Conditional NF-L transgene expression in mice for in vivo analysis of turnover and transport rate of neurofilaments

Journal of Neuroscience

Volumn 27, Issue 18, 2007, Pages 4947-4956

  Millecamps, Stéphanie ^a,b   Gowing, Geneviève ^a   Corti, Olga ^c   Mallet, Jacques ^b   Julien, Jean Pierre ^a  

^a LAVAL UNIVERSITY   (Canada)

^b CNRS   (France)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Axonal transport; Doxycycline; Neurofilaments; Proteolysis; Transgenic; Turnover

Indexed keywords

DOXYCYCLINE; NEUROFILAMENT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HYPOGLOSSAL NERVE; IN VITRO STUDY; LONGEVITY; MOTONEURON; MOUSE; NERVE FIBER; NERVE FIBER TRANSPORT; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCIATIC NERVE; TURNOVER TIME;

ANIMALS; AXONAL TRANSPORT; GENE EXPRESSION REGULATION; HALF-LIFE; HUMANS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NEUROFILAMENT PROTEINS; PROTEIN TRANSPORT;

EID: 34247890153     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5299-06.2007     Document Type: Article

References (32)

1. Ackerley S, Grierson AJ, Brownlees J, Thornhill P, Anderton BH, Leigh PN, Shaw CE, Miller CC (2000) Glutamate slows axonal transport of neurofilaments in transfected neurons. J Cell Biol 150:165-176.
2. Archer DR, Watson DF, Griffin JW (1994) Phosphorylation-dependent immunoreactivity of neurofilaments and the rate of slow axonal transport in the central and peripheral axons of the rat dorsal root ganglion. J Neurochem 62:1119-1125.
3. Asbury AK, Gale MK, Cox SC, Baringer JR, Berg BO (1972) Giant axonal neuropathy-a unique case with segmental neurofilamentous masses. Acta Neuropathol (Berl) 20:237-247.
4. Bizzi A, Crane RC, Autilio-Gambetti L, Gambetti P (1984) Aluminum effect on slow axonal transport: a novel impairment of neurofilament transport. J Neurosci 4:722-731.
5. Bomont P, Cavalier L, Blondeau F, Ben Hamida C, Belal S, Tazir M, Demir E, Topaloglu H, Korinthenberg R, Tuysuz B, Landrieu P, Hentati F, Koenig M (2000) The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy. Nat Genet 26:370-374.
6. Borchelt DR, Davis J, Fischer M, Lee MK, Slunt HH, Ratovitsky T, Regard J, Copeland NG, Jenkins NA, Sisodia SS, Price DL (1996) A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genet Anal 13:159-163.
7. Brown A (2000) Slow axonal transport: stop and go traffic in the axon. Nat Rev Mol Cell Biol 1:153-156.
8. Carpenter S (1968) Proximal axonal enlargement in motor neuron disease. Neurology 18:841-851.
9. Ching GY, Liem RK (1993) Assembly of type IV neuronal intermediate filaments in nonneuronal cells in the absence of preexisting cytoplasmic intermediate filaments. J Cell Biol 122:1323-1335.
10. Collard JF, Cote F, Julien JP (1995) Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis. Nature 375:61-64.
11. Corbo M, Hays AP (1992) Peripherin and neurofilament protein coexist in spinal spheroids of motor neuron disease. J Neuropathol Exp Neurol 51:531-537.
12. Corti O, Sabate O, Horellou P, Colin P, Dumas S, Buchet D, Buc-Caron MH, Mallet J (1999) A single adenovirus vector mediates doxycycline-controlled expression of tyrosine hydroxylase in brain grafts of human neural progenitors. Nat Biotechnol 17:349-354.
13. Cote F, Collard JF, Julien JP (1993) Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis. Cell 73:35-46.
14. Eng H, Lund K, Campenot RB (1999) Synthesis of β-tubulin, actin, and other proteins in axons of sympathetic neurons in compartmented cultures. J Neurosci 19:1-9.
15. Finiels F, Gimenez y Ribotta M, Barkats M, Samolyk ML, Robert JJ, Privat A, Revah F, Mallet J (1995) Specific and efficient gene transfer strategy offers new potentialities for the treatment of motor neurone diseases. NeuroReport 7:373-378.
16. Ghadge GD, Roos RP, Kang UJ, Wollmann R, Fishman PS, Kalynych AM, Barr E, Leiden JM (1995) CNS gene delivery by retrograde transport of recombinant replication-defective adenoviruses. Gene Ther 2:132-137.
17. Gossen M, Bujard H (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 89:5547-5551.
18. Griffin JW, Parhad I, Gold B, Price DL, Hoffman PN, Fahnestock K (1985) Axonal transport of neurofilament proteins in IDPN neurotoxicity. Neurotoxicology 6:43-53.
19. Hendrickson AE, Cowan WM (1971) Changes in the rate of axoplasmic transport during postnatal development of the rabbit's optic nerve and tract. Exp Neurol 30:403-422.
20. Hirano A, Donnenfeld H, Sasaki S, Nakano I (1984a) Fine structural observations of neurofilamentous changes in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 43:461-470.
21. Hirano A, Nakano I, Kurland LT, Mulder DW, Holley PW, Saccomanno G (1984b) Fine structural study of neurofibrillary changes in a family with amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 43:471-480.
22. Hoffman PN, Lasek RJ (1975) The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons. J Cell Biol 66:351-366.
23. Hoffman PN, Lasek RJ, Griffin JW, Price DL (1983) Slowing of the axonal transport of neurofilament proteins during development. J Neurosci 3:1694-1700.
24. Hoffman PN, Griffin JW, Price DL (1984) Control of axonal caliber by neurofilament transport. J Cell Biol 99:705-714.
25. Jacomy H, Zhu Q, Couillard-Despres S, Beaulieu JM, Julien JP (1999) Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunits. J Neurochem 73:972-984.
26. Julien JP, Tretjakoff I, Beaudet L, Peterson A (1987) Expression and assembly of a human neurofilament protein in transgenic mice provide a novel neuronal marking system. Genes Dev 1:1085-1095.
27. Jung C, Shea TB (2004) Neurofilament subunits undergo more rapid translocation within retinas than in optic axons. Brain Res Mol Brain Res 122:188-192.
28. Kleiman R, Banker G, Steward O (1990) Differential subcellular localization of particular mRNAs in hippocampal neurons in culture. Neuron 5:821-830.
29. Komiya Y (1980) Slowing with age of the rate of slow axonal flow in bifurcating axons of rat dorsal root ganglion cells. Brain Res 183:477-480.
30. Lasek RJ (1970) Axonal transport of proteins in dorsal root ganglion cells of the growing cat: a comparison of growing and mature neurons. Brain Res 20:121-126.
31. Lasek RJ, Paggi P, Katz MJ (1992) Slow axonal transport mechanisms move neurofilaments relentlessly in mouse optic axons. J Cell Biol 117:607-616.
32. Lee MK, Xu Z, Wong PC, Cleveland DW (1993) Neurofilaments are obligate heteropolymers in vivo. J Cell Biol 122:1337-1350.