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Volumn 90, Issue 11, 2012, Pages 1237-1245

Homeostatic chemokines guide lymphoma cells to tumor growth-promoting niches within secondary lymphoid organs

Author keywords

B cell lymphoma; Homeostatic cytokines; Lymphoma stroma crosstalk; Microenvironment

Indexed keywords

B LYMPHOCYTE ANTIBODY; BAMINERCEPT; CHEMOKINE; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR5; CXCL13 CHEMOKINE; CYTOKINE; CYTOTOXIC AGENT; FOSTAMATINIB; HOMING RECEPTOR; IBRUTINIB; IDELALISIB; LYMPHOTOXIN; LYMPHOTOXIN BETA RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; PLERIXAFOR; SECONDARY LYMPHOID TISSUE CHEMOKINE; T 140; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1;

EID: 84868113996     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-012-0906-z     Document Type: Article
Times cited : (23)

References (83)
  • 1
    • 77951010885 scopus 로고    scopus 로고
    • Aggressive lymphomas
    • 10.1056/NEJMra0807082 20393178 1:CAS:528:DC%2BC3cXkslajtbY%3D
    • Lenz G, Staudt LM (2010) Aggressive lymphomas. N Engl J Med 362:1417-1429
    • (2010) N Engl J Med , vol.362 , pp. 1417-1429
    • Lenz, G.1    Staudt, L.M.2
  • 4
    • 70249085585 scopus 로고    scopus 로고
    • Stromal cell contributions to the homeostasis and functionality of the immune system
    • 19644499 1:CAS:528:DC%2BD1MXpt1Wgtrg%3D
    • Mueller SN, Germain RN (2009) Stromal cell contributions to the homeostasis and functionality of the immune system. Nat Rev Immunol 9:618-629
    • (2009) Nat Rev Immunol , vol.9 , pp. 618-629
    • Mueller, S.N.1    Germain, R.N.2
  • 5
    • 79953035119 scopus 로고    scopus 로고
    • Stromal cell-immune cell interactions
    • 10.1146/annurev-immunol-031210-101357 21073333 1:CAS:528: DC%2BC3MXltlKnsrk%3D
    • Roozendaal R, Mebius RE (2011) Stromal cell-immune cell interactions. Annu Rev Immunol 29:23-43
    • (2011) Annu Rev Immunol , vol.29 , pp. 23-43
    • Roozendaal, R.1    Mebius, R.E.2
  • 6
    • 0037375522 scopus 로고    scopus 로고
    • Concerted action of the chemokine and lymphotoxin system in secondary lymphoid-organ development
    • 10.1016/S0952-7915(03)00014-1 12633673 1:CAS:528:DC%2BD3sXhvFahsr0%3D
    • Muller G, Lipp M (2003) Concerted action of the chemokine and lymphotoxin system in secondary lymphoid-organ development. Curr Opin Immunol 15:217-224
    • (2003) Curr Opin Immunol , vol.15 , pp. 217-224
    • Muller, G.1    Lipp, M.2
  • 7
    • 2342650412 scopus 로고    scopus 로고
    • The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity
    • 10.1034/j.1600-065X.2003.00073.x 12969315
    • Muller G, Hopken UE, Lipp M (2003) The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity. Immunol Rev 195:117-135
    • (2003) Immunol Rev , vol.195 , pp. 117-135
    • Muller, G.1    Hopken, U.E.2    Lipp, M.3
  • 8
    • 17644400505 scopus 로고    scopus 로고
    • Network communications: Lymphotoxins, LIGHT, and TNF
    • 10.1146/annurev.immunol.23.021704.115719 15771586 1:CAS:528: DC%2BD2MXktFOju7o%3D
    • Ware CF (2005) Network communications: lymphotoxins, LIGHT, and TNF. Annu Rev Immunol 23:787-819
    • (2005) Annu Rev Immunol , vol.23 , pp. 787-819
    • Ware, C.F.1
  • 9
    • 0036658715 scopus 로고    scopus 로고
    • Systemic immunoregulatory and pathogenic functions of homeostatic chemokine receptors
    • 12101256 1:CAS:528:DC%2BD38XlsVWmsLc%3D
    • Muller G, Hopken UE, Stein H, Lipp M (2002) Systemic immunoregulatory and pathogenic functions of homeostatic chemokine receptors. J Leukoc Biol 72:1-8
    • (2002) J Leukoc Biol , vol.72 , pp. 1-8
    • Muller, G.1    Hopken, U.E.2    Stein, H.3    Lipp, M.4
  • 10
    • 3442891136 scopus 로고    scopus 로고
    • Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination
    • 10.1189/jlb.1203652 15155773 1:CAS:528:DC%2BD2cXmtlKrsb4%3D
    • Lopez-Giral S, Quintana NE, Cabrerizo M, Alfonso-Perez M, Sala-Valdes M, De Soria VG, Fernandez-Ranada JM, Fernandez-Ruiz E, Munoz C (2004) Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination. J Leukoc Biol 76:462-471
    • (2004) J Leukoc Biol , vol.76 , pp. 462-471
    • Lopez-Giral, S.1    Quintana, N.E.2    Cabrerizo, M.3    Alfonso-Perez, M.4    Sala-Valdes, M.5    De Soria, V.G.6    Fernandez-Ranada, J.M.7    Fernandez-Ruiz, E.8    Munoz, C.9
  • 11
    • 0032728216 scopus 로고    scopus 로고
    • BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma
    • 10.1172/JCI7830 10562310 1:CAS:528:DyaK1MXntlyqsrc%3D
    • Mazzucchelli L, Blaser A, Kappeler A, Scharli P, Laissue JA, Baggiolini M, Uguccioni M (1999) BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma. J Clin Invest 104:R49-54
    • (1999) J Clin Invest , vol.104 , pp. 49-54
    • Mazzucchelli, L.1    Blaser, A.2    Kappeler, A.3    Scharli, P.4    Laissue, J.A.5    Baggiolini, M.6    Uguccioni, M.7
  • 12
    • 33845630835 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis triggers formation of lymphoid structure in murine lungs
    • 10.1086/508894 17152008 1:CAS:528:DC%2BD2sXpslSgtQ%3D%3D
    • Kahnert A, Hopken UE, Stein M, Bandermann S, Lipp M, Kaufmann SH (2007) Mycobacterium tuberculosis triggers formation of lymphoid structure in murine lungs. J Infect Dis 195:46-54
    • (2007) J Infect Dis , vol.195 , pp. 46-54
    • Kahnert, A.1    Hopken, U.E.2    Stein, M.3    Bandermann, S.4    Lipp, M.5    Kaufmann, S.H.6
  • 13
    • 78149414259 scopus 로고    scopus 로고
    • The chemokine receptor CXCR5 is pivotal for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori-induced inflammation
    • 10.1007/s00109-010-0658-6 1:CAS:528:DC%2BC3cXhtlSjsbjL
    • Winter S, Loddenkemper C, Aebischer A, Rabel K, Hoffmann K, Meyer TF, Lipp M, Hopken UE (2010) The chemokine receptor CXCR5 is pivotal for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori-induced inflammation. J Mol Med (Berl) 88:1169-1180
    • (2010) J Mol Med (Berl) , vol.88 , pp. 1169-1180
    • Winter, S.1    Loddenkemper, C.2    Aebischer, A.3    Rabel, K.4    Hoffmann, K.5    Meyer, T.F.6    Lipp, M.7    Hopken, U.E.8
  • 14
    • 0030582773 scopus 로고    scopus 로고
    • A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
    • 10.1016/S0092-8674(00)81798-5 8978608 1:STN:280:DyaK2s7jtlaisw%3D%3D
    • Forster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M (1996) A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87:1037-1047
    • (1996) Cell , vol.87 , pp. 1037-1047
    • Forster, R.1    Mattis, A.E.2    Kremmer, E.3    Wolf, E.4    Brem, G.5    Lipp, M.6
  • 15
    • 0033214348 scopus 로고    scopus 로고
    • CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
    • 10.1016/S0092-8674(00)80059-8 10520991 1:CAS:528:DyaK1MXmsleqs7o%3D
    • Forster R, Schubel A, Breitfeld D, Kremmer E, Renner-Muller I, Wolf E, Lipp M (1999) CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99:23-33
    • (1999) Cell , vol.99 , pp. 23-33
    • Forster, R.1    Schubel, A.2    Breitfeld, D.3    Kremmer, E.4    Renner-Muller, I.5    Wolf, E.6    Lipp, M.7
  • 16
    • 0027982876 scopus 로고
    • Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
    • 10.1016/0092-8674(94)90337-9 7507411 1:CAS:528:DyaK2cXhs1Srtrg%3D
    • Springer TA (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301-314
    • (1994) Cell , vol.76 , pp. 301-314
    • Springer, T.A.1
  • 17
    • 0030001675 scopus 로고    scopus 로고
    • Lymphocyte homing and homeostasis
    • 10.1126/science.272.5258.60 8600538 1:CAS:528:DyaK28XitVKkt70%3D
    • Butcher EC, Picker LJ (1996) Lymphocyte homing and homeostasis. Science 272:60-66
    • (1996) Science , vol.272 , pp. 60-66
    • Butcher, E.C.1    Picker, L.J.2
  • 19
    • 36148999015 scopus 로고    scopus 로고
    • Lymphoma dissemination: The other face of lymphocyte homing
    • 10.1182/blood-2007-05-075176 17656647 1:CAS:528:DC%2BD2sXht1yqur%2FK
    • Pals ST, de Gorter DJ, Spaargaren M (2007) Lymphoma dissemination: the other face of lymphocyte homing. Blood 110:3102-3111
    • (2007) Blood , vol.110 , pp. 3102-3111
    • Pals, S.T.1    De Gorter, D.J.2    Spaargaren, M.3
  • 20
    • 0034653949 scopus 로고    scopus 로고
    • Cell adhesion receptors in lymphoma dissemination
    • 10706853 1:CAS:528:DC%2BD3cXhvVGgsrg%3D
    • Drillenburg P, Pals ST (2000) Cell adhesion receptors in lymphoma dissemination. Blood 95:1900-1910
    • (2000) Blood , vol.95 , pp. 1900-1910
    • Drillenburg, P.1    Pals, S.T.2
  • 21
    • 0037082511 scopus 로고    scopus 로고
    • Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs
    • 10.1182/blood.V99.4.1109 11830455 1:CAS:528:DC%2BD38XhtlWqs7s%3D
    • Hopken UE, Foss HD, Meyer D, Hinz M, Leder K, Stein H, Lipp M (2002) Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs. Blood 99:1109-1116
    • (2002) Blood , vol.99 , pp. 1109-1116
    • Hopken, U.E.1    Foss, H.D.2    Meyer, D.3    Hinz, M.4    Leder, K.5    Stein, H.6    Lipp, M.7
  • 22
    • 0036119210 scopus 로고    scopus 로고
    • Chemokine receptors and stromal cells in the homing and homeostasis of chronic lymphocytic leukemia B cells
    • 10.1080/10428190290011921 12002747 1:CAS:528:DC%2BD38XntVartrk%3D
    • Burger JA, Kipps TJ (2002) Chemokine receptors and stromal cells in the homing and homeostasis of chronic lymphocytic leukemia B cells. Leuk Lymphoma 43:461-466
    • (2002) Leuk Lymphoma , vol.43 , pp. 461-466
    • Burger, J.A.1    Kipps, T.J.2
  • 23
    • 3142559469 scopus 로고    scopus 로고
    • Homeostatic chemokines drive migration of malignant B cells in patients with non-Hodgkin lymphomas
    • 10.1182/blood-2003-09-3103 15001469 1:CAS:528:DC%2BD2cXlvFSnu70%3D
    • Trentin L, Cabrelle A, Facco M, Carollo D, Miorin M, Tosoni A, Pizzo P, Binotto G, Nicolardi L, Zambello R et al (2004) Homeostatic chemokines drive migration of malignant B cells in patients with non-Hodgkin lymphomas. Blood 104:502-508
    • (2004) Blood , vol.104 , pp. 502-508
    • Trentin, L.1    Cabrelle, A.2    Facco, M.3    Carollo, D.4    Miorin, M.5    Tosoni, A.6    Pizzo, P.7    Binotto, G.8    Nicolardi, L.9    Zambello, R.10
  • 24
    • 33750825517 scopus 로고    scopus 로고
    • CXC chemokine ligand 13 and CC chemokine ligand 19 cooperatively render resistance to apoptosis in B cell lineage acute and chronic lymphocytic leukemia CD23 + CD5+ B cells
    • 17082584
    • Chunsong H, Yuling H, Li W, Jie X, Gang Z, Qiuping Z, Qingping G, Kejian Z, Li Q, Chang AE et al (2006) CXC chemokine ligand 13 and CC chemokine ligand 19 cooperatively render resistance to apoptosis in B cell lineage acute and chronic lymphocytic leukemia CD23 + CD5+ B cells. J Immunol 177:6713-6722
    • (2006) J Immunol , vol.177 , pp. 6713-6722
    • Chunsong, H.1    Yuling, H.2    Li, W.3    Jie, X.4    Gang, Z.5    Qiuping, Z.6    Qingping, G.7    Kejian, Z.8    Li, Q.9    Chang, A.E.10
  • 26
    • 0036907776 scopus 로고    scopus 로고
    • CCR6 is a functional chemokine receptor that serves to identify select B-cell non-Hodgkin's lymphomas
    • 10.1053/hupa.2002.129417 12514792 1:CAS:528:DC%2BD3sXmvVSnuw%3D%3D
    • Rodig SJ, Jones D, Shahsafaei A, Dorfman DM (2002) CCR6 is a functional chemokine receptor that serves to identify select B-cell non-Hodgkin's lymphomas. Hum Pathol 33:1227-1233
    • (2002) Hum Pathol , vol.33 , pp. 1227-1233
    • Rodig, S.J.1    Jones, D.2    Shahsafaei, A.3    Dorfman, D.M.4
  • 28
    • 57749171165 scopus 로고    scopus 로고
    • The biology of Hodgkin's lymphoma
    • 10.1038/nrc2542 19078975 1:CAS:528:DC%2BD1cXhsVylsb%2FL
    • Kuppers R (2009) The biology of Hodgkin's lymphoma. Nat Rev Cancer 9:15-27
    • (2009) Nat Rev Cancer , vol.9 , pp. 15-27
    • Kuppers, R.1
  • 29
    • 79955666386 scopus 로고    scopus 로고
    • Effect of chemokine receptors CCR7 on disseminated behavior of human T cell lymphoma: Clinical and experimental study
    • 10.1186/1756-9966-30-51 21548969 1:CAS:528:DC%2BC3MXmtlKkt7Y%3D
    • Yang J, Wang S, Zhao G, Sun B (2011) Effect of chemokine receptors CCR7 on disseminated behavior of human T cell lymphoma: clinical and experimental study. J Exp Clin Cancer Res 30:51
    • (2011) J Exp Clin Cancer Res , vol.30 , pp. 51
    • Yang, J.1    Wang, S.2    Zhao, G.3    Sun, B.4
  • 30
    • 33749363890 scopus 로고    scopus 로고
    • Mouse modeling in oncologic preclinical and translational research
    • 10.1158/1078-0432.CCR-06-0482 17000663 1:CAS:528:DC%2BD28XpvFShs7s%3D
    • Carver BS, Pandolfi PP (2006) Mouse modeling in oncologic preclinical and translational research. Clin Cancer Res 12:5305-5311
    • (2006) Clin Cancer Res , vol.12 , pp. 5305-5311
    • Carver, B.S.1    Pandolfi, P.P.2
  • 31
    • 3142677977 scopus 로고    scopus 로고
    • Transgenic mice as an in vivo model of lymphomagenesis
    • 10.1016/S0074-7696(04)36004-3 15261738 1:CAS:528:DC%2BD2cXnvVCgsLk%3D
    • Tarantul VZ (2004) Transgenic mice as an in vivo model of lymphomagenesis. Int Rev Cytol 236:123-180
    • (2004) Int Rev Cytol , vol.236 , pp. 123-180
    • Tarantul, V.Z.1
  • 32
    • 0037071401 scopus 로고    scopus 로고
    • Modelling haematopoietic malignancies in the mouse and therapeutical implications
    • 10.1038/sj.onc.1205313 12032781 1:CAS:528:DC%2BD38XksVWrsbc%3D
    • Bernardi R, Grisendi S, Pandolfi PP (2002) Modelling haematopoietic malignancies in the mouse and therapeutical implications. Oncogene 21:3445-3458
    • (2002) Oncogene , vol.21 , pp. 3445-3458
    • Bernardi, R.1    Grisendi, S.2    Pandolfi, P.P.3
  • 33
    • 0028829684 scopus 로고
    • New models of lymphoma in transgenic mice
    • 10.1016/0952-7915(95)80075-1 8573310 1:CAS:528:DyaK2MXpt1yjurc%3D
    • Seldin DC (1995) New models of lymphoma in transgenic mice. Curr Opin Immunol 7:665-673
    • (1995) Curr Opin Immunol , vol.7 , pp. 665-673
    • Seldin, D.C.1
  • 35
    • 45849135641 scopus 로고    scopus 로고
    • The B cell antigen receptor and overexpression of MYC can cooperate in the genesis of B cell lymphomas
    • 10.1371/journal.pbio.0060152 18578569 1:CAS:528:DC%2BD1cXotVejt7s%3D
    • Refaeli Y, Young RM, Turner BC, Duda J, Field KA, Bishop JM (2008) The B cell antigen receptor and overexpression of MYC can cooperate in the genesis of B cell lymphomas. PLoS Biol 6:e152
    • (2008) PLoS Biol , vol.6 , pp. 152
    • Refaeli, Y.1    Young, R.M.2    Turner, B.C.3    Duda, J.4    Field, K.A.5    Bishop, J.M.6
  • 36
    • 77958126430 scopus 로고    scopus 로고
    • B cell follicles and antigen encounters of the third kind
    • 10.1038/ni.1946 20959804 1:CAS:528:DC%2BC3cXhtlSgur%2FM
    • Cyster JG (2010) B cell follicles and antigen encounters of the third kind. Nat Immunol 11:989-996
    • (2010) Nat Immunol , vol.11 , pp. 989-996
    • Cyster, J.G.1
  • 37
    • 0023022625 scopus 로고
    • The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice
    • 10.1016/0092-8674(86)90361-2 3093082 1:CAS:528:DyaL28Xmt1Sju7k%3D
    • Langdon WY, Harris AW, Cory S, Adams JM (1986) The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice. Cell 47:11-18
    • (1986) Cell , vol.47 , pp. 11-18
    • Langdon, W.Y.1    Harris, A.W.2    Cory, S.3    Adams, J.M.4
  • 39
    • 80052482250 scopus 로고    scopus 로고
    • Non-cell-autonomous tumor suppression: Oncogene-provoked apoptosis promotes tumor cell senescence via stromal crosstalk
    • 10.1007/s00109-011-0770-2
    • Reimann M, Schmitt CA, Lee S (2011) Non-cell-autonomous tumor suppression: oncogene-provoked apoptosis promotes tumor cell senescence via stromal crosstalk. J Mol Med (Berl) 89:869-875
    • (2011) J Mol Med (Berl) , vol.89 , pp. 869-875
    • Reimann, M.1    Schmitt, C.A.2    Lee, S.3
  • 40
    • 38149141767 scopus 로고    scopus 로고
    • Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis
    • 10.1172/JCI33700 18097482 1:CAS:528:DC%2BD1cXksFOmtA%3D%3D
    • Maclean KH, Dorsey FC, Cleveland JL, Kastan MB (2008) Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J Clin Invest 118:79-88
    • (2008) J Clin Invest , vol.118 , pp. 79-88
    • MacLean, K.H.1    Dorsey, F.C.2    Cleveland, J.L.3    Kastan, M.B.4
  • 41
    • 0344844551 scopus 로고    scopus 로고
    • B lymphocyte-specific c-Myc expression stimulates early and functional expansion of the vasculature and lymphatics during lymphomagenesis
    • 10.1016/S0002-9440(10)63581-X 14633598 1:CAS:528:DC%2BD2cXkslGh
    • Ruddell A, Mezquita P, Brandvold KA, Farr A, Iritani BM (2003) B lymphocyte-specific c-Myc expression stimulates early and functional expansion of the vasculature and lymphatics during lymphomagenesis. Am J Pathol 163:2233-2245
    • (2003) Am J Pathol , vol.163 , pp. 2233-2245
    • Ruddell, A.1    Mezquita, P.2    Brandvold, K.A.3    Farr, A.4    Iritani, B.M.5
  • 42
    • 79961008660 scopus 로고    scopus 로고
    • Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs
    • 10.1182/blood-2010-11-321265 21586747 1:CAS:528:DC%2BC3MXhtVWltr7J
    • Rehm A, Mensen A, Schradi K, Gerlach K, Wittstock S, Winter S, Buchner G, Dorken B, Lipp M, Hopken UE (2011) Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs. Blood 118:1020-1033
    • (2011) Blood , vol.118 , pp. 1020-1033
    • Rehm, A.1    Mensen, A.2    Schradi, K.3    Gerlach, K.4    Wittstock, S.5    Winter, S.6    Buchner, G.7    Dorken, B.8    Lipp, M.9    Hopken, U.E.10
  • 44
    • 33845455093 scopus 로고    scopus 로고
    • Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes
    • 10.1016/j.immuni.2006.10.011 17112751 1:CAS:528:DC%2BD2sXisFehsw%3D%3D
    • Bajenoff M, Egen JG, Koo LY, Laugier JP, Brau F, Glaichenhaus N, Germain RN (2006) Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25:989-1001
    • (2006) Immunity , vol.25 , pp. 989-1001
    • Bajenoff, M.1    Egen, J.G.2    Koo, L.Y.3    Laugier, J.P.4    Brau, F.5    Glaichenhaus, N.6    Germain, R.N.7
  • 45
    • 0028857781 scopus 로고
    • CD40 ligand is constitutively expressed in a subset of T cell lymphomas and on the microenvironmental reactive T cells of follicular lymphomas and Hodgkin's disease
    • 7573367 1:STN:280:DyaK28%2FhtVamtQ%3D%3D
    • Carbone A, Gloghini A, Gruss HJ, Pinto A (1995) CD40 ligand is constitutively expressed in a subset of T cell lymphomas and on the microenvironmental reactive T cells of follicular lymphomas and Hodgkin's disease. Am J Pathol 147:912-922
    • (1995) Am J Pathol , vol.147 , pp. 912-922
    • Carbone, A.1    Gloghini, A.2    Gruss, H.J.3    Pinto, A.4
  • 48
    • 0038142395 scopus 로고    scopus 로고
    • Macrophage- and dendritic cell-dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF
    • 10.1182/blood-2002-10-3123 12531790 1:CAS:528:DC%2BD3sXktFKhuro%3D
    • Craxton A, Magaletti D, Ryan EJ, Clark EA (2003) Macrophage- and dendritic cell-dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF. Blood 101:4464-4471
    • (2003) Blood , vol.101 , pp. 4464-4471
    • Craxton, A.1    Magaletti, D.2    Ryan, E.J.3    Clark, E.A.4
  • 49
    • 34548436603 scopus 로고    scopus 로고
    • Critical role of monocytes to support normal B cell and diffuse large B cell lymphoma survival and proliferation
    • 10.1189/jlb.0706481 17575267 1:CAS:528:DC%2BD2sXhtValu7rI
    • Mueller CG, Boix C, Kwan WH, Daussy C, Fournier E, Fridman WH, Molina TJ (2007) Critical role of monocytes to support normal B cell and diffuse large B cell lymphoma survival and proliferation. J Leukoc Biol 82:567-575
    • (2007) J Leukoc Biol , vol.82 , pp. 567-575
    • Mueller, C.G.1    Boix, C.2    Kwan, W.H.3    Daussy, C.4    Fournier, E.5    Fridman, W.H.6    Molina, T.J.7
  • 50
    • 1342282154 scopus 로고    scopus 로고
    • Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL
    • 14978135 1:CAS:528:DC%2BD2cXhsVCqsbw%3D
    • He B, Chadburn A, Jou E, Schattner EJ, Knowles DM, Cerutti A (2004) Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL. J Immunol 172:3268-3279
    • (2004) J Immunol , vol.172 , pp. 3268-3279
    • He, B.1    Chadburn, A.2    Jou, E.3    Schattner, E.J.4    Knowles, D.M.5    Cerutti, A.6
  • 51
    • 14044259331 scopus 로고    scopus 로고
    • Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: Implications for Burkitt's lymphoma
    • 15728515 1:CAS:528:DC%2BD2MXhsFeqtrY%3D
    • Ogden CA, Pound JD, Batth BK, Owens S, Johannessen I, Wood K, Gregory CD (2005) Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: implications for Burkitt's lymphoma. J Immunol 174:3015-3023
    • (2005) J Immunol , vol.174 , pp. 3015-3023
    • Ogden, C.A.1    Pound, J.D.2    Batth, B.K.3    Owens, S.4    Johannessen, I.5    Wood, K.6    Gregory, C.D.7
  • 52
    • 40049088602 scopus 로고    scopus 로고
    • The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages
    • 10.1016/j.critrevonc.2007.07.004 17913510
    • Allavena P, Sica A, Solinas G, Porta C, Mantovani A (2008) The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages. Crit Rev Oncol Hematol 66:1-9
    • (2008) Crit Rev Oncol Hematol , vol.66 , pp. 1-9
    • Allavena, P.1    Sica, A.2    Solinas, G.3    Porta, C.4    Mantovani, A.5
  • 53
    • 10244279184 scopus 로고    scopus 로고
    • Mechanisms and functional significance of tumour-induced dendritic-cell defects
    • 10.1038/nri1498 15573129 1:CAS:528:DC%2BD2cXhtVarsb7P
    • Gabrilovich D (2004) Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nat Rev Immunol 4:941-952
    • (2004) Nat Rev Immunol , vol.4 , pp. 941-952
    • Gabrilovich, D.1
  • 54
    • 33645286546 scopus 로고    scopus 로고
    • Regulatory T cells, tumour immunity and immunotherapy
    • 10.1038/nri1806 16557261 1:CAS:528:DC%2BD28XivVyru7k%3D
    • Zou W (2006) Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 6:295-307
    • (2006) Nat Rev Immunol , vol.6 , pp. 295-307
    • Zou, W.1
  • 55
    • 33747622050 scopus 로고    scopus 로고
    • Dendritic cells and tumor microenvironment: A dangerous liaison
    • 10.1080/08820130600803429 16916762 1:CAS:528:DC%2BD28XpvVCks7g%3D
    • Fricke I, Gabrilovich DI (2006) Dendritic cells and tumor microenvironment: a dangerous liaison. Immunol Invest 35:459-483
    • (2006) Immunol Invest , vol.35 , pp. 459-483
    • Fricke, I.1    Gabrilovich, D.I.2
  • 56
    • 66149118659 scopus 로고    scopus 로고
    • Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism
    • 10.1158/0008-5472.CAN-08-2826 19293186 1:CAS:528:DC%2BD1MXjvVWitrw%3D
    • Norian LA, Rodriguez PC, O'Mara LA, Zabaleta J, Ochoa AC, Cella M, Allen PM (2009) Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism. Cancer Res 69:3086-3094
    • (2009) Cancer Res , vol.69 , pp. 3086-3094
    • Norian, L.A.1    Rodriguez, P.C.2    O'Mara, L.A.3    Zabaleta, J.4    Ochoa, A.C.5    Cella, M.6    Allen, P.M.7
  • 57
    • 34249000341 scopus 로고    scopus 로고
    • Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development
    • 10.1084/jem.20061120 17438063 1:CAS:528:DC%2BD2sXlsFSjtr4%3D
    • Aspord C, Pedroza-Gonzalez A, Gallegos M, Tindle S, Burton EC, Su D, Marches F, Banchereau J, Palucka AK (2007) Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development. J Exp Med 204:1037-1047
    • (2007) J Exp Med , vol.204 , pp. 1037-1047
    • Aspord, C.1    Pedroza-Gonzalez, A.2    Gallegos, M.3    Tindle, S.4    Burton, E.C.5    Su, D.6    Marches, F.7    Banchereau, J.8    Palucka, A.K.9
  • 58
    • 84855167728 scopus 로고    scopus 로고
    • The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance
    • Janikashvili N, Bonnotte B, Katsanis E, Larmonier N The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance. Clin Dev Immunol 2011: 430394
    • (2011) Clin Dev Immunol , pp. 430394
    • Janikashvili, N.1    Bonnotte, B.2    Katsanis, E.3    Larmonier, N.4
  • 59
    • 78751689059 scopus 로고    scopus 로고
    • Immunosuppressive CD14 + HLA-DR(low)/-monocytes in B-cell non-Hodgkin lymphoma
    • 10.1182/blood-2010-05-283820 21063024 1:CAS:528:DC%2BC3MXhslKks7g%3D
    • Lin Y, Gustafson MP, Bulur PA, Gastineau DA, Witzig TE, Dietz AB (2010) Immunosuppressive CD14 + HLA-DR(low)/-monocytes in B-cell non-Hodgkin lymphoma. Blood 117:872-881
    • (2010) Blood , vol.117 , pp. 872-881
    • Lin, Y.1    Gustafson, M.P.2    Bulur, P.A.3    Gastineau, D.A.4    Witzig, T.E.5    Dietz, A.B.6
  • 60
    • 66149099328 scopus 로고    scopus 로고
    • Functional alteration of the lymphoma stromal cell niche by the cytokine context: Role of indoleamine-2,3 dioxygenase
    • 10.1158/0008-5472.CAN-08-3000 19276371 1:CAS:528:DC%2BD1MXjvVWitb4%3D
    • Maby-El Hajjami H, Ame-Thomas P, Pangault C, Tribut O, DeVos J, Jean R, Bescher N, Monvoisin C, Dulong J, Lamy T et al (2009) Functional alteration of the lymphoma stromal cell niche by the cytokine context: role of indoleamine-2,3 dioxygenase. Cancer Res 69:3228-3237
    • (2009) Cancer Res , vol.69 , pp. 3228-3237
    • Maby-El Hajjami, H.1    Ame-Thomas, P.2    Pangault, C.3    Tribut, O.4    Devos, J.5    Jean, R.6    Bescher, N.7    Monvoisin, C.8    Dulong, J.9    Lamy, T.10
  • 61
    • 33846255324 scopus 로고    scopus 로고
    • Human mesenchymal stem cells isolated from bone marrow and lymphoid organs support tumor B-cell growth: Role of stromal cells in follicular lymphoma pathogenesis
    • 10.1182/blood-2006-05-020800 16985173 1:CAS:528:DC%2BD2sXivVyrs7g%3D
    • Ame-Thomas P, Maby-El Hajjami H, Monvoisin C, Jean R, Monnier D, Caulet-Maugendre S, Guillaudeux T, Lamy T, Fest T, Tarte K (2007) Human mesenchymal stem cells isolated from bone marrow and lymphoid organs support tumor B-cell growth: role of stromal cells in follicular lymphoma pathogenesis. Blood 109:693-702
    • (2007) Blood , vol.109 , pp. 693-702
    • Ame-Thomas, P.1    Maby-El Hajjami, H.2    Monvoisin, C.3    Jean, R.4    Monnier, D.5    Caulet-Maugendre, S.6    Guillaudeux, T.7    Lamy, T.8    Fest, T.9    Tarte, K.10
  • 62
    • 80052487336 scopus 로고    scopus 로고
    • Mesenchymal stromal cell 'licensing': A multistep process
    • 10.1038/leu.2011.108 21617697 1:CAS:528:DC%2BC3MXhtFCqs7fL
    • Krampera M (2011) Mesenchymal stromal cell 'licensing': a multistep process. Leukemia 25:1408-1414
    • (2011) Leukemia , vol.25 , pp. 1408-1414
    • Krampera, M.1
  • 63
    • 13844307760 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia
    • 10.1056/NEJMra041720 15728813 1:CAS:528:DC%2BD2MXhsFCiu74%3D
    • Chiorazzi N, Rai KR, Ferrarini M (2005) Chronic lymphocytic leukemia. N Engl J Med 352:804-815
    • (2005) N Engl J Med , vol.352 , pp. 804-815
    • Chiorazzi, N.1    Rai, K.R.2    Ferrarini, M.3
  • 64
    • 70350734809 scopus 로고    scopus 로고
    • The microenvironment in mature B-cell malignancies: A target for new treatment strategies
    • 10.1182/blood-2009-06-225326 19636060 1:CAS:528:DC%2BD1MXhtlensLfF
    • Burger JA, Ghia P, Rosenwald A, Caligaris-Cappio F (2009) The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood 114:3367-3375
    • (2009) Blood , vol.114 , pp. 3367-3375
    • Burger, J.A.1    Ghia, P.2    Rosenwald, A.3    Caligaris-Cappio, F.4
  • 65
    • 0032055818 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells
    • 9516138 1:CAS:528:DyaK1cXitF2hs7s%3D
    • Lagneaux L, Delforge A, Bron D, De Bruyn C, Stryckmans P (1998) Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells. Blood 91:2387-2396
    • (1998) Blood , vol.91 , pp. 2387-2396
    • Lagneaux, L.1    Delforge, A.2    Bron, D.3    De Bruyn, C.4    Stryckmans, P.5
  • 66
    • 0029984077 scopus 로고    scopus 로고
    • Integrin function in chronic lymphocytic leukemia
    • 8639849 1:CAS:528:DyaK28Xjt1Cks7Y%3D
    • Vincent AM, Cawley JC, Burthem J (1996) Integrin function in chronic lymphocytic leukemia. Blood 87:4780-4788
    • (1996) Blood , vol.87 , pp. 4780-4788
    • Vincent, A.M.1    Cawley, J.C.2    Burthem, J.3
  • 67
    • 0033748035 scopus 로고    scopus 로고
    • Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse
    • 10.1073/pnas.97.23.12694 11070085 1:CAS:528:DC%2BD3cXotFyns7s%3D
    • Luther SA, Tang HL, Hyman PL, Farr AG, Cyster JG (2000) Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proc Natl Acad Sci USA 97:12694-12699
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12694-12699
    • Luther, S.A.1    Tang, H.L.2    Hyman, P.L.3    Farr, A.G.4    Cyster, J.G.5
  • 69
    • 77949379050 scopus 로고    scopus 로고
    • B-cell-derived lymphotoxin promotes castration-resistant prostate cancer
    • 10.1038/nature08782 20220849 1:CAS:528:DC%2BC3cXjtFSnurs%3D
    • Ammirante M, Luo JL, Grivennikov S, Nedospasov S, Karin M (2010) B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature 464:302-305
    • (2010) Nature , vol.464 , pp. 302-305
    • Ammirante, M.1    Luo, J.L.2    Grivennikov, S.3    Nedospasov, S.4    Karin, M.5
  • 70
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • 10.1038/nature01322 12490959 1:CAS:528:DC%2BD38XpsFygtb4%3D
    • Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420:860-867
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 71
    • 47249139528 scopus 로고    scopus 로고
    • Inhibition of the lymphotoxin pathway as a therapy for autoimmune disease
    • 10.1111/j.1600-065X.2008.00633.x 18613838 1:CAS:528:DC%2BD1cXptlGlsLc%3D
    • Browning JL (2008) Inhibition of the lymphotoxin pathway as a therapy for autoimmune disease. Immunol Rev 223:202-220
    • (2008) Immunol Rev , vol.223 , pp. 202-220
    • Browning, J.L.1
  • 72
    • 77956625008 scopus 로고    scopus 로고
    • The unexpected role of lymphotoxin beta receptor signaling in carcinogenesis: From lymphoid tissue formation to liver and prostate cancer development
    • 10.1038/onc.2010.260 20603617 1:CAS:528:DC%2BC3cXotlWktb0%3D
    • Wolf MJ, Seleznik GM, Zeller N, Heikenwalder M (2010) The unexpected role of lymphotoxin beta receptor signaling in carcinogenesis: from lymphoid tissue formation to liver and prostate cancer development. Oncogene 29:5006-5018
    • (2010) Oncogene , vol.29 , pp. 5006-5018
    • Wolf, M.J.1    Seleznik, G.M.2    Zeller, N.3    Heikenwalder, M.4
  • 73
    • 72949093335 scopus 로고    scopus 로고
    • From pathogenesis to treatment of chronic lymphocytic leukaemia
    • 19956173 1:CAS:528:DC%2BD1MXhsFSgt7jN
    • Zenz T, Mertens D, Kuppers R, Dohner H, Stilgenbauer S (2010) From pathogenesis to treatment of chronic lymphocytic leukaemia. Nat Rev Cancer 10:37-50
    • (2010) Nat Rev Cancer , vol.10 , pp. 37-50
    • Zenz, T.1    Mertens, D.2    Kuppers, R.3    Dohner, H.4    Stilgenbauer, S.5
  • 74
    • 84859398461 scopus 로고    scopus 로고
    • Nurture versus nature: The microenvironment in chronic lymphocytic leukemia
    • 10.1182/asheducation-2011.1.96
    • Burger JA (2011) Nurture versus nature: the microenvironment in chronic lymphocytic leukemia. Hematol Am Soc Hematol Educ Program 2011:96-103
    • (2011) Hematol Am Soc Hematol Educ Program , vol.2011 , pp. 96-103
    • Burger, J.A.1
  • 75
    • 78649786160 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors in chronic lymphocytic leukemia (CLL): From understanding the basics towards therapeutic targeting
    • 10.1016/j.semcancer.2010.09.005 20883788 1:CAS:528:DC%2BC3cXhsFajt7rO
    • Burger JA (2010) Chemokines and chemokine receptors in chronic lymphocytic leukemia (CLL): from understanding the basics towards therapeutic targeting. Semin Cancer Biol 20:424-430
    • (2010) Semin Cancer Biol , vol.20 , pp. 424-430
    • Burger, J.A.1
  • 76
    • 77951002653 scopus 로고    scopus 로고
    • Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
    • 10.1182/blood-2009-08-236471 19965662 1:CAS:528:DC%2BC3cXksFOhs70%3D
    • Friedberg JW, Sharman J, Sweetenham J, Johnston PB, Vose JM, Lacasce A, Schaefer-Cutillo J, De Vos S, Sinha R, Leonard JP et al (2010) Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood 115:2578-2585
    • (2010) Blood , vol.115 , pp. 2578-2585
    • Friedberg, J.W.1    Sharman, J.2    Sweetenham, J.3    Johnston, P.B.4    Vose, J.M.5    Lacasce, A.6    Schaefer-Cutillo, J.7    De Vos, S.8    Sinha, R.9    Leonard, J.P.10
  • 77
    • 77955625479 scopus 로고    scopus 로고
    • The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
    • 10.1073/pnas.1004594107 20615965
    • Honigberg LA, Smith AM, Sirisawad M, Verner E, Loury D, Chang B, Li S, Pan Z, Thamm DH, Miller RA et al (2010) The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci USA 107:13075-13080
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 13075-13080
    • Honigberg, L.A.1    Smith, A.M.2    Sirisawad, M.3    Verner, E.4    Loury, D.5    Chang, B.6    Li, S.7    Pan, Z.8    Thamm, D.H.9    Miller, R.A.10
  • 78
    • 78751553221 scopus 로고    scopus 로고
    • CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
    • 10.1182/blood-2010-03-275305 20959606 1:CAS:528:DC%2BC3MXht1aqtro%3D
    • Lannutti BJ, Meadows SA, Herman SE, Kashishian A, Steiner B, Johnson AJ, Byrd JC, Tyner JW, Loriaux MM, Deininger M et al (2011) CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood 117:591-594
    • (2011) Blood , vol.117 , pp. 591-594
    • Lannutti, B.J.1    Meadows, S.A.2    Herman, S.E.3    Kashishian, A.4    Steiner, B.5    Johnson, A.J.6    Byrd, J.C.7    Tyner, J.W.8    Loriaux, M.M.9    Deininger, M.10
  • 79
    • 70349237504 scopus 로고    scopus 로고
    • B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: Specific targeting with a novel spleen tyrosine kinase inhibitor, R406
    • 10.1182/blood-2009-03-212837 19491390 1:CAS:528:DC%2BD1MXps1eitL0%3D
    • Quiroga MP, Balakrishnan K, Kurtova AV, Sivina M, Keating MJ, Wierda WG, Gandhi V, Burger JA (2009) B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406. Blood 114:1029-1037
    • (2009) Blood , vol.114 , pp. 1029-1037
    • Quiroga, M.P.1    Balakrishnan, K.2    Kurtova, A.V.3    Sivina, M.4    Keating, M.J.5    Wierda, W.G.6    Gandhi, V.7    Burger, J.A.8
  • 80
    • 84855458019 scopus 로고    scopus 로고
    • Enhancement of the anti-tumor activity of therapeutic monoclonal antibodies by CXCR4 antagonists
    • 10.3109/10428194.2011.601698 21740294 1:CAS:528:DC%2BC38Xjs1CrsA%3D%3D
    • Hu Y, Gale M, Shields J, Garron C, Swistak M, Nguyen TH, Jacques G, Fogle R, Siders W, Kaplan J (2012) Enhancement of the anti-tumor activity of therapeutic monoclonal antibodies by CXCR4 antagonists. Leuk Lymphoma 53:130-138
    • (2012) Leuk Lymphoma , vol.53 , pp. 130-138
    • Hu, Y.1    Gale, M.2    Shields, J.3    Garron, C.4    Swistak, M.5    Nguyen, T.H.6    Jacques, G.7    Fogle, R.8    Siders, W.9    Kaplan, J.10
  • 82
    • 42649086026 scopus 로고    scopus 로고
    • CCR7 and its ligands: Balancing immunity and tolerance
    • 10.1038/nri2297 18379575 1:CAS:528:DC%2BD1cXltFejsbs%3D
    • Forster R, Davalos-Misslitz AC, Rot A (2008) CCR7 and its ligands: balancing immunity and tolerance. Nat Rev Immunol 8:362-371
    • (2008) Nat Rev Immunol , vol.8 , pp. 362-371
    • Forster, R.1    Davalos-Misslitz, A.C.2    Rot, A.3
  • 83
    • 80052439434 scopus 로고    scopus 로고
    • Manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice
    • 10.1016/j.ajpath.2011.04.012 21801869 1:CAS:528:DC%2BC3MXhtFGjsL7I
    • Winter S, Rehm A, Wichner K, Scheel T, Batra A, Siegmund B, Berek C, Lipp M, Hopken UE (2011) Manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice. Am J Pathol 179:754-765
    • (2011) Am J Pathol , vol.179 , pp. 754-765
    • Winter, S.1    Rehm, A.2    Wichner, K.3    Scheel, T.4    Batra, A.5    Siegmund, B.6    Berek, C.7    Lipp, M.8    Hopken, U.E.9


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