Covalent Modification of Mutant Rat P2X2 Receptors with a Thiol-Reactive Fluorophore Allows Channel Activation by Zinc or Acidic pH without ATP

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Dellal, Shlomo S ^a,b   Hume, Richard I ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYSTEINE; FLUORESCENT DYE; MALEIMIDE DERIVATIVE; PURINERGIC P2X2 RECEPTOR; SURAMIN; THIOL; ZINC;

ACIDITY; ANIMAL CELL; ARTICLE; CELL ACTIVATION; CHANNEL GATING; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; NONHUMAN; OOCYTE; PH; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; WILD TYPE; XENOPUS;

ADENOSINE TRIPHOSPHATE; ANIMALS; GENE EXPRESSION; HYDROGEN-ION CONCENTRATION; MALEIMIDES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OOCYTES; QUINOLINIUM COMPOUNDS; RATS; RECEPTORS, PURINERGIC P2X2; SURAMIN; XENOPUS LAEVIS; ZINC;

ALEXA; RATTUS;

EID: 84868124518     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047147     Document Type: Article

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