The kinase SGK1 in the endoderm and mesoderm promotes ectodermal survival by down-regulating components of the death-inducing signaling complex

Science Signaling

Volumn 4, Issue 156, 2011, Pages

  Endo, Tatsuya ^a   Kusakabe, Morioh ^a,b   Sunadome, Kazunori ^a   Yamamoto, Takuya ^a   Nishida, Eisuke ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 10; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OSTEOGENIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; BMP7.1 PROTEIN, XENOPUS; DEATH INDUCING PROTEIN, HUMAN; DEATH-INDUCING PROTEIN, HUMAN; IMMEDIATE EARLY PROTEIN; LUCIFERASE; MITOCHONDRIAL PROTEIN; MULTIPROTEIN COMPLEX; OLIGONUCLEOTIDE; PROTEIN SERINE THREONINE KINASE; SERUM GLUCOCORTICOID REGULATED KINASE; SERUM-GLUCOCORTICOID REGULATED KINASE; XENOPUS PROTEIN;

APOPTOSIS; ARTICLE; CELL SURVIVAL; ECTODERM; EMBRYO; EMBRYO DEVELOPMENT; ENDODERM; EYE MALFORMATION; GENE EXPRESSION; GENE SILENCING; HEAD; HUMAN; HUMAN CELL; MESODERM; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; XENOPUS; ANIMAL; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; GENE EXPRESSION REGULATION; GENETICS; IMMUNOBLOTTING; IN SITU HYBRIDIZATION; METABOLISM; MORPHOGENESIS; NICK END LABELING; PHYSIOLOGY; PRENATAL DEVELOPMENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; XENOPUS LAEVIS;

ANIMALIA;

ANIMALS; APOPTOSIS; BODY PATTERNING; BONE MORPHOGENETIC PROTEIN 7; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; ECTODERM; ENDODERM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMEDIATE-EARLY PROTEINS; IMMUNOBLOTTING; IN SITU HYBRIDIZATION; IN SITU NICK-END LABELING; LUCIFERASES; MESODERM; MICROARRAY ANALYSIS; MITOCHONDRIAL PROTEINS; MULTIPROTEIN COMPLEXES; NF-KAPPA B; OLIGONUCLEOTIDES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; XENOPUS LAEVIS; XENOPUS PROTEINS;

EID: 78751553093     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2001211     Document Type: Article

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43. Acknowledgments: We thank T. Araki, T. Suzuki, and K. Miyatake for technical advice and helpful discussion. Author contributions: T.E. and M.K. conceived and designed the study. T.E. performed the experiments. T.E., K.S., and T.Y. analyzed the microarray data. T.E., M.K., and E.N. wrote the manuscript. E.N. supervised the project. Funding: This work was supported by grants from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (to E.N. and M.K.) and Core Research for Evolutional Science and Technology, Japan Science and Technology (to E.N.). T.E. is a research fellow of the Japan Society for the Promotion of Science. Competing interests: The authors declare that they have no competing interests. Accession number: The microarray data have been deposited in the Gene Expression Omnibus with accession code GSE26381.