Isoprenylation of RhoB is necessary for its degradation: A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway

Journal of Biological Chemistry

Volumn 277, Issue 51, 2002, Pages 49389-49396

  Stamatakis, Konstantinos ^a   Cernuda Morollón, Eva ^a   Hernández Perera, Octavio ^a,b   Pérez Sala, Dolores ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CHOLESTEROL; DEGRADATION; GENES; PROTEINS; RHODIUM COMPOUNDS;

ISOPRENYLATION;

BIOCHEMISTRY;

CHOLESTEROL; DIMETHYLALLYLTRANSFERASE; FARNESYL DIPHOSPHATE; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID; MEVALONIC ACID; PROTEIN RHOB; RHO FACTOR; SIMVASTATIN; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHOLESTEROL SYNTHESIS; CYTOSOL; DRUG EFFECT; ENZYME ACTIVITY; METABOLITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; REACTION ANALYSIS; UPREGULATION;

3T3 CELLS; ANIMALS; ANTICHOLESTEREMIC AGENTS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CATTLE; CELLS, CULTURED; CHOLESTEROL; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; IMMUNOBLOTTING; IN SITU HYBRIDIZATION; MEVALONIC ACID; MICE; MODELS, BIOLOGICAL; MUTATION; PERTUSSIS TOXIN; PLASMIDS; PROTEIN BINDING; PROTEIN ISOPRENYLATION; RHOB GTP-BINDING PROTEIN; RNA, MESSENGER; SIMVASTATIN; SUBCELLULAR FRACTIONS; TIME FACTORS; TRANSFECTION; UP-REGULATION;

ANIMALIA;

EID: 0037147207     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M204049200     Document Type: Article

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