QSAR study of the α1-adrenoceptor antagonist activity of WB4101 derivatives

Pharmacy and Pharmacology Communications

Volumn 4, Issue 2, 1998, Pages 89-93

  Dearden, J C ^a   Cronin, M T D ^a   Higgins, C ^a   Mottram, D R ^a   Kapur, H ^a  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; UNINDEXED DRUG;

ARTICLE; CALCULATION; COMPUTER PROGRAM; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; VAS DEFERENS;

EID: 0031914426     PISSN: 14608081     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. 1-adrenoceptor antagonists: a chemometric study. J. Mol. Struct. (Theochem) 331: 79-93
2. Giardina, D., Pigini, U. G.-M., Piloni, M., Melchiorre, C. (1990) Structure-activity relationships in 1,4-benzodioxan-related compounds. 2. Role of the amine function on α-adrenoceptor blocking activity. Farmaco 45: 1289-1298
3. Kapur, H. (1979) The α-Receptor Blocking Properties of a Series of Benzodioxanes and the Relationship to Antihypertensive Action. Ph.D. Thesis, Liverpool Polytechnic
4. Kapur, H., Mottram, D. R., Green, P. N. (1978) Receptor interaction for the α-antagonist WB4101 (2-(N[2,6-dimethoxyphenoxyethyl])aminomethyl-1,4-benzodioxane). J. Pharm. Pharmacol. 30: 259-260
5. Kapur, H., Green, P. N., Mottram, D. R. (1979) Further studies on receptor interaction for the α-antagonist WB 4101. J. Pharm. Pharmacol. 31: 188-189
6. Mottram, D. R. (1981) Differential blockade of pre- and postsynaptic α-adrenoceptors by the 2-R and 2-S enantiomers of WB4101. J. Pharm. Pharmacol. 31: 767-771
7. 1-adrenergic antagonists. J. Mol. Struct. (Theochem) 276: 327-340
8. 1-adrenoceptor recognition. Farmaco 49: 587-606