Functional evidence of inverse agonism in vascular smooth muscle

British Journal of Pharmacology

Volumn 119, Issue 1, 1996, Pages 158-164

  Noguera, M Antonia ^a   Ivorra, M Dolores ^a   D'Ocon, Pilar ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Intracellular calcium stores; Inverse agonism; Vascular smooth muscle; 1 adrenoceptors

Indexed keywords

2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; BENOXATHIAN; CALCIUM ION; CHLOROETHYLCLONIDINE; CLONIDINE; CONTRACTILE PROTEIN; METHOXAMINE; NORADRENALIN;

ANIMAL TISSUE; AORTA; ARTICLE; BLOOD VESSEL TONE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; EXTRACELLULAR CALCIUM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR SMOOTH MUSCLE;

EID: 0029790928     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15689.x     Document Type: Article

References (37)

1. I-adrenoceptor mediating contractions of rat aorta, vas deferens and spleen. Br. J. Pharmacol., 109, 80-87.
2. BLACK, J.V. & SHANKLEY, N.P. (1995). Inverse agonists exposed. Nature, 374, 214-215.
3. 2-adrenoceptor. Nature, 374, 272-276.
4. IB-adrenoceptor-mediated contraction to phenylephrine of the rat spleen. Br. J. Pharmacol., 116, 2327-2333.
5. CHULIA, S., IVORRA, M.D., LUGNIER, C., VILA, E., NOGUERA, M.A. & D'OCON, M.P. (1994). Mechanism of the cardiovascular activity of laudanosine: comparison with papaverine and other benzylisoquinolines. Br. J. Pharmacol., 113, 1377-1385.
6. D'OCON, M.P., IVORRA, M.D., CHULIÁ, S. & NOGUERA, M.A. (1995). Study of the contractile response elicited by extracellular calcium after depletion of noradrenaline-sensitive internal calcium stores in rat aorta. Br. J. Pharmacol., 114, 417P.
7. 2+ influx: how many mechanisms for how many channels?. Trends Pharmacol. Sci., 15, 77-83.
8. 1-Adrenoceptor classification: sharpening Occam's razor. Trends Pharmacol. Sci., 15, 167-170.
9. FURCHGOTT, R.F. & ZAWADZKI, J.V. (1980). The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 288, 373-376.
10. 1-adrenoceptors: consensus update. Pharmacol. Rev., 47, 267-270.
11. IVORRA, MD, LUGNIER, C., CATRET, M., ANSELMI, E., CORTES, D., D'OCON, M.P. (1993). Investigations of the dual contractile/ relaxant properties showed by antioquine in rat aorta. Br. J. Pharmacol., 109, 502-509.
12. 1D-adrenoceptor mediating the contractile response of rat aorta to noradrenaline. Br. J. Pharmacol., 115, 981-986.
13. 1A/D-adrenoceptor subtype are consistent with the a]A-adrenoceptor characterized in rat cerebral cortex and vas deferens. Br. J. Pharmacol., 111, 1003-1008.
14. ID-adrenoceptor antagonist isolated from Fissisligma glaucescens. Br. J. Pharmacol., 112, 1174-1180.
15. 2+ store depletion in human platelets. Cell Calcium, 15, 381-390.
16. LEFKOWITZ, R.J., COTECCHIA, S., SAMANA, P. & COSTA, T (1993). Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. Trends. Pharmacol. Sci., 14, 303-307.
17. MILLIGAN, G., BOND, R.A. & LEE, M. (1995). Inverse agonism: pharmacological curiosity or potential therapeutic strategy?. Trends Pharmacol. Sci., 16, 10-13.
18. 2+. Pharmacol. Rev., 40, 87-119.
19. NELSON, M.T., STANDEN, N.B., BRAYDEN, J.E. & WORLEY, J.F. (1988). Noradrenaline contracts arteries by activating voltage-dependent calcium channels. Nature, 336, 382-385.
20. NOGUERA, M.A., CALATAYUD, S. & D'OCON, M.P. (1993). Actions of alpha-adrenoceptor blocking agents on two types of intracellular calcium stores mobilized by noradrenaline in rat aorta. Naunyn, Schmiedeberg's Arch. Pharmacol., 348, 472-477.
21. NOGUERA, M.A. & D'OCON, M.P. (1992). Different and common intracellular calcium-stores mobilized by noradrenaline and caffeine in vascular smooth muscle. Naunyn Schmiedeberg's Arch. Pharmacol., 345, 333-341.
22. NOGUERA, M.A. & D'OCON, M.P. (1993a). Evidence that depletion of internal calcium stores sensitive to noradrenaline elicits a contractile response dependent on extracellular calcium in rat aorta. Br. J. Pharmacol., 110, 861-867.
23. NOGUERA, M.A. & D'OCON, M.P. (1993b). Effects of different agents on the contractile response elicited by extracellular calcium after depletion of internal calcium stores in rat isolated aorta. J. Pharm. Pharmacol., 45, 701-706.
24. 2+ stores in ileal smooth muscle of the rat. Br. J. Pharmacol., 114, 1165-1170.
25. 1-adrenoceptors in mammalian aortae: subclassification based on chlorethylclonidine WB 4101 and nifedipine. J. Vasc. Res., 29, 33-40.
26. - channels in response to noradrenaline in vascular myocytes. Br. J. Pharmacol., 104, 1000-1006.
27. 2+ store in portal vein smooth muscle cells. J. Biol. Chem., 268, 3866-3872.
28. 2+ and K+ current by means of a phosphatase and a diffusible messenger. Nature, 364, 814-818.
29. I-adrenoceptor. Eur. J. Pharmacol., 199, 279-289.
30. PUTNEY, J.W. (1986). A model for receptor-regulated calcium entry. Cell Calcium, 7, 1-12.
31. PUTNEY, J.W. (1990). Capacitative calcium-entry revisited. Cell Calcium, 11, 611-634.
32. 2+ influx. Nature, 364, 809-814.
33. SCHÜTZ, W. & FREISSMUTH, M. (1992). Reverse intrinsic activity of antagonists on G protein-coupled receptors. Trends Phurmacol. Sci., 13, 376-379.
34. IB-udrenoceptor subtype. Br. J. Pharmacol., 114, 745-750.
35. 2+ current. Am. J. Physiol., 264, H1319-1322.
36. 2+ selective channel in vascular endothelium. Am. J. Physiol., 267, C920-925.
37. I-adrenoceptors in the rat aorta. Br. J. Pharmacol., 110, 124P.