Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET

Nuclear Medicine and Biology

Volumn 39, Issue 8, 2012, Pages 1266-1274

  Deroose, Christophe M ^a,b,c   Chitneni, Satish K ^b,c   Gijsbers, Rik ^b,c   Vermaelen, Peter ^a,c   Ibrahimi, Abdelilah ^b,c   Balzarini, Jan ^d   Baekelandt, Veerle ^b,c   Verbruggen, Alfons ^b,c   Nuyts, Johan ^a,c   Debyser, Zeger ^b,c   Bormans, Guy M ^b,c   Mortelmans, Luc ^a,c  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c KU Leuven   (Belgium)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Bicyclic nucleoside analogue; Herpes simplex virus type 1 thymidine kinase; Mouse; Positron emission tomography; Reporter gene; Varicella zoster virus thymidine kinase

Indexed keywords

3 (2' DEOXY BETA DEXTRO RIBOFURANOSYL) 6 (3 FLUOROETHOXYPHENYL) 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2 ONE F 18; 3 (2' DEOXY BETA DEXTRO RIBOFURANOSYL) 6 (3 METHOXYPHENYL) 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2 ONE C 11; 3 (2' DEOXY BETA DEXTRO RIBOFURANOSYL) 6 (4 FLUOROETHOXYPHENYL) 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2 ONE F 18; 3 (2' DEOXY BETA DEXTRO RIBOFURANOSYL) 6 (4 METHOXYPHENYL) 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2 ONE C 11; BICYCLIC NUCLEOSIDE DERIVATIVE; DRUG METABOLITE; HYBRID PROTEIN; LENTIVIRUS VECTOR; NUCLEOSIDE DERIVATIVE; THYMIDINE; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOACCUMULATION; CELL LEVEL; CONTROLLED STUDY; DRUG HALF LIFE; DRUG METABOLISM; DRUG UPTAKE; FEMALE; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VIVO STUDY; ISOTOPE LABELING; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; REPORTER GENE; THYMIDINE KINASE GENE; TUMOR XENOGRAFT; VALIDATION STUDY; VARICELLA ZOSTER VIRUS; VIRAL GENE DELIVERY SYSTEM; VIRUS GENE;

ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; FLUORINE RADIOISOTOPES; GENES, REPORTER; GENETIC VECTORS; HEK293 CELLS; HERPESVIRUS 3, HUMAN; HUMANS; INTRACELLULAR SPACE; KINETICS; LENTIVIRUS; MALE; MICE; NUCLEOSIDES; POSITRON-EMISSION TOMOGRAPHY; PROSTATIC NEOPLASMS; REPRODUCIBILITY OF RESULTS; THYMIDINE KINASE; TRANSDUCTION, GENETIC; VIRAL LOAD;

EID: 84867889097     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2012.06.014     Document Type: Article

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