Liver uptake of radiolabeled targeting proteins and peptides: Considerations for targeting peptide conjugate design

Drug Discovery Today

Volumn 17, Issue 21-22, 2012, Pages 1224-1232

  Hosseinimehr, Seyed Jalal ^a,b   Tolmachev, Vladimir ^a   Orlova, Anna ^c  

^a UPPSALA UNIVERSITY   (Sweden)

^b MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

1,4,7 TRIAZACYCLONONANE 1,4,7 TRIACETIC ACID; ARGINYLGLYCYLASPARTIC ACID; BOMBESIN; BOMBESIN 1,4,7,10 TETRAAZACYCLODODECANE N,N',N'',N''' TETRAACETIC ACID IN 111; BREAST CANCER RESISTANCE PROTEIN; CHELATING AGENT; CYTOCHROME P450; FLUORODEOXYGLUCOSE F 18; MULTIDRUG RESISTANCE PROTEIN; ORGANIC ANION TRANSPORTER; ORGANIC CATION TRANSPORTER; PENTETIC ACID; PENTETIC ACID MACROGOL IN 111; PENTETREOTIDE; PENTETREOTIDE IN 111; RADIOPHARMACEUTICAL AGENT; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TECHNETIUM 99M; TETRAXETAN; TRICARBONYL TC 99M; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; BODY WEIGHT; CONJUGATE; CONJUGATION; DRUG ACCUMULATION; DRUG DESIGN; DRUG ELIMINATION; DRUG EXCRETION; DRUG STRUCTURE; DRUG UPTAKE; ENDOCYTOSIS; HEPATIC ARTERY; HYDROPHILICITY; ISOTOPE LABELING; KIDNEY METASTASIS; KUPFFER CELL; LIPOPHILICITY; LIVER CELL; LIVER METABOLISM; LIVER METASTASIS; LIVER SINUSOID; NONHUMAN; PHYSICAL CHEMISTRY; PROTEIN TARGETING; PROTEIN TRANSPORT; RADIOACTIVITY; RETICULOENDOTHELIAL SYSTEM; REVIEW; SCINTISCANNING; STRUCTURE ACTIVITY RELATION;

ANIMALS; DRUG DESIGN; HUMANS; INDIVIDUALIZED MEDICINE; LIVER; MOLECULAR TARGETED THERAPY; NEOPLASMS; PEPTIDES; PROTEINS; RADIOISOTOPES; RADIOPHARMACEUTICALS;

EID: 84868101162     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2012.07.002     Document Type: Review

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