Multiple functions of FADD in apoptosis, NF-κB-related signaling, and heart development in Xenopus embryos

Genes to Cells

Volumn 17, Issue 11, 2012, Pages 875-896

  Sakamaki, Kazuhiro ^a   Takagi, Chiyo ^b   Kitayama, Atsushi ^b   Kurata, Tomoko ^b   Yamamoto, Takamasa S ^b   Chiba, Kumiko ^a   Kominami, Katsuya ^a   Jung, Sang Kee ^c   Okawa, Katsuya ^d   Nozaki, Masami ^e   Kubota, Hiroshi Y ^a   Ueno, Naoto ^b  

^a KYOTO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

^c Tensei suisan Co Ltd   (Japan)

^d KYOWA HAKKO KOGYO CO LTD   (Japan)

^e OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CULLIN; CULLIN 4; FAS ASSOCIATED DEATH DOMAIN PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYO DEVELOPMENT; HEART DEVELOPMENT; IN SITU HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; XENOPUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, DIFFERENTIATION; APOPTOSIS; BLASTOMERES; CULLIN PROTEINS; EMBRYO, NONMAMMALIAN; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKDOWN TECHNIQUES; HEART; HEK293 CELLS; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; MORPHOLINOS; NF-KAPPA B; PEPTIDE FRAGMENTS; RECEPTORS, IMMUNOLOGIC; SEQUENCE ANALYSIS, DNA; SEQUENCE DELETION; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; XENOPUS; XENOPUS PROTEINS;

MAMMALIA;

EID: 84868137425     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/gtc.12004     Document Type: Article

References (81)

1. Akira, S. & Takeda, K. (2004) Toll-like receptor signalling. Nat. Rev. Immunol. 4, 499-511.
2. Aliprantis, A.O., Yang, R.B., Weiss, D.S., Godowski, P. & Zychlinsky, A. (2000) The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO J. 19, 3325-3336.
3. Bannerman, D.D., Tupper, J.C., Kelly, J.D., Winn, R.K. & Harlan, J.M. (2002) The Fas-associated death domain protein suppresses activation of NF-kappa B by LPS and IL-1 beta. J. Clin. Invest. 109, 419-425.
4. Baoprasertkul, P., Xu, P., Peatman, E., Kucuktas, H. & Liu, Z. (2007) Divergent Toll-like receptors in catfish (Ictalurus punctatus): TLR5S, TLR20, TLR21. Fish Shellfish Immunol. 23, 1218-1230.
5. Beg, A.A., Sha, W.C., Bronson, R.T., Ghosh, S. & Baltimore, D. (1995) Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 376, 167-170.
6. Boldin, M.P., Varfolomeev, E.E., Pancer, Z., Mett, I.L., Camonis, J.H. & Wallach, D. (1995) A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J. Biol. Chem. 270, 7795-7798.
7. Brown, R.T., Ades, I.Z. & Nordan, R.P. (1995) An acute phase response factor/NF-kappa B site downstream of the junB gene that mediates responsiveness to interleukin-6 in a murine plasmacytoma. J. Biol. Chem. 270, 31129-31135.
8. Bushdid, P.B., Brantley, D.M., Yull, F.E., Blaeuer, G.L., Hoffman, L.H., Niswander, L. & Kerr, L.D. (1998) Inhibition of NF-kappaB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis. Nature 392, 615-618.
9. Chao, W., Shen, Y., Li, L., Zhao, H., Meiler, S.E., Cook, S.A. & Rosenzweig, A. (2005) Fas-associated death domain protein inhibits TNF-alpha mediated NF-kappaB activation in cardiomyocytes. Am. J. Physiol. Heart Circ. Physiol. 289, H2073-H2080.
10. Charrier, J.B., Teillet, M.A., Lapointe, F. & Le Douarin, N.M. (1999) Defining subregions of Hensen's node essential for caudalward movement, midline development and cell survival. Development 126, 4771-4783.
11. Cheng, G. & Baltimore, D. (1996) TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation. Genes Dev. 10, 963-973.
12. Chinnaiyan, A.M., O'Rourke, K., Tewari, M. & Dixit, V.M. (1995) FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81, 505-512.
13. Correa, R.G., Tergaonkar, V., Ng, J.K., Dubova, I., Izpisua-Belmonte, J.C. & Verma, I.M. (2004) Characterization of NF-kappa B/I kappa B proteins in zebra fish and their involvement in notochord development. Mol. Cell. Biol. 24, 5257-5268.
14. Dealy, M.J., Nguyen, K.V., Lo, J., Gstaiger, M., Krek, W., Elson, D., Arbeit, J., Kipreos, E.T. & Johnson, R.S. (1999) Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E. Nat. Genet. 23, 245-248.
15. Endo, T., Kusakabe, M., Sunadome, K., Yamamoto, T. & Nishida, E. (2011) The kinase SGK1 in the endoderm and mesoderm promotes ectodermal survival by down-regulating components of the death-inducing signaling complex. Sci. Signal. 4, ra2.
16. Frisch, S.M. (1999) Evidence for a function of death-receptor-related, death-domain- containing proteins in anoikis. Curr. Biol. 9, 1047-1049.
17. Goto, T., Hasegawa, K., Kinoshita, T. & Kubota, H.Y. (2001) A novel POZ/zinc finger protein, champignon, interferes with gastrulation movements in Xenopus. Dev. Dyn. 221, 14-25.
18. Gregory-Evans, C.Y., Moosajee, M., Hodges, M.D., Mackay, D.S., Game, L., Vargesson, N., Bloch-Zupan, A., Ruschendorf, F., Santos-Pinto, L., Wackens, G. & Gregory-Evans, K. (2007) SNP genome scanning localises oto-dental syndrome to chromosome 11q13 and microdeletions at this locus implicate FGF3 in dental and inner ear disease and FADD in ocular coloboma. Hum. Mol. Genet. 16, 2482-2493.
19. Grempler, R., Kienitz, A., Werner, T., Meyer, M., Barthel, A., Ailett, F., Sutherland, C., Walther, R. & Schmoll, D. (2004) Tumour necrosis factor alpha decreases glucose-6-phosphatase gene expression by activation of nuclear factor kappaB. Biochem. J. 382, 471-479.
20. Grossmann, M., Metcalf, D., Merryfull, J., Beg, A., Baltimore, D. & Gerondakis, S. (1999) The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects. Proc. Natl Acad. Sci. USA 96, 11848-11853.
21. Harland, R.M. (1991) In situ hybridization: an improved whole-mount method for Xenopus embryos. Methods Cell Biol. 36, 685-695.
22. Hemmati-Brivanlou, A., Frank, D., Bolce, M.E., Brown, B.D., Sive, H.L. & Harland, R.M. (1990) Localization of specific mRNAs in Xenopus embryos by whole-mount in situ hybridization. Development 110, 325-330.
23. Hensey, C. & Gautier, J. (1998) Programmed cell death during Xenopus development: a spatio-temporal analysis. Dev. Biol. 203, 36-48.
24. Hensey, C. & Gautier, J. (1999) Developmental regulation of induced and programmed cell death in Xenopus embryos. Ann. NY Acad. Sci. 887, 105-119.
25. Hernandez-Gutierrez, S., Garcia-Pelaez, I., Zentella-Dehesa, A., Ramos-Kuri, M., Hernandez-Franco, P., Hernandez-Sanchez, F. & Rojas, E. (2006) NF-kappaB signaling blockade by Bay 11-7085 during early cardiac morphogenesis induces alterations of the outflow tract in chicken heart. Apoptosis 11, 1101-1109.
26. Hu, W.H., Johnson, H. & Shu, H.B. (2000) Activation of NF-kappaB by FADD, Casper, and caspase-8. J. Biol. Chem. 275, 10838-10844.
27. Imtiyaz, H.Z., Zhou, X., Zhang, H., Chen, D., Hu, T. & Zhang, J.Z. (2009) The death domain of FADD is essential for embryogenesis, lymphocyte development and proliferation. J. Biol. Chem. 284, 9917-9926.
28. Ishizawa, Y.H., Tamura, K., Yamaguchi, T., Matsumoto, K., Komiyama, M., Takamatsu, N., Shiba, T. & Ito, M. (2006) Xenopus death domain-containing proteins FADD and RIP1 synergistically activate JNK and NF-kappaB. Biol. Cell 98, 465-478.
29. Jackson, S. & Xiong, Y. (2009) CRL4s: the CUL4-RING E3 ubiquitin ligases. Trends Biochem. Sci. 34, 562-570.
30. Jacobson, M.D., Weil, M. & Raff, M.C. (1997) Programmed cell death in animal development. Cell 88, 347-354.
31. Jensen, O.N., Podtelejnikov, A. & Mann, M. (1996) Delayed extraction improves specificity in database searches by matrix-assisted laser desorption/ionization peptide maps. Rapid Commun. Mass Spectrom. 10, 1371-1378.
32. Juo, P., Woo, M.S., Kuo, C.J., Signorelli, P., Biemann, H.P., Hannun, Y.A. & Blenis, J. (1999) FADD is required for multiple signaling events downstream of the receptor Fas. Cell Growth Differ. 10, 797-804.
33. Kabra, N.H., Kang, C., Hsing, L.C., Zhang, J. & Winoto, A. (2001) T cell-specific FADD-deficient mice: FADD is required for early T cell development. Proc. Natl Acad. Sci. USA 98, 6307-6312.
34. Kanegae, Y., Tavares, A.T., Izpisua Belmonte, J.C. & Verma, I.M. (1998) Role of Rel/NF-kappaB transcription factors during the outgrowth of the vertebrate limb. Nature 392, 611-614.
35. Kao, K.R. & Lockwood, A. (1996) Negative regulation of dorsal patterning in early embryos by overexpression of XrelA, a Xenopus homologue of NF-kappa B. Mech. Dev. 58, 129-139.
36. Kennedy, M.W., Green, K.A., Ford, R.L., Andrews, P.G., Paterno, G.D., Gillespie, L.L. & Kao, K.R. (2007) Regulation of the response to Nodal-mediated mesoderm induction by Xrel3. Dev. Biol. 311, 383-395.
37. Kominami, K., Takagi, C., Nozaki, M., Kurata, T., Kitayama, A., Nozaki, M., Sawasaki, T., Kuida, K., Endo, Y., Manabe, N., Ueno, N. & Sakamaki, K. (2006) The initiator caspase, caspase-10β, and the BH-3-only molecule, Bid, demonstrate evolutionary conservation in Xenopus of their pro-apoptotic activities in the extrinsic and intrinsic pathways. Genes Cells 11, 701-717.
38. Kouba, D.J., Chung, K.Y., Nishiyama, T., Vindevoghel, L., Kon, A., Klement, J.F., Uitto, J. & Mauviel, A. (1999) Nuclear factor-kappa B mediates TNF-alpha inhibitory effect on alpha 2(I) collagen (COL1A2) gene transcription in human dermal fibroblasts. J. Immunol. 162, 4226-4234.
39. Kuang, A.A., Diehl, G.E., Zhang, J. & Winoto, A. (2000) FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts. J. Biol. Chem. 275, 25065-25068.
40. Li, B., Ruiz, J.C. & Chun, K.T. (2002) CUL-4A is critical for early embryonic development. Mol. Cell. Biol. 22, 4997-5005.
41. Matsuda, A., Suzuki, Y., Honda, G., Muramatsu, S., Matsuzaki, O., Nagano, Y., Doi, T., Shimotohno, K., Harada, T., Nishida, E., Hayashi, H. & Sugano, S. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22, 3307-3318.
42. Muzio, M., Ni, J., Feng, P. & Dixit, V.M. (1997) IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278, 1612-1615.
43. Nagai, T., Ibata, K., Park, E.S., Kubota, M., Mikoshiba, K. & Miyawaki, A. (2002) A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications. Nat. Biotechnol. 20, 87-90.
44. Nakajima, K., Takahashi, A. & Yaoita, Y. (2000) Structure, expression, and function of the Xenopus laevis caspase family. J. Biol. Chem. 275, 10484-10491.
45. Nieuwkoop, P.D. & Faber, J. (1967) Normal Table of Xenopus laevis (Daudin). Amsterdam: North Holland Publishing Co.
46. Nishikawa, A., Murata, E., Akita, M., Kaneko, K., Moriya, O., Tomita, M. & Hayashi, H. (1998) Roles of macrophages in programmed cell death and remodeling of tail and body muscle of Xenopus laevis during metamorphosis. Histochem. Cell Biol. 109, 11-17.
47. O'Neill, L.A. & Bowie, A.G. (2007) The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat. Rev. Immunol. 7, 353-364.
48. Park, H.H., Lo, Y.C., Lin, S.C., Wang, L., Yang, J.K. & Wu, H. (2007) The death domain superfamily in intracellular signaling of apoptosis and inflammation. Annu. Rev. Immunol. 25, 561-586.
49. Prothmann, C., Armstrong, N.J. & Rupp, R.A. (2000) The Toll/IL-1 receptor binding protein MyD88 is required for Xenopus axis formation. Mech. Dev. 97, 85-92.
50. Raff, M.C. (1992) Social controls on cell survival and cell death. Nature 356, 397-400.
51. Ray, A., Gao, X. & Ray, B.K. (1995) Role of a distal enhancer containing a functional NF-kappa B-binding site in lipopolysaccharide-induced expression of a novel alpha 1-antitrypsin gene. J. Biol. Chem. 270, 29201-29208.
52. Richardson, J.C., Gatherer, D. & Woodland, H.R. (1995) Developmental effects of over-expression of normal and mutated forms of a Xenopus NF-kappa B homologue. Mech. Dev. 52, 165-177.
53. Rothe, M., Xiong, J., Shu, H.B., Williamson, K., Goddard, A. & Goeddel, D.V. (1996) I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Proc. Natl Acad. Sci. USA 93, 8241-8246.
54. Rytomaa, M., Martins, L.M. & Downward, J. (1999) Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis. Curr. Biol. 9, 1043-1046.
55. Sakamaki, K., Nozaki, M., Kominami, K. & Satou, Y. (2007) The evolutionary conservation of the core components necessary for the extrinsic apoptotic signaling pathway, in Medaka fish. BMC Genomics 8, 141.
56. Sakamaki, K., Takagi, C., Kominami, K., Sakata, S., Yaoita, Y., Kubota, H.Y., Nozaki, M., Yonehara, S. & Ueno, N. (2004) The adaptor molecule FADD from Xenopus laevis demonstrates evolutionary conservation of its pro-apoptotic activity. Genes Cells 9, 1249-1264.
57. Sakamaki, K., Takagi, C., Yoshino, J., Yokota, H., Nakamura, S., Kominami, K., Hyodo, A., Takamune, K., Yuge, M. & Ueno, N. (2005) Transgenic frogs expressing the highly fluorescent protein Venus under the control of a strong mammalian promoter suitable for monitoring living cells. Dev. Dyn. 233, 562-569.
58. Schweitzer, K., Bozko, P.M., Dubiel, W. & Naumann, M. (2007) CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha. EMBO J. 26, 1532-1541.
59. Singer, J.D., Gurian-West, M., Clurman, B. & Roberts, J.M. (1999) Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev. 13, 2375-2387.
60. Sugiyama, M., Sakaue-Sawano, A., Iimura, T., Fukami, K., Kitaguchi, T., Kawakami, K., Okamoto, H., Higashijima, S.I. & Miyawaki, A. (2009) Illuminating cell-cycle progression in the developing zebrafish embryo. Proc. Natl Acad. Sci. USA 106, 20812-20817.
61. Sun, S.C., Ganchi, P.A., Ballard, D.W. & Greene, W.C. (1993) NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science 259, 1912-1915.
62. Suzuki, A., Thies, R.S., Yamaji, N., Song, J.J., Wozney, J.M., Murakami, K. & Ueno, N. (1994) A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo. Proc. Natl Acad. Sci. USA 91, 10255-10259.
63. Takahashi, K., Kawai, T., Kumar, H., Sato, S., Yonehara, S. & Akira, S. (2006) Cutting edge: roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA. J. Immunol. 176, 4520-4524.
64. Takemoto, K., Nagai, T., Miyawaki, A. & Miura, M. (2003) Spatio-temporal activation of caspase revealed by indicator that is insensitive to environmental effects. J. Cell Biol. 160, 235-243.
65. Tannahill, D. & Wardle, F.C. (1995) Control of axis formation in Xenopus by the NF-kappa B-I kappa B system. Int. J. Dev. Biol. 39, 549-558.
66. Tata, J.R. (1994) Hormonal regulation of programmed cell death during amphibian metamorphosis. Biochem. Cell Biol. 72, 581-588.
67. Tourneur, L. & Chiocchia, G. (2010) FADD: a regulator of life and death. Trends Immunol. 31, 260-269.
68. Tsujita, T., Tsukada, H., Nakao, M., Oshiumi, H., Matsumoto, M. & Seya, T. (2004) Sensing bacterial flagellin by membrane and soluble orthologs of Toll-like receptor 5 in Rainbow Trout (Onchorhynchus mikiss). J. Biol. Chem. 279, 48588-48597.
69. Vaux, D.L. & Korsmeyer, S.J. (1999) Cell death in development. Cell 96, 245-254.
70. Wajant, H. (2003) Death receptors. Essays Biochem. 39, 53-71.
71. Wesche, H., Henzel, W.J., Shillinglaw, W., Li, S. & Cao, Z. (1997) MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7, 837-847.
72. Yamamoto, T.S., Iemura, S., Takagi, C., Shimasaki, S. & Ueno, N. (2000) Characterization of follistatin isoforms in early Xenopus embryogenesis. Int. J. Dev. Biol. 44, 341-348.
73. Yamamoto, T.S., Takagi, C., Hyodo, A.C. & Ueno, N. (2001) Suppression of head formation by Xmsx-1 through the inhibition of intracellular nodal signaling. Development 128, 2769-2779.
74. Yaoita, Y. & Nakajima, K. (1997) Induction of apoptosis and CPP32 expression by thyroid hormone in a myoblastic cell line derived from tadpole tail. J. Biol. Chem. 272, 5122-5127.
75. Yeh, W.C., Pompa, J.L., McCurrach, M.E., Shu, H.B., Elia, A.J., Shahinian, A., Ng, M., Wakeham, A., Khoo, W., Mitchell, K., El-Deiry, W.S., Lowe, S.W., Goeddel, D.V. & Mak, T.W. (1998) FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science 279, 1954-1958.
76. Zhande, R., Dauphinee, S.M., Thomas, J.A., Yamamoto, M., Akira, S. & Karsan, A. (2007) FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction. Mol. Cell. Biol. 27, 7394-7404.
77. Zhang, C., Carl, T.F., Trudeau, E.D., Simmet, T. & Klymkowsky, M.W. (2006) An NF-kappaB and slug regulatory loop active in early vertebrate mesoderm. PLoS ONE 1, e106.
78. Zhang, H., Zhou, X., McQuade, T., Li, J., Chan, F.K. & Zhang, J. (2011) Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 471, 373-376.
79. Zhang, J., Cado, D., Chen, A., Kabra, N.H. & Winoto, A. (1998) Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature 392, 296-300.
80. Zhang, J. & Winoto, A. (1996) A mouse Fas-associated protein with homology to the human Mort1/FADD protein is essential for Fas-induced apoptosis. Mol. Cell. Biol. 16, 2756-2763.
81. Zhou, Q., Krebs, J.F., Snipas, S.J., Price, A., Alnemri, E.S., Tomaselli, K.J. & Salvesen, G.S. (1998) Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex. Biochemistry (Mosc.) 37, 10757-10765.