DNA binding ligands targeting drug-resistant bacteria: Structure, activity, and pharmacology

Journal of Medicinal Chemistry

Volumn 46, Issue 18, 2003, Pages 3914-3929

  Kaizerman, Jacob A ^a   Gross, Matthew I ^a   Ge, Yigong ^a   White, Sarah ^a   Hu, Wenhao ^a   Duan, Jian Xin ^a   Baird, Eldon E ^a   Johnson, Kirk W ^a   Tanaka, Richard D ^a   Moser, Heinz E ^a   Bürli, Roland W ^a  

^a Genesoft Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 [1 METHYL 4 [1 METHYL 4 [1 METHYL 4 (3 CHLOROTHIOPHENE 2 CARBOXAMIDO) 2 PYRROLECARBOXAMIDO] 2 PYRROLECARBOXAMIDO] 2 PYRROLECARBOXAMIDO]ETHYL]MORPHOLINE; ANTIBIOTIC AGENT; BACTERIAL DNA; BACTERIAL RNA; BENZAMIDE DERIVATIVE; BENZOTHIOPHENE DERIVATIVE; ISOQUINOLINE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENETICS; BACTERIAL PERITONITIS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA DRUG COMPLEX; DNA REPLICATION; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG TARGETING; FEMALE; GRAM POSITIVE BACTERIUM; IN VIVO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PENICILLIN RESISTANT STREPTOCOCCUS PNEUMONIAE; RNA TRANSCRIPTION; STRUCTURE ACTIVITY RELATION; VANCOMYCIN RESISTANT ENTEROCOCCUS FAECALIS;

ACUTE TOXICITY TESTS; ANIMALS; ANTI-BACTERIAL AGENTS; DISTAMYCINS; DNA; DRUG RESISTANCE, BACTERIAL; FEMALE; GRAM-POSITIVE BACTERIA; LIGANDS; MICE; MICE, INBRED ICR; MICROBIAL SENSITIVITY TESTS; MORPHOLINES; PERITONITIS; PYRROLES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0041418315     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030097a     Document Type: Article

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