Direct effects of quercetin on impaired reactivity of spontaneously hypertensive rat aortae: Comparative study with ascorbic acid

Clinical and Experimental Pharmacology and Physiology

Volumn 33, Issue 4, 2006, Pages 345-350

  Ajay, Machha ^a   Achike, Francis I ^b   Mustafa, Ali Mohd ^a   Mustafa, Mohd Rais ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

Author keywords

Anti oxidants; Ascorbic acid; Endothelium; Hypertension; Nitric oxide; Quercetin; SHR

Indexed keywords

ACETYLCHOLINE; ANTIOXIDANT; ASCORBIC ACID; FLAVONOID; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; PROSTAGLANDIN SYNTHASE INHIBITOR; QUERCETIN;

ANIMAL MODEL; ANIMAL TISSUE; AORTA; AORTA CONSTRICTION; ARTERY DILATATION; ARTICLE; CARDIOVASCULAR RESPONSE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG EXPOSURE; DRUG MECHANISM; DRUG POTENCY; ESSENTIAL HYPERTENSION; HEART PROTECTION; MALE; NONHUMAN; RAT; RAT STRAIN; SPONTANEOUSLY HYPERTENSIVE RAT; VASCULAR ENDOTHELIUM; VASCULAR RING;

ACETYLCHOLINE; ADRENERGIC ALPHA-AGONISTS; ANIMALS; AORTA; ASCORBIC ACID; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE III; NITROPRUSSIDE; PHENYLEPHRINE; QUERCETIN; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTORS, ADRENERGIC, ALPHA-1; VASODILATOR AGENTS; VITAMINS;

EID: 33645031783     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2006.04373.x     Document Type: Article

References (27)

1. Lassegue B Griendling KK Reactive oxygen species in hypertension AmJHypertens 2004 17 852 60
2. Berry C Brosnan MJ Fennell J Hamilton CA Dominiczak AF Oxidative stress and vascular damage in hypertension CurrOpinNephrolHypertens 2001 10 247 55
3. Cuzzocrea S Mazzon E Dugo L Di Paola R Caputi AP Salvemini D Superoxide: A key player in hypertension FASEBJ 2004 18 1 94 101
4. Katusic ZS Superoxide anion and endothelial regulation of arterial tone FreeRadicBiolMed 1996 20 3 443 8
5. Taddei S Virdis A Ghiadoni L Magagna A Salvetti A Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension Circulation 1998 97 2222 9
6. Rodriguez-Porcel M Herrman J Chade AR et al. Long-term antioxidant intervention improves myocardial microvascular function in experimental hypertension Hypertension 2004 43 2 493 8
7. Hertog MGL Feskens EJM Hollman PCH Katan MB Kromhurt D Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study Lancet 1993 342 1007 11
8. Knekt P Jarvinen R Reunanen A Maatela J Flavonoid intake and coronary mortality in Finland: A cohort study BrMedJ 1996 312 478 81
9. Cook NC Samman S Flavonoids- Chemistry, metabolism, cardioprotective effects, and dietary sources NutrBiochem 1996 7 66 76
10. Heijnen CGM Haenen GRMM Wiseman SA Tijburg LBM Bast A The interaction of tea flavonoids with the NO-system: Discrimination between good and bad Food Chem 2000 70 365 70
11. Nijveldt RJ van Nood E van Hoorn DE Boelens PG van Norren K van Leeuwen PA Flavonoids: A review of probable mechanisms of action and potential applications AmJClinNutr 2001 74 418 25
12. Lorenz M Wessler S Follman E et al. A constituent of green tea, apigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation JBiolChem 2004 279 6190 5
13. Ajay M Gilani AU Mustafa MR Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta Life Sci 2003 74 603 12
14. Wallerath T Poleo D Li H Fostermann U Red wine increases the expression of human endothelial nitric oxide synthase: A mechanism that may contribute to its beneficial cardiovascular effects JAmCollCardiol 2003 41 471 8
15. Kaneyuki T Noda Y Traber MG Mori A Packer L Superoxide anion and hydroxyl radical scavenging activities of vegetable extracts measured using electron spin resonance BiochemMolBiolInt 1999 47 6 979 89
16. Rice-Evans CA Miller NJ Paganga G Structure-antioxidant activity relationships of flavonoids and phenolic acids FreeRadicBiolMed 1996 20 933 56
17. Galisteo M Garcia-Saura MF Jimenez R et al. Effects of quercetin treatment on vascular function in deoxycarticosterone acetate-salt hypertensive rats. Comparative study with verapamil Planta Med 2004 70 4 334 41
18. Ajay M Mustafa MR Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta JCardiovascPharmacol 2005 46 1 36 40
19. Ibarra M Moreno L Vera R et al. Effects of flavonoid quercetin and its methylated metabolite isorhamnetin in isolated arteries from spontaneously hypertensive rats Planta Med 2003 69 11 995 1000
20. Diederich D Yang Z Buhler FR et al. Impaired endothelium-dependent relaxations in hypertensive resistant arteries involve cyclooxygenase pathway AmJPhysiol 1990 258 H445 51
21. Akpaffiong MJ Taylor AA Antihypertensive and vasodilator actions of antioxidants in spontaneously hypertensive rats AmJHypertens 1998 11 1450 60
22. Neumann H Carlsson K Brom G Uptake and localization of O-(betahydroxyethyl) -rutosides in the venous wall, measured by laser scanning microscopy EurJClinPharmacol 1992 43 423 6
23. Ruetten H Zabel U Linz W Schmidt HH Downregulation of soluble guanylyl cyclase in young and aging spontaneously hypertensive rats CircRes 1999 85 6 534 41
24. Morawietz H Weber M Rueckschloss U Lauer N Hacker A Kojda G Upregulation of vascular NAD (P) H oxidase subunit gp91phox and impairment of the nitric oxide signal transduction pathway in hypertension BiochemBiophysicResComm 2001 285 1130 5
25. Kim DO Lee KW Lee HJ Lee CY Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals JAgricFoodChem 2002 50 13 3713 17
26. De Moura RS Miranda DZ Pinto AC et al. Mechanism of the endothelium-dependent vasodilation and the antihypertensive effect of Brazilian red wine JCardiovascPharmacol 2004 44 302 9
27. Woodman OL Boujaoude M Chronic treatment of male rats with diadzein and 17-beta-oestradiol induces the contribution of EDHF to endothelium-dependent relaxation BrJPharmacol 2004 141 322 8