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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 22, 2012, Pages 6888-6895

Discovery of novel pyrrolopyridazine scaffolds as transient receptor potential vanilloid (TRPV1) antagonists

(9) Dorange, Ismet a Forsblom, Rickard a MacSari, Istvan a Svensson, Mats a Bylund, Johan a Besidski, Yevgeni a Blid, Jan a Sohn, Daniel a Gravenfors, Ylva a

a ASTRAZENECA R AND D (Sweden)

Author keywords

Indolizine; Ligand gated ion channel; Pain; Pyrrolopyridazine; TRPV1; Vanilloid receptor

Indexed keywords

GLUTATHIONE; INDOLIZINE DERIVATIVE; NITROGEN; OXYGEN; PYRROLOPYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1 ANTAGONIST;

ARTICLE; CALCIUM TRANSPORT; LIGHT; LIPOPHILICITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; DRUG EVALUATION, PRECLINICAL; HUMANS; INDOLIZIDINES; MICROSOMES, LIVER; PYRIDAZINES; PYRROLES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRPV CATION CHANNELS;

EID: 84867892756 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.09.059 Document Type: Article

Times cited : (14)

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- Scheme 1.

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