Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus

Molecular Therapy

Volumn 6, Issue 1, 2002, Pages 73-82

  Liang, Qianwa ^a   Gotts, Jeff ^a   Satyamurthy, Nagichettiar ^a   Barrio, Jorge ^a   Phelps, Michael E ^a   Gambhir, Sanjiv S ^a   Herschman, Harvey R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adenovirus; Bicistronic vector; Dopamine receptor; Gene therapy; Herpes simplex virus type 1 thymidine kinase; Molecular imaging; PET scanning; Positron emission tomography; Reporter gene

Indexed keywords

ADENOVIRUS VECTOR; DNA; DOPAMINE 2 RECEPTOR; THYMIDINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOMEGALOVIRUS; DRUG MONITORING; ENCEPHALOMYOCARDITIS VIRUS; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSCRIPTION; HERPES SIMPLEX VIRUS; IN VIVO STUDY; INTERNAL RIBOSOME ENTRY SITE; MALE; NON INVASIVE MEASUREMENT; NONHUMAN; PHENOTYPE; POSITRON EMISSION TOMOGRAPHY; QUANTITATIVE ANALYSIS; RAT; REPORTER GENE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ADENOVIRIDAE; ANIMALIA; CYTOMEGALOVIRUS; ENCEPHALOMYOCARDITIS VIRUS; HERPES; HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 0036665466     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2002.0626     Document Type: Article

References (35)

1. Yang, M., et al. (2001). Whole-body and intravital optical imaging of angiogenesis in orthotopically implanted tumors. Proc. Natl. Acad. Sci. USA 98: 2616-2621.
2. Contag, C. H., Jenkins, D., Contag, P. R., and Negrin, R. S. (2000). Use of reporter genes for optical measurements of neoplastic disease in vivo. Neoplasia 2: 41-52.
3. Bhaumik, S., and Gambhir, S. S. (2002). Optical imaging of Renilla luciferase reporter gene expression in living mice. Proc. Natl. Acad. Sci, USA. 99: 377-382.
4. Weissleder, R., et al. (2000). In vivo magnetic resonance imaging of transgene expression. Nat. Med. 6: 351-355.
5. Tjuvajev, J. G., et al. (1996). Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy. Cancer Res. 56: 4087-4095.
6. Herschman, H. R., et al. (2000). Seeing is believing: non-invasive, quantitative and repetitive imaging of reporter gene expression in living animals, using positron emission tomography. J. Neurosci. Res. 59: 699-705.
7. Ray, P., et al. (2001). Monitoring gene therapy with reporter gene imaging. Semin. Nucl. Med. 31: 312-320.
8. Phelps, M. E. (2000). Positron emission tomography provides molecular imaging of biological processes. Proc. Nat. Acad. Sci. USA 97: 9226-9233.
9. Chatziioannou, A. F., et al. (1999). Performance evaluation of microPET: a high-resolution leutetium oxyorthosilicate PET scanner for animal imaging. J. Nucl. Med. 40: 1164-1175.
10. Barrio, J. R., et al. (1989). 3-(2'-[18F]fluoroethyl)spiperone: in vivo biochemical and kinetic characterization in rodents, nonhuman primates, and humans. J. Cereb. Blood Flow Metab. 9: 830-839.
11. Phelps, M. E. (1991). PET: a biological imaging technique. Neurochem. Res. 16: 929-940.
12. 2 receptor as a reporter gene in living animals. Gene Ther. 6: 785-791.
13. 18F]-Fluoropenciclovir: an improved reporter probe for imaging HSV1-tk reporter gene expression in vivo using positron emission tomography. J. Nucl. Med. 42: 96-105.
14. 18F]FHBG): a new potential imaging agent for viral infection and gene therapy using PET. Nucl. Med. Biol. 25: 175-180.
15. Tjuvajev, J. G., et al. (1998). Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography. Cancer Res. 58: 4333-4341.
16. Black, M. E., Newcomb, T. G., Wilson, H-M. P., and Loeb, L. A. (1996). Creation of drug-specific herpes simplex Virus type 1 thymidine kinase mutant for gene therapy. Proc. Natl. Acad. Sci. USA 93: 3525-3529.
17. Gambhir, S. S., et al. (2000). A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography. Proc. Natl. Acad. Sci. USA 97: 2785-2790.
18. Yu, Y., et al. (2000). Quantification of target gene expression by imaging reporter gene expression in living animals. Nat. Med. 6: 933-937.
19. 2 receptor reporter gene in which ligand binding is uncoupled from signal transduction. Gene Ther. 8: 1490-1498.
20. Herz, J., and Girard, R. D. (1993). Adenovirus-mediated transfer of low-density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc. Natl. Acad. Sci. USA 90: 2812-2816.
21. Greco, O., and Dachs, G. U. (2001). Gene directed enzyme/prodrug therapy of cancer: historical appraisal and future prospectives. J. Cell Physiol. 187: 22-36.
22. Jacobs, A., et al. (2001). Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas. Lancet 358: 727-729.
23. Tjuvajev, J. G., et al. (1999). A general approach to the non-invasive imaging of transgenes using cis-linked herpes simplex virus thymidine kinase. Neoplasia 1: 315-320.
24. Kamoshita, N., Tsukiyama-Kohara, K., Kohara, M., and Nomoto, A. (1997). Genetic analysis of internal ribosomal entry site on hepatitis C virus RNA: implication for involvement of the highly ordered structure and cell type-specific transacting factors. Virology 233: 9-18.
25. Rogers, B. E., Zinn, K. R., and Buchsbaum, D. J. (2000). Gene transfer strategies for improving radiolabeled peptide imaging and therapy. Q. J. Nucl. Med. 44: 208-223.
26. 188Re. J. Nucl. Med. 41: 887-895.
27. Hemminki, A., et al. (2001). An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression. Mol. Ther. 4: 223-231, doi:10.1006/mthe.2001.0446.
28. Loimas, S., Wahlfors, J., and Jänne, J. (1998). Herpes simplex virus thymidine kinase-green fluorescent protein fusion gene: new tool for gene transfer studies and gene therapy. Biotechniques 24: 614-618.
29. Steffens, S., et al. (2000). Enhanced green fluorescent protein fusion proteins of herpes simplex virus type 1 thymidine kinase and cytochrome P450 4B1: applications for prodrug-activating gene therapy. Cancer Gene Ther. 7: 806-812.
30. Jacobs, A., et al. (1999). Functional coexpression of HSV-1 thymidine kinase and green fluorescent protein: implications for noninvasive imaging of transgene expression. Neoplasia 1: 154-161.
31. Strathdee, C. A., McLeod, M. R., and Underhill, T. M. (2000). Dominant positive and negative selection using luciferase, green fluorescent protein and β-galactosidase reporter gene fusions. Biotechniques 28: 210-214.
32. Sun, X., et al. (2001). Quantitative imaging of gene induction in living animals. Gene Ther. 8: 1572-1579.
33. Yaghoubi, S. S., et al. (2001). Direct correlation between positron emission tomographic images of two reporter genes delivered by two distinct adenoviral vectors. Gene Ther. 8: 1072-1080.
34. Satyamurthy, N., et al. (1990). 3-(2′-[18F]fluoroethyl)spiperone, a potent dopamine antagonist: synthesis, structural analysis and in vivo utilization in humans. Appl. Radiat. Isot. 41: 113-129.
35. Qi, J., et al. (1998). High-resolution 3D Bayesian image reconstruction using the microPET small-animal scanner. Phys. Med. Biol. 43: 1001-1013.