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Volumn 56, Issue 11, 2012, Pages 1627-1635

Flavone potently stimulates an apical transporter for flavonoids in human intestinal Caco-2 cells

Author keywords

ABC transporter; Caco 2 cells; Flavonoids; Intestinal absorption; Rhodamine 123

Indexed keywords

ANTHOCYANIN; CARRIER PROTEIN; CHLORIDE; FLAVONE; FLAVONE DERIVATIVE; FLAVONOID; GUANIDINE; KAEMPFEROL DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN; ORGANIC CATION TRANSPORTER; PROTEIN TYROSINE KINASE; RHODAMINE; SODIUM; VERAPAMIL;

EID: 84867937725     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201200370     Document Type: Article
Times cited : (14)

References (32)
  • 1
    • 84856370253 scopus 로고    scopus 로고
    • Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults
    • McCullough, M. L., Peterson, J. J., Patel, R., Jacques, P. F. et al., Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults. Am. J. Clin. Nutr. 2012, 95, 454-464.
    • (2012) Am. J. Clin. Nutr. , vol.95 , pp. 454-464
    • McCullough, M.L.1    Peterson, J.J.2    Patel, R.3    Jacques, P.F.4
  • 3
    • 79957800828 scopus 로고    scopus 로고
    • The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems
    • Barnes, S., Prasain, J., D'Alessandro, T., Arabshahi, A. et al., The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems. Food Funct. 2011, 2, 235-244.
    • (2011) Food Funct. , vol.2 , pp. 235-244
    • Barnes, S.1    Prasain, J.2    D'Alessandro, T.3    Arabshahi, A.4
  • 4
    • 0037360264 scopus 로고    scopus 로고
    • Non-nutritive bioactive food constituents of plants: bioavailability of flavonoids
    • Rasmussen, S. E., Breinholt, V. M., Non-nutritive bioactive food constituents of plants: bioavailability of flavonoids. Int. J. Vitam. Nutr. Res. 2003, 73, 101-111.
    • (2003) Int. J. Vitam. Nutr. Res. , vol.73 , pp. 101-111
    • Rasmussen, S.E.1    Breinholt, V.M.2
  • 5
    • 0037219688 scopus 로고    scopus 로고
    • Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans
    • Németh, K., Plumb, G. W., Berrin, J. G., Juge, N. et al., Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. Eur. J. Nutr. 2003, 42, 29-42.
    • (2003) Eur. J. Nutr. , vol.42 , pp. 29-42
    • Németh, K.1    Plumb, G.W.2    Berrin, J.G.3    Juge, N.4
  • 6
    • 4043089112 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of dietary flavonoids in humans
    • Manach, C., Donovan, J. L., Pharmacokinetics and metabolism of dietary flavonoids in humans. Free Radic. Res. 2004, 38, 771-785.
    • (2004) Free Radic. Res. , vol.38 , pp. 771-785
    • Manach, C.1    Donovan, J.L.2
  • 7
    • 77953213772 scopus 로고    scopus 로고
    • Assessment of intestinal absorption of total flavones of Hippophae rhamnoides L. in rat using in situ absorption models
    • Xie, Y., Zeng, X., Li, G., Cai, Z. et al., Assessment of intestinal absorption of total flavones of Hippophae rhamnoides L. in rat using in situ absorption models. Drug Dev. Ind. Pharm. 2010, 36, 787-794.
    • (2010) Drug Dev. Ind. Pharm. , vol.36 , pp. 787-794
    • Xie, Y.1    Zeng, X.2    Li, G.3    Cai, Z.4
  • 8
    • 0033846534 scopus 로고    scopus 로고
    • Cellular uptake of dietary flavonoid quercetin 4'-beta-glucoside by sodium-dependent glucose transporter SGLT1
    • Walgren, R. A., Lin, J. T., Kinne, R. K., Walle, T., Cellular uptake of dietary flavonoid quercetin 4'-beta-glucoside by sodium-dependent glucose transporter SGLT1. J. Pharmacol. Exp. Ther. 2000, 294, 837-843.
    • (2000) J. Pharmacol. Exp. Ther. , vol.294 , pp. 837-843
    • Walgren, R.A.1    Lin, J.T.2    Kinne, R.K.3    Walle, T.4
  • 9
    • 0037377562 scopus 로고    scopus 로고
    • Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter
    • Day A. J., Gee J. M., DuPont M. S., Johnson I. T., Williamson G., Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter. Biochem. Pharmacol. 2003, 65, 1199-1206.
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 1199-1206
    • Day, A.J.1    Gee, J.M.2    DuPont, M.S.3    Johnson, I.T.4    Williamson, G.5
  • 10
    • 0025732815 scopus 로고
    • A model of human small intestinal absorptive cells. 1. Transport barrier
    • Cogburn, J. N., Donovan, M. G., Schasteen, C. S., A model of human small intestinal absorptive cells. 1. Transport barrier. Pharm. Res. 1991, 8, 210-216.
    • (1991) Pharm. Res. , vol.8 , pp. 210-216
    • Cogburn, J.N.1    Donovan, M.G.2    Schasteen, C.S.3
  • 11
    • 83555164706 scopus 로고    scopus 로고
    • Transport mechanisms of flavanone aglycones across Caco-2 cell monolayers and artificial PAMPA membranes
    • Kobayashi, S., Nagai, T., Konishi, Y., Tanabe, S. et al., Transport mechanisms of flavanone aglycones across Caco-2 cell monolayers and artificial PAMPA membranes. J. Pharm. Pharmacol. 2012, 64, 52-60.
    • (2012) J. Pharm. Pharmacol. , vol.64 , pp. 52-60
    • Kobayashi, S.1    Nagai, T.2    Konishi, Y.3    Tanabe, S.4
  • 12
    • 0043127390 scopus 로고    scopus 로고
    • Rapid assessment of P-glycoprotein inhibition and induction in vitro
    • Perloff, M. D., Störmer, E., von Moltke, L. L., Greenblatt, D. J., Rapid assessment of P-glycoprotein inhibition and induction in vitro. Pharm. Res. 2003, 20, 1177-1183.
    • (2003) Pharm. Res. , vol.20 , pp. 1177-1183
    • Perloff, M.D.1    Störmer, E.2    von Moltke, L.L.3    Greenblatt, D.J.4
  • 13
    • 0041402719 scopus 로고    scopus 로고
    • Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells
    • Troutman, M. D., Thakker, D. R., Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells. Pharm. Res. 2003, 20, 1192-1199.
    • (2003) Pharm. Res. , vol.20 , pp. 1192-1199
    • Troutman, M.D.1    Thakker, D.R.2
  • 14
    • 77953917443 scopus 로고    scopus 로고
    • Chrysin blocks topotecan-induced apoptosis in Caco-2 cells in spite of inhibition of ABC-transporters
    • Schumacher, M., Hautzinger, A., Rossmann, A., Holzhauser, S. et al., Chrysin blocks topotecan-induced apoptosis in Caco-2 cells in spite of inhibition of ABC-transporters. Biochem. Pharmacol. 2010, 80, 471-479.
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 471-479
    • Schumacher, M.1    Hautzinger, A.2    Rossmann, A.3    Holzhauser, S.4
  • 15
    • 0025311288 scopus 로고
    • Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells
    • Artursson, P., Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells. J. Pharm. Sci. 1990, 79, 476-482.
    • (1990) J. Pharm. Sci. , vol.79 , pp. 476-482
    • Artursson, P.1
  • 16
    • 0025912322 scopus 로고
    • Active hexose transport across cultured human Caco-2 cells: characterisation and influence of culture conditions
    • Riley, S. A., Warhurst, G., Crowe, P. T., Turnberg, L. A., Active hexose transport across cultured human Caco-2 cells: characterisation and influence of culture conditions. Biochim. Biophys. Acta 1991, 1066, 175-182.
    • (1991) Biochim. Biophys. Acta , vol.1066 , pp. 175-182
    • Riley, S.A.1    Warhurst, G.2    Crowe, P.T.3    Turnberg, L.A.4
  • 17
    • 0038018559 scopus 로고    scopus 로고
    • Divergent evolution of flavonoid 2-oxoglutarate-dependent dioxygenases in parsley
    • Martens, S., Wellmann, F., Britsch, L., Forkmann, G. et al., Divergent evolution of flavonoid 2-oxoglutarate-dependent dioxygenases in parsley. FEBS Lett. 2003, 544, 93-98.
    • (2003) FEBS Lett. , vol.544 , pp. 93-98
    • Martens, S.1    Wellmann, F.2    Britsch, L.3    Forkmann, G.4
  • 18
    • 20444385130 scopus 로고    scopus 로고
    • Molecular evolution of flavonoid dioxygenases in the family Apiaceae
    • Gebhardt, Y., Witte, S., Forkmann, G., Lukacin, R. et al., Molecular evolution of flavonoid dioxygenases in the family Apiaceae. Phytochemistry 2005, 66, 1273-1284.
    • (2005) Phytochemistry , vol.66 , pp. 1273-1284
    • Gebhardt, Y.1    Witte, S.2    Forkmann, G.3    Lukacin, R.4
  • 19
    • 78649631235 scopus 로고    scopus 로고
    • Bioavailability of dietary flavonoids and phenolic compounds
    • Crozier, A., Del Rio, D., Clifford, M. N., Bioavailability of dietary flavonoids and phenolic compounds. Mol. Aspects Med. 2010, 31, 446-467.
    • (2010) Mol. Aspects Med. , vol.31 , pp. 446-467
    • Crozier, A.1    Del Rio, D.2    Clifford, M.N.3
  • 20
    • 80053931165 scopus 로고    scopus 로고
    • Intestinal transit and systemic metabolism of apple polyphenols
    • Kahle, K., Kempf, M., Schreier, P., Scheppach, W. et al., Intestinal transit and systemic metabolism of apple polyphenols. Eur. J. Nutr. 2011, 50, 507-522.
    • (2011) Eur. J. Nutr. , vol.50 , pp. 507-522
    • Kahle, K.1    Kempf, M.2    Schreier, P.3    Scheppach, W.4
  • 21
    • 29944437798 scopus 로고    scopus 로고
    • Dose-dependent levels of epigallocatechin-3-gallate in human colon cancer cells and mouse plasma and tissues
    • Lambert, J. D., Lee, M. J., Diamond, L., Ju, J. et al., Dose-dependent levels of epigallocatechin-3-gallate in human colon cancer cells and mouse plasma and tissues. Drug Metab. Dispos. 2006, 34, 8-11.
    • (2006) Drug Metab. Dispos. , vol.34 , pp. 8-11
    • Lambert, J.D.1    Lee, M.J.2    Diamond, L.3    Ju, J.4
  • 22
    • 78649820061 scopus 로고    scopus 로고
    • Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal Caco-2 cells
    • Manzano, S., Williamson, G., Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal Caco-2 cells. Mol. Nutr. Food Res. 2010, 54, 1773-1780.
    • (2010) Mol. Nutr. Food Res. , vol.54 , pp. 1773-1780
    • Manzano, S.1    Williamson, G.2
  • 23
    • 14844303448 scopus 로고    scopus 로고
    • Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells
    • Johnston, K., Sharp, P., Clifford, M., Morgan, L., Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells. FEBS Lett. 2005, 579, 1653-1657.
    • (2005) FEBS Lett. , vol.579 , pp. 1653-1657
    • Johnston, K.1    Sharp, P.2    Clifford, M.3    Morgan, L.4
  • 24
    • 35848970970 scopus 로고    scopus 로고
    • Inhibition effect of flavonoids on monocarboxylate transporter 1 (MCT1) in Caco-2 cells
    • Shim, C. K., Cheon, E. P., Kang, K. W., Seo, K. S. et al., Inhibition effect of flavonoids on monocarboxylate transporter 1 (MCT1) in Caco-2 cells. J. Pharm. Pharmacol. 2007, 59, 1515-1519.
    • (2007) J. Pharm. Pharmacol. , vol.59 , pp. 1515-1519
    • Shim, C.K.1    Cheon, E.P.2    Kang, K.W.3    Seo, K.S.4
  • 25
    • 58249119578 scopus 로고    scopus 로고
    • Studies of intestinal permeability of 36 flavonoids using Caco-2 cell monolayer model
    • Tian, X. J., Yang, X. W., Yang, X., Wang, K., Studies of intestinal permeability of 36 flavonoids using Caco-2 cell monolayer model. Int. J. Pharm. 2009, 367, 58-64.
    • (2009) Int. J. Pharm. , vol.367 , pp. 58-64
    • Tian, X.J.1    Yang, X.W.2    Yang, X.3    Wang, K.4
  • 26
    • 34848835701 scopus 로고    scopus 로고
    • Effects of diosmin, a flavonoid glycoside in citrus fruits, on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells
    • Yoo, H. H., Lee, M., Chung, H. J., Lee, S. K et al., Effects of diosmin, a flavonoid glycoside in citrus fruits, on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells. J. Agric. Food Chem. 2007, 55, 7620-7625.
    • (2007) J. Agric. Food Chem. , vol.55 , pp. 7620-7625
    • Yoo, H.H.1    Lee, M.2    Chung, H.J.3    Lee, S.K.4
  • 27
    • 79958232077 scopus 로고    scopus 로고
    • Potential role of P-gp for flavone-induced diminished apoptosis and increased adenoma size in the small intestine of APC(min/±) mice
    • Schumacher, M., Hautzinger, A., Rossmann, A., Holzhauser, S. et al., Potential role of P-gp for flavone-induced diminished apoptosis and increased adenoma size in the small intestine of APC(min/±) mice. Cancer Invest. 2011, 29, 396-404.
    • (2011) Cancer Invest. , vol.29 , pp. 396-404
    • Schumacher, M.1    Hautzinger, A.2    Rossmann, A.3    Holzhauser, S.4
  • 29
    • 19444385262 scopus 로고    scopus 로고
    • Modulation of drug transport by selected flavonoids: involvement of P-gp and OCT?
    • Ofer, M., Wolffram, S., Koggel, A., Spahn-Langguth, H. et al., Modulation of drug transport by selected flavonoids: involvement of P-gp and OCT? Eur. J. Pharm. Sci. 2005, 25, 263-271.
    • (2005) Eur. J. Pharm. Sci. , vol.25 , pp. 263-271
    • Ofer, M.1    Wolffram, S.2    Koggel, A.3    Spahn-Langguth, H.4
  • 30
    • 27744454598 scopus 로고    scopus 로고
    • Drug specificity and intestinal membrane localization of human organic cation transporters (OCT)
    • Müller, J., Lips, K. S., Metzner, L., Neubert, R. H. et al., Drug specificity and intestinal membrane localization of human organic cation transporters (OCT). Biochem. Pharmacol. 2005, 70, 1851-160.
    • (2005) Biochem. Pharmacol. , vol.70 , pp. 1851-1160
    • Müller, J.1    Lips, K.S.2    Metzner, L.3    Neubert, R.H.4
  • 31
    • 84859099760 scopus 로고    scopus 로고
    • Thiamine is a substrate of organic cation transporters in Caco-2 cells
    • Lemos, C., Faria, A., Meireles, M., Martel, F. et al., Thiamine is a substrate of organic cation transporters in Caco-2 cells. Eur. J. Pharmacol. 2012, 682, 37-42.
    • (2012) Eur. J. Pharmacol. , vol.682 , pp. 37-42
    • Lemos, C.1    Faria, A.2    Meireles, M.3    Martel, F.4
  • 32
    • 34247520060 scopus 로고    scopus 로고
    • Fluorescein transport properties across artificial lipid membranes, Caco-2 cell monolayers and rat jejunum
    • Berginc, K., Zakelj, S., Levstik, L., Ursic, D. et al., Fluorescein transport properties across artificial lipid membranes, Caco-2 cell monolayers and rat jejunum. Eur. J. Pharm. Biopharm. 2007, 66, 281-285.
    • (2007) Eur. J. Pharm. Biopharm. , vol.66 , pp. 281-285
    • Berginc, K.1    Zakelj, S.2    Levstik, L.3    Ursic, D.4


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