TRPV4 enhances the cellular uptake of aminoglycoside antibiotics

Journal of Cell Science

Volumn 121, Issue 17, 2008, Pages 2871-2879

  Karasawa, Takatoshi ^a   Wang, Qi ^a   Fu, Yi ^a,b   Cohen, David M ^a,b   Steyger, Peter S ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

Aminoglycosides; Cochlea; Drug permeability; Gentamicin; Hair cells; Ototoxicity; Stria vascularis; TRPV4

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; CALCIUM ION; FLUORESCENT DYE; GENTAMICIN; ION CHANNEL; TEXAS RED; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 4;

ANIMAL CELL; ARTICLE; COCHLEA; CONTROLLED STUDY; DRUG CLEARANCE; DRUG PENETRATION; DRUG UPTAKE; ENDOLYMPH; KIDNEY DISTAL TUBULE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

AMINOGLYCOSIDES; ANIMALS; ANTI-BACTERIAL AGENTS; CALCIUM; CELL LINE; DOGS; EAR, INNER; ENDOLYMPH; EXTRACELLULAR SPACE; GENTAMICINS; KIDNEY; METHIONINE; MICE; RATS; TRPV CATION CHANNELS; XANTHENES;

MURINAE;

EID: 53349120910     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.023705     Document Type: Article

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