Evaluation of Citrus aurantifolia peel and leaves extracts for their chemical composition, antioxidant and anti-cholinesterase activities

Journal of the Science of Food and Agriculture

Volumn 92, Issue 15, 2012, Pages 2960-2967

  Loizzo, Monica Rosa ^a   Tundis, Rosa ^a   Bonesi, Marco ^a   Menichini, Federica ^b   De Luca, Damiano ^c   Colica, Carmela ^d   Menichini, Francesco ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

^b ITALIAN MEDICINES AGENCY   (Italy)

^c CALAB   (Italy)

^d INSTITUTE OF NEUROLOGICAL SCIENCES   (Italy)

Author keywords

Alzheimer's disease; Antioxidant activity; Citrus aurantifolia; GC MS analysis; Nutraceuticals; Total phenol and flavonoid content

Indexed keywords

ANTIOXIDANT; CHOLINESTERASE INHIBITOR; FLAVONOID; PHENOL DERIVATIVE; PLANT EXTRACT; SESQUITERPENE; TERPENE;

ARTICLE; CHEMISTRY; FRUIT; LIME (FRUIT); MASS FRAGMENTOGRAPHY; PLANT LEAF;

ANTIOXIDANTS; CHOLINESTERASE INHIBITORS; CITRUS AURANTIIFOLIA; FLAVONOIDS; FRUIT; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MONOTERPENES; PHENOLS; PLANT EXTRACTS; PLANT LEAVES; SESQUITERPENES;

CITRUS AURANTIIFOLIA;

EID: 84867901042     PISSN: 00225142     EISSN: 10970010     Source Type: Journal    
DOI: 10.1002/jsfa.5708     Document Type: Article

References (37)

1. Del Caro A, Piga A, Vacca V and Agabbio M, Changes of flavonoids, vitamin C and antioxidant capacity in minimally processed citrus segments and juices during storage. Food Chem 84: 99-105 (2004).
2. Dhuique-Mayer C, Caris-Veyrat C, Ollitrault P, Curk F and Amiot MJ, Varietal and interspecific influence on micronutrient contents in Citrus from the Mediterranean area. J Agric Food Chem 53: 2140-2145 (2005).
3. Anagnostopoulou MA, Kefalas P, Kokkalou E, Assimopoulou AN and Papageorgiou VP, Analysis of antioxidant compounds in sweet orange peel by HPLC-diode array detection-electrospray ionization mass spectrometry. Biomed Chromatogr 19: 138-148 (2005).
4. Wu T, Guan Y and Ye J, Determination of flavonoids and ascorbic acid in grapefruit peel and juice by capillary electrophoresis with electrochemical detection. Food Chem 100: 1573-1579 (2007).
5. Middleton E, Kandaswami C and Theoharides TC, The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol Rev 52: 673-751 (2000).
6. Poulose SM, Harris ED and Patil BS, Citrus limonoids induce apoptosis in human neuroblastoma cells and have radical scavenging activity. J Nutr 135: 870-877 (2005).
7. Cutuli G, Di Martino E, Lo Giudice V, Pennisi L, Raciti G, Russo F, et al, Trattato di Agrumicoltura. Edagricole, Bologna (1985).
8. Fukumoto S, Sawasaki E, Okuyama S, Miyake Y and Yokogoshi H, Flavor components of monoterpenes in citrus essential oils enhance the release of monoamines from rat brain slices. Nutr Neurosci 9: 73-80 (2006).
9. Asnaashari S, Delazar A, Habibi B, Vasfi R, Nahar L, Hamedeyazdan S, et al, Essential oil from Citrus aurantifolia prevents ketotifen-induced weight-gain in mice. Phytother Res 24: 1893-1897 (2010).
10. Tundis R, Loizzo MR, Bonesi M, Menichini F, Mastellone V, Colica C, et al, Comparative study on the antioxidant capacity and cholinesterase inhibitory activity of Citrus aurantifolia Swingle, C. aurantium L. and C. bergamia Risso and Poit peel essential oils. J Food Sci 71: H40-H46 (2012).
11. Boshtam M, Moshtaghian J, Naderi G, Asgary S and Nayeri H, Antioxidant effects of Citrus aurantifolia (Christm) juice and peel extract on LDL oxidation. J Res Med Sci 16: 951-955 (2011).
12. Soholm B, Clinical improvement of memory and other cognitive functions by Ginkgo biloba: Review of relevant literature. Adv Ther 15: 54-65 (1998).
13. Sastre J, Pallardo FV and Vina J, Mitochondrial oxidative stress plays a key role in aging and apoptosis. IUBMB Life 49: 427-435 (2000).
14. Atta-ur-Rahman and Choudhary MI, Bioactive natural products as a potential source of new pharmacophores. A theory of memory. Pure Appl Chem 73: 555-560 (2001).
15. Mukherjee PK, Kumar V, Mal M and Houghton PJ, Acetylcholinesterase inhibitor from plants. Phytomedicine 14: 289-300 (2007).
16. Kim J, Lee HJ and Lee KW, Naturally occurring phytochemicals for the prevention of Alzheimer's disease. J Neurochem 112: 1415-1430 (2010).
17. Conforti F, Statti G, Tundis R, Loizzo MR and Menichini F, In vitro activities of Citrus medica L. cv. Diamante (Diamante citron) relevant to treatment of diabetes and Alzheimer's disease. Phytother Res 21: 427-433 (2007).
18. Menichini F, Loizzo MR, Bonesi M, Conforti F, De Luca D, Statti GA, et al, Phytochemical profile, antioxidant, anti-inflammatory and hypoglycemic potential of hydroalcoholic extracts from Citrus medica L. cv Diamante flowers, leaves and fruits at two maturity stages. Food Chem Toxicol 49: 1549-1555 (2011).
19. Menichini F, Tundis R, Bonesi M, de Cindio B, Loizzo MR, Conforti F, et al, Chemical composition and bioactivity of Citrus medica L. cv. Diamante essential oil obtained by hydrodistillation, cold-pressing and supercritical carbon dioxide extraction. Nat Prod Res 15: 1-11 (2011).
20. Gao X, Ohlander M, Jeppsson N, Björk L and Trajkovski V, Changes in antioxidant effects and their relationship to phytonutrients in fruits of Sea buckthorn (Hippophae rhamnoides L.) during maturation. J Agric Food Chem 48: 1485-1490 (2000).
21. Yoo KM, Lee CH, Lee H, Moon BK and Lee CY, Relative antioxidant and cytoprotective activities of common herbs. Food Chem 106: 929-936 (2008).
22. Adams RP, Identification of Essential Oil Components by Gas Chromatography/Mass Spectroscopy. Allured Publishing, Carol Stream, IL (2001).
23. Loizzo MR, Tundis R, Menichini F, Statti GA and Menichini F, Influence of ripening stage on health benefits properties of Capsicum annuum var. acuminatum L.: in vitro studies. J Med Food 11: 184-189 (2008).
24. Re R, Pellegrini N, Proteggente A, Pannala A, Yang M and Rice-Evans C, Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 26: 1231-1237 (1996).
25. Benzie IF and Strains JJ, The ferric reducing ability of plasma (FRAP) as a measure of 'antioxidant power': The FRAP Assay. Anal Biochem 239: 70-76 (1996).
26. Menichini F, Tundis R, Loizzo MR, Bonesi M, Marrelli M, Statti GA, et al, Acetylcholinesterase and butyrylcholinesterase inhibition of ethanolic extract and monoterpenes from Pimpinella anisoides V Brig. (Apiaceae). Fitoterapia 80: 297-300 (2009).
27. Ghasemi K, Ghasemi Y and Ebrahimzadeh MA, Antioxidant activity, phenol and flavonoid contents of 13 Citrus species peels and tissues. Pakistan J Pharm Sci 22: 277-281 (2009).
28. Wang AY, Zhou MY and Lin WC, Antioxidative and anti-inflammatory properties of Citrus sulcata extracts. Food Chem 124: 958-963 (2010).
29. Nogata Y, Sakamoto K, Shiratsuchi H, Ishii T, Yano M and Ohta H, Flavonoid composition of fruit tissues of Citrus species. Biosci Biotechnol Biochem 70: 178-192 (2006).
30. Chisholm MG, Characterization of aroma volatiles in key lime essential oils (Citrus aurantifolia Swingle). Flavour Fragr J 18: 106-115 (2003).
31. Pellegrini M, Serafini B, Colombi D, del Rio S, Salvatora M and Bianchi Brighenti F, Total antioxidant capacity of plant foods, beverages and oils consumed in Italy by three different in vitro assays. J Nutr 133: 2812-2819 (2003).
32. Moon JK and Shibamoto T, Antioxidant assays for plant and food components. J Agric Food Chem 57: 1655-1666 (2009).
33. Song YY and Barlow PJ, Antioxidant capacity and phenolic content of selected fruit seeds. Food Chem 88: 411-417 (2004).
34. Rice Evans CA, Miller NJ and Paganga G, Antioxidant properties of phenolic compounds. Trends Plants Sci 4: 152-159 (1997).
35. Ballard CG, Greig NH, Guillozet-Bongaarts AL, Enz A and Darvesh S, Cholinesterases: Roles in the brain during health and disease. Curr Alzheimer Res 2: 307-318 (2005).
36. Miyazawa M and Yamafuji C, Inhibition of acetylcholinesterase activity by byciclic monoterpenoids. J Agric Food Chem 53: 1765-1768 (2005).
37. Loizzo MR, Tundis R, Menichini F and Menichini F, Natural products and their derivatives as cholinesterase inhibitors in the treatment of neurodegenerative disorders: an update. Curr Med Chem 15: 1209-1228 (2008).