Single channel properties of P2X2 purinoceptors

Journal of General Physiology

Volumn 113, Issue 5, 1999, Pages 695-719

  Ding, Shinghua ^a   Sachs, Frederick ^b  

^a The State University of New York   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Adenosine triphosphate; Channel; Kinetics; Permeation; Selectivity

Indexed keywords

ADENOSINE TRIPHOSPHATE; CATION; CATION CHANNEL; CESIUM ION; LITHIUM ION; POTASSIUM ION; PROTON; PURINE P2X RECEPTOR; RUBIDIUM ION; SODIUM ION;

ANIMAL CELL; ARTICLE; BINDING SITE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; EMBRYO; EQUILIBRIUM CONSTANT; HUMAN; HUMAN CELL; ION CONDUCTANCE; ION CURRENT; KIDNEY CELL; MEMBRANE POTENTIAL; NONHUMAN; OOCYTE; PH; XENOPUS;

ADENOSINE TRIPHOSPHATE; ALGORITHMS; ANIMALS; CATIONS; CELL LINE; ELECTRIC STIMULATION; HUMANS; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; ION CHANNELS; KIDNEY; KINETICS; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; OOCYTES; PATCH-CLAMP TECHNIQUES; RECEPTORS, PURINERGIC P2; SODIUM; XENOPUS;

EID: 0032940264     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.113.5.695     Document Type: Article

References (66)

1. Akk, G., and A. Auerbach. 1996. Inorganic, monovalent cations compete with agonists for the transmitter binding site of nicotinic acetylcholine receptors. Biophys. J. 70:2652-2658.
2. Allende, G., V. Casado, J. Mallol, R. Franco, C. Lluis, and E.I. Canela. 1993. Role of histidine residues in agonist and antagonist binding sites of Al adenosine receptor. J. Neurochem. 60:1525-1533.
3. Auerbach, A., and F. Sachs. 1984. Single-channel currents from acetylcholine receptors in embryonic chick muscle. Kinetic and conductance properties of gaps within bursts. Biophys. J. 45:187-198.
4. Auerbach, A., W. Sigurdson, J. Chen, and G. Akk. 1996. Voltage dependence of mouse acetylcholine receptor gating: different charge movements in di-, mono-, and unliganded receptors. J. Physiol. (Camb.). 494:155-170.
5. Barry, P.H., and J.W. Lynch. 1991. Liquid junction potentials and small cell effects in patch-clamp analysis. [Published erratum appears in J. Membr. Biol. 1992. 125:286.] J. Membr. Biol 121:101-117.
6. Bean, B.P. 1990. ATP-activated channels in rat and bullfrog sensory neurons: concentration dependence and kinetics. J. Neurosci. 10: 1-10.
7. Bean, B.P., 1992. Pharmacology and electrophysiology of ATP-activated ion channels. Trends Pharmacol. Sci. 13:87-90.
8. Bean, B.P., C.A. Williams, and P.W. Ceelen. 1990. ATP-activated channels in rat and bullfrog sensory neurons: current-voltage relation and single-channel behavior. J. Neurosci. 10:11-19.
9. Bo, X., Y. Zhang, M. Nassar, G. Burnstock, and R. Schoepfer. 1995. A P2X purinoceptor cDNA conferring a novel pharmacological profile. FEBS Lett. 375:129-133.
10. Brake, A.J., M.J. Wagenbach, and D. Julius. 1994. New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature. 371:519-523.
11. Bretschneider, F., M. Klapperstuck, M. Lohn, and F. Markwardt. 1995. Nonselective cationic currents elicited by extracellular ATP in human B-lymphocytes. Pflügers Arch. 429:691-698.
12. Buell, G., C. Lewis, G. Collo, R.A. North, and A. Surprenant. 1996. An antagonist-insensitive P2X receptor expressed in epithelia and brain. EMBO (Eut Mol. Biol. Organ.) J. 15:55-62.
13. Capiod, T. 1998. ATP-activated cation currents in single guinea-pig hepatocytes. J. Physiol. (Camb.). 507:795-805.
14. Chen, C.C., A.N. Akopian, L. Sivilotti, D. Colquhoun, G. Burnstock, and J.N. Wood. 1995. A P2X purinoceptor expressed by a subset of sensory neurons. Nature. 377:428-431.
15. Chung, S.H., J.B. Moore, L.G. Xia, L.S. Premkumar, and P.W. Gage. 1990. Characterization of single channel currents using digital signal processing techniques based on Hidden Markov Models. Philos. Trans. R. Soc. Lond. B Biol. Sci. 329:265-285.
16. Collo, G., R.A. North, E. Kawashima, E. Merlo-Pich, Neidhart, A. Surprenant, and G. Buell. 1996. Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci. 16:2495-2507.
17. Colquhoun, D., P. Jonas, and B. Sakmann. 1992. Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurones of rat hippocampal slices. J. Physiol. (Camb.). 458:261-287.
18. Defelice, L. 1981. Introduction to Membrane Noise. Plenum Publishing Corp. New York. 231-329.
19. + conduction and selectivity. Science. 280:69-77.
20. Evans, R.J. 1996. Single channel properties of ATP-gated cation channels (P2X receptors) heterologously expressed in Chinese hamster ovary cells. Neurosci. Lett. 212:212-214.
21. Friel, D.D. 1988. An ATP-sensitive conductance in single smooth muscle cells from the rai vas deferens, J. Physiol. (Camb.). 401: 361-380.
22. Hamill, O.P., A. Marty, E. Neher, B. Sakmann, and F.J. Sigworth. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 391:85-100.
23. Hess, G.P. 1993. Determination of the chemical mechanism of neurotransmitter receptor-mediated reactions by rapid chemical kinetic techniques. Biochemistry. 32:989-1000.
24. Hille, B. 1992. Ionic Channels of Excitable Membranes. 2nd edition. Sinauer Associates Inc., Sunderland, MA. 362-389.
25. Horn, R. 1987. Statistical methods for model discrimination. Applications to gating kinetics and permeation of the acetylcholine receptor channel. Biophys. J. 51:255-263.
26. Khakh, B.S., P.P. Humphrey, and A. Surprenant. 1995. Electrophysiological properties of P2X-purinoceptors in rat superior cervical, nodose and guinea-pig coeliac neurones. J. Physiol. (Camb.). 484:385-395.
27. Kim, M., O.J. Yoo, and S. Choe. 1997. Molecular assembly of the extracellular domain of P2X2, an ATP-gated ion channel. Biochem. Biophys. Res. Commun. 240:618-622.
28. King, B.F., S.S. Wildman, L.E. Ziganshina, J. Pintor, and G. Burnstock. 1997. Effects of extracellular pH on agonism and antagonism at a recombinant P2X2 receptor. Br. J. Pharmacol. 121:1445-1453.
29. King, B.F., L.E. Ziganshina, J. Pintor, and G. Burnstock. 1996. Full sensitivity of P2X2 purinoceptor to ATP revealed by changing extracellular pH. Br. J. Pharmacol. 117:1371-1373.
30. Krishtal, O.A., S.M. Marchenko, and A.G. Obukhov. 1988. Canonic channels activated by extracellular ATP in rat sensory neurons. Neuroscience. 27:995-1000.
31. 2+. Voltage and concentration dependence of calcium entry into the pore. J. Gen. Physiol. 88:321-347.
32. Lewis, C., S. Neidhart, C. Holy, R.A. North, G. Buell, and A. Surprenant. 1995. Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature. 377:432-435.
33. Li, C., R.W. Peoples, and F.F. Weight. 1996. Acid pH augments excitatory action of ATP on a dissociated mammalian sensory neuron. Neuroreport. 7:2151-2154.
34. Li, C., R.W. Peoples, and F.F. Weight. 1997. Enhancement of ATP-activated current by protons in dorsal root ganglion neurons. Pflügers Arch. 433:446-454.
35. Magleby, K.L., and L. Song. 1992. Dependency plots suggest the kinetic structure of ion channels. Proc. R. Soc. Lond. B Biol. Sci. 249: 133-142.
36. McQueen, D.S., S.M. Bond, C. Moores, I. Chessell, P.P. Humphrey, and E. Dowd. 1998. Activation of P2X receptors for adenosine triphosphate evokes cardiorespiratory reflexes in anaesthetized rats. J. Physiol. (Camb.). 507:843-855.
37. Nakazawa, K., K. Fujimori, A. Takanaka, and K. Inoue. 1990a. ATP-induced current in isolated outer hair cells of guinea pig cochlea. J. Neurophysiol. (Bethesda). 63:1068-1074.
38. Nakazawa, K., K. Fujimori, A. Takanaka, and K. Inoue. 1990b. An ATP-activated conductance in pheochromocytoma cells and its suppression by extracellular calcium. J. Physiol. (Camb.). 428: 257-272.
39. Nakazawa, K., and P. Hess. 1993. Block by calcium of ATP-activated channels in pheochromocytoma cells. J. Gen. Physiol. 101:377-392.
40. Nakazawa, K., K. Inoue, K. Fujimori, and A. Takanaka. 1991. Effects of ATP antagonists on purinoceptor-operated inward currents in rat phaeochromocytoma cells. Pflügers Arch. 418:214-219.
41. Nicke, A., H.G. Baumert, J. Rettinger, A. Eichele, Lambrecht, E. Mutschler, and G. Schmalzing. 1998. P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels. EMBO (Eur. Mol. Biol. Organ.) J. 17:3016-3028.
42. North, R.A. 1996. Families of ion channels with two hydrophobic segments. Curr. Opin. Cell Biol. 8:474-483.
43. Qin, F., A. Auerbach, and F. Sachs. 1996a. Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events. Biophys. J. 70:264-280.
44. Qin, F., A. Auerbach, and F. Sachs. 1996b. Idealization of single-channel currents using the segmental K-mean method. Biophys. J. 72:A227
45. Rassendren, F., G. Buell, A. Newbolt, R.A. North, and A. Surprenant. 1997a. Identification of amino acid residues contributing to the pore of a P2X receptor. EMBO (Eur. Mol. Biol. Organ.) J. 16:3446-3454.
46. Rassendren, F., G.N. Buell, C. Virginio, G. Collo, R.A. North, and A. Surprenant. 1997b. The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA. J. Biol. Chem. 272: 5482-5486.
47. Rudy, B., and L. Iverson. 1992. Methods in Enzymology. Vol. 207. Academic Press, Inc., San Diego, CA. 266-279.
48. Sands, S.B., and M.E. Barish. 1992. Neuronal nicotinic acetylcholine receptor currents in phaeochromocytoma (PC12) cells: dual mechanisms of rectification. J. Physiol. (Camb.). 447:467-487.
49. Seguela, P., A. Haghighi, J.J. Soghomonian, and E. Cooper. 1996. A novel neuronal P2X ATP receptor ion channel with widespread distribution in the brain. J. Neurosci. 16:448-455.
50. Sigworth, F.J. 1985. Open channel noise. I. Noise in acetylcholine receptor currents suggests conformational fluctuations. Biophys. J. 47:709-720.
51. Sigworth, F.J. 1986. Open channel noise. II. A test for coupling between current fluctuations and conformational transitions in the acetylcholine receptor. Biophys. J. 49:1041-1046.
52. Sigworth, F.J., and S.M. Sine. 1987. Data transformations for improved display and fitting of single-channel dwell time histograms. Biophys. J. 52:1047-1054.
53. Sivilotti, L.G., D.K. McNeil, T.M. Lewis, M.A. Nassar, R. Schoepfer, and D. Colquhoun. 1997. Recombinant nicotinic receptors, expressed in Xenopus oocytes, do not resemble native rat sympathetic ganglion receptors in single-channel behaviour. J. Physiol. (Camb.). 500:123-138.
54. Soto, F., M. Garcia-Guzman, J.M. Gomez-Hernandez, M. Hollmann, C. Karschin, and W. Stühmer. 1996. P2X4: an ATP-activated ionotropic receptor cloned from rat brain. Proc. Natl. Acad. Sci. USA. 93:3684-3688.
55. Stoop, R., A. Surprenant, and R.A. North. 1997. Different sensitivities to pH of ATP-induced currents at four cloned P2X receptors. J. Neurophysiol. 78:1837-1840.
56. Surprenant, A. 1996. Functional properties of native and cloned P2X receptors. Ciba Found. Symp. 198:208-219.
57. Surprenant, A., F. Rassendren, E. Kawashima, R.A. North, and G. Buell. 1996. The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science. 272:735-738.
58. Ugur, M., R.M. Drummond, H. Zou, P. Sheng, J.J. Singer, and J.V. Walsh, Jr. 1997. An ATP-gated cation channel with some P2Z-like characteristics in gastric smooth muscle cells of toad. J. Physiol. (Camb.). 498:427-442.
59. Valera, S., N. Hussy, R.J. Evans, N. Adami, R.A. North, A. Surprenant, and G. Buell. 1994. A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP. Nature. 371:516-519.
60. Vandenberg, C.A., and F. Bezanilla. 1991. Single-channel, macroscopic, and gating currents from sodium channels in the squid giant axon. Biophys. J. 60:1499-1510.
61. Vandenberg, C.A., and R. Horn. 1984. Inactivation viewed through single sodium channels. J. Gen. Physiol. 84:535-564.
62. Walz, W., G. Gimpl, C. Ohlemeyer, and H. Kettenmann. 1994. Extracellular ATP-induced currents in astrocytes: involvement of a cation channel. J. Neurosci. Res. 38:12-18.
63. Wang, C.Z., N. Namba, T. Gonoi, N. Inagaki, and S. Seino. 1996. Cloning and pharmacological characterization of a fourth P2X receptor subtype widely expressed in brain and peripheral tissues including various endocrine tissues. Biochem. Biophys. Res. Commun. 220:196-202.
64. 2+ modulation of ATP-responses at recombinant P2X2 receptors and its dependence on extracellular pH. Br. J. Pharmacol. 123:1214-1220.
65. + channels of bovine chromaffin cells. J. Gen. Physiol. 84:157-186.
66. Zhou, Z., and R.I. Hume. 1998. Two mechanisms for inward rectification of current flow through the purinoceptor P2X2 class of ATP-gated channels. J. Physiol. (Camb.). 507:353-364.