Effects of clozapine on rat striatal muscarinic receptors coupled to inhibition of adenylyl cyclase activity and on the human cloned m4 receptor

British Journal of Pharmacology

Volumn 122, Issue 3, 1997, Pages 401-408

  Olianas, Maria C ^a   Maullu, Carlo ^a   Onali, Pierluigi ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

35S guanosine 5' O (thio)triphosphate binding; 3H N methylscopolamine binding; Clozapine; Cyclic AMP; Human cloned m4 muscarinic receptor; Rat striatal M4 muscarinic receptors

Indexed keywords

2 ETHOXY 1(2H) QUINOLINECARBOXYLIC ACID ETHYL ESTER; ACETYLCHOLINE; ADENYLATE CYCLASE; ATROPINE; CARBACHOL; CLOZAPINE; CYCLIC AMP; DOPAMINE 1 RECEPTOR; FORSKOLIN; GENE PRODUCT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); METHYLSCOPOLAMINE; MUSCARINIC M4 RECEPTOR; MUSCARINIC RECEPTOR; NEUROLEPTIC AGENT; RADIOLIGAND;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CHO CELL; CONCENTRATION RESPONSE; CORPUS STRIATUM; ENZYME ACTIVATION; ENZYME INHIBITION; EXPRESSION VECTOR; FEMALE; MALE; MEMBRANE BINDING; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENYLATE CYCLASE; ALKYLATION; ANIMALS; CELL MEMBRANE; CHO CELLS; CLOZAPINE; CORPUS STRIATUM; CRICETINAE; CYCLIC AMP; FORSKOLIN; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; MALE; MUSCARINIC ANTAGONISTS; N-METHYLSCOPOLAMINE; PROTEIN BINDING; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, MUSCARINIC; SYNAPTOSOMES;

EID: 0030930050     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701357     Document Type: Article

References (30)

1. ARUNLAKSHANA, O. & SCHILD, H.O. (1959). Some quantitative uses of drug antagonists. Br. J. Pharmacol. Chemother., 14, 48-58.
2. BALDESSARINI, R.J. & FRANKENBURG, F.R. (1991). Clozapine: A novel antipsychotic agent. New Engl. J. Med., 324, 746-754.
3. BOLDEN, C., CUSACK, B. & RICHELSON, E. (1992). Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells. J. Pharmacol. Exp. Ther., 260, 576-580.
4. BRADFORD, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
5. BUCKLEY, N.J., BONNNER, T.I & BRANN, M.R. (1988). Localization of a family of muscarinic receptor mRNAs in rat brain. J. Neurosci., 8, 4646-4652.
6. COWARD, D.M. (1992). General pharmacology of clozapine. Br. J. Psychiatry, 160 (suppl. 17), 5-11.
7. DITTMAN, A.H. WEBER, J.P., HINDS, T.R., CHOI, E.-J., MIGEON, J.C., NATHANSON, N.M. & STORM, D.R. (1994). A novel mechanism for coupling of m4 muscarinic acetylcholine receptors to calmodulin-sensitive adenylyl cyclases: Crossover from G protein-coupled inhibition to stimulation. Biochemistry, 33, 943-951.
8. EHLERT, F.J., DELEN, F.M., YUN, S.H., FRIEDMAN, D. & SELF, D.W. (1989). Coupling of subtypes of the muscarinic receptor to adenylate cyclase in corpus striatum and heart. J. Pharmacol. Exp. Ther., 251, 660-671.
9. EHLERT, F.J. & TRAN, L.P. (1990). Regional distribution of M1, M2 and non-M1, non-M2 subtypes of muscarinic binding sites in rat brain. J. Pharmacol. Exp. Ther., 255, 1148-1157.
10. JONES, S.V.P., HEILMAN, C.J. & BRANN, M.R. (1991). Functional responses of cloned muscarinic receptors expressed in CHO-K1 cells. Mol. Pharmacol., 40, 242-247.
11. KELLY, E. & NAHORSKI, S.R. (1986). Specific inhibition of dopamine D-1-mediated cyclic AMP formation by dopamine D-2, muscarinic cholinergic and opiate receptor stimulation in rat striatal slices. J. Neurochem., 47, 1512-1516.
12. KENAKIN, T.P. BOND, R.A. & BONNER, T.I. (1992). Definition of pharmacological receptors. Pharmacol. Rev., 44, 351-362.
13. 35S]GTPγS binding mediated by human muscarinic m1-m4 receptors: antagonist studies. Br. J. Pharmacol., 109, 1120-1127.
14. LEVEY, A.I., KITT, C.A., SIMONDS, W.F., PRICE, D.L. & BRANN, M.R. (1991). Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J. Neurosci., 11, 3218-3226.
15. MCKINNEY, M., ANDERSON, D.J., FORRAY, F. & EL-FAKAHANY, E. (1989). Characterization of the striatal M2 muscarinic receptor mediating inhibition of cyclic AMP using selective antagonists: a comparison with the brainstem M2 receptor. J. Pharmacol Exp. Ther., 250, 565-572.
16. MELTZER, H.Y., CHAI, B.L., THOMPSON, P.A. & YAMAMOTO, B.K. (1994). Effect of scopolamine on the efflux of dopamine and its metabolites after clozapine, haloperidol or thioridazine. J. Pharmacol. Exp. Ther., 268, 1452-1461.
17. MILLER, J.L. & HILEY, C.R. (1974). Antimuscarinic properties of neuroleptics and drug-induced parkinsonism. Nuture, 248, 596-597.
18. MILLER, J.L. & HILLEY, C.R. (1976). Anti-dopaminergic and antimuscarinic effects of dibenzodiazepines: Relationship to drug-induced parkinsonism. Naunyn-Schmiedeberg's. Arch. Pharmacol., 292, 289-293.
19. MUNSON, P.J. & RODBHARD, D. (1980). LIGAND: a versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem., 107, 220-239.
20. NATHANSON, N.M. (1987) Molecular properties of the muscarinic acetylcholine receptor. Ann. Rev. Neurosci., 10, 195-236.
21. 4 ligand muscarinic toxin 3 (MT3). Br. J. Pharmacol., 118, 283-288.
22. OLIANAS, M.C. & ONALI, P. (1991). Muscarinic stimulation of adenylate cyclase activity of rat olfactory bulb. II. Characterization of the antagonist sensitivity and comparison with muscarinic inhibitions of the enzyme in striatum and heart. J. Pharmacol. Exp. Ther., 259, 680-686.
23. 35S]triphosphate) binding by cholinergic muscarinic receptors in membranes of rat olfactory bulb. J. Neurochem., 67, 2549-2556.
24. OLIANAS, M.C., ONALI, P., NEFF, N.H. & COSTA, E. (1983). Muscarinic receptors modulate dopamine-activated adenylate cyclase of rat striatum. J. Neurochem., 41, 1364-1369.
25. RIVEST.. R & MARSDEN, C.A. (1991). Muscarinic antagonists attenuate the increase in accumbens and striatum dopamine metabolism produced by clozapine but not by haloperiodol. Br. J. Pharmacol., 104, 234-238.
26. SALOMON, Y., LONDOS, D. & RODBELL, M. (1974). A highly sensitive adenylate cyclase assay. Anal. Biochem., 58, 541-548.
27. SNYDER, S.H.,. GREENBERG, D. & YAMAMURA, H.I. (1974). Antischizophrenic drugs and brain cholinergic receptors. Arch. Gen. Psychiatry, 31, 58-61.
28. 4) in rat forebrain. Mol. Pharmacol., 38, 267-273.
29. YASUDA, R.P., CIESLA, W., FLORES, L.R., WALL, S.J., LI, M., SATKUS, S.A., WEISSTEIN, J.S., SPAGNOLA, B.V. & WOLFE, B.B. (1993). Development of antisera selective for m4 and m5 muscarinic cholinergic receptors: Distribution of m4 and m5 receptors in rat brain. Mol. Pharmacol., 43, 149-157.
30. 4 receptor agonist. Eur. J. Pharmacol.-Molec. Pharmacol. Sect., 269, R1-R2.