Microwave-accelerated Dimroth rearrangement for the synthesis of 4-anilino-6-nitroquinazolines. Application to an efficient synthesis of a microtubule destabilizing agent

Tetrahedron

Volumn 66, Issue 25, 2010, Pages 4495-4502

  Foucourt, Alicia ^a   Dubouilh Benard, Carole ^a   Chosson, Elizabeth ^a   Corbière, Cécile ^b   Buquet, Catherine ^b   Iannelli, Mauro ^c   Leblond, Bertrand ^d   Marsais, Francis ^e   Besson, Thierry ^a  

^a UNIVERSITÉ DE ROUEN   (France)

^b UNIVERSITÉ DE ROUEN   (France)

^c Milestone Srl   (Italy)

^d ExonHit Therapeutics   (France)

^e IRCOF   (France)

Author keywords

4 Anilinoquinazolines; Dimroth rearrangement; Microwave assisted synthesis

Indexed keywords

4 ANILINO 6 NITROQUINAZOLINE DERIVATIVE; ANILINE DERIVATIVE; ANTINEOPLASTIC AGENT; AZIXA; IMINE; MPC 6827; N (4 METHOXYPHENYL) N,2 DIMETHYLQUINAZOLIN 4 AMINE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DIMROTH REARRANGEMENT; DRUG SYNTHESIS; MICROTUBULE; MICROWAVE RADIATION; PRIORITY JOURNAL;

EID: 77953121625     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2010.04.066     Document Type: Article

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