Manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice

American Journal of Pathology

Volumn 179, Issue 2, 2011, Pages 754-765

  Winter, Susann ^a   Rehm, Armin ^a,b   Wichner, Katharina ^a   Scheel, Tobias ^c   Batra, Arvind ^b   Siegmund, Britta ^b   Berek, Claudia ^c   Lipp, Martin ^a   Höpken, Uta E ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ANTIGEN; CHEMOKINE RECEPTOR CCR7; IMMUNOGLOBULIN G;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN DETECTION; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNE GASTRITIS; B LYMPHOCYTE; BLOOD; CD4+ T LYMPHOCYTE; CELL AGGREGATION; CONTROLLED STUDY; DENDRITIC CELL; GASTRITIS; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOPATHOGENESIS; IMMUNOREACTIVITY; LYMPHOID TISSUE; MACROPHAGE; MESENTERY LYMPH NODE; METAPLASIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; STOMACH MUCOSA; STOMACH PARIETAL CELL; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD11C; AUTOIMMUNE DISEASES; BONE MARROW CELLS; CD4-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; FLOW CYTOMETRY; GASTRITIS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; INTERFERON-GAMMA; INTERLEUKIN-17; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, CCR7; STOMACH;

EID: 80052439434     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.04.012     Document Type: Article

References (43)

1. H.J. Kim, and C. Berek B cells in rheumatoid arthritis Arthritis Res 2 2000 126 131 (Pubitemid 32223709)
2. F. Barone, M. Bombardieri, M.M. Rosado, P.R. Morgan, S.J. Challacombe, S. De Vita, R. Carsetti, J. Spencer, G. Valesini, and C. Pitzalis CXCL13. CCL21, and CXCL12 expression in salivary glands of patients with Sjögren's syndrome and MALT lymphoma: association with reactive and malignant areas of lymphoid organization J Immunol 180 2008 5130 5140
3. Q. Wu, B. Salomon, M. Chen, Y. Wang, L.M. Hoffman, J.A. Bluestone, and Y.X. Fu Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor J Exp Med 193 2001 1327 1332 (Pubitemid 32524783)
4. P.L. Kendall, G. Yu, E.J. Woodward, and J.W. Thomas Tertiary lymphoid structures in the pancreas promote selection of B lymphocytes in autoimmune diabetes J Immunol 178 2007 5643 5651 (Pubitemid 46674360)
5. T. Katakai, T. Hara, M. Sugai, H. Gonda, and A. Shimizu Th1-biased tertiary lymphoid tissue supported by CXC chemokine ligand 13-producing stromal network in chronic lesions of autoimmune gastritis J Immunol 171 2003 4359 4368 (Pubitemid 37238714)
6. D.L. Drayton, S. Liao, R.H. Mounzer, and N.H. Ruddle Lymphoid organ development: from ontogeny to neogenesis Nat Immunol 7 2006 344 353
7. D.M. Carragher, J. Rangel-Moreno, and T.D. Randall Ectopic lymphoid tissues and local immunity Semin Immunol 20 2008 26 42
8. T. Katakai, and A. Shimizu Undesired meeting of lymphocytes: organ-specific infiltration and the organization of ectopic lymphoid tissue in a murine experimental autoimmune gastritis Immunol Lett 118 2008 103 109
9. Henry RA, Kendall PL: CXCL13 blockade disrupts B lymphocyte organization in tertiary lymphoid structures without altering B cell receptor bias or preventing diabetes in nonobese diabetic mice. J Immunol 185:14601465
10. I.R. van Driel, A.G. Baxter, K.L. Laurie, T.D. Zwar, N.L. La Gruta, L.M. Judd, K.L. Scarff, P.A. Silveira, and P.A. Gleeson Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis Autoimmun Rev 1 2002 290 297 (Pubitemid 38352572)
11. J. Field, M.A. Biondo, K. Murphy, F. Alderuccio, and B.H. Toh Experimental autoimmune gastritis: mouse models of human organ-specific autoimmune disease Int Rev Immunol 24 2005 93 110 (Pubitemid 40069749)
12. F. Alderuccio, and B.H. Toh Spontaneous autoimmune gastritis in C3H/He mice: a new mouse model for gastric autoimmunity Am J Pathol 153 1998 1311 1318 (Pubitemid 28465855)
13. R. Forster, A. Schubel, D. Breitfeld, E. Kremmer, I. Renner-Muller, E. Wolf, and M. Lipp CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs Cell 99 1999 23 33 (Pubitemid 29468627)
14. U.E. Hopken, J. Droese, J.P. Li, J. Joergensen, D. Breitfeld, H.G. Zerwes, and M. Lipp The chemokine receptor CCR7 controls lymph node-dependent cytotoxic T cell priming in alloimmune responses Eur J Immunol 34 2004 461 470 (Pubitemid 39255957)
15. G.F. Debes, C.N. Arnold, A.J. Young, S. Krautwald, M. Lipp, J.B. Hay, and E.C. Butcher Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues Nat Immunol 6 2005 889 894 (Pubitemid 43090443)
16. U.E. Hopken, A.M. Wengner, C. Loddenkemper, H. Stein, M.M. Heimesaat, A. Rehm, and M. Lipp CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity Blood 109 2007 886 895 (Pubitemid 46220631)
17. A.C. Davalos-Misslitz, J. Rieckenberg, S. Willenzon, T. Worbs, E. Kremmer, G. Bernhardt, and R. Forster Generalized multi-organ autoimmunity in CCR7-deficient mice Eur J Immunol 37 2007 613 622 (Pubitemid 46916929)
18. R. Forster, A.C. Davalos-Misslitz, and A. Rot CCR7 and its ligands: balancing immunity and tolerance Nat Rev Immunol 8 2008 362 371 (Pubitemid 351595218)
19. P. De Togni, J. Goellner, N.H. Ruddle, P.R. Streeter, A. Fick, S. Mariathasan, S.C. Smith, R. Carlson, L.P. Shornick, and Strauss-Schoenberger Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin Science 264 1994 703 707 (Pubitemid 24185880)
20. K. Hochweller, J. Striegler, G.J. Hammerling, and N. Garbi A novel CD11c DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells. Eur J Immunol 38 2008 2776 2783
21. G.R. van den Brink, J.C. Hardwick, C. Nielsen, C. Xu, F.J. ten Kate, J. Glickman, S.J. van Deventer, D.J. Roberts, and M.P. Peppelenbosch Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract Gut 51 2002 628 633 (Pubitemid 35216847)
22. G.R. van den Brink, J.C. Hardwick, G.N. Tytgat, M.A. Brink, F.J. Ten Kate, S.J. Van Deventer, and M.P. Peppelenbosch Sonic hedgehog regulates gastric gland morphogenesis in man and mouse Gastroenterology 121 2001 317 328 (Pubitemid 32729379)
23. C. Xiao, S.A. Ogle, M.A. Schumacher, M.A. Orr-Asman, M.L. Miller, N. Lertkowit, A. Varro, F. Hollande, and Y. Zavros Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells Gastroenterology 138 2010 550 561 561.e551-558
24. M. Waghray, Y. Zavros, M. Saqui-Salces, M. El-Zaatari, C.B. Alamelumangapuram, A. Todisco, K.A. Eaton, and J.L. Merchant Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog Gastroenterology 138 2010 562 572 572.e561-562
25. A.C. Marshall, F. Alderuccio, K. Murphy, and B.H. Toh Mechanisms of gastric mucosal cell loss in autoimmune gastritis Int Rev Immunol 24 2005 123 134 (Pubitemid 40069751)
26. I.R. van Driel, S. Read, T.D. Zwar, and P.A. Gleeson Shaping the T cell repertoire to a bona fide autoantigen: lessons from autoimmune gastritis Curr Opin Immunol 17 2005 570 576 (Pubitemid 41506899)
27. A. Izcue, J.L. Coombes, and F. Powrie Regulatory lymphocytes and intestinal inflammation Annu Rev Immunol 27 2009 313 338
28. G. Muller, and M. Lipp Concerted action of the chemokine and lymphotoxin system in secondary lymphoid-organ development Curr Opin Immunol 15 2003 217 224 (Pubitemid 36287529)
29. C.F. Ware Network communications: lymphotoxins. LIGHT, and TNF Annu Rev Immunol 23 2005 787 819 (Pubitemid 40563185)
30. M.Y. Kim, K.S. Kim, F. McConnell, and P. Lane Lymphoid tissue inducer cells: architects of CD4 immune responses in mice and men Clin Exp Immunol 157 2009 20 26
31. D. Meier, C. Bornmann, S. Chappaz, S. Schmutz, L.A. Otten, R. Ceredig, H. Acha-Orbea, and D. Finke Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells Immunity 26 2007 643 654 (Pubitemid 46756355)
32. Lochner M, Ohnmacht C, Presley L, Bruhns P, Si-Tahar M, Sawa S, Eberl G: Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells. J Exp Med 208:125134
33. T. Marinkovic, A. Garin, Y. Yokota, Y.X. Fu, N.H. Ruddle, G.C. Furtado, and S.A. Lira Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid J Clin Invest 116 2006 2622 2632 (Pubitemid 44511626)
34. Hopken UE, Winter S, Achtman AH, Kruger K, Lipp M: CCR7 regulates lymphocyte egress and recirculation through body cavities. J Leukoc Biol 87:671682
35. C.H. GeurtsvanKessel, M.A. Willart, I.M. Bergen, L.S. van Rijt, F. Muskens, D. Elewaut, A.D. Osterhaus, R. Hendriks, G.F. Rimmelzwaan, and B.N. Lambrecht Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice J Exp Med 206 2009 2339 2349
36. O. Schulz, E. Jaensson, E.K. Persson, X. Liu, T. Worbs, W.W. Agace, and O. Pabst Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions J Exp Med 206 2009 3101 3114
37. E. Jaensson, H. Uronen-Hansson, O. Pabst, B. Eksteen, J. Tian, J.L. Coombes, P.L. Berg, T. Davidsson, F. Powrie, B. Johansson-Lindbom, and W.W. Agace Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans J Exp Med 205 2008 2139 2149
38. W. Peters, J.G. Cyster, M. Mack, D. Schlondorff, A.J. Wolf, J.D. Ernst, and I.F. Charo CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis J Immunol 172 2004 7647 7653 (Pubitemid 38747630)
39. Dresing P, Borkens S, Kocur M, Kropp S, Scheu S: A fluorescence reporter model defines "Tip-DCs" as the cellular source of interferon beta in murine listeriosis. PLoS One 5:e15567
40. G. Faller, and T. Kirchner Immunological and morphogenic basis of gastric mucosa atrophy and metaplasia Virchows Arch 446 2005 1 9 (Pubitemid 40179149)
41. Hofmann J, Greter M, Du Pasquier L, Becher B: B-cells need a proper house, whereas T-cells are happy in a cave: the dependence of lymphocytes on secondary lymphoid tissues during evolution. Trends Immunol 31:144153
42. M. Greter, J. Hofmann, and B. Becher Neo-lymphoid aggregates in the adult liver can initiate potent cell-mediated immunity PLoS Biol 7 2009 e1000109
43. F.E. Lund, S. Partida-Sanchez, B.O. Lee, K.L. Kusser, L. Hartson, R.J. Hogan, D.L. Woodland, and T.D. Randall Lymphotoxin-alpha-deficient mice make delayed, but effective T and B cell responses to influenza J Immunol 169 2002 5236 5243 (Pubitemid 35217195)