메뉴 건너뛰기




Volumn 287, Issue 45, 2012, Pages 37628-37646

HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and f-actin-binding filamin a or can interact with HCN2

Author keywords

[No Author keywords available]

Indexed keywords

BINDING EVENTS; HAIR CELLS; MECHANOTRANSDUCTION; PROTEIN COMPLEXES; PROTEIN-PROTEIN INTERACTIONS; TERNARY COMPLEX;

EID: 84868305320     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.375832     Document Type: Article
Times cited : (29)

References (62)
  • 1
    • 0037426596 scopus 로고    scopus 로고
    • Hyperpolarization-activated, cyclic AMP-gated, HCN1-like cation channel. The primary, full-length HCN isoform expressed in a saccular hair-cell layer
    • Cho, W. J., Drescher, M. J., Hatfield, J. S., Bessert, D. A., Skoff, R. P., and Drescher, D. G. (2003) Hyperpolarization-activated, cyclic AMP-gated, HCN1-like cation channel. The primary, full-length HCN isoform expressed in a saccular hair-cell layer. Neuroscience 118, 525-5344
    • (2003) Neuroscience , vol.118 , pp. 525-5344
    • Cho, W.J.1    Drescher, M.J.2    Hatfield, J.S.3    Bessert, D.A.4    Skoff, R.P.5    Drescher, D.G.6
  • 2
    • 59149103777 scopus 로고    scopus 로고
    • Calcium-dependent binding of HCN1 channel protein to hair cell stereociliary tip link protein protocadherin 15 CD3
    • Ramakrishnan, N. A., Drescher, M. J., Barretto, R. L., Beisel, K. W., Hatfield, J. S., and Drescher, D. G. (2009)Calcium-dependent binding of HCN1 channel protein to hair cell stereociliary tip link protein protocadherin 15 CD3. J. Biol. Chem. 284, 3227-32388
    • (2009) J. Biol. Chem. , vol.284 , pp. 3227-32388
    • Ramakrishnan, N.A.1    Drescher, M.J.2    Barretto, R.L.3    Beisel, K.W.4    Hatfield, J.S.5    Drescher, D.G.6
  • 3
    • 14044258529 scopus 로고    scopus 로고
    • Duplicated genes with split functions, Independent roles of protocadherin15 orthologues in zebrafish hearing and vision
    • Seiler, C., Finger-Baier, K. C., Rinner, O., Makhankov, Y. V., Schwarz, H., Neuhauss, S. C., and Nicolson, T. (2005) Duplicated genes with split functions. Independent roles of protocadherin15 orthologues in zebrafish hearing and vision. Development 132, 615-6233
    • (2005) Development , vol.132 , pp. 615-6233
    • Seiler, C.1    Finger-Baier, K.C.2    Rinner, O.3    Makhankov, Y.V.4    Schwarz, H.5    Neuhauss, S.C.6    Nicolson, T.7
  • 5
    • 79960999113 scopus 로고    scopus 로고
    • Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction
    • Grati, M., and Kachar, B. (2011) Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction. Proc. Natl. Acad. Sci. U.S.A. 108, 11476-114811
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 11476-114811
    • Grati, M.1    Kachar, B.2
  • 6
    • 0033063883 scopus 로고    scopus 로고
    • Selective expression of serotonin receptor transcripts in the mammalian cochlea and its subdivisions
    • Oh, C. K., Drescher, M. J., Hatfield, J. S., and Drescher, D. G. (1999)Selective expression of serotonin receptor transcripts in the mammalian cochlea and its subdivisions. Brain Res. Mol. Brain Res. 70, 135-1400
    • (1999) Brain Res. Mol. Brain Res. , vol.70 , pp. 135-1400
    • Oh, C.K.1    Drescher, M.J.2    Hatfield, J.S.3    Drescher, D.G.4
  • 10
    • 0242353179 scopus 로고    scopus 로고
    • Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels
    • Much, B., Wahl-Schott, C., Zong, X., Schneider, A., Baumann, L., Moosmang, S., Ludwig, A., and Biel, M. (2003) Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization- activated cyclic nucleotide-gated channels. J. Biol. Chem. 278, 43781-437866
    • (2003) J. Biol. Chem. , vol.278 , pp. 43781-437866
    • Much, B.1    Wahl-Schott, C.2    Zong, X.3    Schneider, A.4    Baumann, L.5    Moosmang, S.6    Ludwig, A.7    Biel, M.8
  • 11
    • 0037110455 scopus 로고    scopus 로고
    • A conserved domain in the NH2 terminus important for assembly and functional expression of pacemaker channels
    • Tran, N., Proenza, C., Macri, V., Petigara, F., Sloan, E., Samler, S., and Accili, E. A. (2002) A conserved domain in the NH2 terminus important for assembly and functional expression of pacemaker channels. J. Biol. Chem. 277, 43588-435922
    • (2002) J. Biol. Chem. , vol.277 , pp. 43588-435922
    • Tran, N.1    Proenza, C.2    MacRi, V.3    Petigara, F.4    Sloan, E.5    Samler, S.6    Accili, E.A.7
  • 12
    • 67651030760 scopus 로고    scopus 로고
    • Hyperpolarization-activated cation channels. from genes to function
    • Biel, M., Wahl-Schott, C., Michalakis, S., and Zong, X. (2009)Hyperpolarization-activated cation channels. From genes to function. Physiol. Rev. 89, 847-8855
    • (2009) Physiol. Rev. , vol.89 , pp. 847-8855
    • Biel, M.1    Wahl-Schott, C.2    Michalakis, S.3    Zong, X.4
  • 14
    • 0032508032 scopus 로고    scopus 로고
    • Molecular identification of a hyperpolarization-activated channel in sea urchin sperm
    • Gauss, R., Seifert, R., and Kaupp, U. B. (1998) Molecular identification of a hyperpolarization-activated channel in sea urchin sperm. Nature 393, 583-5877
    • (1998) Nature , vol.393 , pp. 583-5877
    • Gauss, R.1    Seifert, R.2    Kaupp, U.B.3
  • 15
    • 0033617416 scopus 로고    scopus 로고
    • Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatrial node
    • Ishii, T. M., Takano, M., Xie, L. H., Noma, A., and Ohmori, H. (1999)Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatrial node. J. Biol. Chem. 274, 12835-128399
    • (1999) J. Biol. Chem. , vol.274 , pp. 12835-128399
    • Ishii, T.M.1    Takano, M.2    Xie, L.H.3    Noma, A.4    Ohmori, H.5
  • 16
    • 0033529867 scopus 로고    scopus 로고
    • Molecular characterization of a slowly gating human hyperpolarization- activated channel predominantly expressed in thalamus, heart, and testis
    • Seifert, R., Scholten, A., Gauss, R., Mincheva, A., Lichter, P., and Kaupp, U. B. (1999)Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis. Proc. Natl. Acad. Sci. U.S.A. 96, 9391-93966
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 9391-93966
    • Seifert, R.1    Scholten, A.2    Gauss, R.3    Mincheva, A.4    Lichter, P.5    Kaupp, U.B.6
  • 17
    • 0141817695 scopus 로고    scopus 로고
    • KCNE2 modulates current amplitudes and activation kinetics of HCN. Influence of KCNE family members on HCN4 currents
    • Decher, N., Bundis, F., Vajna, R., and Steinmeyer, K. (2003) KCNE2 modulates current amplitudes and activation kinetics of HCN. Influence of KCNE family members on HCN4 currents. Pflugers Arch. 446, 633-6400
    • (2003) Pflugers Arch. , vol.446 , pp. 633-6400
    • Decher, N.1    Bundis, F.2    Vajna, R.3    Steinmeyer, K.4
  • 18
    • 1942501531 scopus 로고    scopus 로고
    • Structural elements of instantaneous and slow gating in hyperpolarization-activated cyclic nucleotide-gated channels
    • Macri, V., and Accili, E. A. (2004) Structural elements of instantaneous and slow gating in hyperpolarization-activated cyclic nucleotide-gated channels. J. Biol. Chem. 279, 16832-168466
    • (2004) J. Biol. Chem. , vol.279 , pp. 16832-168466
    • MacRi, V.1    Accili, E.A.2
  • 19
    • 21744440389 scopus 로고    scopus 로고
    • Nonequilibrium behavior ofHCNchannels, Insights into the role ofHCN channels in native and engineered pacemakers
    • Azene, E. M., Xue, T., Marbán, E., Tomaselli, G. F., and Li, R. A. (2005) Nonequilibrium behavior ofHCNchannels. Insights into the role ofHCN channels in native and engineered pacemakers. Cardiovasc. Res. 67, 263-2733
    • (2005) Cardiovasc. Res. , vol.67 , pp. 263-2733
    • Azene, E.M.1    Xue, T.2    Marbán, E.3    Tomaselli, G.F.4    Li, R.A.5
  • 20
    • 33748369660 scopus 로고    scopus 로고
    • The enhancement of HCN channel instantaneous current facilitated by slow deactivation is regulated by intracellular chloride concentration
    • Mistrík, P., Pfeifer, A., and Biel, M. (2006) The enhancement of HCN channel instantaneous current facilitated by slow deactivation is regulated by intracellular chloride concentration. Pflugers Arch. 452, 718-7277
    • (2006) Pflugers Arch. , vol.452 , pp. 718-7277
    • Mistrík, P.1    Pfeifer, A.2    Biel, M.3
  • 21
    • 0032508040 scopus 로고    scopus 로고
    • A family of hyperpolarization-activated mammalian cation channels
    • Ludwig, A., Zong, X., Jeglitsch, M., Hofmann, F., and Biel, M. (1998) A family of hyperpolarization-activated mammalian cation channels. Nature 393, 587-5911
    • (1998) Nature , vol.393 , pp. 587-5911
    • Ludwig, A.1    Zong, X.2    Jeglitsch, M.3    Hofmann, F.4    Biel, M.5
  • 22
    • 0037184106 scopus 로고    scopus 로고
    • Separable gating mechanisms in a mammalian pacemaker channel
    • Macri, V., Proenza, C., Agranovich, E., Angoli, D., and Accili, E. A. (2002) Separable gating mechanisms in a mammalian pacemaker channel. J. Biol. Chem. 277, 35939-359466
    • (2002) J. Biol. Chem. , vol.277 , pp. 35939-359466
    • MacRi, V.1    Proenza, C.2    Agranovich, E.3    Angoli, D.4    Accili, E.A.5
  • 23
    • 31744437523 scopus 로고    scopus 로고
    • Distinct populations of HCN pacemaker channels produce voltage-dependent and voltage-independent currents
    • Proenza, C., and Yellen, G. (2006) Distinct populations of HCN pacemaker channels produce voltage-dependent and voltage-independent currents. J. Gen. Physiol. 127, 183-1900
    • (2006) J. Gen. Physiol. , vol.127 , pp. 183-1900
    • Proenza, C.1    Yellen, G.2
  • 24
    • 33847793624 scopus 로고    scopus 로고
    • Dual stretch responses of mHCN2 pacemaker channels. Accelerated activation, accelerated deactivation
    • Lin, W., Laitko, U., Juranka, P. F., and Morris, C. E. (2007) Dual stretch responses of mHCN2 pacemaker channels. Accelerated activation, accelerated deactivation. Biophys. J. 92, 1559-15722
    • (2007) Biophys. J. , vol.92 , pp. 1559-15722
    • Lin, W.1    Laitko, U.2    Juranka, P.F.3    Morris, C.E.4
  • 26
    • 80054043810 scopus 로고    scopus 로고
    • Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A
    • Ehrlicher, A. J., Nakamura, F., Hartwig, J. H., Weitz, D. A., and Stossel, T. P. (2011) Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A. Nature 478, 260-2633
    • (2011) Nature , vol.478 , pp. 260-2633
    • Ehrlicher, A.J.1    Nakamura, F.2    Hartwig, J.H.3    Weitz, D.A.4    Stossel, T.P.5
  • 27
    • 24144463105 scopus 로고    scopus 로고
    • Hypoosmotic cell swelling as a novel mechanism for modulation of cloned HCN2 channels
    • Calloe, K., Elmedyb, P., Olesen, S. P., Jorgensen, N. K., and Grunnet, M. (2005) Hypoosmotic cell swelling as a novel mechanism for modulation of cloned HCN2 channels. Biophys. J. 89, 2159-21699
    • (2005) Biophys. J. , vol.89 , pp. 2159-21699
    • Calloe, K.1    Elmedyb, P.2    Olesen, S.P.3    Jorgensen, N.K.4    Grunnet, M.5
  • 28
    • 80052617001 scopus 로고    scopus 로고
    • HCN2 ion channels play a central role in inflammatory and neuropathic pain
    • Emery, E. C., Young, G. T., Berrocoso, E. M., Chen, L., and McNaughton, P. A. (2011) HCN2 ion channels play a central role in inflammatory and neuropathic pain. Science 333, 1462-14666
    • (2011) Science , vol.333 , pp. 1462-14666
    • Emery, E.C.1    Young, G.T.2    Berrocoso, E.M.3    Chen, L.4    McNaughton, P.A.5
  • 29
    • 65949120713 scopus 로고    scopus 로고
    • Low conductance HCN1 ion channels augment the frequency response of rod and cone photoreceptors
    • Barrow, A. J., and Wu, S. M. (2009)Low conductance HCN1 ion channels augment the frequency response of rod and cone photoreceptors. J. Neurosci. 29, 5841-58533
    • (2009) J. Neurosci. , vol.29 , pp. 5841-58533
    • Barrow, A.J.1    Wu, S.M.2
  • 30
    • 33845268874 scopus 로고    scopus 로고
    • Steady-state adaptation of mechanotransduction modulates the resting potential of auditory hair cells, providing an assay for endolymph [Ca2+]
    • Farris, H. E., Wells, G. B., and Ricci, A. J. (2006) Steady-state adaptation of mechanotransduction modulates the resting potential of auditory hair cells, providing an assay for endolymph [Ca2+]. J. Neurosci. 26, 12526-125366
    • (2006) J. Neurosci. , vol.26 , pp. 12526-125366
    • Farris, H.E.1    Wells, G.B.2    Ricci, A.J.3
  • 31
    • 34548655244 scopus 로고    scopus 로고
    • Modulation of cyclic nucleotide-regulated HCN channels by PIP2 and receptors coupled to phospholipase C
    • Pian, P., Bucchi, A., Decostanzo, A., Robinson, R. B., and Siegelbaum, S. A (2007) Modulation of cyclic nucleotide-regulated HCN channels by PIP2 and receptors coupled to phospholipase C. Pflugers Arch. 455, 125-1455
    • (2007) Pflugers Arch. , vol.455 , pp. 125-1455
    • Pian, P.1    Bucchi, A.2    Decostanzo, A.3    Robinson, R.B.4    Siegelbaum, S.A.5
  • 32
    • 5144227109 scopus 로고    scopus 로고
    • Hair cells require phosphatidylinositol 4, 5-bisphosphate for mechanical transduction and adaptation
    • Hirono, M., Denis, C. S., Richardson, G. P., and Gillespie, P. G. (2004) Hair cells require phosphatidylinositol 4, 5-bisphosphate for mechanical transduction and adaptation. Neuron 44, 309-3200
    • (2004) Neuron , vol.44 , pp. 309-3200
    • Hirono, M.1    Denis, C.S.2    Richardson, G.P.3    Gillespie, P.G.4
  • 34
    • 77952996307 scopus 로고    scopus 로고
    • Dendritic HCN channels shape excitatory postsynaptic potentials at the inner hair cell afferent synapse in the mammalian cochlea
    • Yi, E., Roux, I., and Glowatzki, E. (2010) Dendritic HCN channels shape excitatory postsynaptic potentials at the inner hair cell afferent synapse in the mammalian cochlea. J. Neurophysiol. 103, 2532-25433
    • (2010) J. Neurophysiol. , vol.103 , pp. 2532-25433
    • Yi, E.1    Roux, I.2    Glowatzki, E.3
  • 35
    • 77649144091 scopus 로고    scopus 로고
    • HCNchannels are not required for mechanotransduction in sensory hair cells of the mouse inner ear
    • Horwitz, G. C., Lelli, A., Géléoc, G. S., and Holt, J. R. (2010)HCNchannels are not required for mechanotransduction in sensory hair cells of the mouse inner ear. PLoS One 5, e86277
    • (2010) PLoS One , vol.5
    • Horwitz, G.C.1    Lelli, A.2    Géléoc, G.S.3    Holt, J.R.4
  • 36
    • 70350036029 scopus 로고    scopus 로고
    • Proteolytic processing of HCN2 and co-assembly with HCN4 in the generation of cardiac pacemaker channels
    • Ye, B., and Nerbonne, J. M. (2009)Proteolytic processing of HCN2 and co-assembly with HCN4 in the generation of cardiac pacemaker channels. J. Biol. Chem. 284, 25553-255599
    • (2009) J. Biol. Chem. , vol.284 , pp. 25553-255599
    • Ye, B.1    Nerbonne, J.M.2
  • 37
    • 80051525698 scopus 로고    scopus 로고
    • The magnitudes of hyperpolarizationactivated and low voltage-activated potassium currents co-vary in neurons of the ventral cochlear nucleus
    • Cao, X. J., and Oertel, D. (2011) The magnitudes of hyperpolarizationactivated and low voltage-activated potassium currents co-vary in neurons of the ventral cochlear nucleus. J. Neurophysiol. 106, 630-6400
    • (2011) J. Neurophysiol. , vol.106 , pp. 630-6400
    • Cao, X.J.1    Oertel, D.2
  • 38
    • 77249142044 scopus 로고    scopus 로고
    • Homeostatic regulation of synaptic excitability, Tonic GABAA receptor currents replace Ih in cortical pyramidal neurons of HCN1 knockout mice
    • Chen, X., Shu, S., Schwartz, L. C., Sun, C., Kapur, J., and Bayliss, D. A. (2010) Homeostatic regulation of synaptic excitability. Tonic GABAA receptor currents replace Ih in cortical pyramidal neurons of HCN1 knockout mice. J. Neurosci. 30, 2611-26222
    • (2010) J. Neurosci. , vol.30 , pp. 2611-26222
    • Chen, X.1    Shu, S.2    Schwartz, L.C.3    Sun, C.4    Kapur, J.5    Bayliss, D.A.6
  • 39
  • 40
    • 0028940982 scopus 로고
    • Inwardly rectifying currents of saccular hair cells from the leopard frog
    • Holt, J. R., and Eatock, R. A. (1995) Inwardly rectifying currents of saccular hair cells from the leopard frog. J. Neurophysiol. 73, 1484-15022
    • (1995) J. Neurophysiol. , vol.73 , pp. 1484-15022
    • Holt, J.R.1    Eatock, R.A.2
  • 41
    • 0029757296 scopus 로고    scopus 로고
    • Inwardly rectifying currents in hair cells and supporting cells in the goldfish sacculus
    • Sugihara, I., and Furukawa, T. (1996)Inwardly rectifying currents in hair cells and supporting cells in the goldfish sacculus. J. Physiol. 495, 665-6799
    • (1996) J. Physiol. , vol.495 , pp. 665-6799
    • Sugihara, I.1    Furukawa, T.2
  • 42
    • 79551522275 scopus 로고    scopus 로고
    • Mechanism of spontaneous activity in afferent neurons of the zebrafish lateral-line organ
    • Trapani, J. G., and Nicolson, T. (2011) Mechanism of spontaneous activity in afferent neurons of the zebrafish lateral-line organ. J. Neurosci. 31, 1614-16233
    • (2011) J. Neurosci. , vol.31 , pp. 1614-16233
    • Trapani, J.G.1    Nicolson, T.2
  • 43
    • 0004839694 scopus 로고    scopus 로고
    • Ionic currents expressed in a cell line derived from the organ of Corti of the Immortomouse
    • Jagger, D. J., Holley, M. C., and Ashmore, J. F. (1999)Ionic currents expressed in a cell line derived from the organ of Corti of the Immortomouse. Pflugers Arch. 438, 8-144
    • (1999) Pflugers Arch. , vol.438 , pp. 8-144
    • Jagger, D.J.1    Holley, M.C.2    Ashmore, J.F.3
  • 45
    • 67349280876 scopus 로고    scopus 로고
    • Pairwise coupling of hair cell transducer channels links auditory sensitivity and dynamic range
    • van Netten, S. M., Meulenberg, C. J., Lennan, G. W., and Kros, C. J. (2009)Pairwise coupling of hair cell transducer channels links auditory sensitivity and dynamic range. Pflugers Arch. 458, 273-2811
    • (2009) Pflugers Arch. , vol.458 , pp. 273-2811
    • Van Netten, S.M.1    Meulenberg, C.J.2    Lennan, G.W.3    Kros, C.J.4
  • 46
    • 56649086852 scopus 로고    scopus 로고
    • TRPML3 mutations cause impaired mechano-electrical transduction and depolarization by an inward-rectifier cation current in auditory hair cells of varitint-waddler mice
    • van Aken, A. F., Atiba-Davies, M., Marcotti, W., Goodyear, R. J., Bryant, J. E., Richardson, G. P., Noben-Trauth, K., and Kros, C. J. (2008)TRPML3 mutations cause impaired mechano-electrical transduction and depolarization by an inward-rectifier cation current in auditory hair cells of varitint-waddler mice. J. Physiol. 586, 5403-54188
    • (2008) J. Physiol. , vol.586 , pp. 5403-54188
    • Van Aken, A.F.1    Atiba-Davies, M.2    Marcotti, W.3    Goodyear, R.J.4    Bryant, J.E.5    Richardson, G.P.6    Noben-Trauth, K.7    Kros, C.J.8
  • 48
    • 0026651743 scopus 로고
    • Putative immunolocalization of the mechanoelectrical transduction channels in mammalian cochlear hair cells
    • Hackney, C. M., Furness, D. N., Benos, D. J., Woodley, J. F., and Barratt, J. (1992) Putative immunolocalization of the mechanoelectrical transduction channels in mammalian cochlear hair cells. Proc. Biol. Sci. 248, 215-2211
    • (1992) Proc. Biol. Sci. , vol.248 , pp. 215-2211
    • Hackney, C.M.1    Furness, D.N.2    Benos, D.J.3    Woodley, J.F.4    Barratt, J.5
  • 52
    • 0033230252 scopus 로고    scopus 로고
    • Developmental expression of the potassium current IK, n contributes to maturation of mouse outer hair cells
    • Marcotti, W., and Kros, C. J. (1999)Developmental expression of the potassium current IK, n contributes to maturation of mouse outer hair cells. J. Physiol. 520, 653-6600
    • (1999) J. Physiol. , vol.520 , pp. 653-6600
    • Marcotti, W.1    Kros, C.J.2
  • 53
    • 33746217842 scopus 로고    scopus 로고
    • Tmc1 is necessary for normal functional maturation and survival of inner and outer hair cells in the mouse cochlea
    • Marcotti, W., Erven, A., Johnson, S. L., Steel, K. P., and Kros, C. J. (2006) Tmc1 is necessary for normal functional maturation and survival of inner and outer hair cells in the mouse cochlea. J. Physiol. 574, 677-6988
    • (2006) J. Physiol. , vol.574 , pp. 677-6988
    • Marcotti, W.1    Erven, A.2    Johnson, S.L.3    Steel, K.P.4    Kros, C.J.5
  • 55
    • 33749517212 scopus 로고    scopus 로고
    • The chloride intracellular channel protein CLIC5 is expressed at high levels in hair cell stereocilia and is essential for normal inner ear function
    • Gagnon, L. H., Longo-Guess, C. M., Berryman, M., Shin, J. B., Saylor, K. W., Yu, H., Gillespie, P. G., and Johnson, K. R., (2006) The chloride intracellular channel protein CLIC5 is expressed at high levels in hair cell stereocilia and is essential for normal inner ear function. J. Neurosci. 26, 10188-101988
    • (2006) J. Neurosci. , vol.26 , pp. 10188-101988
    • Gagnon, L.H.1    Longo-Guess, C.M.2    Berryman, M.3    Shin, J.B.4    Saylor, K.W.5    Yu, H.6    Gillespie, P.G.7    Johnson, K.R.8
  • 56
    • 0027960512 scopus 로고
    • Fluorescence imaging of extracellular purinergic receptor sites and putative ecto-ATPase sites on isolated cochlear hair cells
    • Mockett, B. G., Housley, G. D., and Thorne, P. R. (1994) Fluorescence imaging of extracellular purinergic receptor sites and putative ecto-ATPase sites on isolated cochlear hair cells. J. Neurosci. 14, 6992-70077
    • (1994) J. Neurosci. , vol.14 , pp. 6992-70077
    • Mockett, B.G.1    Housley, G.D.2    Thorne, P.R.3
  • 58
    • 58149395091 scopus 로고    scopus 로고
    • Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat
    • Mukherjea, D., Jajoo, S., Whitworth, C., Bunch, J. R., Turner, J. G., Rybak, L. P., and Ramkumar, V. (2008)Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat. J. Neurosci. 28, 13056-130655
    • (2008) J. Neurosci. , vol.28 , pp. 13056-130655
    • Mukherjea, D.1    Jajoo, S.2    Whitworth, C.3    Bunch, J.R.4    Turner, J.G.5    Rybak, L.P.6    Ramkumar, V.7
  • 59
    • 53349120910 scopus 로고    scopus 로고
    • TRPV4 enhances the cellular uptake of aminoglycoside antibiotics
    • Karasawa, T., Wang, Q., Fu, Y., Cohen, D. M., and Steyger, P. S. (2008)TRPV4 enhances the cellular uptake of aminoglycoside antibiotics. J. Cell Sci. 121, 2871-28799
    • (2008) J. Cell Sci. , vol.121 , pp. 2871-28799
    • Karasawa, T.1    Wang, Q.2    Fu, Y.3    Cohen, D.M.4    Steyger, P.S.5
  • 60
    • 0037203841 scopus 로고    scopus 로고
    • Expression of subunits for the cAMP-sensitive, "olfactory" cyclic nucleotide-gated ion channel in the cochlea. Implications for signal transduction
    • Drescher, M. J., Barretto, R. L., Chaturvedi, D., Beisel, K. W., Hatfield, J. S., Khan, K. M., and Drescher, D. G. (2002) Expression of subunits for the cAMP-sensitive "olfactory" cyclic nucleotide-gated ion channel in the cochlea. Implications for signal transduction. Brain Res. Mol. Brain Res. 98, 1-144
    • (2002) Brain Res. Mol. Brain Res. , vol.98 , pp. 1-144
    • Drescher, M.J.1    Barretto, R.L.2    Chaturvedi, D.3    Beisel, K.W.4    Hatfield, J.S.5    Khan, K.M.6    Drescher, D.G.7
  • 62
    • 84934442086 scopus 로고    scopus 로고
    • Surface plasmon resonance (SPR) analysis of binding interactions of proteins in inner-ear sensory epithelia
    • Drescher, D. G., Ramakrishnan, N. A., and Drescher, M. J. (2009)Surface plasmon resonance (SPR) analysis of binding interactions of proteins in inner-ear sensory epithelia. Methods Mol. Biol. 493, 323-3433
    • (2009) Methods Mol. Biol. , vol.493 , pp. 323-3433
    • Drescher, D.G.1    Ramakrishnan, N.A.2    Drescher, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.