Tumor suppressive effects of tocotrienol in vivo and in vitro

Cancer Letters

Volumn 229, Issue 2, 2005, Pages 181-191

  Wada, Sayori ^a   Satomi, Yoshiko ^a   Murakoshi, Michiaki ^b   Noguchi, Noriko ^c,d   Yoshikawa, Toshikazu ^a   Nishino, Hoyoku ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b LION CORPORATION   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d DOSHISHA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cancer control; CYP1A1; Liver and lung cancer; Tocotrienol

Indexed keywords

ALPHA TOCOTRIENOL; BETA TOCOTRIENOL; CYTOCHROME P450 1A1; DELTA TOCOTRIENOL; GAMMA TOCOTRIENOL; TOCOPHEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER PREVENTION; CELL CYCLE S PHASE; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LUNG CARCINOGENESIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROME P-450 CYP1A1; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; LIVER NEOPLASMS; LUNG NEOPLASMS; MALE; MICE; TOCOTRIENOLS; VITAMINS;

EID: 26444439065     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.06.036     Document Type: Article

References (40)

1. L. He, H. Mo, S. Hadisusilo, A.A. Qureshi, and C.E. Elson Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo J. Nutr. 127 1997 668 674
2. M. Okabe, M. Oji, I. Ikeda, H. Tachibana, and K. Yamada Tocotrienol levels in various tissues of Sprague-Dawley rats after intragastric administration of tocotrienols Bioscience, Biotechnology, and Biochemistry 66 2002 1768 1771
3. S. Ikeda, T. Tohyama, H. Yoshimura, K. Hamamura, K. Abe, and K. Yamashita Dietary alpha-tocopherol decreases alpha-tocotrienol but not gamma-tocotrienol concentration in rats J. Nutr. 133 2003 428 434
4. K.C. Hayes, A. Pronczuk, and J.S. Liang Differences in the plasma transport and tissue concentrations of tocopherols and tocotrienols: observations in humans and hamsters Proc. Soc. Exp. Biol. Med. 202 1993 353 359
5. M. Birringer, P. Pfluger, D. Kluth, N. Landes, and R. Brigelius-Flohe Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells J. Nutr. 132 2002 3113 3118
6. S. Schaffer, W.E. Muller, and G.P. Eckert Tocotrienols: constitutional effects in aging and disease J. Nutr. 135 2005 151 154
7. M.J. Wargovich, C. Woods, D.M. Hollis, and M.E. Zander Herbals, cancer prevention and health J. Nutr. 131 2001 3034S 3036S
8. H. Mo, and C.E. Elson Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention Proc. Soc. Exp. Biol. Med. 229 2004 567 585
9. M.C. Shun, W. Yu, A. Gapor, R. Parsons, J. Atkinson, and B.G. Sanders Pro-apoptotic mechanisms of action of a novel vitamin E analog (alpha-TEA) and a naturally occurring form of vitamin E (delta-tocotrienol) in MDA-MB-435 human breast cancer cells Nutr. Cancer 48 2004 95 105
10. M.K. Agarwal, M.L. Agarwal, M. Athar, and S. Gupta Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association Cell Cycle 3 2004 205 211
11. S. Shah, A. Gapor, and P.W. Sylvester Role of caspase-8 activation in mediating vitamin E-induced apoptosis in murine mammary cancer cells Nutr. Cancer 45 2003 236 246
12. B.S. McIntyre, K.P. Briski, A. Gapor, and P.W. Sylvester Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mouse mammary epithelial cells Proc. Soc. Exp. Biol. Med. 224 2000 292 301
13. H. Mo, and C.E. Elson Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids J. Nutr. 129 1999 804 813
14. N. Guthrie, A. Gapor, A.F. Chambers, and K.K. Carroll Inhibition of proliferation of estrogen receptor-negative MDA-MB-435 and -positive MCF-7 human breast cancer cells by palm oil tocotrienols and tamoxifen, alone and in combination J. Nutr. 127 1997 544S 548S
15. F. Galli, A.M. Stabile, M. Betti, C. Conte, A. Pistilli, and M. Rende The effect of alpha- and gamma-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation Arch. Biochem. Biophys. 423 2004 97 102
16. R. Gysin, A. Azzi, and T. Visarius Gamma-tocopherol inhibits human cancer cell cycle progression and cell proliferation by down-regulation of cyclins FASEB J 16 2002 1952 1954
17. S.H. Goh, N.F. Hew, A.W. Norhanom, and M. Yadav Inhibition of tumour promotion by various palm-oil tocotrienols Int. J. Cancer 57 1994 529 531
18. N. Noguchi, R. Hanyu, A. Nonaka, Y. Okimoto, and T. Kodama Inhibition of THP-1 cell adhesion to endothelial cells by alpha-tocopherol and alpha-tocotrienol is dependent on intracellular concentration of the antioxidants Free Radic. Biol. Med. 34 2003 1614 1620
19. Y. Naito, M. Shimozawa, M. Kuroda, N. Nakabe, H. Manabe, and K. Katada Tocotrienols reduce 25-hydroxycholesterol-induced monocyte-endothelial cell interaction by inhibiting the surface expression of adhesion molecules Atherosclerosis 180 2005 19 25
20. D.F. Calvisi, S. Ladu, K. Hironaka, V.M. Factor, and S.S. Thorgeirsson Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-alpha transgenic mouse model of liver cancer J. Hepatol. 41 2004 815 822
21. R.A. Parker, B.C. Pearce, R.W. Clark, D.A. Gordon, and J.J. Wright Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase J. Biol. Chem. 268 1993 11230 11238
22. T. Miyazawa, H. Inokuchi, H. Hirokane, T. Tsuzuki, K. Nakagawa, and M. Igarashi Anti-angiogenic potential of tocotrienol in vitro Biochemistry (Moscow) 69 2004 67 69
23. K. Kline, W. Yu, and B.G. Sanders Vitamin E: mechanisms of action as tumor cell growth inhibitors J. Nutr. 131 2001 161S 163S
24. M. Stapelberg, M. Tomasetti, R. Alleva, N. Gellert, A. Procopio, and J. Neuzil Alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors Biochem. Biophys. Res. Commun. 318 2004 636 641
25. M. Tomasetti, M.R. Rippo, R. Alleva, S. Moretti, L. Andera, and J. Neuzil Alpha-tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells Br. J. Cancer 90 2004 1644 1653
26. K. Takahashi, and G. Loo Disruption of mitochondria during tocotrienol-induced apoptosis in MDA-MB-231 human breast cancer cells Biochem. Pharmacol. 67 2004 315 324
27. J. Iqbal, M. Minhajuddin, and Z.H. Beg Suppression of 7,12-dimethylbenz[alpha]anthracene-induced carcinogenesis and hypercholesterolaemia in rats by tocotrienol-rich fraction isolated from rice bran oil, Eur J. Cancer Prev. 12 2003 447 453
28. J. Iqbal, M. Minhajuddin, and Z.H. Beg Suppression of diethylnitrosamine and 2-acetylaminofluorene-induced hepato carcinogenesis in rats by tocotrienol-rich fraction isolated from rice bran oil Eur. J. Cancer Prev. 13 2004 515 520
29. R.W. Pak, V.J. Lanteri, J.R. Scheuch, and I.S. Sawczuk Review of vitamin E and selenium in the prevention of prostate cancer: implications of the selenium and vitamin E chemoprevention trial Integr. Cancer Ther. 1 2002 338 344
30. N. Noguchi, H. Sakai, Y. Kato, J. Tsuchiya, Y. Yamamoto, and E. Niki Inhibition of oxidation of low density lipoprotein by troglitazone Atherosclerosis 123 1996 227 234
31. M. Heinonen, and V. Piironen The tocopherol, tocotrienol, and vitamin E content of the average Finnish diet, Int J. Vitam. Nutr. Res. 61 1991 27 32
32. D. Sampath, V.A. Rao, and W. Plunkett Mechanisms of apoptosis induction by nucleoside analogs Oncogene 22 2003 9063 9074
33. S.L. Wu, Z.J. Sun, L. Yu, K.W. Meng, X.L. Qin, and C.E. Pan Effect of resveratrol and in combination with 5-FU on murine liver cancer World J. Gastroenterol. 10 2004 3048 3052
34. C.J. Sherr Principles of tumor suppression Cell 116 2004 235 246
35. B. Pucci, P.P. Claudio, V. Masciullo, L. Bellincampi, A. Terrinoni, and K. Khalili pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation Oncogene 21 2002 5897 5905
36. H. Huynh Overexpression of tumour suppressor retino blastoma 2 protein (pRb2/p130) in hepatocellular carcinoma Carcinogenesis 25 2004 1485 1494
37. S.P. Angus, L.J. Wheeler, S.A. Ranmal, X. Zhang, M.P. Markey, and C.K. Mathews Retinoblastoma tumor suppressor targets dNTP metabolism to regulate DNA replication J. Biol. Chem. 277 2002 44376 44384
38. T. Shimada, and Y. Fujii-Kuriyama Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1 Cancer Sci. 95 2004 1 6
39. A.H. Conney Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G.H.A, Clowes Memorial Lecture Cancer Res. 42 1982 4875 4917
40. S.T. Saarikoski, K. Husgafvel-Pursiainen, A. Hirvonen, H. Vainio, F.J. Gonzalez, and S. Anttila Localization of CYP1A1 mRNA in human lung by in situ hybridization: comparison with immunohistochemical findings Int. J. Cancer 77 1998 33 39