Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d] pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors

European Journal of Medicinal Chemistry

Volumn 58, Issue , 2012, Pages 171-183

  Loidreau, Yvonnick ^a   Marchand, Pascal ^b   Dubouilh Benard, Carole ^a   Nourrisson, Marie Renée ^b   Duflos, Muriel ^b   Lozach, Olivier ^c   Loaëc, Nadège ^c,d   Meijer, Laurent ^d   Besson, Thierry ^a  

^a UNIVERSITÉ DE ROUEN   (France)

^b UNIVERSITÉ DE NANTES   (France)

^c Protein Phosphorylation and Human Disease Group   (France)

^d Centre de Perharidy   (France)

Author keywords

Alzheimer's disease; Dimethylformamide dimethylacetal; Dimroth rearrangement; Kinase inhibitor; Microwave assisted chemistry; Thieno 3,2 d pyrimidine

Indexed keywords

2 NITRO 4 (PYRIDO[3',2':4,5]THIENO[3,2 D]PYRIMIDIN 4 YLAMINO)PHENOL; 4 (BENZO[4,5]THIENO[3,2 D]PYRIMIDIN 4 YLAMINO) 2 NITROPHENOL; BENZO[B]THIENO[3,2 D]PYRIMIDIN 4 AMINE; CASEIN KINASE IDELTA; CASEIN KINASE IEPSILON; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3; N (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL)BENZO[4,5]THIENO[3,2 D]PYRIMIDIN 4 AMINE; N (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL)PYRIDO[3',2':4,5]THIENO[3,2 D]PYRIMIDIN 4 AMINE; N (3,4 METHOXYPHENYL)BENZO[B]THIENO[3,2 D]PYRIMIDIN 4 AMINE; N (3,4 METHOXYPHENYL)BENZO[B]THIENO[3,2-D]PYRIMIDIN 4 AMINE; N (3,4 METHOXYPHENYL)PYRIDO[3',2':4,5]THIENO[3,2 D]PYRIMIDIN 4 AMINE; N (3,4,5 TRIMETHOXYPHENYL)BENZO[B]THIENO[3,2 D]PYRIMIDIN 4 AMINE; N (3,4,5 TRIMETHOXYPHENYL)PYRIDO[3',2':4,5]THIENO[3,2 D]PYRIMIDIN 4 AMINE; N (3,5 DIMETHOXYPHENYL)BENZO[B]THIENO[3,2 D]PYRIMIDIN 4 AMINE; N (3,5 DIMETHOXYPHENYL)PYRIDO[3',2':4,5]THIENO[3,2 D]PYRIMIDIN 4 AMINE; N (4 BROMO 2 FLUOROPHENYL)BENZO[B]THIENO[3,2 D]PYRIMIDIN 4 AMINE; N (4 BROMO 2 FLUOROPHENYL)PYRIDO[3',2':4,5]THIENO[3,2 D]PYRIMIDIN 4 AMINE; N (4 METHOXYPHENYL)BENZO[B]THIENO[3,2 D]PYRIMIDIN 4 AMINE; N (4 METHOXYPHENYL)PYRIDO[3',2':4,5]THIENO[3,2 D]PYRIMIDIN 1 AMINE; N (BENZO[D][1,3]DIOXOL 5 YL)BENZO[4,5]THIENO[3,2 D]PYRIMIDIN 4 AMINE; N (BENZO[D][1,3]DIOXOL 5 YL)PYRIDO[3',2':4,5]THIENO[3,2 D]PYRIMIDIN 4 AMINE; N ARYLBENZO[B]THIENO[3,2 D]PYRIMIDIN 4 AMINE DERIVATIVE; N PHENYLBENZO[B]THIENO[3,2 D]PYRIMIDIN 4 AMINE; N PHENYLPYRIDO[3',2':4,5]THIENO[3,2 D]PYRIMIDIN 4 AMINE; PROTEIN P25; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRIDO[3',2':4,5]THIENO[3,2 D]PYRIMIDIN 4 AMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; IN VITRO STUDY; MICROWAVE RADIATION; THERMODYNAMICS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRAZINES; PYRIDONES; PYRIMIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; THIOPHENES;

EID: 84868236760     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.10.006     Document Type: Article

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