Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 20, Issue 6, 2005, Pages 557-568

  Testard, Alexandra ^a   Picot, Laurent ^a   Lozach, Olivier ^b   Blairvacq, Melina ^b   Meijer, Laurent ^b   Murillo, Laurence ^a   Piot, Jean Marie ^a   Thiéry, Valérie ^a   Besson, Thierry ^a  

^a UNIVERSITÉ DE LA ROCHELLE   (France)

^b CNRS   (France)

Author keywords

Breast cancer; CDK; GSK 3; Kinases; Microwave chemistry; Quinazolinones

Indexed keywords

2 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 8 ETHYL[1,3]THIAZOLO[5,4 F]QUINAZOLIN 9(8H) ONE; 3 BENZYL 6 NITROQUINAZOLIN 4 (3H) ONE; 3 ETHYL 6 NITROQUINAZOLIN 4 (3H) ONE; 6 AMINO 3 BENZYLQUINAZOLIN 4 (3H) ONE; 6 AMINO 3 ETHYLQUINAZOLIN 4 (3H) ONE; 7 AMINO 3 ETHYLQUINAZOLIN 4 (3H) ONE; 7 BENZYL 6 OXO 6,7 DIHYDRO[1,3]THIAZOLO[4,5 H]QUINAZOLINE 2 CARBONITRILE; 7 ETHYL 6 OXO 6,7 DIHYDRO[1,3]THIAZOLO[4,5 H]QUINAZOLINE 2 CARBONITRILE; 7 ETHYL 7 NITROQUINAZOLIN 4 (3H) ONE; 8 BENZYL 2 (4,5 DIHYDRO 1H IMIDAZO 2 YL)[1,3]THIAZOLO[5,4 F]QUINAZOLIN 9(8H) ONE; 8 BENZYL 9 OXO 8,9 DIHYDRO[1,3]THIAZOLO[5,4 F]QUINAZOLINE 2 CARBONITRILE; 8 BENZYL 9 OXO 8,9 DIHYDRO[1,3]THIAZOLO[5,4 F]QUINAZOLINE 2 CARBOXIMIDIC ACID ETHYL ESTER; 8 BENZYL N [2 (DIMETHYLAMINO)ETHYL] 9 OXO 8,9 DIHYDRO[1,3]THIAZOLO[5,4 F]QUINAZOLINE 2 CARBOXAMIDINE; 8 BENZYL[1,3]THIAZOLO[5,4F]QUINAZOLIN 9 (8H) ONE; 8 ETHYL 9 OXO 8,9 DIHYDRO[1,3]THIAZOLO[5,4 F]QUINAZOLINE 2 CARBONITRILE; 8 ETHYL 9 OXO 8,9 DIHYDRO[1,3]THIAZOLO[5,4 F]QUINAZOLINE 2 CARBOXIMIDIC ACID ETHYL ESTER; 8 ETHYL[1,3]THIAZOLO[5,4 F]QUINAZOLIN 9 (8H) ONE; CYCLIN DEPENDENT KINASE; GLYCOGEN SYNTHASE KINASE 3; N [2 (DIMETHYLAMINO)ETHYL] 8 ETHYL 9 OXO 8,9 DIHYDRO[1,3]THIAZOLO[5,4 F]QUINAZOLINE 2 CARBOXAMIDINE; OLOMOUCINE; OXINDOLE; PHOSPHOTRANSFERASE INHIBITOR; QUINAZOLINE DERIVATIVE; QUINAZOLINONE DERIVATIVE; ROSCOVITINE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ENZYME INHIBITOR;

ARTICLE; CELL PROLIFERATION; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; MICROWAVE RADIATION; NONHUMAN; PRIORITY JOURNAL; CHEMICAL STRUCTURE; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; RADIATION EXPOSURE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASES; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MICROWAVES; MOLECULAR STRUCTURE; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33644970346     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360500212399     Document Type: Article

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