Expression of subunits for the cAMP-sensitive 'olfactory' cyclic nucleotide-gated ion channel in the cochlea: Implications for signal transduction

Molecular Brain Research

Volumn 98, Issue 1-2, 2002, Pages 1-14

  Drescher, Marian J ^a   Barretto, Roberto L ^a   Chaturvedi, Deepti ^a   Beisel, Kirk W ^b   Hatfield, James S ^c   Khan, Khalid M ^d   Drescher, Dennis G ^a,e  

^a WAYNE STATE UNIVERSITY   (United States)

^b BOYS TOWN NATIONAL RESEARCH HOSPITAL   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d AGA KHAN UNIVERSITY   (Pakistan)

^e WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cochlea; Cyclic nucleotide gated channel; Hair cell; Immunohistochemistry; RT PCR

Indexed keywords

ADENYLATE CYCLASE; COMPLEMENTARY DNA; CYCLIC AMP; CYCLIC NUCLEOTIDE; ION CHANNEL; PROTEIN SUBUNIT;

ANIMAL TISSUE; ARTICLE; BRAIN; CELL MEMBRANE; CHANNEL GATING; COCHLEA; CONTROLLED STUDY; CORTI ORGAN; DNA LIBRARY; DNA SEQUENCE; DNA TRANSCRIPTION; FEMALE; FRACTIONATION; FRAMESHIFT MUTATION; GENE AMPLIFICATION; GENE DELETION; HAIR CELL; IMMUNOREACTIVITY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OLFACTORY SYSTEM; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPIRAL GANGLION; STEREOCILIUM; STOP CODON;

ADENYLATE CYCLASE; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CILIA; COCHLEA; CODON, NONSENSE; CYCLIC AMP; DNA, COMPLEMENTARY; FEMALE; GENE LIBRARY; HAIR CELLS, OUTER; ION CHANNEL GATING; ION CHANNELS; MALE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; OPEN READING FRAMES; ORGAN OF CORTI; PROTEIN SUBUNITS; RATS; RATS, INBRED ACI; RNA, MESSENGER; SECOND MESSENGER SYSTEMS; SEQUENCE ALIGNMENT; SEQUENCE DELETION; SEQUENCE HOMOLOGY; SPIRAL GANGLION; SYNAPTIC TRANSMISSION;

EID: 0037203841     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(01)00289-3     Document Type: Article

References (44)

1. mRNA expression of cAMP-sensitive, cyclic nucleotide-gated ion channel subunit 2 in mouse cochlea and rat cochlear microdissected subfractions
2. mRNA expression of a cyclic nucleotide-gated ion channel subunit 1 in rat cochlear microdissected subfractions
3. G-protein expression in rat inner ear hair cells
4. Characterization of G-protein βγ expression in the inner ear
5. Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs
6. The native rat olfactory cyclic nucleotide-gated channel is composed of three distinct subunits
7. Very low calcium content of cochlear endolymph, an extracellular fluid
8. Heteromeric olfactory cyclic nucleotide-gated channels: A subunit that confers increased sensitivity to cAMP
9. Functional expression of the heteromeric 'olfactory' cyclic nucleotide-gated channel in the hippocampus: A potential effector of synaptic plasticity in brain neurons
10. 2+ channel
11. 2+/calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons
12. Response latency of vertebrate hair cells
13. Kinetics of the receptor current in bullfrog saccular hair cells
14. Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons
15. Potassium-evoked release of endogenous primary amine-containing compounds from the trout saccular macula and saccular nerve in vitro
16. Adenylyl cyclase type I cDNA and PKA RII immunoreactivity identified in rat inner hair cell
17. Expression of adenylyl cyclase type I in cochlear inner hair cells
18. mRNA expression of cAMP-sensitive, cyclic nucleotide-gated ion channel subunit 2 in the organ of Corti
19. Detection of cyclic nucleotide-gated ion channel transcripts in inner-ear epithelia
20. Immunohistochemical localization of adenylyl cyclase isoforms in the lateral wall of the rat cochlea
21. Cyclic nucleotide-gated ion channel subunit expression in the rat cochlea
22. Adaptation of mechanoelectrical transduction in hair cells of the bullfrog's saccule
23. Localization of soluble guanylate cyclase activity in the guinea pig cochlea suggests involvement in regulation of blood flow and supporting cell physiology
24. Properties of cyclic nucleotide-gated channels mediating olfactory transduction: Activation, selectivity, and blockage
25. Cyclic nucleotide-gated ion channels: An extended family with diverse functions
26. Family of cyclic nucleotide-gated ion channels
27. Rat hippocampal neurons express genes for both rod retinal and olfactory cyclic nucleotide-gated channels: Novel targets for cAMP/cGMP function
28. Cyclic nucleotide-activated channels in the frog olfactory receptor plasma membrane
29. A cyclic-AMP-gated conductance in cochlear hair cells
30. A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP
31. s in the organ of Corti
32. A cyclic nucleotide-gated conductance in olfactory receptor cilia
33. Selective expression of serotonin receptor transcripts in the mammalian cochlea and its subdivisions
34. The effects of calcium buffering and cyclic AMP on mechano-electrical transduction in turtle auditory hair cells
35. Hair cells: Transduction, tuning and transmission in the inner ear
36. Concentrations of inorganic ions in guinea pig inner ear fluids. I. Concentrations of potassium and sodium in cochlear and utricular endolymph
37. An isoform of the rod photoreceptor cyclic nucleotide-gated channel beta subunit expressed in olfactory neurons
38. Effects of caffeine and tetracaine on outer hair cell shortening suggest intracellular calcium involvement
39. 2+ channel transcripts in human fibroblasts
40. 'Bundle blot' purification and initial protein characterization of hair cell stereocilia
41. Molecular characterization and in situ localization of a full-length cyclic nucleotide-gated channel in rat brain
42. Type I and type VIII adenylyl cyclases constitute a family whose activation is coupled to cellular deformation through the action of calcium/calmodulin
43. Molecular and pharmacological analysis of cyclic nucleotide-gated channel function in the central nervous system
44. Inactivation of cAMP-dependent conductance of rod outer segment plasma membrane induced by cGMP