Age-related changes in cell surface and senescence markers in the spleen of DBA/2 mice: A flow cytometric analysis

Experimental Gerontology

Volumn 41, Issue 2, 2006, Pages 225-229

  Connoy, Abbie C ^a   Trader, Melissa ^a   High, Kevin P ^a  

^a WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

Author keywords

T cells; Aging; CD28; Flow cytometry; Lyphocyte sub populations; Murine spleen; p16ink4a

Indexed keywords

PROTEIN P16INK4A;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COMPOSITION; CELL POPULATION; CELL SURFACE; CELL TYPE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; SPLEEN; SPLEEN CELL;

AGING; ANIMALS; ANTIGENS, CD28; ANTIGENS, SURFACE; B-LYMPHOCYTES; BIOLOGICAL MARKERS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; FLOW CYTOMETRY; IMMUNOLOGIC MEMORY; LYMPHOCYTE COUNT; MICE; MICE, INBRED DBA; SPLEEN; T-LYMPHOCYTES;

ANIMALIA; MURINAE;

EID: 31544458154     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2005.11.003     Document Type: Article

References (24)

1. F. Barrat, B.M. Lesourd, A. Louise, H.J. Boulouis, S. Vincent-Naulleau, D. Thibault, M. Sanaa, T. Neway, and C.H. Pilet Surface antigen expression in spleen cells of C57B1/6 mice during ageing: influence of sex and parity Clin. Exp. Immunol. 107 1997 593 600
2. N. Boucher, T. Dufeu-Duchesne, E. Vicaut, D. Farge, R.B. Effros, and F. Schachter CD28 expression in T cell aging and human longevity Exp. Gerontol. 33 1998 267 282
3. S.C. Castle Clinical relevance of age-related immune dysfunction Clin. Infect. Dis. 31 2000 578 585
4. AB. Chkhotua, E. Gabusi, A. Altimari, A. D'Errico, M. Yakubovich, J. Vienken, S. Stefoni, P. Chieco, A. Yussim, and W.F. Grigioni Increased expression of p16(INK4a) and p27(Kip1) cyclin-dependent kinase inhibitor genes in aging human kidney and chronic allograft nephropathy Am. J. Kidney Dis. 141 2003 1303 1313
5. G. Colonna-Romano, M. Potestio, A. Aquino, G. Candore, D. Lio, and C. Caruso Gamma/delta T lymphocytes are affected in the elderly Exp. Gerontol. 37 2002 205 211
6. A. Cossarizza, C. Ortolani, D. Monti, and C. Franceschi Cytometric analysis of immunosenescence Cytometry 27 1997 297 313
7. R.B. Effros, N. Boucher, V. Porter, X. Zhu, C. Spaulding, R.L. Walford, M. Kronenberg, D. Cohen, and F. Schachter Decline in CD28+T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence Exp. Gerontol. 29 1994 601 609
8. D.N. Ernst, M.V. Hobbs, B.E. Torbett, A.L. Glasebrook, M.A. Rehse, K. Bottomly, K. Hayakawa, R.R. Hardy, and W.O. Weigle Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+T cells from young and aged mice J. Immunol. 145 1990 1295 1302
9. J.J. Goronzy, J.W. Fulbright, C.S. Crowson, G.A. Poland, W.M. O'Fallon, and C.M. Weyand Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals J. Virol. 75 2001 12182 12187
10. K.P. High Infection as a cause of age-related morbidity and mortality Ageing Res. Rev. 3 2004 1 14
11. High, K.P., in press. Murine models of infectious diseases in the aged, in: Conn P.M. (ed.), Handbook of Models of Human Aging. Elsevier, New York.
12. K. Hiromatsu, Y. Yoshikai, G. Matsuzaki, S. Ohga, K. Muramori, K. Matsumoto, J.A. Bluestone, and K. Nomoto A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice J. Exp. Med. 175 1992 49 56
13. C.J. Kirk, A.M. Freilich, and R.A. Miller Age-related decline in activation of JNK by TCR- and CD28-mediated signals in murine T-lymphocytes Cell. Immunol. 197 1999 75 82
14. J. Krishnamurthy, C. Torrice, M.R. Ramsey, G.I. Kovalev, K. Al Regaiey, L. Su, and N.E. Sharpless Ink4a/Arf expression is a biomarker of aging J. Clin. Invest. 114 2004 1299 1307
15. C.H. Ladel, C. Blum, A. Dreher, K. Reifenberg, and S.H. Kaufmann Protective role of gamma/delta T cells and alpha/beta T cells in tuberculosis Eur. J. Immunol. 25 1995 2877 2881
16. W.T. Lee, and E.S. Vitetta The differential expression of homing and adhesion molecules on virgin and memory T cells in the mouse Cell. Immunol. 132 1991 215 222
17. R.A. Miller The aging immune system: primer and prospectus Science 273 1996 70 74
18. R.A. Miller Age-related changes in T cell surface markers: a longitudinal analysis in genetically heterogeneous mice Mech. Ageing Dev. 96 1997 181 196
19. R.L. Modlin, and P.A. Sieling Immunology. Now presenting: gammadelta T cells Science 309 2005 252 253
20. G.C. Romano, M. Potestio, G. Scialabba, A. Mazzola, G. Candore, D. Lio, and C. Caruso Early activation of gamma-delta T lymphocytes in the elderly Mech. Ageing Dev. 121 2000 231 238
21. M. Saurwein-Teissl, T.L. Lung, F. Marx, C. Gschosser, E. Asch, I. Blasko, W. Parson, G. Bock, D. Schonitzer, E. Trannoy, and B. Grubeck-Loebenstein Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines J. Immunol. 168 2002 5893 5899
22. L.Q. Sun, D.W. Lee, Q. Zhang, W. Xiao, E.H. Raabe, A. Meeker, D. Miao, D.L. Huso, and R.J. Arceci Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG Genes Dev. 18 2004 1035 1046
23. E. Vannier, I. Borggraefe, S.R. Telford III, S. Menon, T. Brauns, A. Spielman, J.A. Gelfand, and H.H. Wortis Age-associated decline in resistance to Babesia microti is genetically determined J. Infect. Dis. 189 2004 1721 1728
24. A. Wakikawa, M. Utsuyama, and K. Hirokawa Altered expression of various receptors on T cells in young and old mice after mitogenic stimulation: a flow cytometric analysis Mech. Ageing Dev. 94 1997 113 122