Combination therapy for radiation-induced bone marrow aplasia in nonhuman primates using synthokine SC-55494 and recombinant human granulocyte colony-stimulating factor

Blood

Volumn 87, Issue 10, 1996, Pages 4129-4135

  MacVittie, Thomas J ^a   Farese, Ann M ^b   Herodin, Francis ^b   Grab, Lisa B ^b   Baum, Charles M ^b   McKearn, John P ^b  

^a UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CEFTRIAXONE; CYTOKINE; GENTAMICIN; HUMAN SERUM ALBUMIN; INTERLEUKIN 3 RECEPTOR; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; SC 55494; SYNTHOKINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBIOTIC PROPHYLAXIS; ARTICLE; BLOOD CELL COUNT; BLOOD TRANSFUSION; BONE MARROW APLASIA; BONE MARROW SUPPRESSION; CONTROLLED STUDY; DRUG EFFICACY; GAMMA IRRADIATION; MACACA; MALE; NEUTROPENIA; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTOPENIA; WHOLE BODY RADIATION;

ANEMIA, APLASTIC; ANIMALS; BLOOD TRANSFUSION; COMBINED MODALITY THERAPY; DRUG EVALUATION, PRECLINICAL; DRUG THERAPY, COMBINATION; FILGRASTIM; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-3; LEUKOCYTES; MACACA MULATTA; MALE; NEUTROPENIA; PEPTIDES; RADIATION INJURIES, EXPERIMENTAL; RECEPTORS, INTERLEUKIN-3; RECOMBINANT PROTEINS; SERUM ALBUMIN; THROMBOCYTOPENIA; WHOLE-BODY IRRADIATION;

EID: 0029929202     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.10.4129.bloodjournal87104129     Document Type: Article

References (47)

1. Moore MAS, Warren, DJ: Interleukin-1 and G-CSF synergism: In vivo stimulation of stem cell recovery and hematopoietic regeneration following 5-fluorouracil treatment in mice. Proc Natl Acad Sci USA 84:7134, 1987
2. Williams DE, Dunn JT, Park LS, Frieden EA, Seiler FR, Farese AM, MacVittie TJ: A GM-CSF/IL-3 fusion protein promotes neutrophil and platelet recovery in sublethally irradiated rhesus monkeys. Biotechnol Ther 4:17, 1993
3. Williams DE, Farese A, MacVittie TJ: PIXY321, but not GM-CSF plus IL-3, promotes hematopoietic reconstitution following lethal irradiation. Blood 82:366a, 1993 (abstr, suppl 1)
4. Farese AM, Williams DE, Seiler FR, MacVittie TJ: Combination protocols of cytokine therapy with interleukin-3 and granulocyte-macrophage colony-stimulating factor in a primate model of radiation-induced marrow aplasia. Blood 82:3012, 1993
5. Gonter PW, Hillyer CD, Strobert EA, Orkin JL, Swenson RB, McClure HM, Myers LA, Winton EF: The effect of varying ratios of administered rhIL-3 and rhGM-CSF on post-chemotherapy marrow regeneration in a nonhuman primate model. Blood 82:365a, 1993 (abstr, suppl 1)
6. Farese AM, Myers LA, MacVittie TJ: Therapeutic efficacy of the combined administration of either recombinant human interleukin-6 and rh-granulocyte colony stimulating factor or rh-granulocyte-macrophage colony stimulating factor in a primate model of radiation-induced marrow aplasia. Exp Hematol 22:684, 1994 (abstr)
7. Patchen ML, Fischer R, MacVittie TJ: Effects of combined administration of IL-6 and G-CSF on recovery from radiation-induced hemopoietic aplasia. Exp Hematol 21:338, 1993
8. Gonter PW, Hillyer CD, Strobert EA, Orkin JL, Swenson RB, McClure HM, Myers LA, Winton EF: Enhanced post-chemotherapy platelet and neutrophil recovery using combination rhIL-6 and rhGM-CSF in a nonhuman primate model. Blood 82:365a, 1993 (abstr, suppl 1)
9. MacVittie TJ, Farese AM, Patchen ML, Myers LA: Therapeutic efficacy of recombinant interleukin-6 alone and combined with recombinant human IL-3 in a nonhuman primate model of high-dose, sublethal radiation-induced marrow aplasia. Blood 84:2515, 1994
10. Winton EF, Srinivasiah J, Kim BK, Hillyer CD, Strobert EA, Orkin JL, Swenson RB, McClure HM, Myers LA, Saral R: Effect of recombinant human interleukin-6 and rhIL-3 on hematopoietic regeneration as demonstrated in a nonhuman primate chemotherapy model. Blood 84:65, 1994
11. Carrington PA, Hill RJ, Levin J, Verotta D: Effects of interleukin 3 and interleukin 6 on platelet recovery in mice treated with 5-fluorouracil. Exp Hematol 20:462, 1992
12. Scheuning FG, Appelbaum FR, Deeg HJ, Sullivane-Pepe M, Graham TC, Hackman R, Zsebo KM, Storb R: Effects of recombinant canine stem cell factor, a c-kit ligand, and recombinant granulocyte colony-stimulating factor on hematopoietic recovery after otherwise lethal total body irradiation. Blood 81:20, 1993
13. Farese AM, Kirschner KF, Patchen ML, Zsebo KM, MacVittie TJ: The effect of recombinant canine stem cell factor and/or recombinant canine granulocyte colony stimulating factor on marrow aplasia recovery in lethally irradiated canines. Exp Hematol 21:585a, 1993
14. McNiece IK, McGrath HE: Granulocyte colony-stimulating factor augments in vitro megakaryocyte colony formation by interleukin-3, Exp Hematol 16:807, 1988
15. Paquette RL, Zhou JY, Yang YC, Clark SC, Koeffler HP: Recombinant gibbon interleukin-3 acts synergistically with recombinant human G-CSF and GM-CSF in vitro. Blood 71:1596, 1988
16. McNiece IK, Andrew R, Stewart M, Clark S, Boone T, Quesenberry P: Action of interleukin-3, G-CSF, and GM-CSF on highly enriched human hematopoietic progenitor cells: Synergistic interaction of GM-CSF plus G-CSF. Blood 74:110, 1989
17. Ikebuchi K, Clark SC, Ihle JN, Souza LM, Ogawa M: Granulocyte colony-stimulating factor enhances interleukin3-dependent proliferation of multipotential hemopoietic progenitors. Proc Natl Acad Sci USA 85:3445, 1988
18. Ulich TR, del Castillo J, McNiece IK, Yin SM, Irwin B, Busser K, Guo KZ: Acute and subacute hematologic effects of multi-colony stimulating factor in combination with granulocyte colony-stimulating factor in vivo. Blood 75:48, 1990
19. Krumwieh D, Weinmann E, Siebold B, Seiler FR: Preclinical studies on synergistic effects of IL-1, IL-3, rhG-CSF, and GM-CSF in cynomolgus monkeys. Int J Cell Cloning 8:229, 1990 (suppl 1)
20. Aglietta M, Sanavio F, Stacchini A, Morelli S, Fubini L, Severino A, Pasquino P, Volta C, Bretti S, Tafuto S, Zola P, Sismondi P, Sklenar I, Piacibello W, Bussolino F, Gavosto F: Interleukin-3 in vivo: Kinetic of response of target cells. Blood 82:2054, 1993
21. Farese AM, Herodin F, McKearn JP, Baum C, Burton E, MacVittie TJ: Acceleration of hematopoietic reconstitution with a synthetic cytokine (SC-55494) following radiation-induced bone marrow aplasia. Blood 87:581, 1996
22. Thomas JW, Baum CM, Hood WF, Klein B, Monahan JB, Paik K, Staten N, Abrams M, McKearn JP: Potent interleukin 3 receptor agonist with selectively enhanced hematopoietic activity relative to recombinant human interleukin 3. Proc Natl Acad Sci USA 92:3779, 1995
23. The Institute of Laboratory Animal Resources, National Research Council: Guide for the Care and Use of Laboratory Animals. Publication No. 86-23. Washington, DC, National Institutes of Health
24. Collins MK, Marvel J, Malde P, Lopez-Rivas A: Interleukin-3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents. J Exp Med 176:1043, 1992
25. Brandt JE, Bhalla K, Hoffman R: Effects of interleukin-3 and c-kit ligand on the survival of various classes of human hematopoietic progenitor cells. Blood 83:1507, 1994
26. Williams GT, Smith CA, Spooncer E, Dexter TM, Taylor DR: Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature 343:76, 1990
27. Wogum AW, Visser TP, de Jong MO, Egeland T, Wagemaker G: Differential expression of receptors for interleukin-3 on subsets of CD34 expressing hematopoietic cells of rhesus monkeys. Blood 85:581, 1995
28. van Gils FCJM, Budel LM, Burger H, van Leen RW, Lowenberg B, Wagemaker G: Interleukin-3 receptors on rhesus monkey bone marrow cells: Species specificity of human IL-3, binding characteristics, and lack of competition with GM-CSF. Exp Hematol 22:248, 1994
29. Kuter DJ, Beeler DL, Rosenberg RD: The purification of megapoietin: A physiological regulator of megakaryocyte growth and development production. Proc Natl Acad Sci USA 91:11104, 1994
30. Kato T, Ogami K, Shimada Y, Iwamatsu A, Schma Y, Akahori H, Horie K, Kokubo A, Kudo Y, Maeda E, Kobayashi K, Ohashi H, Ozawa T, Inoue H, Kawamura K, Miyazaki H: Purification and characterization of thrombopoietin. J Biochem 118:229, 1995
31. Lok S, Kaushansky K, Holly RD, Kuljper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumber H, Johnson R, Prunkard D, Ching AFT, Mathewes SL, Balley MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565, 1994
32. de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kaung WJ, Oles KJ, Hultgren B, Solberg LA Jr, Goeddel DV, Eaton DL: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-MpI ligand. Nature 369:533, 1994
33. Bartley T, Bogenberger J, Hunt P, Li YS, Lu HS, Martin F, Change MS, Samal B, Nichol JL, Swift S, Johnson MJ, Hsu RY, Parker VP, Suggs S, Skrine JD, Merewether LA, Clogston C, Hsu E, Hokom MM, Hornkohl A, Choi E, Pangeliana M, Sun Y, Mar V, McNinch J, Simonet L, Jacobsen F, Xie C, Shutter J, Chute H, Basu R, Selander L, Trollinger D, Sieu L, Padilla D, Trail G, Elliott G, Izumi R, Covey T, Crouse J, Garcia A, Xu W, Del Castillo J, Biron J, Cole S, Hu MC-T , Pacifici R, Ponting I, Saris C, Wen D, Yung WP, Lin H, Bosselman RA: Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI. Cell 77:1117, 1994
34. Monahan JB, Hood WF, Joy WD, Caparon MH, Paik K, Goldberg SB, Klein BK, Staten NR, Pegg LE, Bauer SC, Mina MS, Abrams MA, Hirsch JL, Abegg AL, Giri JG, Baum CM, McKearn JP: Functional characterization of SC68420 - A multifunctional agonist which activates both IL-3 and G-CSF receptors. Blood 86:154a, 1995 (abstr, suppl 1)
35. McKearn JP, Hood WF, Monahan JB, Joy WD, Caparon MH, Paik K, Bauer SC, Lee SC, Goldberg SB, Klein BK, Staten NR, Pegg LE, Abrams MA, Hirsch JL, Abegg AL, Donnelly AM, Giri JG, Tsai BS, Keith RH, Baum CM: Myelopoietin - A multifunctional agonist of human IL-3 and G-CSF receptors. Blood 86:259a, 1995 (abstr, suppl 1)
36. Beckmann MP, Heimfeld S, Fei R, Tsui A, Fogarty BL, Vanderbosch LJ, Bordonaro H, Roecklein B, Torok-Storb B, McKearn JP, Baum CM: Novel hematopoietic factors enhance ex vivo expansion of human CD34+ hematopoietic progenitor cells. Blood 86:492a, 1995 (abstr, suppl 1)
37. Ulich TR, del Castillo J, Yin S, Swift S, Padilla D, Senaldi G, Bennett L, Shutter J, Bogenberger J, Sun D, Samal B, Shimamoto G, Lee R, Steinbrink R, Boone T, Sheridan WP, Hunt P: Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood 86:971, 1995
38. Hokom MM, Lacey D, Kinsler O, Choi E, Kaufman S, Faust J, Rowen C, Dywer E, Nichol JL, Grasel T, Wilson J, Steinbrink R, Hecht R, Grampp G, Bartley T, Li Y-S, Boone T, Hunt P: Megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice. Blood 86:4486, 1995
39. Farese AM, Hunt P, Boone TC, MacVittie TJ: Recombinant human megakaryocyte growth and development factor (r-HuMGDF) simulates megakaryocytopoiesis in normal primates. Blood 85:55, 1995
40. Winton EF Thomas GR, Marian ML, Bucur SZ, McClure HM, Eaton DL: Prediction of a threshold and optimally effective thrombocytopoietic dose of recombinant human thrombopoietin (rhTPO) in nonhuman primates based on murine pharmacokinetic data. Exp Hematol 23:879a, 1995
41. Thibodeaux H, Mathias J, Eaton DL, Thomas GR: Evaluation of thrombopoietin (TPO) in murine models of thrombocytopenia induced by whole body irradiation and cancer chemotherapeutic agents. Blood 86:497a, 1995 (abstr, suppl 1)
42. Grossmann A, Lenox JS, Humes JM, Ren HP, Kaushansky K, Sprugel KH: Effects of the combined administration of TPO and G-CSF on recovery from myelosuppression in mice. Blood 86:371a, 1995 (abstr, suppl 1)
43. Farese AM, Hunt P, Grab LB, MacVittie TJ: Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony stimulating factor enhances multi-lineage hematopoietic reconstitution in nonhuman primates following radiation-induced marrow aplasia. J Clin Invest (in press)
44. Farese AM, Hunt P, Grab LB, MacVittie TJ: Evaluation of administration protocols of pegylated megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet recovery in a primate model of radiation-induced bone marrow aplasia. Blood 86:497a, 1995 (abstr, suppl 1)
45. Neelis KJ, WognumAW, Eaton D, Thomas R, Wagemaker G: Preclinical evaluation of thrombopoietin in rhesus monkeys. Blood 86:256a, 1995 (abstr, suppl 1)
46. Harker LA, Marzec UM, Kelly AB, Hanson SR: Enhanced hematopoietic regeneration in primate model of myelosuppressive chemotherapy by pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in combination with granulocyte colony stimulating factor (G-CSF). Blood 86:497a, 1995 (abstr, suppl 1)
47. MacVittie TJ, Farese AM, Grab LB, Baum C, McKearn JP: Stimulation of multilineage hematopoietic recovery in a nonhuman primate, bone marrow aplasia model by a multifunctional agonist of human IL-3 and G-CSF receptors. Blood 86:499a, 1995 (abstr, suppl 1)