Amino acids of the α(1B)-adrenergic receptor involved in agonist binding: Differences in docking catecholamines to receptor subtypes

FEBS Letters

Volumn 399, Issue 1-2, 1996, Pages 9-13

  Cavalli, Antonella ^a   Fanelli, Francesca ^b   Taddei, Carlo ^c   De Benedetti, Pier G ^b   Cotecchia, Susanna ^a,d  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c Recordati SpA   (Italy)

^d University of Lausanne Departement de Pharmacologie et de Toxicologie   (Switzerland)

Author keywords

Adrenergic receptor; Catecholamine; G protein coupled receptor; Molecular dynamics

Indexed keywords

ADRENALIN; ALPHA ADRENERGIC RECEPTOR; CATECHOLAMINE; GUANINE NUCLEOTIDE BINDING PROTEIN; NORADRENALIN; OXEDRINE; PHENYLEPHRINE; PRAZOSIN; RECEPTOR SUBTYPE; ADRENERGIC RECEPTOR ALPHA(1B); ALPHA 1 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; AMINO ACID;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CATTLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ENANTIOMER; EVOLUTION; HAMSTER; HYDROGEN BOND; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; RAT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; ANIMAL; CELL STRAIN COS1; CHEMISTRY; DRUG POTENTIATION; GENETICS; METABOLISM; PROTEIN BINDING;

ADRENERGIC ALPHA-AGONISTS; AMINO ACIDS; ANIMALS; COS CELLS; CRICETINAE; EPINEPHRINE; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; RECEPTORS, ADRENERGIC, ALPHA-1;

EID: 0030577241     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(96)01286-0     Document Type: Article

References (15)

1. [1] Savarese, T.M. and Fraser, C.M. (1992) Biochem. J. 283, 1-19.
2. [2] Ruffolo, R.R. (1983) in: Adrenergic Receptors and Catecholamine Actions (G. Kunos ed.) Part B, pp. 1-50, John Wiley, New York.
3. [3] Strader, C.D., Sigal, I.S., Register, R.B., Candelore, M.R., Rands, E. and Dixon, R.A. (1987) Proc. Natl. Acad. Sci. 84, 4384-4388.
4. [4] Wang, C.-D., Buck, M.A.Q. and Fraser, C.M. (1991) Mol. Pharmacol. 40, 168-179.
5. [5] Strader, C.D., Candelore, M.R., Hill, W.S., Sigal, I.S. and Dixon, R.A. (1989) J. Biol. Chem. 264, 13572-13578.
6. [6] Hwa, J. and Perez, D.M. (1996) J. Biol. Chem. 271, 6322-6327.
7. [7] Cox, B.A., Henningsen, R.A., Spamoyannis, A., Neve, R.L. and Neve, K.A. (1992) J. Neurochem. 59, 627-635.
8. [8] Pollock, N.J., Manelli, A.M., Hutchins, C.W., Steffey, M.E., MacKenzie, R.G. and Frail, D.E. (1992) J. Biol. Chem. 267, 17780-17786.
9. [9] Cotecchia, S., Schwinn, D.A., Randall, R.R., Lefkowitz, R.J., Caron, M.G. and Kobilka, B.K. (1988) Proc. Natl. Acad. Sci. USA 85, 7159-7163.
10. [10] Lattion, A.L., Diviani, D. and Cotecchia, S. (1994) J. Biol. Chem. 269, 22887-22893.
11. [11] Scheer, A., Fanelli, F., Costa, T., De Benedetti, P.G. and Cotecchia, S. (1996) EMBO J. 15, 3566-3578.
12. [12] Brooks, B.R., Bruccoleri, R.E., Olafson, B.D., States, D.J., Swaminathan, S. and Karplus, M. (1983) J. Comput. Chem. 4, 187-217.
13. [13] Schwinn, D.A., Lomasney, J.W., Lorenz, W., Szklut, P.J., Fremeau, R.T., Yang-Feng, T.L., Caron, M.G., Lefkowitz, R.J. and Cotecchia, S. (1990) J. Biol. Chem. 256, 8183-8189.
14. [14] Lomasney, J.W., Cotecchia, S., Lorenz, W., Leung, W.-Y., Schwinn, D.A., Yang-Feng, T.L., Brownstein, M., Lefkowitz, R.J. and Caron, M.G. (1991) J. Biol. Chem. 266, 6365-6369.
15. [15] Hwa, J., Graham, R.M. and Perez, D.M. (1996) J. Biol. Chem. 270, 23189-23196.