Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives

Journal of Medicinal Chemistry

Volumn 54, Issue 13, 2011, Pages 4474-4489

  Giraud, Francis ^a,b   Alves, Georges ^a,b   Debiton, Eric ^c   Nauton, Lionel ^a,b   Théry, Vincent ^a,b   Durieu, Emilie ^d   Ferandin, Yoan ^d   Lozach, Olivier ^d   Meijer, Laurent ^d   Anizon, Fabrice ^a,b   Pereira, Elisabeth ^a,b   Moreau, Pascale ^a,b  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b CNRS   (France)

^c INSERM   (France)

^d STATION BIOLOGIQUE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3 ACETYL 7 BROMO 1H INDOLE; 4 (4 BROMO 1H INDOL 3 YL) 5 (3 METHOXYPHENYL)PYRIMIDIN 2 AMINE; 4 (4 BROMO 1H INDOL 3 YL) 5 (4 ACETYLPHENYL)PYRIMIDIN 2 AMINE; 4 (4 BROMO 1H INDOL 3 YL) 5 (4 TRIFLUOROMETHYLPHENYL)PYRIMIDIN 2 AMINE; 4 (4 BROMO 1H INDOL 3 YL)PYRIMIDIN 2 AMINE; 4 (5 BROMO 1H INDOL 3 YL) 5 (3 METHOXYPHENYL)PYRIMIDIN 2 AMINE; 4 (5 BROMO 1H INDOL 3 YL) 5 (4 ACETYLPHENYL)PYRIMIDIN 2 AMINE; 4 (5 BROMO 1H INDOL 3 YL) 5 (4 TRIFLUOROMETHYLPHENYL)PYRIMIDIN 2 AMINE; 4 (5 BROMO 1H INDOL 3 YL)PYRIMIDIN 2 AMINE; 4 (6 BROMO 1H INDOL 3 YL) 5 (3 METHOXYPHENYL)PYRIMIDIN 2 AMINE; 4 (6 BROMO 1H INDOL 3 YL) 5 (4 ACETYLPHENYL)PYRIMIDIN 2 AMINE; 4 (6 BROMO 1H INDOL 3 YL) 5 (4 TRIFLUOROMETHYLPHENYL)PYRIMIDIN 2 AMINE; 4 (6 BROMO 1H INDOL 3 YL)PYRIMIDIN 2 AMINE; 4 (7 BROMO 1H INDOL 3 YL) 5 (3 METHOXYPHENYL)PYRIMIDIN 2 AMINE; 4 (7 BROMO 1H INDOL 3 YL) 5 (4 ACETYLPHENYL)PYRIMIDIN 2 AMINE; 4 (7 BROMO 1H INDOL 3 YL) 5 (4 TRIFLUOROMETHYLPHENYL)PYRIMIDIN 2 AMINE; 4 (7 BROMO 1H INDOL 3 YL)PYRIMIDIN 2 AMINE; 4 [2 AMINO 4 (4 BROMO 1H INDOL 3 YL)PYRIMIDIN 5 YL]BENZAMIDE; 4 [2 AMINO 4 (5 BROMO 1H INDOL 3 YL)PYRIMIDIN 5 YL]BENZAMIDE; 4 [2 AMINO 4 (6 BROMO 1H INDOL 3 YL)PYRIMIDIN 5 YL]BENZAMIDE; 4 [2 AMINO 4 (7 BROMO 1H INDOL 3 YL)PYRIMIDIN 5 YL]BENZAMIDE; 5 IODO 4 (4 BROMO 1H INDOL 3 YL)PYRIMIDIN 2 AMINE; 5 IODO 4 (5 BROMO 1H INDOL 3 YL)PYRIMIDIN 2 AMINE; 5 IODO 4 (6 BROMO 1H INDOL 3 YL)PYRIMIDIN 2 AMINE; 5 IODO 4 (7 BROMO 1H INDOL 3 YL)PYRIMIDIN 2 AMINE; ANTINEOPLASTIC AGENT; MERIDIANIN DERIVATIVE; N [4 (METHYLPHENYL)SULFONYL] 3 ACETYL 7 BROMO 1H INDOLE; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLE ALKALOIDS; MICE; MODELS, MOLECULAR; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960196093     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200464w     Document Type: Article

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