Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta

Atherosclerosis

Volumn 204, Issue 1, 2009, Pages 34-39

  Lodi, Federica ^a,b   Jimenez, Rosario ^c   Moreno, Laura ^a,b   Kroon, Paul A ^d   Needs, Paul W ^d   Hughes, David A ^d   Santos Buelga, Celestino ^e   Gonzalez Paramas, Ana ^e   Cogolludo, Angel ^a,b   Lopez Sepulveda, Rocío ^c   Duarte, Juan ^c   Perez Vizcaino, Francisco ^a,b  

^a SCHOOL OF MEDICINE   (Spain)

^b Hospital Joan March   (Spain)

^c UNIVERSITY OF GRANADA   (Spain)

^d INSTITUTE OF FOOD RESEARCH   (United Kingdom)

^e UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Endothelial dysfunction; Nitric oxide; Oxidative stress; Quercetin conjugates

Indexed keywords

ACETYLCHOLINE; AGLYCONE; DIETHYLDITHIOCARBAMIC ACID; DRUG METABOLITE; ENDOTHELIN 1; ISORHAMNETIN 3 GLUCURONIDE; LUCIGENIN; NITRIC OXIDE; OXYGEN; QUERCETIN; QUERCETIN 3 GLUCURONIDE; QUERCETIN 3' SULFATE; QUERCETIN DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CELL PROTECTION; CHEMOLUMINESCENCE; CONJUGATION; CONTROLLED STUDY; DRUG EFFECT; DRUG METABOLISM; ENDOTHELIAL DYSFUNCTION; GLUCURONIDATION; IN VITRO STUDY; INCUBATION TIME; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER; SULFATION; THORACIC AORTA; TISSUE HOMOGENATE; TREATMENT OUTCOME; VASODILATATION; WISTAR RAT;

ACETYLCHOLINE; ANIMALS; ANTIOXIDANTS; AORTA, THORACIC; BIOTRANSFORMATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; FLAVONOLS; GLUCURONIDES; NADPH OXIDASE; NITRIC OXIDE; OXIDATIVE STRESS; QUERCETIN; RATS; RATS, WISTAR; SULFATES; SUPEROXIDES; VASODILATION; VASODILATOR AGENTS;

EID: 67349151315     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2008.08.007     Document Type: Article

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