A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression

Journal of Medicinal Chemistry

Volumn 50, Issue 26, 2007, Pages 6627-6637

  Chitneni, Satish K ^b   Deroose, Christophe M ^a,c   Balzarini, Jan ^d   Gijsbers, Rik ^e   Celen, Sofie ^b   Debyser, Zeger ^e   Mortelmans, Luc ^c   Verbruggen, Alfons M ^b   Bormans, Guy M ^b,f  

^a KU Leuven   (Belgium)

^b Department of Pharmaceutical and Pharmacological Sciences   (Belgium)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^e UNIVERSITY OF LEUVEN   (Belgium)

^f Onderwijs and Navorsing 2 Herestraat 49 Bus 821 ^*  (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2' DEOXY BETA DEXTRO RIBOFURANOSYL) 6 (4 METHOXYPHENYL) 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 (2' DEOXY BETA DEXTRO RIBOFURANOSYL) 6 [4 (1 FLUOROETHOXY)PHENYL] 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2(3H) ONE; 3 METHOXYPHENYL BICYCLIC NUCLEOSIDE ANALOG; 4 FLUOROETHOXYPHENYL BICYCLIC NUCLEOSIDE ANALOG; BICYCLO COMPOUND; CARBON 11; FLUORINE 18; FLUORODEOXYGLUCOSE F 18; NUCLEOSIDE ANALOG; THYMIDINE KINASE; TRACER; UNCLASSIFIED DRUG; 3 (2' DEOXYRIBOFURANOSYL) 6 (4 (1 FLUOROETHOXY)PHENYL) 2,3 DIHYDROFURO(2,3 D)PYRIMIDIN 2(3H) ONE; 3 (2' DEOXYRIBOFURANOSYL) 6 (4 METHOXYPHENYL) 2,3 DIHYDROFURO(2,3 D)PYRIMIDIN 2(3H) ONE; 3-(2'-DEOXYRIBOFURANOSYL)-6-(4-(1-FLUOROETHOXY)PHENYL)-2,3-DIHYDROFURO(2,3-D)PYRIMIDIN-2(3H)-ONE; 3-(2'-DEOXYRIBOFURANOSYL)-6-(4-METHOXYPHENYL)-2,3-DIHYDROFURO(2,3-D)PYRIMIDIN-2(3H)-ONE; CARBON; FLUORINE; FUSED HETEROCYCLIC RINGS; PYRIMIDINE NUCLEOSIDE; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; DRUG DISTRIBUTION; DRUG SCREENING; DRUG SYNTHESIS; DRUG TRANSPORT; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PARTITION COEFFICIENT; POSITRON EMISSION TOMOGRAPHY; RADIOCHEMISTRY; REPORTER GENE; VARICELLA ZOSTER VIRUS; ANIMAL; BIOSYNTHESIS; CELL LINE; ENZYMOLOGY; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TISSUE DISTRIBUTION;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CARBON RADIOISOTOPES; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORINE RADIOISOTOPES; GENES, REPORTER; HERPESVIRUS 3, HUMAN; HUMANS; MALE; MICE; PHOSPHORYLATION; POSITRON-EMISSION TOMOGRAPHY; PYRIMIDINE NUCLEOSIDES; RADIOPHARMACEUTICALS; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE KINASE; TISSUE DISTRIBUTION;

EID: 37349129267     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm700971p     Document Type: Article

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