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Volumn 31, Issue 5, 2012, Pages 396-409

Post-Stroke immunodeficiency: Effects of sensitization and tolerization to brain antigens

Author keywords

Immunodeficiency; Stroke; Systemic inflammatory response syndrome; Tolerization

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRAIN ANTIGEN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TUMOR NECROSIS FACTOR ALPHA;

EID: 84867829523     PISSN: 08830185     EISSN: 15635244     Source Type: Journal    
DOI: 10.3109/08830185.2012.723078     Document Type: Review
Times cited : (15)

References (111)
  • 1
    • 79954579638 scopus 로고    scopus 로고
    • Stroke and the immune system: From pathophysiology to new therapeutic strategies
    • Macrez R, Ali C, Toutirais O, et al. Stroke and the immune system: From pathophysiology to new therapeutic strategies. Lancet Neurol. 2011;10:471-480.
    • (2011) Lancet Neurol , vol.10 , pp. 471-480
    • MacRez, R.1    Ali, C.2    Toutirais, O.3
  • 2
    • 71049180369 scopus 로고    scopus 로고
    • Inflammatory mechanisms in ischemic stroke: Therapeutic approaches
    • Lakhan SE, Kirchgessner A, Hofer M. Inflammatory mechanisms in ischemic stroke: Therapeutic approaches. J TranslMed. 2009;7:97.
    • (2009) J TranslMed , vol.7 , pp. 97
    • Lakhan, S.E.1    Kirchgessner, A.2    Hofer, M.3
  • 3
    • 0033638849 scopus 로고    scopus 로고
    • The sympathetic nerve-an integrative interface between two supersystems: The brain and the immune system
    • Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES. The sympathetic nerve-an integrative interface between two supersystems: The brain and the immune system. Pharmacol Rev. 2000;52:595-638.
    • (2000) Pharmacol Rev , vol.52 , pp. 595-638
    • Elenkov, I.J.1    Wilder, R.L.2    Chrousos, G.P.3    Vizi, E.S.4
  • 4
    • 77954404460 scopus 로고    scopus 로고
    • Inflammatory response during ischaemicprocesses: Adhesion molecules and immunomodulation
    • Cuenca-LopezMD, Brea D,GalindoMF, et al. Inflammatory response during ischaemicprocesses: Adhesion molecules and immunomodulation. Rev Neurol. 2010;51:30-40.
    • (2010) Rev Neurol , vol.51 , pp. 30-40
    • Cuenca-Lopez, M.D.1    Brea, D.2    Galindo, M.F.3
  • 5
    • 0031762340 scopus 로고    scopus 로고
    • Glutamate antagonists in therapy of stroke
    • Prass K, Dirnagl U. Glutamate antagonists in therapy of stroke. Restor Neurol Neurosci. 1998;13:3-10.
    • (1998) Restor Neurol Neurosci , vol.13 , pp. 3-10
    • Prass, K.1    Dirnagl, U.2
  • 6
    • 64149090337 scopus 로고    scopus 로고
    • Inflammatory and neuroimmunomodulatory changes in acute cerebral ischemia
    • Brea D, Sobrino T, Ramos-Cabrer P, Castillo J. Inflammatory and neuroimmunomodulatory changes in acute cerebral ischemia. Cerebrovasc Dis. 2009;27(Suppl 1):48-64.
    • (2009) Cerebrovasc Dis , vol.27 , Issue.SUPPL. 1 , pp. 48-64
    • Brea, D.1    Sobrino, T.2    Ramos-Cabrer, P.3    Castillo, J.4
  • 8
    • 0030852741 scopus 로고    scopus 로고
    • Production of tumor necrosis factor-alpha and interleukin-1beta by human cerebralmicrovascular endothelium after percussive trauma
    • Gourin CG, Shackford SR. Production of tumor necrosis factor-alpha and interleukin-1beta by human cerebralmicrovascular endothelium after percussive trauma. J Trauma. 1997;42:1101-1107.
    • (1997) J Trauma , vol.42 , pp. 1101-1107
    • Gourin, C.G.1    Shackford, S.R.2
  • 9
    • 77955850207 scopus 로고    scopus 로고
    • Inflammation after stroke: Mechanisms and therapeutic approaches
    • Ahmad M, Graham SH. Inflammation after stroke: Mechanisms and therapeutic approaches. Transl Stroke Res. 2010;1:74-84.
    • (2010) Transl Stroke Res , vol.1 , pp. 74-84
    • Ahmad, M.1    Graham, S.H.2
  • 10
    • 78149245608 scopus 로고    scopus 로고
    • The neurovascular unit, matrix proteases, and innate inflammation
    • del Zoppo GJ.The neurovascular unit, matrix proteases, and innate inflammation. Ann N Y Acad Sci. 2010;1207:46-49.
    • (2010) Ann N y Acad Sci , vol.1207 , pp. 46-49
    • Del Zoppo, G.J.1
  • 11
    • 33747781747 scopus 로고    scopus 로고
    • Inflammation in stroke and focal cerebral ischemia
    • Huang J, Upadhyay UM, Tamargo RJ. Inflammation in stroke and focal cerebral ischemia. Surg Neurol. 2006;66:232-245.
    • (2006) Surg Neurol , vol.66 , pp. 232-245
    • Huang, J.1    Upadhyay, U.M.2    Tamargo, R.J.3
  • 12
    • 36649022397 scopus 로고    scopus 로고
    • Inflammation in ischemic brain injury: Timing is important
    • Kriz J. Inflammation in ischemic brain injury: Timing is important. Crit Rev Neurobiol. 2006;18:145-157.
    • (2006) Crit Rev Neurobiol , vol.18 , pp. 145-157
    • Kriz, J.1
  • 13
    • 52249113133 scopus 로고    scopus 로고
    • Immune and inflammatory responses to stroke good or bad
    • McCombe PA, Read SJ. Immune and inflammatory responses to stroke: good or bad? Int J Stroke. 2008;3:254-265.
    • (2008) Int J Stroke , vol.3 , pp. 254-265
    • McCombe, P.A.1    Read, S.J.2
  • 14
    • 27944503933 scopus 로고    scopus 로고
    • Central nervous system injury-induced immune deficiency syndrome
    • Meisel C, Schwab JM, Prass K, et al. Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci. 2005;6:775-786.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 775-786
    • Meisel, C.1    Schwab, J.M.2    Prass, K.3
  • 15
  • 16
    • 0034695179 scopus 로고    scopus 로고
    • Vagal immune-to-brain communication: A visceral chemosensory pathway
    • Goehler LE, Gaykema RP, Hansen MK, et al. Vagal immune-to-brain communication: A visceral chemosensory pathway. Auton Neurosci. 2000;85:49-59.
    • (2000) Auton Neurosci , vol.85 , pp. 49-59
    • Goehler, L.E.1    Gaykema, R.P.2    Hansen, M.K.3
  • 18
    • 14744289048 scopus 로고    scopus 로고
    • Blood-brain barrier transport of cytokines: A mechanism for neuropathology
    • Banks WA. Blood-brain barrier transport of cytokines: A mechanism for neuropathology. Curr PharmDes. 2005;11:973-984.
    • (2005) Curr PharmDes , vol.11 , pp. 973-984
    • Banks, W.A.1
  • 19
    • 0034961762 scopus 로고    scopus 로고
    • Role of circumventricular organs in pro-inflammatory cytokine-induced activation of the hypothalamic-pituitary-adrenal axis
    • Buller KM. Role of circumventricular organs in pro-inflammatory cytokine-induced activation of the hypothalamic-pituitary-adrenal axis. Clin Exp Pharmacol Physiol. 2001;28:581-589.
    • (2001) Clin Exp Pharmacol Physiol , vol.28 , pp. 581-589
    • Buller, K.M.1
  • 20
    • 0015411202 scopus 로고
    • Various frontiers in neuroendocrinology
    • Fortier C. Various frontiers in neuroendocrinology. UnionMed Can. 1972;101:2067-2071.
    • (1972) UnionMed Can , vol.101 , pp. 2067-2071
    • Fortier, C.1
  • 21
    • 33746892676 scopus 로고    scopus 로고
    • It takes nerve to tell T and B cells what to do
    • Kin NW, Sanders VM. It takes nerve to tell T and B cells what to do. J Leukoc Biol. 2006;79:1093-1104.
    • (2006) J Leukoc Biol , vol.79 , pp. 1093-1104
    • Kin, N.W.1    Sanders, V.M.2
  • 22
    • 0031135311 scopus 로고    scopus 로고
    • Differential expression of the beta2-adrenergic receptor by Th1 andTh2 clones: Implications for cytokine production and B cell help
    • Sanders VM, Baker RA, Ramer-Quinn DS, et al. Differential expression of the beta2-adrenergic receptor by Th1 andTh2 clones: Implications for cytokine production and B cell help. J Immunol. 1997;158:4200-4210.
    • (1997) J Immunol , vol.158 , pp. 4200-4210
    • Sanders, V.M.1    Baker, R.A.2    Ramer-Quinn, D.S.3
  • 23
    • 0032159216 scopus 로고    scopus 로고
    • Beta-adrenoceptor-mediated inhibition of IFN-gamma,IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the beta2-adrenoceptor subtype
    • Borger P, Hoekstra Y, Esselink MT, et al. Beta-adrenoceptor-mediated inhibition of IFN-gamma,IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the beta2-adrenoceptor subtype. AmJ Respir CellMol Biol. 1998;19:400-407.
    • (1998) AmJ Respir CellMol Biol , vol.19 , pp. 400-407
    • Borger, P.1    Hoekstra, Y.2    Esselink, M.T.3
  • 24
    • 0033998375 scopus 로고    scopus 로고
    • Neural influence on immune responses: Underlying suppositions and basic principles of neural-immune signaling
    • Felten DL. Neural influence on immune responses: Underlying suppositions and basic principles of neural-immune signaling. Prog Brain Res. 2000;122:381-389.
    • (2000) Prog Brain Res , vol.122 , pp. 381-389
    • Felten, D.L.1
  • 25
    • 0029552165 scopus 로고
    • Adrenergic regulation of haematopoiesis
    • Maestroni GJ. Adrenergic regulation of haematopoiesis. Pharmacol Res. 1995;32:249-253.
    • (1995) Pharmacol Res , vol.32 , pp. 249-253
    • Maestroni, G.J.1
  • 26
    • 33947515643 scopus 로고    scopus 로고
    • Infection after acute ischemic stroke: A manifestation of braininduced immunodepression
    • Chamorro A, Urra X, Planas AM. Infection after acute ischemic stroke: A manifestation of braininduced immunodepression. Stroke. 2007;38:1097-1103.
    • (2007) Stroke , vol.38 , pp. 1097-1103
    • Chamorro, A.1    Urra, X.2    Planas, A.M.3
  • 27
    • 0033519323 scopus 로고    scopus 로고
    • Dynamic norepinephrine alterations in bonemarrow: Evidence of functional innervation
    • Tang Y, Shankar R, Gamelli R, Jones S. Dynamic norepinephrine alterations in bonemarrow: Evidence of functional innervation. J Neuroimmunol. 1999;96:182-189.
    • (1999) J Neuroimmunol , vol.96 , pp. 182-189
    • Tang, Y.1    Shankar, R.2    Gamelli, R.3    Jones, S.4
  • 28
    • 0042886941 scopus 로고    scopus 로고
    • Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation
    • Prass K,Meisel C,Hoflich C, et al. Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J ExpMed. 2003;198:725-736.
    • (2003) J ExpMed , vol.198 , pp. 725-736
    • Prass, K.1    Meisel, C.2    Hoflich, C.3
  • 29
    • 0031849214 scopus 로고    scopus 로고
    • Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury
    • Woiciechowsky C, Asadullah K, Nestler D, et al. Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury. Nat Med. 1998;4:808-813.
    • (1998) Nat Med , vol.4 , pp. 808-813
    • Woiciechowsky, C.1    Asadullah, K.2    Nestler, D.3
  • 30
    • 33845453452 scopus 로고    scopus 로고
    • Catecholamines, infection, and death in acute ischemic stroke
    • Chamorro A, Amaro S, Vargas M, et al. Catecholamines, infection, and death in acute ischemic stroke. J Neurol Sci. 2007;252:29-35.
    • (2007) J Neurol Sci , vol.252 , pp. 29-35
    • Chamorro, A.1    Amaro, S.2    Vargas, M.3
  • 31
    • 59349092158 scopus 로고    scopus 로고
    • Stroke-induced immunodepression and post-stroke infections: Lessons from the preventive antibacterial therapy in stroke trial
    • Klehmet J, Harms H, Richter M, et al. Stroke-induced immunodepression and post-stroke infections: Lessons from the preventive antibacterial therapy in stroke trial. Neuroscience. 2009;158:1184-1193.
    • (2009) Neuroscience , vol.158 , pp. 1184-1193
    • Klehmet, J.1    Harms, H.2    Richter, M.3
  • 32
    • 0036889766 scopus 로고    scopus 로고
    • Cytokines and neuro-immune-endocrine interactions: A role for the hypothalamic-pituitary-adrenal revolving axis
    • Haddad JJ, Saade NE, Safieh-Garabedian B. Cytokines and neuro-immune-endocrine interactions: A role for the hypothalamic-pituitary- adrenal revolving axis. J Neuroimmunol. 2002;133:1-19.
    • (2002) J Neuroimmunol , vol.133 , pp. 1-19
    • Haddad, J.J.1    Saade, N.E.2    Safieh-Garabedian, B.3
  • 33
    • 0029037126 scopus 로고
    • The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation
    • Chrousos GP.The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl JMed. 1995;332:1351-1362.
    • (1995) N Engl J Med , vol.332 , pp. 1351-1362
    • Chrousos, G.P.1
  • 34
    • 1542376082 scopus 로고    scopus 로고
    • Seruminterleukin-6 predicts cortisol release in acute stroke patients
    • Szczudlik A,Dziedzic T, Bartus S, et al. Seruminterleukin-6 predicts cortisol release in acute stroke patients. J Endocrinol Invest. 2004;27:37-41.
    • (2004) J Endocrinol Invest , vol.27 , pp. 37-41
    • Szczudlik, A.1    Dziedzic, T.2    Bartus, S.3
  • 35
    • 0036191449 scopus 로고    scopus 로고
    • Early IL-6 plasma concentrations correlate with severity of brain injury and pneumonia in brain-injured patients
    • Woiciechowsky C, Schoning B, Cobanov J, et al. Early IL-6 plasma concentrations correlate with severity of brain injury and pneumonia in brain-injured patients. J Trauma. 2002;52:339-345.
    • (2002) J Trauma , vol.52 , pp. 339-345
    • Woiciechowsky, C.1    Schoning, B.2    Cobanov, J.3
  • 36
    • 0030802018 scopus 로고    scopus 로고
    • Glucocorticoids and immune function: Unknown dimensions and new frontiers
    • Wilckens T,De Rijk R. Glucocorticoids and immune function: Unknown dimensions and new frontiers. Immunol Today. 1997;18:418-424.
    • (1997) Immunol Today , vol.18 , pp. 418-424
    • Wilckens, T.1    De Rijk, R.2
  • 37
    • 0037018104 scopus 로고    scopus 로고
    • In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)-andTh2-inducing cytokines
    • Barrat FJ, Cua DJ, Boonstra A, et al. In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)-andTh2-inducing cytokines. J ExpMed. 2002;195:603-616.
    • (2002) J ExpMed , vol.195 , pp. 603-616
    • Barrat, F.J.1    Cua, D.J.2    Boonstra, A.3
  • 39
    • 0029972142 scopus 로고    scopus 로고
    • Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes
    • Meagher LC, Cousin JM, Seckl JR, Haslett C. Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes. J Immunol. 1996;156:4422-4428.
    • (1996) J Immunol , vol.156 , pp. 4422-4428
    • Meagher, L.C.1    Cousin, J.M.2    Seckl, J.R.3    Haslett, C.4
  • 40
    • 0343484923 scopus 로고    scopus 로고
    • Inhibition ofTh1 immune response by glucocorticoids: Dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes
    • Franchimont D, Galon J, Gadina M, et al. Inhibition ofTh1 immune response by glucocorticoids: Dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes. J Immunol. 2000;164:1768-1774.
    • (2000) J Immunol , vol.164 , pp. 1768-1774
    • Franchimont, D.1    Galon, J.2    Gadina, M.3
  • 41
    • 0029925751 scopus 로고    scopus 로고
    • Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro
    • Ramirez F, Fowell DJ, Puklavec M, et al. Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro. J Immunol. 1996;156:2406-2412.
    • (1996) J Immunol , vol.156 , pp. 2406-2412
    • Ramirez, F.1    Fowell, D.J.2    Puklavec, M.3
  • 42
    • 3042647294 scopus 로고    scopus 로고
    • Low and high circulating cortisol levels predict mortality and cognitive dysfunction early after stroke
    • Marklund N, Peltonen M, Nilsson TK, Olsson T. Low and high circulating cortisol levels predict mortality and cognitive dysfunction early after stroke. J InternMed. 2004;256:15-21.
    • (2004) J InternMed , vol.256 , pp. 15-21
    • Marklund, N.1    Peltonen, M.2    Nilsson, T.K.3    Olsson, T.4
  • 43
    • 0029847171 scopus 로고    scopus 로고
    • The paraventricular nucleus of the hypothalamus and the functional neuroanatomy of visceromotor responses to stress
    • Sawchenko PE, Brown ER, Chan RK, et al. The paraventricular nucleus of the hypothalamus and the functional neuroanatomy of visceromotor responses to stress. Prog Brain Res. 1996;107:201-222.
    • (1996) Prog Brain Res , vol.107 , pp. 201-222
    • Sawchenko, P.E.1    Brown, E.R.2    Chan, R.K.3
  • 44
    • 0142178155 scopus 로고    scopus 로고
    • The cholinergic anti-inflammatory pathway: A missing link in neuroimmunomodulation
    • Pavlov VA, Wang H, Czura CJ, et al. The cholinergic anti-inflammatory pathway: A missing link in neuroimmunomodulation.MolMed. 2003;9:125-134.
    • (2003) MolMed , vol.9 , pp. 125-134
    • Pavlov, V.A.1    Wang, H.2    Czura, C.J.3
  • 45
    • 0034713266 scopus 로고    scopus 로고
    • Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
    • Borovikova LV, Ivanova S, Zhang M, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 2000;405:458-462.
    • (2000) Nature , vol.405 , pp. 458-462
    • Borovikova, L.V.1    Ivanova, S.2    Zhang, M.3
  • 46
    • 0018663658 scopus 로고
    • Immunological observations on patients with acute cerebral vascular disease
    • Czlonkowska A, Cyrta B, Korlak J. Immunological observations on patients with acute cerebral vascular disease. J Neurol Sci. 1979;43:455-464.
    • (1979) J Neurol Sci , vol.43 , pp. 455-464
    • Czlonkowska, A.1    Cyrta, B.2    Korlak, J.3
  • 47
    • 0026663251 scopus 로고
    • Neuroendocrine-immune interactions associated with loss and restoration of immune system function in spinal cord injury and stroke patients
    • Cruse JM, Lewis RE, Bishop GR, et al. Neuroendocrine-immune interactions associated with loss and restoration of immune system function in spinal cord injury and stroke patients. Immunol Res. 1992;11:104-116.
    • (1992) Immunol Res , vol.11 , pp. 104-116
    • Cruse, J.M.1    Lewis, R.E.2    Bishop, G.R.3
  • 48
    • 33750478991 scopus 로고    scopus 로고
    • Interleukin 10, monocytes and increased risk of early infection in ischaemic stroke
    • Chamorro A,Amaro S, VargasM, et al. Interleukin 10, monocytes and increased risk of early infection in ischaemic stroke. J Neurol Neurosurg Psychiatry. 2006;77:1279-1281.
    • (2006) J Neurol Neurosurg Psychiatry , vol.77 , pp. 1279-1281
    • Chamorro, A.1    Amaro, S.2    Vargas, M.3
  • 49
    • 33646874015 scopus 로고    scopus 로고
    • Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages
    • Offner H, Subramanian S, Parker SM, et al. Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages. J Immunol. 2006;176: 6523-6531.
    • (2006) J Immunol , vol.176 , pp. 6523-6531
    • Offner, H.1    Subramanian, S.2    Parker, S.M.3
  • 50
    • 0348012898 scopus 로고    scopus 로고
    • Changes in monocytic expression of aminopeptidase N/CD13 aftermajor trauma
    • Huschak G, Zur Nieden K, Stuttmann R, Riemann D. Changes in monocytic expression of aminopeptidase N/CD13 aftermajor trauma. Clin Exp Immunol. 2003;134:491-496.
    • (2003) Clin Exp Immunol , vol.134 , pp. 491-496
    • Huschak, G.1    Zur Nieden, K.2    Stuttmann, R.3    Riemann, D.4
  • 51
    • 70349693909 scopus 로고    scopus 로고
    • Infarct volume is amajor determiner of post-stroke immune cell function and susceptibility to infection
    • Hug A, Dalpke A,Wieczorek N, et al. Infarct volume is amajor determiner of post-stroke immune cell function and susceptibility to infection. Stroke. 2009;40:3226-3232.
    • (2009) Stroke , vol.40 , pp. 3226-3232
    • Hug, A.1    Dalpke, A.2    Wieczorek, N.3
  • 52
    • 47749135669 scopus 로고    scopus 로고
    • Preventive antibacterial therapy in acute ischemic stroke: A randomized controlled trial
    • Harms H, Prass K,Meisel C, et al. Preventive antibacterial therapy in acute ischemic stroke: A randomized controlled trial. Plos One. 2008;3:e2158.
    • (2008) Plos One , vol.3
    • Harms, H.1    Prass, K.2    Meisel, C.3
  • 53
    • 0342626639 scopus 로고    scopus 로고
    • Impaired antigen presentation by humanmonocytes during endotoxin tolerance
    • Wolk K,DockeWD, von Baehr V, et al. Impaired antigen presentation by humanmonocytes during endotoxin tolerance. Blood. 2000;96:218-223.
    • (2000) Blood , vol.96 , pp. 218-223
    • Wolk, K.1    Docke, W.D.2    Von Baehr, V.3
  • 54
    • 0042623535 scopus 로고    scopus 로고
    • Cause-specific mortality after first cerebral infarction: A population-based study
    • Vernino S, Brown RD, Jr., Sejvar JJ, et al. Cause-specific mortality after first cerebral infarction: A population-based study. Stroke. 2003;34:1828-1832.
    • (2003) Stroke , vol.34 , pp. 1828-1832
    • Vernino, S.1    Brown Jr., R.D.2    Sejvar, J.J.3
  • 55
    • 33846583388 scopus 로고    scopus 로고
    • Stroke-induced immunodepression: Experimental evidence and clinical relevance
    • Dirnagl U, Klehmet J, Braun JS, et al. Stroke-induced immunodepression: Experimental evidence and clinical relevance. Stroke. 2007;38:770-773.
    • (2007) Stroke , vol.38 , pp. 770-773
    • Dirnagl, U.1    Klehmet, J.2    Braun, J.S.3
  • 56
    • 63549126466 scopus 로고    scopus 로고
    • Urinary tract infection after stroke
    • Stott DJ, Falconer A,Miller H, et al. Urinary tract infection after stroke. QJM. 2009;102:243-249.
    • (2009) QJM , vol.102 , pp. 243-249
    • Stott, D.J.1    Falconer, A.2    Miller, H.3
  • 57
    • 62949210528 scopus 로고    scopus 로고
    • Stroke-associated infection is an independent risk factor for poor outcome after acute ischemic stroke: Data from the Netherlands Stroke Survey
    • Vermeij FH, Scholte op ReimerWJ, deMan P, et al. Stroke-associated infection is an independent risk factor for poor outcome after acute ischemic stroke: Data from the Netherlands Stroke Survey. Cerebrovasc Dis. 2009;27:465-471.
    • (2009) Cerebrovasc Dis , vol.27 , pp. 465-471
    • Vermeij, F.H.1    Scholte Op Reimer, W.J.2    Deman, P.3
  • 58
    • 0035079977 scopus 로고    scopus 로고
    • Screening for dysphagia and aspiration in acute stroke: A systematic review
    • Perry L, Love CP. Screening for dysphagia and aspiration in acute stroke: A systematic review. Dysphagia. 2001;16:7-18.
    • (2001) Dysphagia , vol.16 , pp. 7-18
    • Perry, L.1    Love, C.P.2
  • 59
    • 33749001962 scopus 로고    scopus 로고
    • Stroke propagates bacterial aspiration to pneumonia in amodel of cerebral ischemia
    • Prass K, Braun JS,Dirnagl U, et al. Stroke propagates bacterial aspiration to pneumonia in amodel of cerebral ischemia. Stroke. 2006;37:2607-2612.
    • (2006) Stroke , vol.37 , pp. 2607-2612
    • Prass, K.1    Braun, J.S.2    Dirnagl, U.3
  • 60
    • 33748988163 scopus 로고    scopus 로고
    • Association of serial biochemical markers with acute ischemic stroke: The National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator Stroke Study
    • Jauch EC, Lindsell C, Broderick J, et al. Association of serial biochemical markers with acute ischemic stroke: The National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator Stroke Study. Stroke. 2006;37:2508-2513.
    • (2006) Stroke , vol.37 , pp. 2508-2513
    • Jauch, E.C.1    Lindsell, C.2    Broderick, J.3
  • 61
    • 60549104213 scopus 로고    scopus 로고
    • Brain antigens in functionally distinct antigenpresenting cell populations in cervical lymph nodes in MS and EAE
    • van Zwam M, Huizinga R, Melief MJ, et al. Brain antigens in functionally distinct antigenpresenting cell populations in cervical lymph nodes in MS and EAE. J Mol Med (Berl). 2009;87:273-286.
    • (2009) J Mol Med (Berl , vol.87 , pp. 273-286
    • Van Zwam, M.1    Huizinga, R.2    Melief, M.J.3
  • 62
    • 0028854369 scopus 로고
    • Lymphocytic infiltration and expression of intercellular adhesion molecule-1 in photochemically induced ischemia of the rat cortex
    • Jander S, Kraemer M, Schroeter M, et al. Lymphocytic infiltration and expression of intercellular adhesion molecule-1 in photochemically induced ischemia of the rat cortex. J Cereb Blood Flow Metab. 1995;15:42-51.
    • (1995) J Cereb Blood Flow Metab , vol.15 , pp. 42-51
    • Jander, S.1    Kraemer, M.2    Schroeter, M.3
  • 63
    • 0036161092 scopus 로고    scopus 로고
    • Flow cytometric analysis of inflammatory cells in ischemic rat brain
    • Campanella M, Sciorati C, Tarozzo G, BeltramoM. Flow cytometric analysis of inflammatory cells in ischemic rat brain. Stroke. 2002;33:586-592.
    • (2002) Stroke , vol.33 , pp. 586-592
    • Campanella, M.1    Sciorati, C.2    Tarozzo, G.3    Beltramo, M.4
  • 64
    • 0026547691 scopus 로고
    • Myelin antigen reactive T cells in cerebrovascular diseases
    • WangWZ, Olsson T, Kostulas V, et al.Myelin antigen reactive T cells in cerebrovascular diseases. Clin Exp Immunol. 1992;88:157-162.
    • (1992) Clin Exp Immunol , vol.88 , pp. 157-162
    • Wang, W.Z.1    Olsson, T.2    Kostulas, V.3
  • 65
    • 0016183214 scopus 로고
    • Cellular-immune response tomyelin protein: Absence in multiple sclerosis and presence in cerebrovascular accidents
    • Youngchaiyud U, Coates AS,WhittinghamS,Mackay IR. Cellular-immune response tomyelin protein: Absence in multiple sclerosis and presence in cerebrovascular accidents. Aust N Z J Med. 1974;4:535-538.
    • (1974) Aust N Z J Med , vol.4 , pp. 535-538
    • Youngchaiyud, U.1    Coates, A.S.2    Whittingham, S.3    MacKay, I.R.4
  • 66
    • 0035957077 scopus 로고    scopus 로고
    • Antibodies to brain antigens following stroke
    • BornsteinNM, Aronovich B, Korczyn AD, et al. Antibodies to brain antigens following stroke.Neurology. 2001;56:529-530.
    • (2001) Neurology , vol.56 , pp. 529-530
    • Bornstein, N.M.1    Aronovich, B.2    Korczyn, A.D.3
  • 67
    • 0141615744 scopus 로고    scopus 로고
    • Blood test detecting autoantibodies to Nmethyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke
    • Dambinova SA, Khounteev GA, Izykenova GA, et al. Blood test detecting autoantibodies to Nmethyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke. Clin Chem. 2003;49:1752-1762.
    • (2003) Clin Chem , vol.49 , pp. 1752-1762
    • Dambinova, S.A.1    Khounteev, G.A.2    Izykenova, G.A.3
  • 70
    • 24744435520 scopus 로고    scopus 로고
    • Sensitization to brain antigens after stroke is augmented by lipopolysaccharide
    • Becker KJ, Kindrick DL, Lester MP, et al. Sensitization to brain antigens after stroke is augmented by lipopolysaccharide. J Cereb Blood FlowMetab. 2005;25:1634-1644.
    • (2005) J Cereb Blood FlowMetab , vol.25 , pp. 1634-1644
    • Becker, K.J.1    Kindrick, D.L.2    Lester, M.P.3
  • 71
    • 0031022715 scopus 로고    scopus 로고
    • Accessory molecule and costimulation requirements for CD4 T cell response
    • Croft M, Dubey C. Accessory molecule and costimulation requirements for CD4 T cell response. Crit Rev Immunol. 1997;17:89-118.
    • (1997) Crit Rev Immunol , vol.17 , pp. 89-118
    • Croft, M.1    Dubey, C.2
  • 72
    • 0023949553 scopus 로고
    • Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
    • Hickey WF, Kimura H. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science. 1988;239:290-292.
    • (1988) Science , vol.239 , pp. 290-292
    • Hickey, W.F.1    Kimura, H.2
  • 73
    • 0035318421 scopus 로고    scopus 로고
    • Presence of B7-2 (CD86) and lack of B7-1 (CD(80) onmyelin phagocytosingMHC-II-positive rat microglia is associated with nondestructive immunity in vivo
    • Bechmann I, Peter S, Beyer M, et al. Presence of B7-2 (CD86) and lack of B7-1 (CD(80) onmyelin phagocytosingMHC-II-positive rat microglia is associated with nondestructive immunity in vivo. FASEB J. 2001;15:1086-1088.
    • (2001) FASEB J , vol.15 , pp. 1086-1088
    • Bechmann, I.1    Peter, S.2    Beyer, M.3
  • 74
    • 0242643750 scopus 로고    scopus 로고
    • The brain as an immune privileged site: Dendritic cells of the central nervous system inhibit T cell activation
    • Suter T, Biollaz G, Gatto D, et al. The brain as an immune privileged site: Dendritic cells of the central nervous system inhibit T cell activation. Eur J Immunol. 2003;33:2998-3006.
    • (2003) Eur J Immunol , vol.33 , pp. 2998-3006
    • Suter, T.1    Biollaz, G.2    Gatto, D.3
  • 75
    • 0035116418 scopus 로고    scopus 로고
    • Neurons reduce glial responses to lipopolysaccharide (LPS) and prevent injury of microglial cells from over-activation by LPS
    • Chang RC, Chen W, Hudson P, et al. Neurons reduce glial responses to lipopolysaccharide (LPS) and prevent injury of microglial cells from over-activation by LPS. J Neurochem. 2001;76:1042-1049.
    • (2001) J Neurochem , vol.76 , pp. 1042-1049
    • Chang, R.C.1    Chen, W.2    Hudson, P.3
  • 76
    • 84863338224 scopus 로고    scopus 로고
    • Neuroprotection from stroke in the absence ofMHCI or PirB
    • Adelson JD, Barreto GE, Xu L, et al. Neuroprotection from stroke in the absence ofMHCI or PirB. Neuron. 2012;73:1100-1107.
    • (2012) Neuron , vol.73 , pp. 1100-1107
    • Adelson, J.D.1    Barreto, G.E.2    Xu, L.3
  • 77
    • 77953612092 scopus 로고    scopus 로고
    • CNS immune responses following experimental stroke
    • Zierath D, Thullbery M, Hadwin J, et al. CNS immune responses following experimental stroke. Neurocrit Care. 2010;12:274-284.
    • (2010) Neurocrit Care , vol.12 , pp. 274-284
    • Zierath, D.1    Thullbery, M.2    Hadwin, J.3
  • 78
    • 79952093029 scopus 로고    scopus 로고
    • TNF gene cluster deletion abolishes lipopolysaccharidemediated sensitization of the neonatal brain to hypoxic ischemic insult
    • Kendall GS, Hirstova M, Horn S, et al. TNF gene cluster deletion abolishes lipopolysaccharidemediated sensitization of the neonatal brain to hypoxic ischemic insult. Lab Invest. 2011;91:328-341.
    • (2011) Lab Invest , vol.91 , pp. 328-341
    • Kendall, G.S.1    Hirstova, M.2    Horn, S.3
  • 79
    • 59349084695 scopus 로고    scopus 로고
    • Sensitization and tolerization to brain antigens in stroke
    • Becker KJ. Sensitization and tolerization to brain antigens in stroke. Neuroscience. 2009;158:1090-1097.
    • (2009) Neuroscience , vol.158 , pp. 1090-1097
    • Becker, K.J.1
  • 80
    • 79952575531 scopus 로고    scopus 로고
    • Evaluating the role of Toll-like receptors in diseases of the central nervous system
    • Carty M, Bowie AG. Evaluating the role of Toll-like receptors in diseases of the central nervous system. Biochem Pharmacol. 2011;81:825-837.
    • (2011) Biochem Pharmacol , vol.81 , pp. 825-837
    • Carty, M.1    Bowie, A.G.2
  • 81
    • 0742324857 scopus 로고    scopus 로고
    • Toll-like receptors and acquired immunity
    • Pasare C, Medzhitov R. Toll-like receptors and acquired immunity. Semin Immunol. 2004;16:23-26.
    • (2004) Semin Immunol , vol.16 , pp. 23-26
    • Pasare, C.1    Medzhitov, R.2
  • 82
    • 80051814602 scopus 로고    scopus 로고
    • Targeting ofToll-like receptors: A decade of progress incombating infectious diseases
    • HedayatM,NeteaMG,Rezaei N.Targeting ofToll-like receptors: A decade of progress incombating infectious diseases. Lancet Infect Dis. 2011;11:702-712.
    • (2011) Lancet Infect Dis , vol.11 , pp. 702-712
    • Hedayat, M.1    Netea, M.G.2    Rezaei, N.3
  • 83
    • 84855184185 scopus 로고    scopus 로고
    • Prophylactic and therapeutic implications of toll-like receptor ligands
    • Hedayat M, Takeda K, Rezaei N. Prophylactic and therapeutic implications of toll-like receptor ligands.Med Res Rev. 2012;32(2):294-325.
    • (2012) Med Res Rev , vol.32 , Issue.2 , pp. 294-325
    • Hedayat, M.1    Takeda, K.2    Rezaei, N.3
  • 84
    • 33646478589 scopus 로고    scopus 로고
    • Therapeutic targeting of pattern-recognition receptors
    • Rezaei N. Therapeutic targeting of pattern-recognition receptors. Int Immunopharmacol. 2006;6:863-869.
    • (2006) Int Immunopharmacol , vol.6 , pp. 863-869
    • Rezaei, N.1
  • 85
    • 84867799461 scopus 로고    scopus 로고
    • Toll-like receptor signaling pathways in cardiovascular diseases: Hallenges and opportunities
    • Bijani FM, Vallejo JG, Rezaei N. Toll-like receptor signaling pathways in cardiovascular diseases: Hallenges and opportunities. Int Rev Immunol. 2012.
    • (2012) Int Rev Immunol
    • Bijani, F.M.1    Vallejo, J.G.2    Rezaei, N.3
  • 86
    • 0030050062 scopus 로고    scopus 로고
    • Effects of in vitrohyperthermia on proliferative responses and lymphocyte activity
    • HuangYH,HaegerstrandA, Frostegard J. Effects of in vitrohyperthermia on proliferative responses and lymphocyte activity. Clin Exp Immunol. 1996;103:61-66.
    • (1996) Clin Exp Immunol , vol.103 , pp. 61-66
    • Huang, Y.H.1    Haegerstrand, A.2    Frostegard, J.3
  • 87
    • 27644447853 scopus 로고    scopus 로고
    • Responses ofmicroglia in vitro to the gram-positive bacterial component, lipoteichoic acid
    • Jiang-Shieh YF, Yeh KY,Wei IH, et al. Responses ofmicroglia in vitro to the gram-positive bacterial component, lipoteichoic acid. J Neurosci Res. 2005;82:515-524.
    • (2005) J Neurosci Res , vol.82 , pp. 515-524
    • Jiang-Shieh, Y.F.1    Yeh, K.Y.2    Wei, I.H.3
  • 88
    • 0142155221 scopus 로고    scopus 로고
    • Toll-like receptors and inflammation in the CNS
    • Lee SJ, Lee S. Toll-like receptors and inflammation in the CNS. Curr Drug Targets Inflamm Allergy. 2002;1:181-191.
    • (2002) Curr Drug Targets Inflamm Allergy , vol.1 , pp. 181-191
    • Lee, S.J.1    Lee, S.2
  • 89
    • 34250841122 scopus 로고    scopus 로고
    • Cutting edge: T cells respond to lipopolysaccharide innately via TLR4 signaling
    • Zanin-Zhorov A, Tal-Lapidot G, Cahalon L, et al. Cutting edge: T cells respond to lipopolysaccharide innately via TLR4 signaling. J Immunol. 2007;179:41-44.
    • (2007) J Immunol , vol.179 , pp. 41-44
    • Zanin-Zhorov, A.1    Tal-Lapidot, G.2    Cahalon, L.3
  • 90
    • 64149088746 scopus 로고    scopus 로고
    • Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity
    • Manicassamy S, Ravindran R, Deng J, et al. Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity. Nat Med. 2009;15:401-409.
    • (2009) Nat Med , vol.15 , pp. 401-409
    • Manicassamy, S.1    Ravindran, R.2    Deng, J.3
  • 91
    • 0037383183 scopus 로고    scopus 로고
    • Nosocomial pneumonia after acute stroke: Implications for neurological intensive caremedicine
    • Hilker R, Poetter C, Findeisen N, et al. Nosocomial pneumonia after acute stroke: Implications for neurological intensive caremedicine. Stroke. 2003;34:975-981.
    • (2003) Stroke , vol.34 , pp. 975-981
    • Hilker, R.1    Poetter, C.2    Findeisen, N.3
  • 92
    • 34247849272 scopus 로고    scopus 로고
    • Infection after acute stroke is associatedwith poor short-termoutcome
    • Kwan J,Hand P. Infection after acute stroke is associatedwith poor short-termoutcome. ActaNeurol Scand. 2007;115:331-338.
    • (2007) ActaNeurol Scand , vol.115 , pp. 331-338
    • Kwan, J.1    Hand, P.2
  • 93
    • 0842265186 scopus 로고    scopus 로고
    • Pneumonia and urinary tract infection after acute ischaemic stroke: A tertiary analysis of the GAIN international trial
    • Aslanyan S,Weir CJ,DienerHC, et al. Pneumonia and urinary tract infection after acute ischaemic stroke: A tertiary analysis of the GAIN international trial. Eur J Neurol. 2004;11:49-53.
    • (2004) Eur J Neurol , vol.11 , pp. 49-53
    • Aslanyan, S.1    Weir, C.J.2    Diener, H.C.3
  • 94
    • 84855398420 scopus 로고    scopus 로고
    • Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage
    • Sansing LH, Harris TH, Welsh FA, et al. Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage. Ann Neurol. 2011;70:646-656.
    • (2011) Ann Neurol , vol.70 , pp. 646-656
    • Sansing, L.H.1    Harris, T.H.2    Welsh, F.A.3
  • 95
    • 84864562100 scopus 로고    scopus 로고
    • Toll-like receptor 2 deficiency leads to delayed exacerbation of ischemic injury
    • Bohacek I, Cordeau P, Lalancette Hebert M, et al. Toll-like receptor 2 deficiency leads to delayed exacerbation of ischemic injury. J Neuroinflammation. 2012;9:191.
    • (2012) J Neuroinflammation , vol.9 , pp. 191
    • Bohacek, I.1    Cordeau, P.2    Lalancette Hebert, M.3
  • 96
    • 78149264099 scopus 로고    scopus 로고
    • Howinflammationmodulates central nervous system vessel activation and provides targets for intervention-A personal perspective
    • Hallenbeck J.Howinflammationmodulates central nervous system vessel activation and provides targets for intervention-a personal perspective. Ann N Y Acad Sci. 2010;1207:1-7.
    • (2010) Ann N y Acad Sci , vol.1207 , pp. 1-7
    • Hallenbeck, J.1
  • 97
    • 0024601050 scopus 로고
    • Endothelial leukocyte adhesion molecule 1: An inducible receptor for neutrophils related to complement regulatory proteins and lectins
    • Bevilacqua MP, Stengelin S, Gimbrone MA, Jr., Seed B. Endothelial leukocyte adhesion molecule 1: An inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science. 1989;243:1160-1165.
    • (1989) Science , vol.243 , pp. 1160-1165
    • Bevilacqua, M.P.1    Stengelin, S.2    Gimbrone Jr., M.A.3    Seed, B.4
  • 98
    • 0345598137 scopus 로고    scopus 로고
    • Mucosal tolerance to E-selectin provides cell-mediated protection against ischemic brain injury
    • Chen Y, Ruetzler C, Pandipati S, et al.Mucosal tolerance to E-selectin provides cell-mediated protection against ischemic brain injury. Proc Natl Acad Sci U S A. 2003;100:15107-15112.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15107-15112
    • Chen, Y.1    Ruetzler, C.2    Pandipati, S.3
  • 99
    • 56349145206 scopus 로고    scopus 로고
    • Mucosal tolerance to E-selectin provides protection against cerebral ischemia-reperfusion injury in rats
    • YunW,Qing-Cheng L, Lei Y, Jia-Yin M.Mucosal tolerance to E-selectin provides protection against cerebral ischemia-reperfusion injury in rats. J Neuroimmunol. 2008;205:73-79.
    • (2008) J Neuroimmunol , vol.205 , pp. 73-79
    • Yun, W.1    Qing-Cheng, L.2    Lei, Y.3    Jia-Yin, M.4
  • 100
    • 61349199500 scopus 로고    scopus 로고
    • Mucosal tolerance to E-selectin promotes the survival of newly generated neuroblasts via regulatory T-cell induction after stroke in spontaneously hypertensive rats
    • Ishibashi S,Maric D,Mou Y, et al.Mucosal tolerance to E-selectin promotes the survival of newly generated neuroblasts via regulatory T-cell induction after stroke in spontaneously hypertensive rats. J Cereb Blood FlowMetab. 2009;29:606-620.
    • (2009) J Cereb Blood FlowMetab , vol.29 , pp. 606-620
    • Ishibashi, S.1    Maric, D.2    Mou, Y.3
  • 101
    • 38549090260 scopus 로고    scopus 로고
    • Mucosal tolerization to E-selectin protects against memory dysfunction and white matter damage in a vascular cognitive impairment model
    • Wakita H, Ruetzler C, Illoh KO, et al. Mucosal tolerization to E-selectin protects against memory dysfunction and white matter damage in a vascular cognitive impairment model. J Cereb Blood FlowMetab. 2008;28:341-353.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 341-353
    • Wakita, H.1    Ruetzler, C.2    Illoh, K.O.3
  • 102
    • 0034885046 scopus 로고    scopus 로고
    • Themucosal milieu creates tolerogenic dendritic cells and T(R)1 and T(H)3 regulatory cells
    • Weiner HL.Themucosal milieu creates tolerogenic dendritic cells and T(R)1 and T(H)3 regulatory cells. Nat Immunol. 2001;2:671-672.
    • (2001) Nat Immunol , vol.2 , pp. 671-672
    • Weiner, H.L.1
  • 103
    • 0033105296 scopus 로고    scopus 로고
    • Role of central nervous system microvascular pericytes in activation of antigen-primed splenic T-lymphocytes
    • Balabanov R, Beaumont T, Dore-Duffy P. Role of central nervous system microvascular pericytes in activation of antigen-primed splenic T-lymphocytes. J Neurosci Res. 1999;55:578-587.
    • (1999) J Neurosci Res , vol.55 , pp. 578-587
    • Balabanov, R.1    Beaumont, T.2    Dore-Duffy, P.3
  • 104
    • 0141703239 scopus 로고    scopus 로고
    • CD4+CD25+T regulatory cells control anti-islet CD8+T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes
    • Green EA,Gorelik L,McGregor CM, et al. CD4+CD25+T regulatory cells control anti-islet CD8+T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc Natl Acad Sci USA. 2003;100:10878-10883.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10878-10883
    • Green, E.A.1    Gorelik, L.2    McGregor, C.M.3
  • 105
    • 0026046280 scopus 로고
    • Antigen-driven bystander suppression after oral administration of antigens
    • Miller A, Lider O, Weiner HL. Antigen-driven bystander suppression after oral administration of antigens. J ExpMed. 1991;174:791-798.
    • (1991) J ExpMed , vol.174 , pp. 791-798
    • Miller, A.1    Lider, O.2    Weiner, H.L.3
  • 106
    • 0033557738 scopus 로고    scopus 로고
    • Intranasally induced immunological tolerance is determined by characteristics of the draining lymph nodes: StudieswithOVA and human cartilage gp-39
    • Wolvers DA, Coenen-de Roo CJ,Mebius RE, et al. Intranasally induced immunological tolerance is determined by characteristics of the draining lymph nodes: StudieswithOVA and human cartilage gp-39. J Immunol. 1999;162:1994-1998.
    • (1999) J Immunol , vol.162 , pp. 1994-1998
    • Wolvers, D.A.1    Coenen-De Roo, C.J.2    Mebius, R.E.3
  • 107
    • 0346366987 scopus 로고    scopus 로고
    • Nasal vaccination with myelin oligodendrocyte glycoprotein reduces stroke size by inducing IL-10-producing CD4+ T cells
    • Frenkel D, Huang Z, Maron R, et al. Nasal vaccination with myelin oligodendrocyte glycoprotein reduces stroke size by inducing IL-10-producing CD4+ T cells. J Immunol. 2003;171:6549-6555.
    • (2003) J Immunol , vol.171 , pp. 6549-6555
    • Frenkel, D.1    Huang, Z.2    Maron, R.3
  • 108
    • 44449167217 scopus 로고    scopus 로고
    • Induction of immunologic tolerance tomyelin basic protein prevents central nervous system autoimmunity and improves outcome after stroke
    • Gee JM, Kalil A,ThullberyM, Becker KJ. Induction of immunologic tolerance tomyelin basic protein prevents central nervous system autoimmunity and improves outcome after stroke. Stroke. 2008;39:1575-1582.
    • (2008) Stroke , vol.39 , pp. 1575-1582
    • Gee, J.M.1    Kalil, A.2    Thullbery, M.3    Becker, K.J.4
  • 109
    • 77958013973 scopus 로고    scopus 로고
    • Long termimmunologic consequences of experimental stroke andmucosal tolerance
    • Gee JM, Zierath D, Hadwin J, et al. Long termimmunologic consequences of experimental stroke andmucosal tolerance. Exp Transl StrokeMed. 2009;1:3.
    • (2009) Exp Transl StrokeMed , vol.1 , pp. 3
    • Gee, J.M.1    Zierath, D.2    Hadwin, J.3
  • 110
    • 0036712364 scopus 로고    scopus 로고
    • Induction of mucosal tolerance to E-selectin prevents ischemic and hemorrhagic stroke in spontaneously hypertensive genetically stroke-prone rats
    • Takeda H, Spatz M, Ruetzler C, et al. Induction of mucosal tolerance to E-selectin prevents ischemic and hemorrhagic stroke in spontaneously hypertensive genetically stroke-prone rats. Stroke. 2002;33:2156-2163.
    • (2002) Stroke , vol.33 , pp. 2156-2163
    • Takeda, H.1    Spatz, M.2    Ruetzler, C.3
  • 111
    • 33845662118 scopus 로고    scopus 로고
    • Oral tolerance: Therapeutic implications for autoimmune diseases
    • Faria AM,Weiner HL.Oral tolerance: Therapeutic implications for autoimmune diseases. ClinDev Immunol. 2006;13:143-157.
    • (2006) ClinDev Immunol , vol.13 , pp. 143-157
    • Faria, A.M.1    Weiner, H.L.2


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