Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective α1B- adrenoceptor antagonist

European Journal of Medicinal Chemistry

Volumn 58, Issue , 2012, Pages 184-191

  Fumagalli, Laura ^a   Pallavicini, Marco ^a   Budriesi, Roberta ^b   Gobbi, Marco ^c   Straniero, Valentina ^a   Zagami, Michael ^a   Chiodini, Giuseppe ^a   Bolchi, Cristiano ^a   Chiarini, Alberto ^b   Micucci, Matteo ^b   Valoti, Ermanno ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

1 Adrenoreceptor; 5 HT1A receptor; 8 Substituted 1,4 benzodioxane; Antagonist affinity; Binding affinity; Inverse agonist; WB4101 analogues

Indexed keywords

1,4 BENZODIOXAN DERIVATIVE; 2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; ALPHA 2A ADRENERGIC RECEPTOR; CHLORINE; FLUORINE; HYDROXYL GROUP; LEAD; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ISOMERISM; MALE; NONHUMAN; PROSTATE; RAT; SPLEEN; THORACIC AORTA; VAS DEFERENS;

ANIMALS; AORTA, THORACIC; CALCIUM; DIOXANES; GUINEA PIGS; HUMANS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, SEROTONIN, 5-HT1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84868258622     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.09.049     Document Type: Article

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