Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography

Journal of Medicinal Chemistry

Volumn 50, Issue 5, 2007, Pages 1041-1049

  Chitneni, Satish K ^a   Deroose, Christophe M ^a   Balzarini, Jan ^b   Gijsbers, Rik ^a   Celen, Sofie J L ^a   De Groot, Tjibbe J ^a   Debyser, Zeger ^a   Mortelmans, Luc ^a   Verbruggen, Alfons M ^a   Bormans, Guy M ^a,c  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c NONE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2' DEOXY BETA DEXTRO RIBOFURANOSYL) 6 (3 FLUOROETHOXYPHENYL) 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2 ONE F 18; 3 (2' DEOXY BETA DEXTRO RIBOFURANOSYL) 6 (3 METHOXYPHENYL) 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2 ONE C 11; ALKYLATING AGENT; BICYCLO COMPOUND; CARBON 11; FLUORINE 18; NUCLEOSIDE ANALOG; PHENOL; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; DRUG DISTRIBUTION; DRUG SYNTHESIS; DRUG UPTAKE; EVALUATION; GENE EXPRESSION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; ISOTOPE LABELING; MOUSE; NEUROIMAGING; NON INVASIVE MEASUREMENT; NONHUMAN; PLASMA; POSITRON EMISSION TOMOGRAPHY; REACTION ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS; VARICELLA ZOSTER VIRUS;

ANIMALS; BRAIN; CARBON RADIOISOTOPES; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORINE RADIOISOTOPES; GENE EXPRESSION; HERPESVIRUS 3, HUMAN; HUMANS; MALE; MICE; POSITRON-EMISSION TOMOGRAPHY; PYRIMIDINE NUCLEOSIDES; RADIOPHARMACEUTICALS; THYMIDINE KINASE; TISSUE DISTRIBUTION;

EID: 33847783726     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060964m     Document Type: Article

References (29)

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