HEHEHE-tagged affibody molecule may be purified by IMAC, is conveniently labeled with [99mTc(CO)3]+, and shows improved biodistribution with reduced hepatic radioactivity accumulation

Bioconjugate Chemistry

Volumn 21, Issue 11, 2010, Pages 2013-2022

  Tolmachev, Vladimir ^a,b   Hofström, Camilla ^c   Malmberg, Jennie ^a   Ahlgren, Sara ^b   Hosseinimehr, Seyed Jalal ^a,d   Sandström, Mattias ^e   Abrahmsén, Lars ^f   Orlova, Anna ^a   Gräslund, Torbjörn ^c  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^d MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^f Affibody AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AFFIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HISTIDINE; METAL ION; POLYHISTIDINE TAG; RADIOISOTOPE; RECOMBINANT PROTEIN; SCAFFOLD PROTEIN; TECHNETIUM 99M; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BINDING; DRUG DISTRIBUTION; DRUG SYNTHESIS; IMMOBILIZED METAL AFFINITY CHROMATOGRAPHY; IN VITRO STUDY; LIVER; MALE; MOLECULAR IMAGING; MOLECULAR PROBE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN TARGETING; RADIOACTIVITY; TISSUE DISTRIBUTION;

MURINAE; MUS;

EID: 78649309723     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc1002357     Document Type: Article

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