Antioxidant effects of Citrus aurantifolia (Christm) juice and peel extract on LDL oxidation

Journal of Research in Medical Sciences

Volumn 16, Issue 7, 2011, Pages 951-955

  Boshtam, Maryam ^a   Moshtaghian, Jamal ^b   Naderi, Gholamali ^a   Asgary, Seddigheh ^c   Nayeri, Hashem ^d  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF ISFAHAN   (Iran)

^c ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

Antioxidant; Citrus aurantifolia (Christm); Juice; LDL oxidation; Peel

Indexed keywords

ANTIOXIDANT; CITRUS AURANTIFOLIA EXTRACT; DIMETHYL SULFOXIDE; FLAVONOID; LOW DENSITY LIPOPROTEIN; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD ANALYSIS; CHEMICAL MODIFICATION; CITRUS AURANTIFOLIA JUICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; FRUIT JUICE; IN VITRO STUDY; LIPID OXIDATION; LIPOPROTEIN BLOOD LEVEL; PHYSICAL CHEMISTRY; THERAPY EFFECT;

EID: 80052899796     PISSN: 17351995     EISSN: 17357136     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989; 320(14): 915-924.
2. Jeon SM, Bok SH, Jang MK, Lee MK, Nam KT, Park YB, et al. Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits. Life Sci 2001; 69(24): 2855-2866.
3. Retsky KL, Freeman MW, Frei B. Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti-rather than pro-oxidant activity of vitamin C in the presence of transition metal ions. J Biol Chem 1993; 268(2): 1304-1309.
4. Mojzisova G, Kuchta M. Dietary flavonoids and risk of coronary heart disease. Physiol Res 2001; 50(6): 529-535.
5. Miyake Y, Sakurai C, Usuda M, Fukumoto S, Hiramitsu M, Sakaida K, et al. Difference in plasma metabolite concentration after ingestion of lemon flavonoids and their aglycones in humans. J Nutr Sci Vitaminol (Tokyo) 2006; 52(1): 54-60.
6. Kamata K, Kobayashi T, Matsumoto T, Kanie N, Oda S, Kaneda A, et al. Effects of chronic administration of fruit extract (Citrus unshiu Marc) on endothelial dysfunction in streptozotocin-induced diabetic rats. Biol Pharm Bull 2005; 28(2): 267-270.
7. Sinclair WB. Some soluble and insoluble constituents of citrus fruits. In: Sinclair WB, Editor. The biochemistry and physiology of the lemon and other citrus fruits. California: University of California, Division of Agriculture and Natural Resources; 1984. p. 79-82.
8. Miyake Y, Yamamoto K, Osawa T. Isolation of eriocitrin (eriodictyol 7-rutinoside) from lemon fruit (Citrus limon BURM. f.) and its anti-oxidative activity. Food Sci Technol Int 1997; 3: 84-89.
9. Bronzert TJ, Brewer HB, Jr. New micromethod for measuring cholesterol in plasma lipoprotein fractions. Clin Chem 1977; 23(11): 2089-2098.
10. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193(1): 265-275.
11. Hooper L, Kroon PA, Rimm EB, Cohn JS, Harvey I, Le Cornu KA, et al. Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2008; 88(1): 38-50.
12. Chan T, Galati G, O'Brien PJ. Oxygen activation during peroxidase catalysed metabolism of flavones or flavanones. Chem Biol Interact 1999; 122(1): 15-25.
13. Ratty AK, Das NP. Effects of flavonoids on non-enzymatic lipid peroxidation: structure-activity relationship. Biochem Med Metab Biol 1988; 39(1): 69-79.
14. Ishikawa T, Suzukawa M, Ito T, Yoshida H, Ayaori M, Nishiwaki M, et al. Effect of tea flavonoid supplementation on the susceptibility of low-density lipoprotein to oxidative modification. Am J Clin Nutr 1997; 66(2): 261-266.
15. Gattuso G, Barreca D, Gargiulli C, Leuzzi U, Caristi C. Flavonoid composition of Citrus juices. Molecules 2007; 12(8): 1641-1673.
16. Bendich A, Machlina LJ, Scandurraa O, Burtonb OG, Wayner DD. The antioxidant role of vitamin C. Advances in Free Radical Biology & Medicine 1986; 2(2): 419-444.
17. Steinbrecher UP. Role of superoxide in endothelial-cell modification of low-density lipoproteins. Biochim Biophys Acta 1988; 959(1): 20-30.
18. Esterbauer H, Striegl G, Puhl H, Oberreither S, Rotheneder M, El Saadani M, et al. The role of vitamin E and carotenoids in preventing oxidation of low density lipoproteins. Ann N Y Acad Sci 1989; 570: 254-67.
19. Jialal I, Vega GL, Grundy SM. Physiologic levels of ascorbate inhibit the oxidative modification of low density lipoprotein. Atherosclerosis 1990; 82(3): 185-191.
20. Jialal I, Grundy SM. Preservation of the endogenous antioxidants in low density lipoprotein by ascorbate but not probucol during oxidative modification. J Clin Invest 1991; 87(2): 597-601.