From bedside to bench: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Comorbidity and Multiple Morbidity in Older Adults

Aging Clinical and Experimental Research

Volumn 20, Issue 3, 2008, Pages 181-188

  Boyd, Cynthia M ^a   Ritchie, Christine S ^b   Tipton, Edmond F ^c   Studenski, Stephanie A ^d   Wieland, Darryl ^e,f  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^c BIRMINGHAM VA MEDICAL CENTER   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^f NONE   (United States)

Author keywords

Burden of illness; Health status assessment; Nosology; Pathological conditions; Signs and symptoms

Indexed keywords

AGING; ARTICLE; CLINICAL RESEARCH; COMORBIDITY; GERIATRIC ASSESSMENT; GERIATRIC CARE; GERIATRIC DISORDER; HEALTH CARE COST; HEALTH CARE DELIVERY; HEALTH CARE SYSTEM; HEALTH CARE UTILIZATION; HEALTH SERVICE; HUMAN; MORBIDITY; MULTIMORBIDITY; PRACTICE GUIDELINE; PREVALENCE; QUALITY OF LIFE;

EID: 48449089561     PISSN: 15940667     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03324775     Document Type: Article

References (68)

1. Wolff JL, Starfield B, Anderson G. Prevalence, expenditures, and complications of multiple chronic conditions in the elderly. Arch Intern Med 2002; 162: 2269-76.
2. Boyd CM, Darer J, Boult C, Fried LP, Boult L, Wu AW. Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA 2005; 294: 716-24.
3. Feinstein AR. The pretherapeutic classification of comorbidity in chronic disease. J Chronic Dis 1970; 23: 455-68.
4. Satariano WA, Silliman RA. Comorbidity: implications for research and practice in geriatric oncology. Crit Rev Oncol Hematol 2003; 48: 239-48.
5. Gijsen R, Hoeymans N, Schellevis FG, Ruwaard D, Satariano WA, van den Bos GA. Causes and consequences of comorbidity: a review. J Clin Epidemiol 2001; 54: 661-74.
6. Fortin M, Lapointe L, Hudon C, Vanasse A, Ntetu AL, Maltais D. Multimorbidity and quality of life in primary care: a systematic review. Health Qual Life Outcomes 2004; 2: 51.
7. University of Sherbrooke C. International Research Community on Multimorbidity. https://www.med.usherbrooke.ca/cirmo/ mission_anglais.htm. Accessed June 27, 2007.
8. Boyd CM, Weiss CO, Halter J, Han KC, Ershler WB, Fried LP. Framework for evaluating disease severity measures in older adults with comorbidity. J Gerontol A Biol Sci Med Sci 2007; 62: 286-95.
9. Karlamangla A, Tinetti M, Guralnik J, Studenski S, Wetle T, Reuben D. Comorbidity in older adults: nosology of impairment, diseases, and conditions. J Gerontol A Biol Sci Med Sci 2007; 62: 296-300.
10. Lash TL, Mor V, Wieland D, Ferrucci L, Satariano W, Silliman RA. Methodology, design, and analytic techniques to address measurement of comorbid disease. J Gerontol A Biol Sci Med Sci 2007; 62: 281-5.
11. Yancik R, Ershler W, Satariano W, Hazzard W, Cohen HJ, Ferucci L. Report of the national institute on aging task force on comorbidity. J Gerontol A Biol Sci Med Sci 2007; 62: 275-80.
12. Tinetti ME, Fried T. The end of the disease era. Am J Med 2004; 116: 179-85.
13. Safford M, Allison J, Kiefe C. Patient complexity: More than comorbidity. J Gen Intern Med 2007; 22 (Suppl 3): 382-90.
14. Inouye SK, Studenski S, Tinetti ME, Kuchel GA. Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept. J Am Geriatr Soc 2007; 55: 780-91.
15. Hazzard WR. Scientific progress in geriatric syndromes: earning an "A" on the 2007 report card on academic geriatrics. J Am Geriatr Soc 2007; 55: 794-6.
16. Verbrugge LM, Lepkowski JM, Imanaka Y. Comorbidity and its impact on disability. Milbank Q 1989; 67: 450-84.
17. Fried LP, Bandeen-Roche K, Kasper JD, Guralnik JM. Association of comorbidity with disability in older women: the Women's Health and Aging Study. J Clin Epidemiol 1999; 52: 27-37.
18. Ettinger WH, Davis MA, Neuhaus JM, Mallon KP. Long-term physical functioning in persons with knee osteoarthritis from NHANES. I: Effects of comorbid medical conditions. J Clin Epidemiol 1994; 47: 809-15.
19. Kriegsman DM, Deeg DJ, Stalman WA. Comorbidity of somatic chronic diseases and decline in physical functioning: the Longitudinal Aging Study Amsterdam. J Clin Epidemiol 2004; 57: 55-65.
20. Wolff JL, Boult C, Boyd C, Anderson G. Newly reported chronic conditions and onset of functional dependency. J Am Geriatr Soc 2005; 53: 851-5.
21. Fortin M, Hudon C, Dubois MF, Almirall J, Lapointe L, Soubhi H. Comparative assessment of three different indices of multimorbidity for studies on health-related quality of life. Health Qual Life Outcomes 2005; 3: 74.
22. Comoni-Huntley JC, Foley DJ, Guralnik JM. Co-morbidity analysis: a strategy for understanding mortality, disability and use of health care facilities of older people. Int J Epidemiol 1991; 20 (Suppl 1): S8-17.
23. Walter LC, Covinsky KE. Cancer screening in elderly patients: a framework for individualized decision making. JAMA 2001; 285: 2750-6.
24. Tinetti ME, Bogardus ST Jr, Agostini JV. Potential pitfalls of disease-specific guidelines for patients with multiple conditions. N Engl J Med 2004; 351: 2870-4.
25. Lee SJ, Lindquist K, Segal MR, Covinsky KE. Development and validation of a prognostic index for 4-year mortality in older adults. JAMA 2006; 295: 801-8.
26. Gill TM, Baker DI, Gottschalk M, Peduzzi PN, Allore H, Byers A. A program to prevent functional decline in physically frail, elderly persons who live at home. N Engl J Med 2002; 347: 1068-74.
27. Heiat A, Gross CP, Krumholz HM. Representation of the elderly, women, and minorities in heart failure clinical trials. Arch Intern Med 2002; 162: 1682-8.
28. Kravitz RL, Duan N, Braslow J. Evidence-based medicine, heterogeneity of treatment effects, and the trouble with averages. Milbank Q 2004; 82: 661-87.
29. Lee PY, Alexander KP, Hammill BG, Pasquali SK, Peterson ED. Representation of elderly persons and women in published randomized trials of acute coronary syndromes. JAMA 2001; 286: 708-13.
30. Mason NA, Bailie GR, Satayathum S, et al. HMG-coenzyme A reductase inhibitor use is associated with mortality reduction in hemodialysis patients. Am J Kidney Dis 2005; 45: 119-26.
31. Wanner C, Krane V, Marz W, et al. Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis. N Engl J Med 2005; 353: 238-48.
32. Inouye SK, Bogardus ST Jr, Charpentier PA, et al. A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med 1999; 40: 69-76.
33. Tinetti ME, Baker D, Gallo WT, Nanda A, Charpentier P, O'Leary J. Evaluation of restorative care vs usual care for older adults receiving an acute episode of home care. JAMA 2002; 87: 1098-105.
34. Leff B, Burton L, Mader SL, et al. Hospital at home: feasibility and outcomes of a program to provide hospital-level care at home for acutely ill older patients. Ann Intern Med 2005; 143: 798-808.
35. Tinetti ME, Baker DI, McAvay G, et al. A multifactorial intervention to reduce the risk of falling among elderly people living in the community. N Engl J Med 1994; 331: 821-7.
36. Belcher VN, Fried TR, Agostini JV, Tinetti ME. Views of older adults on patient participation in medication-related decision making. J Gen Intern Med 2006; 21: 298-303.
37. Holmes HM, Hayley DC, Alexander GC, Sachs GA. Reconsidering medication appropriateness for patients late in life. Arch Intern Med 2006; 166: 605-9.
38. Greenfield S, Apolone G, McNeil BJ, Cleary PD. The importance of co-existent disease in the occurrence of postoperative complications and one-year recovery in patients undergoing total hip replacement. Comorbidity and outcomes after hip replacement. Med Care 1993; 31: 141-54.
39. Inouye SK, Bogardus ST Jr, Vitagliano G, et al. Burden of illness score for elderly persons: risk adjustment incorporating the cumulative impact of diseases, physiologic abnormalities, and functional impairments. Med Care 2003; 41: 70-83.
40. Zimmerman JE, Wagner DP, Draper EA, Wright L, Alzola C, Knaus WA. Evaluation of acute physiology and chronic health evaluation III predictions of hospital mortality in an independent database. Crit Care Med 1998; 26: 1317-26.
41. Litwin MS, Greenfield S, Elkin EP, Lubeck DP, Broering JM, Kaplan SH. Assessment of prognosis with the total illness burden index for prostate cancer: aiding clinicians in treatment choice. Cancer 2007; 109: 1777-83.
42. Kunik ME, Roundy K, Veazey C, et al. Surprisingly high prevalence of anxiety and depression in chronic breathing disorders. Chest 2005; 127: 1205-11.
43. Romanelli J, Fauerbach JA, Bush DE, Ziegelstein RC. The significance of depression in older patients after myocardial infarction. J Am Geriatr Soc 2002; 50: 817-22.
44. Newman AB, Gottdiener JS, McBumie MA, et al. Associations of subclinical cardiovascular disease with frailty. J Gerontol A Biol Sci Med Sci 2001; 56: M158-66.
45. Newman AB, Fitzpatrick AL, Lopez O, et al. Dementia and Alzheimer's disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort. J Am Geriatr Soc 2005; 53: 1101-7.
46. From AM, Leibson CL, Bursi F, et al. Diabetes in heart failure: prevalence and impact on outcome in the population. Am J Med 2006; 119: 591-9.
47. McGinnis KA, Fine MJ, Sharma RK, et al. Understanding racial disparities in HIV using data from the veterans aging cohort 3-site study and VA administrative data. Am J Public Health 2003; 93: 1728-33.
48. Piette JD, Kerr EA. The impact of comorbid chronic conditions on diabetes care. Diabetes Care 2006; 29: 725-31.
49. Asch SM, Kilbourne AM, Gifford AL, et al. Underdiagnosis of depression in HIV: who are we missing? J Gen Intern Med 2003; 18: 450-60.
50. Nutting PA, Rost K, Smith J, Werner JJ, Elliot C. Competing demands from physical problems: effect on initiating and completing depression care over 6 months. Arch Fam Med 2000; 9: 1059-64.
51. Marr PL, Elkin EP, Arredondo SA, Broering JM, DuChane J, Carroll PR. Comorbidity and primary treatment for localized prostate cancer: data from CaPSURE. J Urol 2006; 175: 1326-31.
52. Bynum JP, Braunstein JB, Sharkey P, Haddad K, Wu AW. The influence of health status, age, and race on screening mammography in elderly women. Arch Intern Med 2005; 165: 2083-8.
53. Yancik R, Wesley MN, Ries LA, Havlik RJ, Edwards BK, Yates JW. Effect of age and comorbidity in postmenopausal breast cancer patients aged 55 years and older. JAMA 2001; 285: 885-92.
54. Tammemagi CM, Nerenz D, Neslund-Dudas C, Feldkamp C, Nathanson D. Comorbidity and survival disparities among black and white patients with breast cancer. JAMA 2005; 294: 1765-72.
55. Betz ME, Gebo KA, Barber E, et al. Patterns of diagnoses in hospital admissions in a multistate cohort of HIV-positive adults in 2001. Med Care 2005; 43 (Suppl 9): III3-14.
56. Braithwaite RS, Justice AC, Chang CC, et al. Estimating the proportion of patients infected with HIV who will die of comorbid diseases. Am J Med 2005; 118: 890-8.
57. Cook JA, Grey D, Burke-Miller J, et al. Effects of treated and untreated depressive symptoms on highly active antiretroviral therapy use in a US multi-site cohort of HIV-positive women. AIDS Care 2006; 18: 93-100.
58. Leavitt BJ, Ross CS, Spence B, et al. Long-term survival of patients with chronic obstructive pulmonary disease undergoing coronary artery bypass surgery. Circulation 2006; 114 (Suppl 1): 1430-4.
59. Glaser R, Robles TF, Sheridan J, Malarkey WB, Kiecolt-Glaser JK. Mild depressive symptoms are associated with amplified and prolonged inflammatory responses after influenza virus vaccination in older adults. Arch Gen Psychiatry 2003; 60: 1009-14.
60. de Jonge P, Ormel J, Slaets JP, et al. Depressive symptoms in elderly patients predict poor adjustment after somatic events. Am J Geriatr Psychiatry 2004; 12: 57-64.
61. Niefeld MR, Braunstein JB, Wu AW, Saudek CD, Weller WE, Anderson GE. Preventable hospitalization among elderly Medicare beneficiaries with type 2 diabetes. Diabetes Care 2003; 26: 1344-9.
62. Fultz SL, Goulet JL, Weissman S, et al. Differences between infectious diseases-certified physicians and general medicine-certified physicians in the level of comfort with providing primary care to patients. Clin Infect Dis 2005; 41: 738-43.
63. Kinder LS, Katon WJ, Ludman E, et al. Improving depression care in patients with diabetes and multiple complications. J Gen Intern Med 2006; 21:1036-41.
64. Higgins TS Jr, Ritchie CS, Stetson BA, Burke JD, Looney SW. An examination of the moderating effect of treatment with antidepressants on the association of heart disease with depression in males with type 2 diabetes attending a Veterans Affairs Medical Center. Diabetes Res Clin Pract 2007; 75: 220-8.
65. Lin EH, Katon W, Von Korff M, et al. Effect of improving depression care on pain and functional outcomes among older adults with arthritis: a randomized controlled trial. JAMA 2003; 290: 2428-9.
66. Ferrucci L, Ble A, Bandinelli S, Lauretani F, Suthers K, Guralnik JM. A flame burning within. Aging Clin Exp Res 2004; 16: 240-3.
67. Volpato S, Blaum C, Resnick H, Ferrucci L, Fried LP, Guralnik JM. Comorbidities and impairments explaining the association between diabetes and lower extremity disability: The Women's Health and Aging Study. Diabetes Care 2002; 25: 678-83.
68. Starfield B. Threads and yarns: weaving the tapestry of comorbidity. Ann Fam Med 2006; 4: 101-3.