N-4-t-Butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the A-region

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 1, 2012, Pages 215-224

  Kim, Yong Soo ^a   Kil, Min Jung ^a   Kang, Sang Uk ^a   Ryu, Hyungchul ^a   Kim, Myeong Seop ^a   Cho, Yongsung ^a   Bhondwe, Rahul S ^a   Thorat, Shivaji A ^a   Sun, Wei ^b   Liu, Keliang ^b   Lee, Jin Hee ^c   Choi, Sun ^c   Pearce, Larry V ^d   Pavlyukovets, Vladimir A ^d   Morgan, Matthew A ^d   Tran, Richard ^d   Lazar, Jozsef ^d   Blumberg, Peter M ^d   Lee, Jeewoo ^a  

^a Seoul National University   (South Korea)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c Ewha Womans University   (South Korea)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Analgesic; Capsaicin; Molecular modeling; Resiniferatoxin; TRPV1 antagonists

Indexed keywords

ETHYL 2 (2 CHLORO 4 NITROPHENYL)PROPIONATE; ETHYL 2 (3 BROMO 4 NITROPHENYL)PROPIONATE; ETHYL 2 (3 CHLORO 4 NITROPHENYL)PROPIONATE; ETHYL 2 (3 CYANO 4 NITROPHENYL)PROPIONATE; ETHYL 2 (3 FLUORO 4 NITROPHENYL)PROPIONATE; ETHYL 2 (3 IODO 4 NITROPHENYL)PROPIONATE; ETHYL 2 (3 MORPHOLINO 4 NITROPHENYL)PROPIONATE; ETHYL 2 (3 PIPERIDINO 4 NITROPHENYL)PROPIONATE; ETHYL 2 (3,5 DIFLUORO 4 NITROPHENYL)PROPIONATE; ETHYL 2 (4 AMINO 2 CHLOROPHENYL)PROPIONATE; ETHYL 2 (4 AMINO 2 FLUOROPHENYL)PROPIONATE; ETHYL 2 (4 AMINO 3 BROMOPHENYL)PROPIONATE; ETHYL 2 (4 AMINO 3 CHLOROPHENYL)PROPIONATE; ETHYL 2 (4 AMINO 3 CYANOPHENYL)PROPIONATE; ETHYL 2 (4 AMINO 3 FLUOROPHENYL)PROPIONATE; ETHYL 2 (4 AMINO 3 IODOPHENYL)PROPIONATE; ETHYL 2 (4 AMINO 3 MORPHOLINOPHENYL)PROPIONATE; ETHYL 2 (4 AMINO 3 PIPERIDINOPHENYL)PROPIONATE; ETHYL 2 (4 AMINO 3,5 DIFLUOROPHENYL)PROPIONATE; ETHYL 2 [2 CHLORO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONATE; ETHYL 2 [2 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONATE; ETHYL 2 [3 (TERT BUTOXYCARBONYL)PIPERAZINO 4 NITROPHENYL]PROPIONATE; ETHYL 2 [3 BROMO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONATE; ETHYL 2 [3 CHLORO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONATE; ETHYL 2 [3 CYANO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONATE; ETHYL 2 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONATE; ETHYL 2 [3 IODO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONATE; ETHYL 2 [3,5 DIFLUORO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANILLOID RECEPTOR 1 ANTAGONIST;

ALKYLATION; ANALGESIC ACTIVITY; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HYDROGEN BOND; HYDROLYSIS; HYDROPHOBICITY; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PROTEIN BINDING; RAT; SEQUENCE HOMOLOGY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; BINDING SITES; CHO CELLS; COMPUTER SIMULATION; CRICETINAE; CRICETULUS; HUMANS; HYDROGEN BONDING; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRPV CATION CHANNELS;

EID: 84855188641     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.11.008     Document Type: Article

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