Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats

Food and Function

Volumn 3, Issue 6, 2012, Pages 643-650

  Galindo, P ^a   Gonzalez Manzano S ^b   Zarzuelo, M J ^a   Gomez Guzman M ^a   Quintela, A M ^a   Gonzalez Paramas A ^b   Santos Buelga, C ^b   Perez Vizcaino F ^c,d   Duarte, J ^a   Jimenez R ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSITY OF SALAMANCA   (Spain)

^c SCHOOL OF MEDICINE   (Spain)

^d INSTITUTO DE INVESTIGACIÓN SANITARIA DEL HOSPITAL CLÍNICO SAN CARLOS IDISSC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-HYPERTENSIVE ACTIVITIES; ENDOTHELIAL DYSFUNCTION; INTRAPERITONEAL ADMINISTRATION; METABOLITE PROFILES; ORAL ADMINISTRATION; SPONTANEOUSLY HYPERTENSIVE RATS; SYSTOLIC BLOOD PRESSURE; VASCULAR OXIDATIVE STRESS;

METABOLITES; PHENOLS; RATS;

FLAVONOIDS;

ANTIHYPERTENSIVE AGENT; PROTECTIVE AGENT; QUERCETIN;

ANIMAL; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECT; GENE EXPRESSION; HEART RATE; HUMAN; HYPERTENSION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; GENE EXPRESSION; HEART RATE; HUMANS; HYPERTENSION; INJECTIONS, INTRAPERITONEAL; MALE; PROTECTIVE AGENTS; QUERCETIN; RATS; RATS, INBRED SHR;

EID: 84867864631     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c2fo10268d     Document Type: Article

References (49)

1. P. M. Kris-Etherton, M. Lefevre, G. R. Beecher, M. D. Gross, C. L. Keen and T. D. Etherton, Bioactive compounds in nutrition and health-research methodologies for establishing biological function: the antioxidant and anti-inflammatory effects of flavonoids on atherosclerosis, Annu. Rev. Nutr., 2004, 24, 511-538.
2. M. F. Ullah and M. W. Khan, Food as medicine: potential therapeutic tendencies of plant derived polyphenolic compounds, Asian Pac. J. Cancer Prev., 2008, 9, 187-195.
3. A. Scalbert and G. Williamson, Dietary intake and bioavailability of polyphenols, J. Nutr., 2000, 130, 2073S-2085S.
4. C. Manach, A. Scalbert, C. Morand, C. Rémésy and L. Jiménez, Polyphenols: food sources and bioavailability, Am. J. Clin. Nutr., 2004, 79, 727-747.
5. M. G. Hertog, E. J. Feskens, P. C. Hollman, M. B. Katan and D. Kromhout, Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study, Lancet, 1993, 342, 1007-1011.
6. P. Knekt, J. Kumpulainen, R. Jarvinen, H. Rissanen, M. Heliovaara, A. Reunanen, T. Hakulinen and A. Aromaa, Flavonoid intake and risk of chronic diseases, Am. J. Clin. Nutr., 2002, 76, 560-568.
7. I. C. Arts and P. C. Hollman, Polyphenols and disease risk in epidemiologic studies, Am. J. Clin. Nutr., 2005, 81, 317S-325S.
8. J. V. Formica and W. Regelson, Review of the biology of quercetin and related bioflavonoids, Food Chem. Toxicol, 1995, 33, 1061-180.
9. J. Duarte, R. Pérez-Palencia, F. Vargas, M. A. Ocete, F. Pérez-Vizcaino, A. Zarzuelo and J. Tamargo, Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats, Br. J. Pharmacol., 2001, 133, 117-124.
10. J. Duarte, R. Jiménez, F. O'Valle, M. Galisteo, R. Pérez-Palencia, F. Vargas, F. Pérez-Vizcaíno, A. Zarzuelo and J. Tamargo, Protective effects of the flavonoid quercetin in chronic nitric oxide deficient rats, J. Hypertens., 2002, 20, 1843-1854.
11. M. Galisteo, M. F. García-Saura, R. Jiménez, I. C. Villar, R. Wangensteen, A. Zarzuelo, F. Vargas and J. Duarte, Effects of quercetin treatment on vascular function in deoxycorticosterone acetate-salt hypertensive rats. Comparative study with verapamil, Planta Med., 2004, 70, 334-341.
12. M. F. García-Saura, M. Galisteo, I. C. Villar, A. Bermejo, A. Zarzuelo, F. Vargas and J. Duarte, Effects of chronic quercetin treatment in experimental renovascular hypertension, Mol. Cell. Biochem., 2005, 270, 147-155.
13. M. Sánchez, M. Galisteo, R. Vera, I. C. Villar, A. Zarzuelo, J. Tamargo, F. Pérez-Vizcaíno and J. Duarte, Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats, J. Hypertens., 2006, 24, 75-84.
14. I. Mackraj, T. Govender and S. Ramesar, The antihypertensive effects of quercetin in a salt-sensitive model of hypertension, J. Cardiovasc. Pharmacol., 2008, 51, 239-245.
15. R. L. Edwards, T. Lyon, S. E. Litwin, A. Rabovsky, J. D. Symons and T. Jalili, Quercetin reduces blood pressure in hypertensive subjects, J. Nutr., 2001, 137, 2405-2411.
16. Y. Y. Yamamoto and E. Oue, Antihypertensive effect of quercetin in rats fed with a high-fat high-sucrose diet, Bioscl, Biotechnol, Biochem., 2006, 70, 933-939.
17. M. F. Montenegro, E. M. Neto-Neves, C. A. Dias-Junior, C. S. Ceron, M. M. Castro, V. A. Gomes, A. Kanashiro and J. E. Tanus-Santos, Quercetin restores plasma nitrite and nitroso species levels in renovascular hypertension, Naunyn-Schmiedebergs Arch. Pharmacol, 2010, 382, 293-301.
18. F. Perez-Vizcaino and J. Duarte, Flavonols and cardiovascular disease, Mol. Aspects Med, 2010, 31, 478-494.
19. F. Perez-Vizcaino, J. Duarte, R. Jimenez, C. Santos-Buelga and A. Osuna, Antihypertensive effects of the flavonoid quercetin, Pharmacol. Rep., 2009, 61, 67-75.
20. S. Benito, D. Lopez, M. P. Sáiz, S. Buxaderas, J. Sánchez, P. Puig-Parellada and M. T. Mitjavila, A flavonoid-rich diet increases nitric oxide production in rat aorta, Br. J. Pharmacol., 2002, 135, 910-916.
21. T. Jalili, J. Carlstrom, S. Kim, D. Freeman, H. Jin, T. C. Wu, S. E. Litwin and J. David Symons, Quercetin-supplemented diets lower blood pressure and attenuate cardiac hypertrophy in rats with aortic constriction, J. Cardiovasc. Pharmacol., 2006, 47, 531-541.
22. J. Carlstrom, J. D. Symons, T. C. Wu, R. S. Bruno, S. E. Litwin and T. Jalili, A quercetin supplemented diet does not prevent cardiovascular complications in spontaneously hypertensive rats, J. Nutr., 2007, 137, 628-633.
23. M. Romero, R. Jiménez, B. Hurtado, J. M. Moreno, I. Rodríguez-Gómez, R. López-Sepúlveda, A. Zarzuelo, F. Pérez-Vizcaino, J. Tamargo, F. Vargas and J. Duarte, Lack of beneficial metabolic effects of quercetin in adult spontaneously hypertensive rats, Eur. J. Pharmacol., 2010, 627, 242-250.
24. Y. Kawai, S. Saito, T. Nishikawa, A. Ishisaka, K. Murota and J. Terao, Different profiles of quercetin metabolites in rat plasma: comparison of two administration methods, Biosci., Biotechnol, Biochem., 2009, 73, 517-523.
25. R. Jimenez, R. López-Sepülveda, M. Kadmiri, M. Romero, R. Vera, M. Sanchez, F. Vargas, F. O'Valle, A. Zarzuelo, M. Duenas, C. Santos-Buelga and J. Duarte, Polyphenols restore endothelial function in DOCA-salt hypertension: role of endothelin-I and NADPH oxidase, Free Radical Biol. Med., 2007, 43, 462-673.
26. M. J. Mulvany and W. Halpern, Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats, Circ. Res., 1977, 41, 19-26.
27. F. Lodi, A. Cogolludo, J. Duarte, L. Moreno, A. Coviello, M. Peral De Bruno, R. Vera, M. Galisteo, R. Jiménez, J. Tamargo and F. Perez-Vizcaino, Increased NADPH oxidase activity mediates spontaneous aortic tone in genetically hypertensive rats, Eur. J. Pharmacol., 2006, 544, 97-103.
28. S. Egert, A. Bosy-Westphal, J. Seiberl, C. Kürbitz, U. Settler, S. Plachta-Danielzik, A. E. Wagner, J. Frank, J. Schrezenmeir, G. Rimbach, S. Wolffram and M. J. Müller, Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled crossover study, Br. J. Nutr., 2009, 102, 1065-1074.
29. G. Lukas, S. D. Brindle and P. Greengard, The route of absorption of intraperitoneally administered compounds, J. Pharmacol. Exp. Ther., 1971, 178, 562-564.
30. E. M. Hein, K. Rose, G. van't Slot, A. W. Friedrich and H. U. Humpf, Deconjugation and degradation of flavonol glycosides by pig cecal microbiota characterized by fluorescence in situ hybridization (FISH), J. Agric. Food Chem., 2008, 56, 2281-2290.
31. S. Barnes, J. Prasain, T. D'Alessandro, A. Arabshahi, N. Botting, M. A. Lila, G. Jackson, E. M. Janle and C. M. Weaver, The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems. Food Funct., 2011, 2, 235-44.
32. V. Crespy, C. Morand, C. Besson, N. Cotelle, H. Vézin, C. Demigné and C. Rémésy, The splanchnic metabolism of flavonoids highly differed according to the nature of the compound, Am. J. Physiol. Gastroinlest. Liver Physiol., 2003, 284, G980-G988.
33. B. A. Graf, C. Ameho, G. G. Dolnikowski, P. E. Milbury, C. Y. Chen and J. B. Blumberg, Rat gastrointestinal tissues metabolize quercetin, J. Nutr., 2006, 136, 39-44.
34. K. A. O'Leary, A. J. Day, P. W. Needs, F. A. Mellon, N. M. O'Brien and G. Williamson, Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism, Biochem. Pharmacol., 2003, 65. 479-191.
35. C. Menéndez, M. Dueñas, P. Galindo, S. González- Manzano, R. Jiménez, L. Moreno, M. J. Zarzuelo, I. Rodríguez- Gómez, J. Duarte, C. Santos-Buelga and F. Perez-Vizcaino, Vascular deconjugation of quercetin glucuronide. The flavonoid paradox revealed?, Mol. Nutr. Food Res., 2011, 55, 1780-1790.
36. P. Galindo, I. Rodriguez-Gómez, S. González-Manzano, M. Dueñas, R. Jiménez, C. Menéndez, F. Vargas, J. Tamargo, C. Santos-Buelga, F. Pérez-Vizcaíno and J Duarte, Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation, Plos One, 2012, 7, e32673.
37. S. Grunfeld, C. A. Hamilton, S. Mesaros, S. W. McClain, A. F. Dominiczak, D. F. Bohr and T. Malinski, Role of superoxide in the depressed nitric oxide production by the endothelium of genetically hypertensive rats, Hypertension, 1995, 26, 854-857.
38. H. Suzuki, A. Swei, B. W. Zweifach and G. W. Schmid-Schönbein, In vivo evidence for microvascular oxidative stress in spontaneously hypertensive rats. Hydroethidine microfluorography, Hypertension, 1995, 25, 1083-1089.
39. M. Jameson, F. X. Dai, T. Lüscher, J. Skopec, A. Diederich and D. Diederich, Endothelium-derived contracting factors in resistance arteries of young spontaneously hypertensive rats before development of overt hypertension, Hypertension, 1993, 21, 280-288.
40. K. Wingler, S. Wünsch, R. Kreutz, L. Rothermund, M. Paul and H. H. Schmidt, Upregulation of the vascular NAD(P)H-oxidase isoforms Noxl and Nox4 by the renin-angiotensin system in vitro and in vivo, Free Radical Biol. Med., 2001, 31, 1456-1464.
41. S. Wind, K. Beuerlein, M. E. Armitage, A. Taye, A. H. Kumar, D. Janowitz, C. Neff, A. M. Shah, K. Wingler and H. H. Schmidt, Oxidative stress and endothelial dysfunction in aortas of aged spontaneously hypertensive rats by NOX1/2 is reversed by NADPH oxidase inhibition, Hypertension, 2010, 56, 490-497.
42. A. M Briones, F. Tabet, G. E. Callera, A. C. Montezano, A. Yogi, Y. He, M. T. Quinn, M. Salaices and R. M. Touyz, Differential regulation of Nox 1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR, J. Am. Soc. Hypertens., 2011, 5, 137-153.
43. C. A. Hamilton, M. J. Brosnan, S. Al-Benna, G. Berg and A. F. Dominiczak, NAD(P)H oxidase inhibition improves endothelial function in rat and human blood vessels, Hypertension, 2002, 40, 755-762.
44. A. Machha and M. R. Mustafa, Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta, J. Cardiovasc. Pharmacol, 2005, 46, 36-40.
45. M. Ajay, F. I. Achike, A. M. Mustafa and M. R. Mustafa, Direct effects of quercetin on impaired reactivity of spontaneously hypertensive rat aortae: comparative study with ascorbic acid, Clin. Exp. Pharmacol. Physiol., 2006, 33, 345-350.
46. C. Manach, C. Morand, V. Crespy, C. Demigné, O. Texier, F. Régérat and C. Rémésy, Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties, FEBS Lett., 1998, 426, 331-336.
47. S. P. Boyle, V. L. Dobson, S. J. Duthie, D. C. Hinselwood, J. A. Kyle and A. R. Collins, Bioavailability and efficiency of rutin as an antioxidant: a human supplementation study, Eur. J. Clin. Nutr., 2000, 54, 774-782.
48. F. Lodi, R. Jimenez, L. Moreno, P. A. Kroon, P. W. Needs, D. A. Hughes, C. Santos-Buelga, A. Gonzalez-Paramas, A. Cogolludo, R. Lopez-Sepulveda, J. Duarte and F. Perez-Vizcaino, Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta, Atherosclerosis, 2009, 204, 34-39.
49. J. van Duynhoven, E. E. Vaughan, D. M. Jacobs, R. A. Kemperman, E. J. van Velzen, G. Gross, L. C. Roger, S. Possemiers, A. K. Smilde, J. Doré, J. A. Westerhuis and T. Van de Wiele, Metabolic fate of polyphenols in the human superorganism, Proc. Natl. Acad. Sci. U. S. A., 2011, 108, 4531-4518.