Promotion of hepatocellular carcinoma by hepatitis C virus

Digestive Diseases

Volumn 30, Issue 5, 2012, Pages 445-452

  Bhler, Sandra ^a   Bartenschlager, Ralf ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

ER stress; Hepatitis C virus; Hepatocellular carcinoma; Liver cancer; Steatosis

Indexed keywords

AFLATOXIN; NONSTRUCTURAL PROTEIN 2; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4B; NONSTRUCTURAL PROTEIN 5B;

ALCOHOL CONSUMPTION; ARTICLE; CANCER RISK; CELL CULTURE; CELL CYCLE; CELL CYCLE REGULATION; CELL PROLIFERATION; CELL SURVIVAL; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DNA DAMAGE; ENDOPLASMIC RETICULUM STRESS; FIBROGENESIS; HEPATITIS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNE RESPONSE; IN VIVO STUDY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FIBROSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEATOSIS; TUMOR PROMOTION; VIRUS REPLICATION;

CARCINOMA, HEPATOCELLULAR; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; FATTY LIVER; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; STRESS, PHYSIOLOGICAL; VIRUS REPLICATION;

EID: 84868148482     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000341688     Document Type: Article

References (48)

1. Perz JF, Armstrong GL, Farrington LA, Hutin YJ, Bell BP: The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol 2006; 45: 529-538.
2. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90.
3. Altekruse SF, McGlynn KA, Reichman ME: Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol 2009; 27: 1485-1491.
4. Bartenschlager R, Sparacio S: Hepatitis C virus molecular clones and their replication capacity in vivo and in cell culture. Virus Res 2007; 127: 195-207.
5. Lindenbach BD, Meuleman P, Ploss A, Vanwolleghem T, Syder AJ, McKeating JA, Lanford RE, Feinstone SM, Major ME, Leroux-Roels G, Rice CM: Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro. Proc Natl Acad Sci USA 2006; 103: 3805-3809.
6. Levrero M: Viral hepatitis and liver cancer: the case of hepatitis C. Oncogene 2006; 25: 3834-3847.
7. Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ: Viral hepatocarcinogenesis: from infection to cancer. Liver Int 2008; 28: 175-188.
8. Rice CM: New insights into HCV replication: potential antiviral targets. Top Antivir Med 2011; 19: 117-120.
9. Alvisi G, Madan V, Bartenschlager R: Hepatitis C virus and host cell lipids: an intimate connection. RNA Biol 2011; 8: 258-269.
10. Poenisch M, Bartenschlager R: New insights into structure and replication of the hepatitis C virus and clinical implications. Semin Liver Dis 2010; 30: 333-347.
11. Zeisel MB, Fofana I, Fafi-Kremer S, Baumert TF: Hepatitis C virus entry into hepatocytes: molecular mechanisms and targets for antiviral therapies. J Hepatol 2011; 54: 566-576.
12. Bartenschlager R, Penin F, Lohmann V, Andre P: Assembly of infectious hepatitis C virus particles. Trends Microbiol 2011; 19: 95-103.
13. Sainz B, Jr., Barretto N, Martin DN, Hiraga N, Imamura M, Hussain S, Marsh KA, Yu X, Chayama K, Alrefai WA, Uprichard SL: Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor. Nat Med 2012; 18: 281-285.
14. Lupberger J, Zeisel MB, Xiao F, Thumann C, Fofana I, Zona L, Davis C, Mee CJ, Turek M, Gorke S, Royer C, Fischer B, Zahid MN, Lavillette D, Fresquet J, Cosset FL, Rothenberg SM, Pietschmann T, Patel AH, Pessaux P, Doffoel M, Raffelsberger W, Poch O, Mc Keating JA, Brino L, Baumert TF: EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nat Med 2011; 17: 589-595.
15. Lohmann V, Körner F, Koch JO, Herian U, Theilmann L, Bartenschlager R: Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 1999; 285: 110-113.
16. McGivern DR, Lemon SM: Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer. Oncogene 2011; 30: 1969-1983.
17. Yamashita T, Honda M, Kaneko S: Molecular mechanisms of hepatocarcinogenesis in chronic hepatitis C virus infection. J Gastroenterol Hepatol 2011; 26: 960-964.
18. Seth D, Haber PS, Syn WK, Diehl AM, Day CP: Pathogenesis of alcohol-induced liver disease: classical concepts and recent advances. J Gastroenterol Hepatol 2011; 26: 1089-1105.
19. Hwang SJ, Lee SD: Hepatic steatosis and hepatitis C: still unhappy bedfellows? J Gastroenterol Hepatol 2011; 26(suppl 1): 96-101.
20. Owsianka AM, Patel AH: Hepatitis C virus core protein interacts with a human DEAD box protein DDX3. Virology 1999; 257: 330-340.
21. McGivern DR, Villanueva RA, Chinnaswamy S, Kao CC, Lemon SM: Impaired replication of hepatitis C virus containing mutations in a conserved NS5B retinoblastoma protein-binding motif. J Virol 2009; 83: 7422-7433.
22. Appel N, Schaller T, Penin F, Bartenschlager R: From structure to function: new insights into hepatitis C virus RNA replication. J Biol Chem 2006; 281: 9833-9836.
23. Bartosch B, Thimme R, Blum HE, Zoulim F: Hepatitis C virus-induced hepatocarcinogenesis. J Hepatol 2009; 51: 810-820.
24. Fung J, Lai CL, Yuen MF: Hepatitis B and C virus-related carcinogenesis. Clin Microbiol Infect 2009; 15: 964-970.
25. Banerjee A, Ray RB, Ray R: Oncogenic potential of hepatitis C virus proteins. Viruses 2010; 2: 2108-2133.
26. Beckham CJ, Parker R: P bodies, stress granules, and viral life cycles. Cell Host Microbe 2008; 3: 206-212.
27. Colgan SM, Hashimi AA, Austin RC: Endoplasmic reticulum stress and lipid dysregulation. Expert Rev Mol Med 2011; 13:e4.
28. Egger D, Wolk B, Gosert R, Bianchi L, Blum HE, Moradpour D, Bienz K: Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex. J Virol 2002; 76: 5974-5984.
29. Gosert R, Egger D, Lohmann V, Bartenschlager R, Blum HE, Bienz K, Moradpour D: Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons. J Virol 2003; 77: 5487-5492.
30. Thiele C, Spandl J: Cell biology of lipid droplets. Curr Opin Cell Biol 2008; 20: 378-385.
31. Goodman JM: The gregarious lipid droplet. J Biol Chem 2008; 283: 28005-28009.
32. Martin S, Parton RG: Lipid droplets: a unified view of a dynamic organelle. Nat Rev Mol Cell Biol 2006; 7: 373-378.
33. Miyanari Y, Atsuzawa K, Usuda N, Watashi K, Hishiki T, Zayas M, Bartenschlager R, Wakita T, Hijikata M, Shimotohno K: The lipid droplet is an important organelle for hepatitis C virus production. Nat Cell Biol 2007; 9: 1089-1097.
34. Boulant S, Targett-Adams P, McLauchlan J: Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus. J Gen Virol 2007; 88: 2204-2213.
35. Shavinskaya A, Boulant S, Penin F, Mc Lauchlan J, Bartenschlager R: The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly. J Biol Chem 2007; 282: 37158-37169.
36. Moradpour D, Wakita T, Tokushige K, Carlson RI, Krawczynski K, Wands JR: Characterization of three novel monoclonal antibodies against hepatitis C virus core protein. J Med Virol 1996; 48: 234-241.
37. Barba G, Harper F, Harada T, Kohara M, Goulinet S, Matsuura Y, Eder G, Schaff Z, Chapman MJ, Miyamura T, Brechot C: Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets. Proc Natl Acad Sci USA 1997; 94: 1200-1205.
38. Domitrovich AM, Felmlee DJ, Siddiqui A: Hepatitis C virus nonstructural proteins inhibit apolipoprotein B100 secretion. J Biol Chem 2005; 280: 39802-39808.
39. Boulant S, Douglas MW, Moody L, Budkowska A, Targett-Adams P, McLauchlan J: Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule-and dynein-dependent manner. Traffic 2008; 9: 1268-1282.
40. Angus AG, Dalrymple D, Boulant S, Mc-Givern DR, Clayton RF, Scott MJ, Adair R, Graham S, Owsianka AM, Targett-Adams P, Li K, Wakita T, McLauchlan J, Lemon SM, Patel AH: Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core protein. J Gen Virol 2010; 91: 122-132.
41. Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV Jr, Ott M: Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Nat Med 2010; 16: 1295-1298.
42. Harris C, Herker E, Farese RV Jr, Ott M: Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for coreinduced steatosis. J Biol Chem 2011; 286: 42615-42625.
43. Mercer DF, Schiller DE, Elliott JF, Douglas DN, Hao C, Rinfret A, Addison WR, Fischer KP, Churchill TA, Lakey JR, Tyrrell DL, Kneteman NM: Hepatitis C virus replication in mice with chimeric human livers. Nat Med 2001; 7: 927-933.
44. Meuleman P, Libbrecht L, De Vos R, de Hemptinne B, Gevaert K, Vandekerckhove J, Roskams T, Leroux-Roels G: Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera. Hepatology 2005; 41: 847-856.
45. Bissig KD, Wieland SF, Tran P, Isogawa M, Le TT, Chisari FV, Verma IM: Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. J Clin Invest 2010; 120: 924-930.
46. Washburn ML, Bility MT, Zhang L, Kovalev GI, Buntzman A, Frelinger JA, Barry W, Ploss A, Rice CM, Su L: A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease. Gastroenterology 2011; 140: 1334-1344.
47. Dorner M, Horwitz JA, Robbins JB, Barry WT, Feng Q, Mu K, Jones CT, Schoggins JW, Catanese MT, Burton DR, Law M, Rice CM, Ploss A: A genetically humanized mouse model for hepatitis C virus infection. Nature 2011; 474: 208-211.
48. Ruggieri A, Dazert E, Metz P, Hofmann S, Bergeest JP, Mazur J, Bankhead P, Hiet MS, Kallis S, Alvisi G, Samuel CE, Lohmann V, Kaderali L, Rohr K, Frese M, Stoecklin G, Bartenschlager R: Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection. Cell Host Microbe 2012;12:71-85.