2-(4-Methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the B and C-regions

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 3, 2012, Pages 1310-1318

  Sun, Wei ^a   Liu, Keliang ^a   Ryu, Hyungchul ^b   Kang, Dong Wook ^b   Kim, Yong Soo ^b   Kim, Myeong Seop ^b   Cho, Yongsung ^b   Bhondwe, Rahul S ^b   Thorat, Shivaji A ^b   Kim, Ho Shin ^b   Pearce, Larry V ^c   Pavlyukovets, Vladimir A ^c   Tran, Richard ^c   Morgan, Matthew A ^c   Lazar, Jozsef ^c   Ryder, Christopher B ^c   Toth, Attila ^c   Blumberg, Peter M ^c   Lee, Jeewoo ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Seoul National University   (South Korea)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Analgesic; Capsaicin; Resiniferatoxin; TRPV1 antagonists

Indexed keywords

2 (3 FLUORO 4 METHANESULFONYLAMINOPHENYL) N (4 IODOBENZYL) PROPIONAMIDE; 2 (4 METHYLSULFONYLAMINOPHENYL) PROPANAMIDE; N (1 NAPHTHYLMETHYL) 2 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONAMIDE; N (1,2,3,4 TETRAHYDRO 1 NAPHTHALENYL) 2 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONAMIDE; N (2 BROMO 4 TERT BUTYLBENZYL) 2 (3 FLUORO 4 METHANESULFONYLAMINOPHENYL) PROPIONAMIDE; N (3,3 DIPHENYL 2 PROPENYL) 2 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONAMIDE; N (3,4 DICHLOROBENZYL) 2 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONAMIDE; N (4 BIPHENYLMETHYL) 2 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONAMIDE; N (4 BROMOBENZYL) 2 (3 FLUORO 4 METHANESULFONYLAMINOPHENYL) PROPIONAMIDE; N (4 CHLOROBENZYL) 2 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL] PROPIONAMIDE; N (4 CYCLOHEXYLBENZYL) 2 (3 FLUORO 4 METHANESULFONYLAMINOPHENYL) PROPIONAMIDE; N (4 CYCLOPENT 2 ENYLBENZYL) 2 (3 FLUORO 4 METHANESULFONYLAMINOPHENYL) PROPIONAMIDE; N (4 CYCLOPENTYLBENZYL) 2 (3 FLUORO 4 METHANESULFONYLAMINOPHENYL) PROPIONAMIDE; N (4 CYCLOPROPYLBENZYL) 2 (3 FLUORO 4 METHANESULFONYLAMINOPHENYL) PROPIONAMIDE; N (4 ISOPROPYLBENZYL) 2 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONAMIDE; N (4 METHOXYBENZYL) 2 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONAMIDE; N (4 TERT BUTYLBENZYL) 1 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL]CYCLOPROPANECARBOXAMIDE; N (4 TERT BUTYLBENZYL) 1 [3 METHOXY 4 (METHYLSULFONYLAMINO)PHENYL]CYCLOPROPANECARBOXAMIDE; N (4 TERT BUTYLBENZYL) 1 [4 (METHYLSULFONYLAMINO)PHENYL]CYCLOPROPANECARBOXAMIDE; N (4 TERT BUTYLBENZYL) 2 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL] 2 METHYLPROPIONAMIDE; N (4 TERT BUTYLBENZYL) 2 [3 METHOXY 4 (METHYLSULFONYLAMINO)PHENYL] 2 METHYLPROPIONAMIDE; N (4 TERT BUTYLBENZYL) 2 [4 (METHYLSULFONYLAMINO) PHENYL] 2 METHYLPROPIONAMIDE; N (4 TRIFLUOROMETHYLBENZYL) 2 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONAMIDE; N 4 TERT BUTYLBENZYL 2 (3 FLUORO 4 METHYLSULFONYLAMINOPHENYL) PROPANAMIDE; N [1 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL]ETHYL] 3 (4 TERT BUTYLPHENYL) 2 PROPENAMIDE; N [1 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL]ETHYL] 3 (4 TERT BUTYLPHENYL) PROPANAMIDE; N [1 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL]ETHYL] 3 (4 TERT BUTYLPHENYL)ACETAMIDE; N [3,3 DI(4 METHYLPHENYL) 2 PROPENYL] 2 [3 FLUORO 4 (METHYLSULFONYLAMINO)PHENYL]PROPIONAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANILLOID RECEPTOR 1 ANTAGONIST;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG POTENCY; DRUG STRUCTURE; IN VITRO STUDY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANALGESICS; ANIMALS; CHO CELLS; CRICETINAE; HUMANS; MESYLATES; PHENYLPROPIONATES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRPV CATION CHANNELS;

EID: 84856223261     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.12.014     Document Type: Article

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