Structure-affinity studies for a novel series of homochiral naphtho and tetrahydronaphtho analogues of α 1 antagonist WB-4101

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 18, 2004, Pages 4937-4951

  Bolchi, Cristiano ^a   Catalano, Paolo ^b   Fumagalli, Laura ^a   Gobbi, Marco ^b   Pallavicini, Marco ^a   Pedretti, Alessandro ^a   Villa, Luigi ^a   Vistoli, Giulio ^a   Valoti, Ermanno ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

1 Adrenergic receptor subtypes; 1 Antagonist; 5 HT 1A serotoninergic receptor; Binding affinity; WB 4101; WB 4101 analogues

Indexed keywords

2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; ALPHA 1 ADRENERGIC RECEPTOR; ANTIVIRUS AGENT; DIOXANE DERIVATIVE; NAPHTHALENE DERIVATIVE; NAPHTHODIOXANE; RECEPTOR SUBTYPE; SEROTONIN 1A RECEPTOR; TETRAHYDRONAPHTHODIOXANE; UNCLASSIFIED DRUG;

ALPHA CHAIN; ARTICLE; BINDING AFFINITY; DRUG BINDING SITE; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; PHARMACOPHORE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; CHO CELLS; CRICETINAE; DIOXANES; RECEPTORS, ADRENERGIC, ALPHA-1; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES;

EID: 4444222928     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.06.040     Document Type: Article

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