High potency zinc modulation of human P2X2 receptors and low potency zinc modulation of rat P2X2 receptors share a common molecular mechanism

Journal of Biological Chemistry

Volumn 287, Issue 26, 2012, Pages 22099-22111

  Punthambaker, Sukanya ^a   Blum, Jacob A ^a   Hume, Richard I ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CENTRAL AXIS; CHARGED RESIDUES; HIGH POTENCY; HOMOLOGY MODELS; LOW POTENCY; MOLECULAR MECHANISM; SUBUNIT INTERFACES; ZEBRAFISH; ZINC-BINDING SITES;

AMINO ACIDS; MODULATION; RATS;

ZINC;

ALANINE; HISTIDINE; LYSINE; PURINERGIC P2X2 RECEPTOR; ZINC;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS LINKING; CRYSTAL STRUCTURE; FEMALE; GENE MUTATION; HUMAN; IC 50; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; SPECIES DIFFERENCE; SURFACE CHARGE; VESTIBULE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BINDING SITES; CROSS-LINKING REAGENTS; ELECTROPHYSIOLOGY; HISTIDINE; HUMANS; ION CHANNELS; LIGANDS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTAGENESIS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PURINERGIC P2X RECEPTOR ANTAGONISTS; RATS; RECEPTORS, PURINERGIC P2X2; ZINC;

EID: 84862668708     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.369157     Document Type: Article

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