 0032968914 scopus 로고    scopus 로고
    • Activation of M1-like muscarinic receptors is required for the induction of corticostriatal LTP
    • DOI 10.1016/S0028-3908(98)00199-3, PII S0028390898001993
    • Calabresi P, Centonze D, Gubellini P, Bernardi G (1999) Activation of M1-like muscarinic receptors is required for the induction of corticostriatal LTP. Neuropharmacology 38:323-326 (Pubitemid 29073555)
    • (1999) Neuropharmacology , vol.38 , Issue.2 , pp. 323-326
    • Calabresi, P.1    Centonze, D.2    Gubellini, P.3    Bernardi, G.4
  • 31
    • 0035968007 scopus 로고    scopus 로고
    • Impulsive choice induced in rats by lesions of the nucleus accumbens core
    • DOI 10.1126/science.1060818
    • Cardinal RN, Pennicott DR, Sugathapala CL, Robbins TW, Everitt BJ (2001) Impulsive choice induced in rats by lesions of the nucleus accumbens core. Science 292:2499-2501 (Pubitemid 32601663)
    • (2001) Science , vol.292 , Issue.5526 , pp. 2499-2501
    • Cardinal, R.N.1    Pennicott, D.R.2    Sugathapala, C.L.3    Robbins, T.W.4    Everitt, B.J.5
  • 36
    • 61349093537 scopus 로고    scopus 로고
    • Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders
    • Conn PJ, Jones CK, Lindsley CW (2009) Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders. Trends Pharmacol Sci 30:148-155
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 148-155
    • Conn, P.J.1    Jones, C.K.2    Lindsley, C.W.3
  • 37
    • 0033515114 scopus 로고    scopus 로고
    • 3H]AF-DX 384 is reduced in the caudate-putamen of subjects with schizophrenia
    • DOI 10.1016/S0024-3205(99)00114-9, PII S0024320599001149
    • Crook JM, Dean B, Pavey G, Copolov D (1999) The binding of [3 H]AF-DX 384 is reduced in the caudate-putamen of subjects with schizophrenia. Life Sci 64:1761-1771 (Pubitemid 29185535)
    • (1999) Life Sciences , vol.64 , Issue.19 , pp. 1761-1771
    • Crook, J.M.1    Dean, B.2    Pavey, G.3    Copolov, D.4
  • 38
    • 0034282537 scopus 로고    scopus 로고
    • Decreased muscarinic receptor binding in subjects with schizophrenia: A study of the human hippocampal formation
    • Crook JM, Tomaskovic-Crook E, Copolov DL, Dean B (2000) Decreased muscarinic receptor binding in subjects with schizophrenia: a study of the human hippocampal formation. Biol Psychiatry 48:381-388
    • (2000) Biol Psychiatry , vol.48 , pp. 381-388
    • Crook, J.M.1    Tomaskovic-Crook, E.2    Copolov, D.L.3    Dean, B.4
  • 39
    • 0034975130 scopus 로고    scopus 로고
    • Low muscarinic receptor binding in prefrontal cortex from subjects with schizophrenia: A study of brodmann's areas 8, 9, 10, and 46 and the effects of neuroleptic drug treatment
    • DOI 10.1176/appi.ajp.158.6.918
    • Crook JM, Tomaskovic-Crook E, Copolov DL, Dean B (2001) Low muscarinic receptor binding in prefrontal cortex from subjects with schizophrenia: a study of Brodmann's areas 8, 9, 10, and 46 and the effects of neuroleptic drug treatment. Am J Psychiatry 158:918-925 (Pubitemid 32547622)
    • (2001) American Journal of Psychiatry , vol.158 , Issue.6 , pp. 918-925
    • Crook, J.M.1    Tomaskovic-Crook, E.2    Copolov, D.L.3    Dean, B.4
  • 40
    • 44649111951 scopus 로고    scopus 로고
    • Neurobehavioral mechanisms of impulsivity: Fronto-striatal systems and functional neurochemistry
    • Dalley JW, Mar AC, Economidou D, Robbins TW (2008) Neurobehavioral mechanisms of impulsivity: fronto-striatal systems and functional neurochemistry. Pharmacol Biochem Behav 90:250-260
    • (2008) Pharmacol Biochem Behav , vol.90 , pp. 250-260
    • Dalley, J.W.1    Mar, A.C.2    Economidou, D.3    Robbins, T.W.4
  • 41
    • 79951842958 scopus 로고    scopus 로고
    • M1 and M4 receptors modulate hippocampal pyramidal neurons
    • Dasari S, Gulledg AT (2011) M1 and M4 receptors modulate hippocampal pyramidal neurons. J Neurophysiol 105:779-792
    • (2011) J Neurophysiol , vol.105 , pp. 779-792
    • Dasari, S.1    Gulledg, A.T.2
  • 42
    • 0026070134 scopus 로고
    • Dopamine in schizophrenia: A review and reconceptualization
    • Davis KL, Kahn RS, Ko G, Davidson M (1991) Dopamine in schizophrenia: a review and reconceptualization. Am J Psychiatry 148:1474-1486
    • (1991) Am J Psychiatry , vol.148 , pp. 1474-1486
    • Davis, K.L.1    Kahn, R.S.2    Ko, G.3    Davidson, M.4
  • 43
    • 0027371230 scopus 로고
    • Effect of M1- and M2-muscarinic drugs on striatal dopamine release and metabolism: An in vivo microdialysis study comparing normal and 6-hydroxydopamine-lesioned rats
    • DOI 10.1016/0006-8993(93)90642-Z
    • De Klippel N, Sarre S, Ebinger G, Michotte Y (1993) Effect of M1- and M2-muscarinic drugs on striatal dopamine release and metabolism: an in vivo microdialysis study comparing normal and 6-hydroxydopamine-lesioned rats. Brain Res 630:57-64 (Pubitemid 23342826)
    • (1993) Brain Research , vol.630 , Issue.1-2 , pp. 57-64
    • De Klippel, N.1    Sarre, S.2    Ebinger, G.3    Michotte, Y.4
  • 44
    • 4043079375 scopus 로고    scopus 로고
    • Linkage of M5 muscarinic and α7-nicotinic receptor genes on 15q13 to Schizophrenia
    • DOI 10.1159/000079102
    • De Luca V, Wang H, Squassina A, Wong GW, Yeomans J, Kennedy JL (2004) Linkage of M5 muscarinic and alpha7-nicotinic receptor genes on 15q13 to schizophrenia. Neuropsychobiology 50:124-127 (Pubitemid 39077830)
    • (2004) Neuropsychobiology , vol.50 , Issue.2 , pp. 124-127
    • De Luca, V.1    Wang, H.2    Squassina, A.3    Wong, G.W.H.4    Yeomans, J.5    Kennedy, J.L.6
  • 45
    • 0030091175 scopus 로고    scopus 로고
    • 1 receptors is decreased in the caudate-putamen of subjects with schizophrenia
    • Dean B, Crook JM, Opeskin K, Hill C, Keks N, Copolov DL (1996) The density of muscarinic M1 receptors is decreased in the caudate-putamen of subjects with schizophrenia. Mol Psychiatry 1:54-58 (Pubitemid 126442395)
    • (1996) Molecular Psychiatry , vol.1 , Issue.1 , pp. 54-58
    • Dean, B.1    Crook, J.M.2    Opeskin, K.3    Hill, C.4    Keks, N.5    Copolov, D.L.6
  • 46
    • 0036932174 scopus 로고    scopus 로고
    • 1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia
    • DOI 10.1038/sj.mp.4001199
    • Dean B, McLeod M, Keriakous D, McKenzie J, Scarr E (2002) Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia. Mol Psychiatry 7:1083-1091 (Pubitemid 36044267)
    • (2002) Molecular Psychiatry , vol.7 , Issue.10 , pp. 1083-1091
    • Dean, B.1    McLeod, M.2    Keriakous, D.3    McKenzie, J.4    Scarr, E.5
  • 47
    • 0042562047 scopus 로고    scopus 로고
    • Muscarinic receptors in schizophrenia
    • DOI 10.2174/1566524033479654
    • Dean B, Bymaster FP, Scarr E (2003) Muscarinic receptors in schizophrenia. Curr Mol Med 3:419-426. http://www.ncbi.nlm.nih.gov/pubmed/ 7768353 (Pubitemid 36975101)
    • (2003) Current Molecular Medicine , vol.3 , Issue.5 , pp. 419-426
    • Dean, B.1    Bymaster, F.P.2    Scarr, E.3
  • 48
    • 2942665783 scopus 로고    scopus 로고
    • A comparison of M1 and M4 muscarinic receptors in the thalamus from control subjects and subjects with schizophrenia
    • DOI 10.1016/j.tharel.2003.12.001, PII S1472928804000032
    • Dean B, Gray L, Keriakous D, Scarr E (2004) A comparison of M1 and M4 muscarinic receptors in the thalamus from control subjects and subjects with schizophrenia. Thalamus Relat Syst 2:287-295 (Pubitemid 38771968)
    • (2004) Thalamus and Related Systems , vol.2 , Issue.4 , pp. 287-295
    • Dean, B.1    Gray, L.2    Keriakous, D.3    Scarr, E.4
  • 49
    • 79955779990 scopus 로고    scopus 로고
    • Involvement of a subpopulation of neuronal M4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M1/M4 preferring muscarinic receptor agonist xanomeline
    • Dencker D, Wortwein G, Weikop P, Jeon J, Thomsen M, Sager TN, Mork A, Woldbye DPD, Wess J, Fink-Jensen A (2011) Involvement of a subpopulation of neuronal M4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M1/M4 preferring muscarinic receptor agonist xanomeline. J Neurosci 31:5905-5908
    • (2011) J Neurosci , vol.31 , pp. 5905-5908
    • Dencker, D.1    Wortwein, G.2    Weikop, P.3    Jeon, J.4    Thomsen, M.5    Sager, T.N.6    Mork, A.7    Woldbye, D.P.D.8    Wess, J.9    Fink-Jensen, A.10
  • 50
    • 27444444269 scopus 로고    scopus 로고
    • Decreased density of muscarinic receptors in the superior temporal gyrus in schizophrenia
    • DOI 10.1002/jnr.20600
    • Deng C, Huang XF (2005) Decreased density of muscarinic receptors in the superior temporal gyrus in schizophrenia. J Neurosci Res 81:883-890 (Pubitemid 41532154)
    • (2005) Journal of Neuroscience Research , vol.81 , Issue.6 , pp. 883-890
    • Deng, C.1    Huang, X.-F.2
  • 51
    • 70350327418 scopus 로고    scopus 로고
    • Comorbid anxiety in patients with psychosis
    • Dernovsek MZ, Sprah L (2009) Comorbid anxiety in patients with psychosis. Psychiatr Danub 21 (suppl 1):43-50
    • (2009) Psychiatr Danub , vol.21 , Issue.SUPPL. 1 , pp. 43-50
    • Dernovsek, M.Z.1    Sprah, L.2
  • 52
    • 0019521227 scopus 로고
    • Physostigmine and lithium response in the schizophrenias
    • Edelstein P, Schultz JR, Hirschowitz J, Kanter DR, Garver DL (1981) Physostigmine and lithium response in the schizophrenias. Am J Psychiatry 138:1078-1081 (Pubitemid 11012809)
    • (1981) American Journal of Psychiatry , vol.138 , Issue.8 , pp. 1078-1081
    • Edelstein, P.1    Schultz, J.R.2    Hirschowitz, J.3
  • 53
    • 0029658797 scopus 로고    scopus 로고
    • Muscarinic M2 and M3 receptor function in smooth muscle
    • Eglen RM (1996) Muscarinic M2 and M3 receptor function in smooth muscle. Proc West Pharmacol Soc 39:57-60
    • (1996) Proc West Pharmacol Soc , vol.39 , pp. 57-60
    • Eglen, R.M.1
  • 54
    • 0029013930 scopus 로고
    • Muscarinic acetylcholine receptors: Signal transduction through multiple effectors
    • Felder CC (1995) Muscarinic acetylcholine receptors: Signal transduction through multiple effectors. FASEB J 9:619-625
    • (1995) FASEB J , vol.9 , pp. 619-625
    • Felder, C.C.1
  • 55
    • 0034676312 scopus 로고    scopus 로고
    • Therapeutic opportunities for muscarinic receptors in the central nervous system
    • DOI 10.1021/jm990607u
    • Felder CC, Bymaster FP, Ward J, DeLapp N (2000) Therapeutic opportunities for muscarinic receptors in the central nervous system. J Med Chem 43:4333-4353 (Pubitemid 32046857)
    • (2000) Journal of Medicinal Chemistry , vol.43 , Issue.23 , pp. 4333-4353
    • Felder, C.C.1    Bymaster, F.P.2    Ward, J.3    DeLapp, N.4
  • 56
    • 3042819787 scopus 로고    scopus 로고
    • Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors
    • Fisher JT, Vincent SG, Gomeza J, Yamada M, Wess J (2004) Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors. FASEB J 18:711-713
    • (2004) FASEB J , vol.18 , pp. 711-713
    • Fisher, J.T.1    Vincent, S.G.2    Gomeza, J.3    Yamada, M.4    Wess, J.5
  • 57
    • 3142746642 scopus 로고    scopus 로고
    • Cholinergic targets for cognitive enhancement in schizophrenia: Focus on cholinesterase inhibitors and muscarinic agonists
    • Friedman JL (2004) Cholinergic targets for cognitive enhancement in schizophrenia: focus on cholinesterase inhibitors and muscarinic agonists. Psychopharmacology (Berl) 174:45-53
    • (2004) Psychopharmacology (Berl) , vol.174 , pp. 45-53
    • Friedman, J.L.1
  • 58
    • 3342880696 scopus 로고    scopus 로고
    • 3 muscarinic receptor single- and double-knockout mice
    • DOI 10.1124/mol.66.2.260
    • Gautam D, Heard TS, Cui Y, Miller G, Bloodworth L, Wess J (2004) Cholinergic stimulation of salivary secretion studied with M1 and M3 muscarinic receptor single- and double-knockout mice. Mol Pharmacol 66(2):260-7 (Pubitemid 38989482)
    • (2004) Molecular Pharmacology , vol.66 , Issue.2 , pp. 260-267
    • Gautam, D.1    Heard, T.S.2    Cui, Y.3    Miller, G.4    Bloodworth, L.5    Wess, J.6
  • 62
    • 0034050617 scopus 로고    scopus 로고
    • Dissociation of haloperidol, clozapine, and olanzapine effects on electrical activity of mesocortical dopamine neurons and dopamine release in the prefrontal cortex
    • DOI 10.1016/S0893-133X(00)00087-7, PII S0893133X00000877
    • Gessa GL, Devoto P, Diana M, Flore G, Melis M, Pistis M (2000) Dissociation of haloperidol, clozapine, and olanzapine effects on electrical activity of mesocortical dopamine neurons and dopamine release in the prefrontal cortex. Neuropsychopharmacology 22:642-649 (Pubitemid 30219407)
    • (2000) Neuropsychopharmacology , vol.22 , Issue.6 , pp. 642-649
    • Gessa, G.L.1    Devoto, P.2    Diana, M.3    Flore, G.4    Melis, M.5    Pistis, M.6
  • 63
    • 79958274304 scopus 로고    scopus 로고
    • The treatment of cognitive impairment in schizophrenia
    • Goff DC, Hill M, Barch D (2011) The treatment of cognitive impairment in schizophrenia. Pharmacol Biochem Behav 99:245-253
    • (2011) Pharmacol Biochem Behav , vol.99 , pp. 245-253
    • Goff, D.C.1    Hill, M.2    Barch, D.3
  • 65
    • 0024565684 scopus 로고
    • Cholinergic projections to the substantia nigra from the pedunculopontine and laterodorsal tegmental nuclei
    • DOI 10.1016/0306-4522(89)90008-0
    • Gould E, Woolf NJ, Butcher LL (1989) Cholinergic projections to the substantia nigra from the pedunculopontine and laterodorsal tegmental nuclei. Neuroscience 28:611-623 (Pubitemid 19081019)
    • (1989) Neuroscience , vol.28 , Issue.3 , pp. 611-623
    • Gould, E.1    Woolf, N.J.2    Butcher, L.L.3
  • 66
    • 34548348729 scopus 로고    scopus 로고
    • Molecular targets for treating cognitive dysfunction in schizophrenia
    • DOI 10.1093/schbul/sbm074
    • Gray JA, Roth BL (2007) Molecular targets for treating cognitive dysfunction in schizophrenia. Schizophr Bull 33:1100-1119 (Pubitemid 47347917)
    • (2007) Schizophrenia Bulletin , vol.33 , Issue.5 , pp. 1100-1119
    • Gray, J.A.1    Roth, B.L.2
  • 67
    • 0029918481 scopus 로고    scopus 로고
    • What are the functional consequences of neurocognitive deficits in schizophrenia?
    • Green MF (1996) What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry 153:321-330 (Pubitemid 26074706)
    • (1996) American Journal of Psychiatry , vol.153 , Issue.3 , pp. 321-330
    • Green, M.F.1
  • 68
    • 45749136445 scopus 로고    scopus 로고
    • Allosteric modulation of muscarinic acetylcholine receptors
    • DOI 10.2174/157015907781695946
    • Gregory KJ, Sexton PM, Christopoulos A (2007) Allosteric Modulation of Muscarinic Acetylcholine Receptors. Curr Neuropharmacol 5:157-167 (Pubitemid 351863857)
    • (2007) Current Neuropharmacology , vol.5 , Issue.3 , pp. 157-167
    • Gregory, K.J.1    Sexton, P.M.2    Christopoulos, A.3
  • 69
    • 44649122753 scopus 로고    scopus 로고
    • Release-enhancing pre-synaptic muscarinic and nicotinic receptors co-exist and interact on dopaminergic nerve endings of rat nucleus accumbens
    • DOI 10.1111/j.1471-4159.2008.05307.x
    • Grilli M, Patti L, Robino F, Zappettini S, Raiteri M, Marchi M (2008) Release-enhancing presynaptic muscarinic and nicotinic receptors co-exist and interact on dopaminergic nerve endings of rat nucleus accumbens. J Neurochem 105:2205-2213 (Pubitemid 351782252)
    • (2008) Journal of Neurochemistry , vol.105 , Issue.6 , pp. 2205-2213
    • Grilli, M.1    Patti, L.2    Robino, F.3    Zappettini, S.4    Raiteri, M.5    Marchi, M.6
  • 70
    • 0031749164 scopus 로고    scopus 로고
    • Activation of midbrain presumed dopaminergic neurones by muscarinic cholinergic receptors: An in vivo electrophysiological study in the rat
    • DOI 10.1038/sj.bjp.0701850
    • Gronier B, Rasmussen K (1998) Activation of midbrain presumed dopaminergic neurons by muscarinic cholinergic receptors: an in vivo electrophysiological study in the rat. Br J Pharmacol 124:455-464 (Pubitemid 28254500)
    • (1998) British Journal of Pharmacology , vol.124 , Issue.3 , pp. 455-464
    • Gronier, B.1    Rasmussen, K.2
  • 71
    • 0035844157 scopus 로고    scopus 로고
    • The M1 receptor is required for muscarinic activation of mitogen-activated protein (MAP) kinase in murine cerebral cortical neurons
    • Hamilton SE, Nathanson NM (2001) The M1 receptor is required for muscarinic activation of mitogen-activated protein (MAP) kinase in murine cerebral cortical neurons. J Biol Chem 276:15850-15853
    • (2001) J Biol Chem , vol.276 , pp. 15850-15853
    • Hamilton, S.E.1    Nathanson, N.M.2
  • 73
    • 17044406214 scopus 로고    scopus 로고
    • The primacy of cognition in schizophrenia
    • Heinrichs RW (2005) The primacy of cognition in schizophrenia. Am Psychol 60:229-242
    • (2005) Am Psychol , vol.60 , pp. 229-242
    • Heinrichs, R.W.1
  • 74
    • 74949104026 scopus 로고    scopus 로고
    • Effect of second-generation antipsychotics on cognition: Current issues and future challenges
    • Hill SK, Bishop JR, Palumbo D, Sweeney JA (2010) Effect of second-generation antipsychotics on cognition: current issues and future challenges. Expert Rev Neurother 10:43-57
    • (2010) Expert Rev Neurother , vol.10 , pp. 43-57
    • Hill, S.K.1    Bishop, J.R.2    Palumbo, D.3    Sweeney, J.A.4
  • 75
    • 0031871774 scopus 로고    scopus 로고
    • The legacy of atropos, the fate who cut the thread of life
    • Holtzman RS (1998) The legacy of Atropos, the fate who cut the thread of life. Anesthesiology 89:241-249
    • (1998) Anesthesiology , vol.89 , pp. 241-249
    • Holtzman, R.S.1
  • 76
    • 0034934938 scopus 로고    scopus 로고
    • Cholinergic systems and schizophrenia: Primary pathology or epiphenomena?
    • DOI 10.1016/S0891-0618(01)00101-6, PII S0891061801001016
    • Hyde TM, Crook JM (2001) Cholinergic systems and schizophrenia: primary pathology or epiphenomena? J Chem Neuroanat 22:53-63 (Pubitemid 32695509)
    • (2001) Journal of Chemical Neuroanatomy , vol.22 , Issue.1-2 , pp. 53-63
    • Hyde, T.M.1    Crook, J.M.2
  • 79
    • 0020967493 scopus 로고
    • Adverse effects of anticholinergic medication on positive schizophrenic symptoms
    • Johnstone EC, Crow TJ, Ferrier IN, Frith CD, Owens DG, Bourne RC, Gamble SJ (1983) Adverse effects of anticholinergic medication on positive schizophrenic symptoms. Psychol Med 13:513-527 (Pubitemid 13019017)
    • (1983) Psychological Medicine , vol.13 , Issue.3 , pp. 513-527
    • Johnstone, E.C.1    Crow, T.J.2    Ferrier, I.N.3
  • 80
    • 14344259676 scopus 로고    scopus 로고
    • Pharmacologic interactions between the muscarinic cholinergic and dopaminergic systems in the modulation of prepulse inhibition in rats
    • DOI 10.1124/jpet.104.075887
    • Jones CK, Eberle EL, Shaw DB, McKinzie DL, Shannon HE (2005) Pharmacologic interactions between the muscarinic cholinergic and dopaminergic systems in the modulation of prepulse inhibition in rats. J Pharmacol Exp Ther 312:1055-1063 (Pubitemid 40293764)
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.312 , Issue.3 , pp. 1055-1063
    • Jones, C.K.1    Eberle, E.L.2    Shaw, D.B.3    McKinzie, D.L.4    Shannon, H.E.5
  • 82
    • 0035673012 scopus 로고    scopus 로고
    • Extended radioligand binding profile of iloperidone: A broad spectrum dopamine/serotonin/norepinephrine receptor antagonist for the management of psychotic disorders
    • DOI 10.1016/S0893-133X(01)00285-8, PII S0893133X01002858
    • Kalkman HO, Subramanian N, Hoyer D (2001) Extended radioligand binding profile of iloperidone: a broad spectrum dopamine/serotonin/norepinephrine receptor antagonist for the management of psychotic disorders. Neuropsychopharmacology 25:904-914 (Pubitemid 34031895)
    • (2001) Neuropsychopharmacology , vol.25 , Issue.6 , pp. 904-914
    • Kalkman, H.O.1    Subramanian, N.2    Hoyer, D.3
  • 84
    • 42049123448 scopus 로고    scopus 로고
    • Efficacy and safety of donepezil in patients with schizophrenia or schizoaffective disorder: Significant placebo/practice effects in a 12-week, randomized, double-blind, placebo-controlled trial
    • DOI 10.1038/sj.npp.1301499, PII 1301499
    • Keefe RS, Malhotra AK, Meltzer HY, Kane JM, Buchanan RW, Murthy A, Sovel M, Li C, Goldman R (2008) Efficacy and safety of donepezil in patients with schizophrenia or schizoaffective disorder: significant placebo/practice effects in a 12-week, randomized, double-blind, placebo-controlled trial. Neuropsychopharmacology 33:1217-1228 (Pubitemid 351521707)
    • (2008) Neuropsychopharmacology , vol.33 , Issue.6 , pp. 1217-1228
    • Keefe, R.S.E.1    Malhotra, A.K.2    Meltzer, H.Y.3    Kane, J.M.4    Buchanan, R.W.5    Murthy, A.6    Sovel, M.7    Li, C.8    Goldman, R.9
  • 86
    • 76749144987 scopus 로고    scopus 로고
    • Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties
    • Leach K, Loiacono RE, Felder CC, McKinzie DL, Mogg A, Shaw DB, Sexton PM, Christopoulos A (2010) Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties. Neuropsychopharmacology 35:855-869
    • (2010) Neuropsychopharmacology , vol.35 , pp. 855-869
    • Leach, K.1    Loiacono, R.E.2    Felder, C.C.3    McKinzie, D.L.4    Mogg, A.5    Shaw, D.B.6    Sexton, P.M.7    Christopoulos, A.8
  • 87
    • 0019998012 scopus 로고
    • 3H]dopamine release in vitro by endogenous acetylcholine
    • DOI 10.1016/0006-8993(82)91147-7
    • Lehmann J, Langer SZ (1982) Muscarinic receptors on dopamine terminals in the cat caudate nucleus: neuromodulation of [3H]dopamine release in vitro by endogenous acetylcholine. Brain Res 248:61-69 (Pubitemid 12024459)
    • (1982) Brain Research , vol.248 , Issue.1 , pp. 61-69
    • Lehmann, J.1    Langer, S.Z.2
  • 88
    • 0027465882 scopus 로고
    • Immunological localization of m1-m5 muscarinic acetylcholine receptors in peripheral tissues and brain
    • Levey AI (1993) Immunological localization of m1-m5 muscarinic acetylcholine receptors in peripheral tissues and brain. Life Sci 52:441-448
    • (1993) Life Sci , vol.52 , pp. 441-448
    • Levey, A.I.1
  • 89
    • 0029042321 scopus 로고
    • Expression of m1-m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervations
    • Levey AI, Edmunds SM, Koliatsos V, Wiley RG, Heilman CJ (1995) Expression of m1-m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervations. J Neurosci 15:4077-4092
    • (1995) J Neurosci , vol.15 , pp. 4077-4092
    • Levey, A.I.1    Edmunds, S.M.2    Koliatsos, V.3    Wiley, R.G.4    Heilman, C.J.5
  • 90
    • 0031933103 scopus 로고    scopus 로고
    • Olanzapine increases in vivo dopamine and norepinephrine release in rat prefrontal cortex, nucleus accumbens and striatum
    • DOI 10.1007/s002130050551
    • Li XM, Perry KW, Wong DT, Bymaster FP (1998) Olanzapine increases in vivo dopamine and norepinephrine release in rat prefrontal cortex, nucleus accumbens, and striatum. Psychopharmacology (Berl) 136:153-161 (Pubitemid 28137955)
    • (1998) Psychopharmacology , vol.136 , Issue.2 , pp. 153-161
    • Li, X.-M.1    Perry, K.W.2    Wong, D.T.3    Bymaster, F.P.4
  • 91
    • 34548797583 scopus 로고    scopus 로고
    • 1 receptor agonist, increases acetylcholine and dopamine release in rat medial prefrontal cortex and hippocampus
    • DOI 10.1016/j.ejphar.2007.06.025, PII S0014299907007273
    • Li Z, Bonhaus DW, Huang M, Prus AJ, Dai J, Meltzer HY (2007) AC260584 (4-[3-(4butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one), a selective muscarinic M1 receptor agonist, increases acetylcholine and dopamine release in rat medial prefrontal cortex and hippocampus. Eur J Pharmacol 572:129-137 (Pubitemid 47429641)
    • (2007) European Journal of Pharmacology , vol.572 , Issue.2-3 , pp. 129-137
    • Li, Z.1    Bonhaus, D.W.2    Huang, M.3    Prus, A.J.4    Dai, J.5    Meltzer, H.Y.6
  • 92
    • 53049096358 scopus 로고    scopus 로고
    • Effect of muscarinic receptor agonists xanomeline and sabcomeline on acetylcholine and dopamine efflux in the rat brain: Comparison with effects of (4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one (AC260584) and N-desmethylclozapine
    • Li Z, Snigdha S, Roseman AS, Dai J, Meltzer HY (2008) Effect of muscarinic receptor agonists xanomeline and sabcomeline on acetylcholine and dopamine efflux in the rat brain: comparison with effects of (4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one (AC260584) and N-desmethylclozapine. Eur J Pharmacol 596:89-97
    • (2008) Eur J Pharmacol , vol.596 , pp. 89-97
    • Li, Z.1    Snigdha, S.2    Roseman, A.S.3    Dai, J.4    Meltzer, H.Y.5
  • 93
    • 0141533278 scopus 로고    scopus 로고
    • Association of muscarinic M1 receptor genetic polymorphisms with psychiatric symptoms and cognitive function in schizophrenic patients
    • DOI 10.1159/000072880
    • Liao DL, Hong CJ, Chen HM, Chen YE, Lee SM, Chang CY, Chen H, Tsai SJ (2003) Association of muscarinic m1 receptor genetic polymorphisms with psychiatric symptoms and cognitive function in schizophrenic patients. Neuropsychobiology 48:72-76 (Pubitemid 37176870)
    • (2003) Neuropsychobiology , vol.48 , Issue.2 , pp. 72-76
    • Liao, D.-L.1    Hong, C.-J.2    Chen, H.-M.3    Chen, Y.-E.4    Lee, S.-M.5    Chang, C.-Y.6    Chen, H.7    Tsai, S.-J.8
  • 95
    • 80052024632 scopus 로고    scopus 로고
    • Antipsychotic effects of N-desmethylclozapine on sensorimotor gating function in rats: Possible involvement of activation of M(1) muscarinic receptors
    • Maehara S, Satow A, Hikichi H, Ohta H (2011a) Antipsychotic effects of N-desmethylclozapine on sensorimotor gating function in rats: possible involvement of activation of M(1) muscarinic receptors. Eur J Pharmacol 667:242-249
    • (2011) Eur J Pharmacol , vol.667 , pp. 242-249
    • Maehara, S.1    Satow, A.2    Hikichi, H.3    Ohta, H.4
  • 96
    • 80053265886 scopus 로고    scopus 로고
    • Ameliorative effect of N-desmethylclozapine in animal models of social deficits and cognitive functions
    • Maehara S, Okuda S, Ohta H (2011b) Ameliorative effect of N-desmethylclozapine in animal models of social deficits and cognitive functions. Brain Res Bull 86:146-151
    • (2011) Brain Res Bull , vol.86 , pp. 146-151
    • Maehara, S.1    Okuda, S.2    Ohta, H.3
  • 98
    • 0021966825 scopus 로고
    • On the presence in the cerebral cortex of muscarinic receptor subtypes which differ in neuronal localization, function and pharmacological properties
    • Marchi M, Raiteri M (1985) On the presence in the cerebral cortex of muscarinic receptor subtypes which differ in neuronal localization, function and pharmacological properties. J Pharmacol Exp Ther 235:230-233 (Pubitemid 15242387)
    • (1985) Journal of Pharmacology and Experimental Therapeutics , vol.235 , Issue.1 , pp. 230-233
    • Marchi, M.1    Raiteri, M.2
  • 101
    • 77954115000 scopus 로고    scopus 로고
    • Cognitive effects of muscarinic M1 functional agonists in non-human primates and clinical trials
    • McArthur RA, Gray J, Schreiber R (2010) Cognitive effects of muscarinic M1 functional agonists in non-human primates and clinical trials. Curr Opin Investig Drugs 11:740-760
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 740-760
    • McArthur, R.A.1    Gray, J.2    Schreiber, R.3
  • 102
    • 33751520710 scopus 로고    scopus 로고
    • Coexistence of muscarinic long-term depression with electrically induced long-term potentiation and depression at CA3-CA1 synapses
    • DOI 10.1152/jn.00144.2006
    • McCutchen E, Scheiderer CL, Dobrunz LE, McMahon LL (2006) Coexistence of muscarinic longterm depression with electrically induced long-term potentiation and depression at CA3-CA1 synapses. J Neurophysiol 96:3114-3121 (Pubitemid 44837857)
    • (2006) Journal of Neurophysiology , vol.96 , Issue.6 , pp. 3114-3121
    • McCutchen, E.1    Scheiderer, C.L.2    Dobrunz, L.E.3    McMahon, L.L.4
  • 103
    • 67651174448 scopus 로고    scopus 로고
    • N-desmethylclozapine: Is there evidence for its antipsychotic potential?
    • Mendoza MC, Lindenmayer JP (2009) N-desmethylclozapine: is there evidence for its antipsychotic potential? Clin Neuropharmacol 32:154-157
    • (2009) Clin Neuropharmacol , vol.32 , pp. 154-157
    • Mendoza, M.C.1    Lindenmayer, J.P.2
  • 104
    • 0035879062 scopus 로고    scopus 로고
    • 1 muscarinic acetylcholine receptor
    • Miyakawa T, Yamada M, Duttaroy A, Wess J (2001) Hyperactivity and intact hippocampusdependent learning in mice lacking the M1 muscarinic acetylcholine receptor. J Neurosci 21:5239-5250 (Pubitemid 32622949)
    • (2001) Journal of Neuroscience , vol.21 , Issue.14 , pp. 5239-5250
    • Miyakawa, T.1    Yamada, M.2    Duttaroy, A.3    Wess, J.4
  • 105
    • 0025239750 scopus 로고
    • Acute effects of typical and atypical antipsychotic drugs on the release of dopamine from the prefrontal cortex, nucleus accumbens, and striatum of the rat: An in vivo microdialysis study
    • Moghaddam B, Bunney BS (1990) Acute effects of typical and atypical antipsychotic drugs on the release of dopamine from the prefrontal cortex, nucleus accumbens, and striatum of the rat: an in vivo microdialysis study. J Neurochem 54:1755-1760
    • (1990) J Neurochem , vol.54 , pp. 1755-1760
    • Moghaddam, B.1    Bunney, B.S.2
  • 106
    • 0033553589 scopus 로고    scopus 로고
    • Affinity profiles of various muscarinic antagonists for cloned human muscarinic acetylcholine receptor (mAChR) subtypes and mAChRs in rat heart and submandibular gland
    • DOI 10.1016/S0024-3205(99)00188-5, PII S0024320599001885
    • Moriya H, Takagi Y, Nakanishi T, Hayashi M, Tani T, Hirotsu I (1999) Affinity profiles of various muscarinic antagonists for cloned human muscarinic acetylcholine receptor (mAChR) subtypes and mAChRs in rat heart and submandibular gland. Life Sci 64:2351-2358 (Pubitemid 29274228)
    • (1999) Life Sciences , vol.64 , Issue.25 , pp. 2351-2358
    • Moriya, H.1    Takagi, Y.2    Nakanishi, T.3    Hayashi, M.4    Tani, T.5    Hirotsu, I.6
  • 107
    • 0027177289 scopus 로고
    • Association of m1 and m2 muscarinic receptor proteins with asymmetric synapses in the primate cerebral cortex: Morphological evidence for cholinergic modulation of excitatory neurotransmission
    • Mrzljak L, Levey AI, Goldman-Rakic PS (1993) Association of m1 and m2 muscarinic receptor proteins with asymmetric synapses in the primate cerebral cortex: morphological evidence for cholinergic modulation of excitatory neurotransmission. Proc Natl Acad Sci USA 90:5194-5198 (Pubitemid 23183004)
    • (1993) Proceedings of the National Academy of Sciences of the United States of America , vol.90 , Issue.11 , pp. 5194-5198
    • Mrzljak, L.1    Levey, A.I.2    Goldman-Rakic, P.S.3
  • 108
    • 33750625280 scopus 로고    scopus 로고
    • Pharmacological treatment of primary negative symptoms in schizophrenia: A systematic review
    • DOI 10.1016/j.schres.2006.07.002, PII S0920996406003112
    • Murphy BP, Chung YC, Park TW, McGorry PD (2006) Pharmacological treatment of primary negative symptoms in schizophrenia: a systematic review. Schizophr Res 88:5-25 (Pubitemid 44693240)
    • (2006) Schizophrenia Research , vol.88 , Issue.1-3 , pp. 5-25
    • Murphy, B.P.1    Chung, Y.-C.2    Park, T.-W.3    McGorry, P.D.4
  • 110
    • 0016729528 scopus 로고
    • The role of central cholinergic mechanisms in schizophrenia
    • Neubauer H, Adams M, Redfern P (1975) The role of central cholinergic mechanisms in schizophrenia. Med Hypotheses 1:32-34
    • (1975) Med Hypotheses , vol.1 , pp. 32-34
    • Neubauer, H.1    Adams, M.2    Redfern, P.3
  • 111
    • 33845683345 scopus 로고    scopus 로고
    • Alterations of muscarinic and GABA receptor binding in the posterior cingulate cortex in schizophrenia
    • DOI 10.1016/j.pnpbp.2006.07.004, PII S0278584606002934
    • Newell KA, Zavitsanou K, Jew SK, Huang XF (2007) Alterations of muscarinic and GABA receptor binding in the posterior cingulate cortex in schizophrenia. Prog Neuropsycho-pharmacol Biol Psychiatry 31:225-233 (Pubitemid 44959255)
    • (2007) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.31 , Issue.1 , pp. 225-233
    • Newell, K.A.1    Zavitsanou, K.2    Jew, S.K.3    Huang, X.-F.4
  • 112
    • 0030930050 scopus 로고    scopus 로고
    • Effects of clozapine on rat striatal muscarinic receptors coupled to inhibition of adenylyl cyclase activity and on the human cloned m4 receptor
    • DOI 10.1038/sj.bjp.0701357
    • Olianas MC, Maullu C, Onali P (1997) Effects of clozapine on rat striatal muscarinic receptors coupled to inhibition of adenylyl cyclase activity and on the human cloned m4 receptor. Br J Pharmacol 122:401-408 (Pubitemid 27429713)
    • (1997) British Journal of Pharmacology , vol.122 , Issue.3 , pp. 401-408
    • Olianas, M.C.1    Maullu, C.2    Onali, P.3
  • 114
    • 0029348250 scopus 로고
    • Acetylcholine and hallucinations: Disease-related compared to druginduced alterations in human consciousness
    • Perry EK, Perry RH (1995) Acetylcholine and hallucinations: disease-related compared to druginduced alterations in human consciousness. Brain Cogn 28:240-258
    • (1995) Brain Cogn , vol.28 , pp. 240-258
    • Perry, E.K.1    Perry, R.H.2
  • 115
    • 0035871580 scopus 로고    scopus 로고
    • The muscarinic agonist xanomeline increases monoamine release and immediate early gene expression in the rat prefrontal cortex
    • DOI 10.1016/S0006-3223(00)01017-9, PII S0006322301010179
    • Perry KW, Nisenbaum LK, George CA, Shannon HE, Felder CC, Bymaster FP (2001) The muscarinic agonist xanomeline increases monoamine release and immediate early gene expression in the rat prefrontal cortex. Biol Psychiatry 49:716-725 (Pubitemid 32328121)
    • (2001) Biological Psychiatry , vol.49 , Issue.8 , pp. 716-725
    • Perry, K.W.1    Nisenbaum, L.K.2    George, C.A.3    Shannon, H.E.4    Felder, C.C.5    Bymaster, F.P.6
  • 116
    • 84981878828 scopus 로고
    • The inhibition of conditioned response and counteraction of schizophrenia by muscarinic stimulation of the brain
    • Pfeifer CC, Jenny EH (1957) The inhibition of conditioned response and counteraction of schizophrenia by muscarinic stimulation of the brain. Ann N Y Acad Sci 66:753-764
    • (1957) Ann N y Acad Sci , vol.66 , pp. 753-764
    • Pfeifer, C.C.1    Jenny, E.H.2
  • 119
  • 123
    • 0033987196 scopus 로고    scopus 로고
    • 1 receptors
    • DOI 10.1016/S0304-3940(99)00914-3, PII S0304394099009143
    • Rouse ST, Hamilton SE, Potter LT, Nathanson NM, Conn PJ (2000) Muscarinic-induced modulation of potassium conductances is unchanged in mouse hippocampal pyramidal cells that lack functional M1 receptors. Neurosci Lett 278:61-64 (Pubitemid 30009897)
    • (2000) Neuroscience Letters , vol.278 , Issue.1-2 , pp. 61-64
    • Rouse, S.T.1    Hamilton, S.E.2    Potter, L.T.3    Nathanson, N.M.4    Conn, P.J.5
  • 124
    • 0141869018 scopus 로고    scopus 로고
    • Long-term effects of BIBN-99, a selective muscarinic M2 receptor antagonist, on improving spatial memory performance in aged cognitively impaired rats
    • DOI 10.1016/S0166-4328(03)00116-5
    • Rowe WB, O'Donnell JP, Pearson D, Rose GM, Meaney MJ, Quirion R (2003) Long-term effects of BIBN-99, a selective muscarinic M2 receptor antagonist, on improving spatial memory performance in aged cognitively impaired rats. Behav Brain Res 145:171-178 (Pubitemid 37188642)
    • (2003) Behavioural Brain Research , vol.145 , Issue.1-2 , pp. 171-178
    • Rowe, W.B.1    O'Donnell, J.-P.2    Pearson, D.3    Rose, G.M.4    Meaney, M.J.5    Quirion, R.6
  • 127
    • 0031040861 scopus 로고    scopus 로고
    • Cognitive functions of cortical acetylcholine: Toward a unifying hypothesis
    • Sarter M, Bruno JP (1996) Cognitive functions of cortical acetylcholine: toward a unifying hypothesis. Brain Res Brain Res Rev 23:28-46
    • (1996) Brain Res Brain Res Rev , vol.23 , pp. 28-46
    • Sarter, M.1    Bruno, J.P.2
  • 129
    • 31744438772 scopus 로고    scopus 로고
    • 35S] GTPγS binding in schizophrenia
    • DOI 10.1016/j.lfs.2005.06.038, PII S0024320505009070
    • Scarr E, Keriakous D, Crossland N, Dean B (2006) No change in cortical muscarinic M2, M3 receptors or [35 S]-GTPgammaS binding in schizophrenia. Life Sci 78:1231-1237 (Pubitemid 43176718)
    • (2006) Life Sciences , vol.78 , Issue.11 , pp. 1231-1237
    • Scarr, E.1    Keriakous, D.2    Crossland, N.3    Dean, B.4
  • 130
    • 34247643222 scopus 로고    scopus 로고
    • Altered hippocampal muscarinic M4, but not M1, receptor expression from subjects with schizophrenia
    • DOI 10.1016/j.biopsych.2006.08.050, PII S0006322306011619, Multiple Genotypes and Brain Development in Schizophrenia
    • Scarr E, Sundram S, Keriakous D, Dean B (2007) Altered hippocampal muscarinic M4, but not M1, receptor expression from subjects with schizophrenia. Biol Psychiatry 61:1161-1170 (Pubitemid 46669465)
    • (2007) Biological Psychiatry , vol.61 , Issue.10 , pp. 1161-1170
    • Scarr, E.1    Sundram, S.2    Keriakous, D.3    Dean, B.4
  • 131
    • 70350446516 scopus 로고    scopus 로고
    • Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia
    • Scarr E, Cowie TF, Kanellakis S, Sundram S, Pantelis C, Dean B (2009) Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia. Mol Psychiatry 14:1017-1023
    • (2009) Mol Psychiatry , vol.14 , pp. 1017-1023
    • Scarr, E.1    Cowie, T.F.2    Kanellakis, S.3    Sundram, S.4    Pantelis, C.5    Dean, B.6
  • 134
    • 8544262202 scopus 로고    scopus 로고
    • 2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity
    • DOI 10.1523/JNEUROSCI.3581-04.2004
    • Seeger T, Fedorova I, Zheng F, Miyakawa T, Koustova E, Gomeza J, Basile AS, Alzheimer C, Wess J (2004) M2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity. J Neurosci 24:10117-10127 (Pubitemid 39492037)
    • (2004) Journal of Neuroscience , vol.24 , Issue.45 , pp. 10117-10127
    • Seeger, T.1    Fedorova, I.2    Zheng, F.3    Miyakawa, T.4    Koustova, E.5    Gomeza, J.6    Basile, A.S.7    Alzheimer, C.8    Wess, J.9
  • 135
    • 58649100010 scopus 로고    scopus 로고
    • Asenapine: A novel psychopharmacologic agent with a unique human receptor signature
    • Shahid M, Walker GB, Zorn SH, Wong EH (2009) Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol 23:65-73
    • (2009) J Psychopharmacol , vol.23 , pp. 65-73
    • Shahid, M.1    Walker, G.B.2    Zorn, S.H.3    Wong, E.H.4
  • 140
    • 30644461032 scopus 로고    scopus 로고
    • 1 muscarinic acetylcholine receptors in the mouse hippocampus
    • DOI 10.1523/JNEUROSCI.2338-05.2005
    • Shinoe T, Matsui M, Taketo MM, Manabe T (2005) Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus. J Neurosci 25:11194-11200 (Pubitemid 43089564)
    • (2005) Journal of Neuroscience , vol.25 , Issue.48 , pp. 11194-11200
    • Shinoe, T.1    Matsui, M.2    Taketo, M.M.3    Manabe, T.4
  • 143
    • 0023126290 scopus 로고
    • Anticholinergic-neuroleptic antagonism in terms of positive and negative symptoms of schizophrenia: Implications for psychobiological subtyping
    • Singh MM, Kay SR, Opler LA (1987) Anticholinergic-neuroleptic antagonism in terms of positive and negative symptoms of schizophrenia: implications for psychobiological subtyping. Psychol Med 17:39-48 (Pubitemid 17055152)
    • (1987) Psychological Medicine , vol.17 , Issue.1 , pp. 39-48
    • Singh, M.M.1    Kay, S.R.2    Opler, L.A.3
  • 146
    • 59149084955 scopus 로고    scopus 로고
    • M5 muscarinic receptor knockout mice show reduced morphineinduced locomotion but increased locomotion after cholinergic antagonism in the ventral tegmental area
    • Steidl S, Yeomans JS (2009) M5 muscarinic receptor knockout mice show reduced morphineinduced locomotion but increased locomotion after cholinergic antagonism in the ventral tegmental area. J Pharmacol Exp Ther 328:263-275
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 263-275
    • Steidl, S.1    Yeomans, J.S.2
  • 149
    • 0030040463 scopus 로고    scopus 로고
    • Electrophysiological effects of olanzapine, a novel atypical antipsychotic, on A9 and A10 dopamine neurons
    • Stockton ME, Rasmussen K (1996) Electrophysiological effects of olanzapine, a novel atypical antipsychotic, on A9 and A10 dopamine neurons. Neuropsychopharmacology 14:97-105
    • (1996) Neuropsychopharmacology , vol.14 , pp. 97-105
    • Stockton, M.E.1    Rasmussen, K.2
  • 150
  • 152
    • 71649112617 scopus 로고    scopus 로고
    • Multiple muscarinic pathways mediate the suppression of voltage-gated ca2+ channels in mouse intestinal smooth muscle cells
    • Tanahashi Y, Unno T, Matsuyama H, Ishii T, Yamada M, Wess J, Komori S (2009) Multiple muscarinic pathways mediate the suppression of voltage-gated Ca2+ channels in mouse intestinal smooth muscle cells. Br J Pharmacol 158:1874-1883
    • (2009) Br J Pharmacol , vol.158 , pp. 1874-1883
    • Tanahashi, Y.1    Unno, T.2    Matsuyama, H.3    Ishii, T.4    Yamada, M.5    Wess, J.6    Komori, S.7
  • 156
    • 73349107462 scopus 로고    scopus 로고
    • Contrasting effects of allosteric and orthosteric agonists on m1 muscarinic acetylcholine receptor internalization and downregulation
    • Thomas RL, Langmead CJ, Wood MD, Challiss RA (2009) Contrasting effects of allosteric and orthosteric agonists on m1 muscarinic acetylcholine receptor internalization and downregulation. J Pharmacol Exp Ther 331:1086-1095
    • (2009) J Pharmacol Exp Ther , vol.331 , pp. 1086-1095
    • Thomas, R.L.1    Langmead, C.J.2    Wood, M.D.3    Challiss, R.A.4
  • 159
    • 34247629419 scopus 로고    scopus 로고
    • 5 muscarinic acetylcholine receptor knockout mice
    • DOI 10.1007/s00213-006-0682-y
    • Thomsen M, Wortwein G, Fink-Jensen A, Woldbye DP, Wess J, Caine SB (2007) Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice. Psychopharmacology (Berl) 192:97-110 (Pubitemid 46673887)
    • (2007) Psychopharmacology , vol.192 , Issue.1 , pp. 97-110
    • Thomsen, M.1    Wortwein, G.2    Fink-Jensen, A.3    Woldbye, D.P.D.4    Wess, J.5    Caine, S.B.6
  • 160
  • 161
    • 0032498873 scopus 로고    scopus 로고
    • Depressive signs and symptoms in schizophrenia: A prospective blinded trial of olanzapine and haloperidol
    • Tollefson GD, Sanger TM, Lu Y, Thieme ME (1998) Depressive signs and symptoms in schizophrenia: a prospective blinded trial of olanzapine and haloperidol. Arch Gen Psychiatry 55:250-258
    • (1998) Arch Gen Psychiatry , vol.55 , pp. 250-258
    • Tollefson, G.D.1    Sanger, T.M.2    Lu, Y.3    Thieme, M.E.4
  • 163
    • 0042575347 scopus 로고    scopus 로고
    • Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice
    • DOI 10.1038/sj.mp.4001270
    • Tzavara ET, Bymaster FP, Felder CC, Wade M, Gomeza J, Wess J, McKinzie DL, Nomikos GG (2003) Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice. Mol Psychiatry 8:673-679 (Pubitemid 36980624)
    • (2003) Molecular Psychiatry , vol.8 , Issue.7 , pp. 673-679
    • Tzavara, E.T.1    Bymaster, F.P.2    Felder, C.C.3    Wade, M.4    Gomeza, J.5    Wess, J.6    McKinzie, D.L.7    Nomikos, G.G.8
  • 164
    • 9444239189 scopus 로고    scopus 로고
    • 4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: Relevance to the pathophysiology and treatment of related CNS pathologies
    • DOI 10.1096/fj.04-1575fje
    • Tzavara ET, Bymaster FP, Davis RJ, Wade MR, Perry KW, Wess J, McKinzie DL, Felder C, Nomikos GG (2004) M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies. FASEB J 18:1410-1412 (Pubitemid 39561597)
    • (2004) FASEB Journal , vol.18 , Issue.12 , pp. 1410-1412
    • Tzavara, E.T.1    Bymaster, F.P.2    Davis, R.J.3    Wade, M.R.4    Perry, K.W.5    Wess, J.6    McKinzie, D.L.7    Felder, C.8    Nomikos, G.G.9
  • 165
    • 0032458542 scopus 로고    scopus 로고
    • Efficacy of xanomeline in Alzheimer disease: Cognitive improvement measured using the Computerized Neuropsychological Test Battery (CNTB)
    • Veroff AE, Bodick NC, Offen WW, Sramek JJ, Cutler NR (1998) Efficacy of xanomeline in Alzheimer disease: cognitive improvement measured using the Computerized Neuropsychological Test Battery (CNTB). Alzheimer Dis Assoc Disord 12:304-312 (Pubitemid 29050744)
    • (1998) Alzheimer Disease and Associated Disorders , vol.12 , Issue.4 , pp. 304-312
    • Veroff, A.E.1    Bodick, N.C.2    Offen, W.W.3    Sramek, J.J.4    Cutler, N.R.5
  • 166
    • 0025313499 scopus 로고
    • Localization of m5 muscarinic receptor mRNA in rat brain examined by in situ hybridization histochemistry
    • DOI 10.1016/0304-3940(90)90064-G
    • Vilaró MT, Palacios JM, Mengod G (1990) Localization of m5 muscarinic receptor mRNA in rat brain examined by in situ hybridization histochemistry. Neurosci Lett 114:154-159 (Pubitemid 20188950)
    • (1990) Neuroscience Letters , vol.114 , Issue.2 , pp. 154-159
    • Vilaro, M.T.1    Palacios, J.M.2    Mengod, G.3
  • 167
    • 0026031282 scopus 로고
    • Muscarinic cholinergic receptors in the rat caudate-putamen and olfactory tubercle belong predominantly to the m4 class: In situ hybridization and receptor autoradiography evidence
    • Vilaró MT, Wiederhold KH, Palacios JM, Mengod G (1991) Muscarinic cholinergic receptors in the rat caudate-putamen and olfactory tubercle belong predominantly to the m4 class: in situ hybridization and receptor autoradiography evidence. Neuroscience 40:159-167
    • (1991) Neuroscience , vol.40 , pp. 159-167
    • Vilaró, M.T.1    Wiederhold, K.H.2    Palacios, J.M.3    Mengod, G.4
  • 168
    • 52649135145 scopus 로고    scopus 로고
    • Methylphenidateinduced increases in vesicular dopamine sequestration and dopamine release in the striatum: The role of muscarinic and dopamine D2 receptors
    • Volz TJ, Farnsworth SJ, Rowley SD, Hanson GR, Fleckenstein AE (2008) Methylphenidateinduced increases in vesicular dopamine sequestration and dopamine release in the striatum: the role of muscarinic and dopamine D2 receptors. J Pharmacol Exp Ther 327:335-340
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 335-340
    • Volz, T.J.1    Farnsworth, S.J.2    Rowley, S.D.3    Hanson, G.R.4    Fleckenstein, A.E.5
  • 169
    • 9644281566 scopus 로고    scopus 로고
    • Decreased amphetamine-induced locomotion and improved latent inhibition in mice mutant for the M5 muscarinic receptor gene found in the human 15q schizophrenia region
    • DOI 10.1038/sj.npp.1300502
    • Wang H, Ng K, Hayes D, Gao X, Forster G, Blaha C, Yeomans J (2004) Decreased amphetamineinduced locomotion and improved latent inhibition in mice mutant for the M5 muscarinic receptor gene found in the human 15q schizophrenia region. Neuropsychopharmacology 29:2126-2139 (Pubitemid 39578903)
    • (2004) Neuropsychopharmacology , vol.29 , Issue.12 , pp. 2126-2139
    • Wang, H.1    Ng, K.2    Hayes, D.3    Gao, X.4    Forster, G.5    Blaha, C.6    Yeomans, J.7
  • 170
    • 0021060772 scopus 로고
    • Increased muscarinic cholinergic receptors in prefrontal cortices of medicated schizophrenics
    • DOI 10.1016/0024-3205(83)90290-4
    • Watanabe S, Nishikawa T, Takashima M, Toru M (1983) Increased muscarinic cholinergic receptors in prefrontal cortices of medicated schizophrenics. Life Sci 33:2187-2196 (Pubitemid 14234456)
    • (1983) Life Sciences , vol.33 , Issue.22 , pp. 2187-2196
    • Watanabe, S.1    Nishikawa, T.2    Takashima, M.3    Toru, M.4
  • 172
  • 173
    • 0025130727 scopus 로고
    • Expression of muscarinic acetylcholine and dopamine receptor mRNAs in rat basal ganglia
    • Weiner DM, Levey AI, Brann MR (1990) Expression of muscarinic acetylcholine and dopamine receptor mRNAs in rat basal ganglia. Proc Natl Acad Sci 87:7050-7054
    • (1990) Proc Natl Acad Sci , vol.87 , pp. 7050-7054
    • Weiner, D.M.1    Levey, A.I.2    Brann, M.R.3
  • 175
    • 84856668794 scopus 로고    scopus 로고
    • Novel muscarinic receptor mutant mouse models
    • Wess J (2012) Novel muscarinic receptor mutant mouse models. Handbook Exp Pharmacol 208:95-117
    • (2012) Handbook Exp Pharmacol , vol.208 , pp. 95-117
    • Wess, J.1
  • 176
    • 34548362105 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors: Mutant mice provide new insights for drug development
    • DOI 10.1038/nrd2379, PII NRD2379
    • Wess J, Eglen RM, Gautam D (2007) Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov 6:721-733 (Pubitemid 47342315)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.9 , pp. 721-733
    • Wess, J.1    Eglen, R.M.2    Gautam, D.3
  • 177
    • 33748527479 scopus 로고    scopus 로고
    • Comorbid schizophrenia and substance abuse: A review of epidemiology and course
    • DOI 10.1080/10550490600860114, PII M6882W641X767P81
    • Westermeyer J (2006) Comorbid schizophrenia and substance abuse: a review of epidemiology and course. Am J Addict 15:345-355 (Pubitemid 44373580)
    • (2006) American Journal on Addictions , vol.15 , Issue.5 , pp. 345-355
    • Westermeyer, J.1
  • 178
    • 0025941928 scopus 로고
    • Cholinergic systems in Mammalian brain and spinal cord
    • Woolf NJ (1991) Cholinergic systems in mammalian brain and spinal cord. Prog Neurobiol 37:475-524
    • (1991) Prog Neurobiol , vol.37 , pp. 475-524
    • Woolf, N.J.1
  • 179
    • 54149090275 scopus 로고    scopus 로고
    • World Health Organization 2004 update
    • World Health Organization (2004) The global burden of disease. 2004 update. http://www.who.int/healthinfo/global-burden-disease/GBD-report- 2004update-full.pdf
    • (2004) The Global Burden of Disease
  • 182
    • 77949818715 scopus 로고    scopus 로고
    • Preferential localization of muscarinic M1 receptor on dendritic shaft and spine of cortical pyramidal cells and its anatomical evidence for volume transmission
    • Yamasaki M, Matsui M, Watanabe M (2010) Preferential localization of muscarinic M1 receptor on dendritic shaft and spine of cortical pyramidal cells and its anatomical evidence for volume transmission. J Neurosci 30:4408-4418
    • (2010) J Neurosci , vol.30 , pp. 4408-4418
    • Yamasaki, M.1    Matsui, M.2    Watanabe, M.3
  • 184
    • 0028914212 scopus 로고
    • Role of tegmental cholinergic neurons in dopaminergic activation, antimuscarinic psychosis and schizophrenia
    • Yeomans JS (1995) Role of tegmental cholinergic neurons in dopaminergic activation, antimuscarinic psychosis and schizophrenia. Neuropsychopharmacology 12:3-16
    • (1995) Neuropsychopharmacology , vol.12 , pp. 3-16
    • Yeomans, J.S.1
  • 185
    • 1642415654 scopus 로고    scopus 로고
    • Investigation of m1/m4 muscarinic receptors in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression disorder
    • Zavitsanou K, Katsifis A, Mattner F, Huang XF (2004) Investigation of m1/m4 muscarinic receptors in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression disorder. Neuropsychopharmacology 29:619-625
    • (2004) Neuropsychopharmacology , vol.29 , pp. 619-625
    • Zavitsanou, K.1    Katsifis, A.2    Mattner, F.3    Huang, X.F.4
  • 186
    • 17044413243 scopus 로고    scopus 로고
    • M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders
    • Zavitsanou K, Katsifis A, Huang XF (2005) M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders. Brain Res Bull 65:397-403
    • (2005) Brain Res Bull , vol.65 , pp. 397-403
    • Zavitsanou, K.1    Katsifis, A.2    Huang, X.F.3
  • 187
    • 0031043685 scopus 로고    scopus 로고
    • Muscarinic m4 receptor activation by some atypical antipsychotic drugs
    • DOI 10.1016/S0014-2999(96)00956-9, PII S0014299996009569
    • Zeng XP, Le F, Richelson E (1997) Muscarinic m4 receptor activation by some atypical antipsychotic drugs. Eur J Pharmacol 321:349-354 (Pubitemid 27105938)
    • (1997) European Journal of Pharmacology , vol.321 , Issue.3 , pp. 349-354
    • Zeng, X.P.1    Le, F.2    Richelson, E.3
  • 188
    • 0036703638 scopus 로고    scopus 로고
    • 5 muscarinic receptor knock-out mice
    • Zhang W, Yamada M, Gomeza J, Basile AS, Wess J (2002) Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice. J Neurosci 22:6347-6352 (Pubitemid 35386389)
    • (2002) Journal of Neuroscience , vol.22 , Issue.15 , pp. 6347-6352
    • Zhang, W.1    Yamada, M.2    Gomeza, J.3    Basile, A.S.4    Wess, J.5


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