Ubiquitinated p62-positive, TDP-43-negative inclusions in cerebellum in frontotemporal lobar degeneration with TAR DNA binding protein 43

Neuropathology

Volumn 30, Issue 2, 2010, Pages 197-199

  Pikkarainen, Maria ^a   Hartikainen, Päivi ^b   Alafuzoff, Irina ^a,c  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; PROTEIN P62; TAR DNA BINDING PROTEIN; UBIQUITIN;

ALZHEIMER DISEASE; AMYGDALOID NUCLEUS; BRAIN REGION; CELL NUCLEUS INCLUSION BODY; CEREBELLUM CORTEX; DEGENERATIVE DISEASE; DEMENTIA; FRONTOTEMPORAL DEMENTIA; HUMAN; IMMUNOHISTOCHEMISTRY; LETTER; LEWY BODY; MEYNERT BASAL NUCLEUS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PURKINJE CELL; SUBSTANTIA NIGRA; UBIQUITINATION; VAGUS NERVE DORSAL NUCLEUS;

CEREBELLUM; DNA-BINDING PROTEINS; FRONTOTEMPORAL LOBAR DEGENERATION; HUMANS; INCLUSION BODIES; RNA-BINDING PROTEINS; UBIQUITINATION;

EID: 77949881379     PISSN: 09196544     EISSN: 14401789     Source Type: Journal    
DOI: 10.1111/j.1440-1789.2009.01043.x     Document Type: Letter

References (16)

1. King A, Al-Sarraj S, Shaw C. Frontotemporal lobar degeneration with ubiquitinated tau-negative inclusions and additional alpha-synuclein pathology but also unusual cerebellar ubiquitinated p62-positive, TDP-43-negative inclusions. Neuropathology 2008; Aug 18. DOI: 10.1111/j.1440-1789.2008.00966.x [EPub ahead of print.]
2. Mackenzie IR, Neumann M, Bigio EH et al. Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations. Acta Neuropathol 2009; 117: 1518.
3. Sampathu DM, Neumann M, Kwong LK et al. Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies. Am J Pathol 2006 169 : 1343 1352.
4. Pikkarainen M, Hartikainen P, Alafuzoff I. Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions visualized with ubiquitin-binding protein p62 immunohistochemistry. J Neuropathol Exp Neurol 2008 67 : 280 298.
5. Arai T, Hasegawa M, Akiyama H et al. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun 2006 351 : 602 611.
6. Uchikado H, Lin WL, DeLucia MW, Dickson DW. Alzheimer disease with amygdala Lewy bodies: a distinct form of alpha-synucleinopathy. J Neuropathol Exp Neurol 2006 65 : 685 697.
7. Amador-Ortiz C, Lin WL, Ahmed Z et al. TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. Ann Neurol 2007 61 : 435 445.
8. Higashi S, Iseki E, Yamamoto R et al. Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies. Brain Res 2007 12 : 284 294.
9. Uryu K, Nakashima-Yasuda H, Forman MS et al. Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies. J Neuropathol Exp Neurol 2008 67 : 555 564.
10. Hasegawa M, Arai T, Akiyama H et al. TDP-43 is deposited in the Guam parkinsonism-dementia complex brains. Brain 2007 130 : 1386 1394.
11. Nakashima-Yasuda H, Uryu K, Robinson J et al. Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases. Acta Neuropathol 2007 114 : 221 229.
12. Freeman SH, Spires-Jones T, Hyman BT, Growdon JH, Frosch MP. TAR-DNA binding protein 43 in Pick disease. J Neuropathol Exp Neurol 2008 67 : 62 67.
13. Geser F, Winton MJ, Kwong LK et al. Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam. Acta Neuropathol 2008 115 : 133 145.
14. Schwab C, Arai T, Hasegawa M, Yu S, McGeer PL. Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease. J Neuropathol Exp Neurol 2008 67 : 1159 1165.
15. Arai T, Mackenzie IR, Hasegawa M et al. Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies. Acta Neuropathol 2009 117 : 125 136.
16. Fujishiro H, Uchikado H, Arai T et al. Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease. Acta Neuropathol 2009 117 : 151 158.