Concerted action of the chemokine and lymphotoxin system in secondary lymphoid-organ development

Current Opinion in Immunology

Volumn 15, Issue 2, 2003, Pages 217-224

  Müller, Gerd ^a   Lipp, Martin ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; LYMPHOTOXIN;

LYMPH NODE; LYMPHATIC SYSTEM; LYMPHOID TISSUE; NASOPHARYNX; NONHUMAN; ORGANOGENESIS; PEYER PATCH; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0037375522     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(03)00014-1     Document Type: Review

References (59)

1. Cyster J.G. Chemokines and cell migration in secondary lymphoid organs. Science. 286:1999;2098-2102.
2. Kunkel E.J., Butcher E.C. Chemokines and the tissue-specific migration of lymphocytes. Immunity. 16:2002;1-4.
3. Horuk R. Chemokine receptors. Cytokine Growth Factor Rev. 12:2001;313-335.
4. Reif K., Ekland E.H., Ohl L., Nakano H., Förster R., Lipp M., Cyster J.G. Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature. 416:2002;94-99 This report demonstrates that positioning of antigen-triggered B cells at the boundary of the T- and B-cell zone is controlled by the expression levels of CCR7 and CXCR5 on these cells, as well as by their sensitivity towards the corresponding ligands expressed in adjacent but non-overlapping areas of the spleen.
5. Förster R., Mattis A.E., Kremmer E., Wolf E., Brem G., Lipp M. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell. 87:1996;1037-1047.
6. Ansel K.M., Ngo V.N., Hyman P.L., Luther S.A., Förster R., Sedgwick J.D., Browning J.L., Lipp M., Cyster J.G. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature. 406:2000;309-314.
7. Fu Y.X., Chaplin D.D. Development and maturation of secondary lymphoid tissues. Annu. Rev. Immunol. 17:1999;399-433.
8. Adachi S., Yoshida H., Kataoka H., Nishikawa S. Three distinctive steps in Peyer's patch formation of murine embryo. Int. Immunol. 9:1997;507-514.
9. + cells that can differentiate to APC, NK, cells and follicular cells but not T or B cells. Immunity. 7:1997;493-504.
10. 7 integrin defines a distinct pathway of lymphoid progenitors committed to T cells, fetal intestinal lymphotoxin producer, NK, and dendritic cells. J. Immunol. 167:2001;2511-2521.
11. Hashi H., Yoshida H., Honda K., Fraser S., Kubo H., Awane M., Takabayashi A., Nakano H., Yamaoka Y., Nishikawa S. Compartmentalization of Peyer's patch anlagen before lymphocyte entry. J. Immunol. 166:2001;3702-3709.
12. - cells to colonize lymph nodes. Proc. Natl. Acad. Sci. USA. 93:1996;11019-11024.
13. 7 integrins in formation of the gut-associated lymphoid tissue. Nature. 382:1996;366-370.
14. Honda K., Nakano H., Yoshida H., Nishikawa S., Rennert P., Ikuta K., Tamechika M., Yamaguchi K., Fukumoto T., Chiba T.et al. Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis. J. Exp. Med. 193:2001;621-630 The authors explore the interaction of hematopoietic and mesenchymal cells during Peyer's patch organogenesis, thereby defining signaling events required for the initial steps in secondary lymphoid-organ formation.
15. + lymphoid progenitor cells is a prerequisite for the mutual interaction with mesenchymal cells of Peyer's patch anlagen.
16. Koni P.A., Sacca R., Lawton P., Browning J.L., Ruddle N.H., Flavell R.A. Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice. Immunity. 6:1997;491-500.
17. Fütterer A., Mink K., Luz A., Kosco-Vilbois M.H., Pfeffer K. The lymphotoxin β receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity. 9:1998;59-70.
18. Banks T.A., Rouse B.T., Kerley M.K., Blair P.J., Godfrey V.L., Kuklin N.A., Bouley D.M., Thomas J., Kanangat S., Mucenski M.L. Lymphotoxin-α-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. J. Immunol. 155:1995;1685-1693.
19. De Togni P., Goellner J., Ruddle N.H., Streeter P.R., Fick A., Mariathasan S., Smith S.C., Carlson R., Shornick L.P., Strauss-Schoenberger J.et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 264:1994;703-707.
20. Adachi S., Yoshida H., Honda K., Maki K., Saijo K., Ikuta K., Saito T., Nishikawa S.I. Essential role of IL-7 receptor alpha in the formation of Peyer's patch anlagen. Int. Immunol. 10:1998;1-6.
21. Yokota Y., Mansouri A., Mori S., Sugawara S., Adachi S., Nishikawa S., Gruss P. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature. 397:1999;702-706.
22. Sun Z., Unutmaz D., Zou Y.R., Sunshine M.J., Pierani A., Brenner-Morton S., Mebius R.E., Littman D.R. Requirement for RORγ in thymocyte survival and lymphoid organ development. Science. 288:2000;2369-2373.
23. DiSanto J.P., Muller W., Guy-Grand D., Fischer A., Rajewsky K. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc. Natl. Acad. Sci. USA. 92:1995;377-381.
24. Ngo V.N., Korner H., Gunn M.D., Schmidt K.N., Riminton D.S., Cooper M.D., Browning J.L., Sedgwick J.D., Cyster J.G. Lymphotoxin α/β and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J. Exp. Med. 189:1999;403-412.
25. Caamaño J.H., Rizzo C.A., Durham S.K., Barton D.S., Raventos-Suarez C., Snapper C.M., Bravo R. Nuclear factor (NF)-κB2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses. J. Exp. Med. 187:1998;185-196.
26. Franzoso G., Carlson L., Poljak L., Shores E.W., Epstein S., Leonardi A., Grinberg A., Tran T., Scharton-Kersten T., Anver M.et al. Mice deficient in nuclear factor (NF)-κB/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture. J. Exp. Med. 187:1998;147-159.
27. Franzoso G., Carlson L., Xing L., Poljak L., Shores E.W., Brown K.D., Leonardi A., Tran T., Boyce B.F., Siebenlist U. Requirement for NF-κB in osteoclast and B-cell development. Genes Dev. 11:1997;3482-3496.
28. Li Q., Verma I.M. NF-κB regulation in the immune system. Nat. Rev. Immunol. 2:2002;725-734.
29. Hu Y., Baud V., Delhase M., Zhang P., Deerinck T., Ellisman M., Johnson R., Karin M. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase. Science. 284:1999;316-320.
30. Senftleben U., Cao Y., Xiao G., Greten F.R., Krahn G., Bonizzi G., Chen Y., Hu Y., Fong A., Sun S.C.et al. Activation by IKKα of a second evolutionary conserved NF-κB signaling pathway. Science. 293:2001;1495-1499 This report establishes a non-canonical NF-κB signaling pathway that critically depends on IKKα but independent of IKKβ. IKKα activates the processing of NF-κB2 and induces a subset of NF-κB target genes critically involved in B cell maturation and the formation of secondary lymphoid organs.
31. Dejardin E., Droin N.M., Delhase M., Haas E., Cao Y., Makris C., Li Z.W., Karin M., Ware C.F., Green D.R. The lymphotoxin-β receptor induces different patterns of gene expression via two NF-κB pathways. Immunity. 17:2002;525-535 Activation of NF-κB following ligation of the LTβR employs two different pathways, resulting in the activation of different sets of genes. Signaling via NIK and IKKα, resulting in the conversion of p100 to p52, is particular important for the expression of homeostatic chemokines involved in lymphoid organogenesis. Signaling along the canonical pathway via IKKβ appears to contribute to the production of p52 by the simultaneous induction of p100.
32. Weih D.S., Yilmaz Z.B., Weih F. Essential role of RelB in germinal center and marginal zone formation and proper expression of homing chemokines. J Immunol. 167:2001;1909-1919.
33. Paxian S., Merkle H., Riemann M., Wilda M., Adler G., Hameister H., Liptay S., Pfeffer K., Schmid R.M. Abnormal organogenesis of Peyer's patches in mice deficient for NF-κB1, NF-κB2, and Bcl-3. Gastroenterology. 122:2002;1853-1868.
34. Matsushima A., Kaisho T., Rennert P.D., Nakano H., Kurosawa K., Uchida D., Takeda K., Akira S., Matsumoto M. Essential role of nuclear factor (NF)-κB-inducing kinase and inhibitor of κB (IκB) kinase alpha in NF-κB activation through lymphotoxin β receptor, but not through tumor necrosis factor receptor I. J. Exp. Med. 193:2001;631-636.
35. Miyawaki S., Nakamura Y., Suzuka H., Koba M., Yasumizu R., Ikehara S., Shibata Y. A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur. J. Immunol. 24:1994;429-434.
36. Pasparakis M., Alexopoulou L., Grell M., Pfizenmaier K., Bluethmann H., Kollias G. Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor. Proc. Natl. Acad. Sci. USA. 94:1997;6319-6323.
37. Pasparakis M., Alexopoulou L., Episkopou V., Kollias G. Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J. Exp. Med. 184:1996;1397-1411.
38. Neumann B., Luz A., Pfeffer K., Holzmann B. Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor. J. Exp. Med. 184:1996;259-264.
39. Korner H., Cook M., Riminton D.S., Lemckert F.A., Hoek R.M., Ledermann B., Kontgen F., Fazekas de St Groth B., Sedgwick J.D. Distinct roles for lymphotoxin-α and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur. J. Immunol. 27:1997;2600-2609.
40. Cao Y., Bonizzi G., Seagroves T.N., Greten F.R., Johnson R., Schmidt E.V., Karin M. IKKα provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell. 107:2001;763-775.
41. Claudio E., Brown K., Park S., Wang H., Siebenlist U. BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells. Nat. Immunol. 3:2002;958-965.
42. Coope H.J., Atkinson P.G., Huhse B., Belich M., Janzen J., Holman M.J., Klaus G.G., Johnston L.H., Ley S.C. CD40 regulates the processing of NF-κB2 p100 to p52. EMBO J. 21:2002;5375-5385.
43. Schiemann B., Gommerman J.L., Vora K., Cachero T.G., Shulga-Morskaya S., Dobles M., Frew E., Scott M.L. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science. 293:2001;2111-2114.
44. Mauri D.N., Ebner R., Montgomery R.I., Kochel K.D., Cheung T.C., Yu G.L., Ruben S., Murphy M., Eisenberg R.J., Cohen G.H.et al. LIGHT, a new member of the TNF superfamily, and lymphotoxin α are ligands for herpesvirus entry mediator. Immunity. 8:1998;21-30.
45. + T cell function in mice lacking the TNF superfamily member LIGHT. J. Immunol. 168:2002;4832-4835.
46. -/- mice develop intact lymphoid organs, this member of the TNF-family of cytokines appears to cooperate with LTβ in the formation of mesenteric lymph nodes. This was demonstrated by comparing LTβ single knockout and LIGHT/LTβ double-knockout mice. In addition, the authors show that LIGHT provides co-stimulatory signals supporting T cell activation.
47. Li J., Sarosi I., Yan X.Q., Morony S., Capparelli C., Tan H.L., McCabe S., Elliott R., Scully S., Van G.et al. RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc. Natl. Acad. Sci. USA. 97:2000;1566-1571.
48. Dougall W.C., Glaccum M., Charrier K., Rohrbach K., Brasel K., De Smedt T., Daro E., Smith J., Tometsko M.E., Maliszewski C.R.et al. RANK is essential for osteoclast and lymph node development. Genes Dev. 13:1999;2412-2424.
49. Kong Y.Y., Yoshida H., Sarosi I., Tan H.L., Timms E., Capparelli C., Morony S., Oliveira-dos-Santos A.J., Van G., Itie A.et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis. Nature. 397:1999;315-323.
50. Kim D., Mebius R.E., MacMicking J.D., Jung S., Cupedo T., Castellanos Y., Rho J., Wong B.R., Josien R., Kim N.et al. Regulation of peripheral lymph node genesis by the tumor necrosis factor family member TRANCE. J. Exp. Med. 192:2000;1467-1478.
51. Luther S.A., Bidgol A., Hargreaves D.C., Schmidt A., Xu Y., Paniyadi J., Matloubian M., Cyster J.G. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J. Immunol. 169:2002;424-433.
52. Fan L., Reilly C.R., Luo Y., Dorf M.E., Lo D. Cutting edge: ectopic expression of the chemokine TCA4/SLC is sufficient to trigger lymphoid neogenesis. J. Immunol. 164:2000;3955-3959.
53. Luther S.A., Lopez T., Bai W., Hanahan D., Cyster J.G. BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. Immunity. 12:2000;471-481.
54. Okada T., Ngo V.N., Ekland E.H., Förster R., Lipp M., Littman D.R., Cyster J.G. Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J. Exp. Med. 196:2002;65-75 This is a detailed investigation of organ-specific requirements for chemokines mediating B cell entry into lymph nodes and Peyer's patches, thereby unraveling the partial redundancy in the function of CXCL13, CCL21, CCL19 and CXCL12.
55. Vassileva G., Soto H., Zlotnik A., Nakano H., Kakiuchi T., Hedrick J.A., Lira S.A. The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes. J. Exp. Med. 190:1999;1183-1188.
56. Gunn M.D., Kyuwa S., Tam C., Kakiuchi T., Matsuzawa A., Williams L.T., Nakano H. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med. 189:1999;451-460.
57. + cells and therefore independent of the IL-7Rα/LTα1β2/LTβR signaling pathway. It is shown, however, that the microarchitecture and immunological competence of NALT depends on LTα.
58. + cells.
59. Csencsits K.L., Jutila M.A., Pascual D.W. Nasal-associated lymphoid tissue: phenotypic and functional evidence for the primary role of peripheral node addressin in naive lymphocyte adhesion to high endothelial venules in a mucosal site. J. Immunol. 163:1999;1382-1389.