The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat α1B-adrenoceptors

Neuropharmacology

Volumn 59, Issue 1-2, 2010, Pages 49-57

  Nojimoto, F D ^a   Mueller, A ^a   Hebeler Barbosa, F ^a   Akinaga, J ^a   Lima, V ^a   Kiguti, L R de A ^a   Pupo, A S ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

1 Adrenoceptor subtypes; Amitriptyline; Imipramine; Nortriptyline; Tricyclic antidepressants

Indexed keywords

5 METHYLURAPIDIL; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; AMITRIPTYLINE; CALCIUM; IMIPRAMINE; NORADRENALIN; NORTRIPTYLINE; PRAZOSIN; ADRA1A PROTEIN, HUMAN; ADRA1A PROTEIN, RAT; ADRA1B PROTEIN, HUMAN; ADRA1B PROTEIN, RAT; ALPHA 1 ADRENERGIC RECEPTOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; CELL LINE; CELL MEMBRANE; DOSE RESPONSE; DRUG EFFECTS; INTRACELLULAR SPACE; METABOLISM; SMOOTH MUSCLE; WISTAR RAT;

AMITRIPTYLINE; ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CALCIUM; CELL LINE; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMIPRAMINE; INTRACELLULAR SPACE; MALE; MUSCLE, SMOOTH; NORTRIPTYLINE; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS;

EID: 77953238499     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.03.015     Document Type: Article

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